• CONCLUSION: Additional clinical parameters initially not included in the description of the ACS risk scores provided independent prognostic value, whereby improved global risk assessment. (pulsus.com)
  • In this article, we provide updated data on ruxolitinib therapy for patients with myelofibrosis and offer expert opinion on the appropriate use of this agent in the community practice. (cancernetwork.com)
  • Portal hypertension occurs in approximately 7% of patients with primary myelofibrosis and may be related to increased portal flow resulting from marked splenomegaly and to intrahepatic obstruction resulting from thrombotic obliteration of small portal veins. (medscape.com)
  • Patients with primary myelofibrosis are also prone to developing infectious complications because of defects in humoral immunity. (medscape.com)
  • In patients with primary myelofibrosis, the hematopoietic system is most affected. (medscape.com)
  • Extramedullary hematopoiesis in the spleen of a patient with primary myelofibrosis. (medscape.com)
  • Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
  • However, modern myelofibrosis prognostication systems utilized in risk-adapted treatment approaches do not include bone marrow fibrosis as a prognostic variable. (haematologica.org)
  • Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
  • Myelofibrosis appears to be part of the natural history of the disease but is a reactive, reversible process that does not itself impede hematopoiesis and by itself has no prognostic significance. (basicmedicalkey.com)
  • In approximately 15% of patients, however, myelofibrosis is accompanied by significant extramedullary hematopoiesis, hepatosplenomegaly, and transfusion-dependent anemia, which are manifestations of stem cell failure. (basicmedicalkey.com)
  • The present study aimed to analyze the correlation between platelet-to-lymphocyte ratio (PLR) and platelet-to-neutrophil ratio (PNR) with prognosis of patients who underwent mechanical thrombectomy (MT). (the-jcen.org)
  • F. R. Carvalho - fabianarc@ affects the treatment and prognosis of patients. (bvsalud.org)
  • A major problem for urologists is identifying prognostic factors that can predict cancer progression. (biomedcentral.com)
  • Epidemiology, clinical and prognostic factors of Invasive Meningococcal Disease in a reference center in Paraguay. (una.py)
  • In patients with MT, PLR and PNR on admission could be predictive factors of prognosis and mortality at 3 months. (the-jcen.org)
  • However, the independent functional outcomes of patients after MT is in the 50% range, and is influenced by various factors [ 26 , 35 , 38 ]. (the-jcen.org)
  • Various studies have been conducted to determine the ratios of platelets with WBC subtypes, as diagnostic or prognostic predictive factors. (the-jcen.org)
  • The aim of this study was to improve traditional RSs designed for predicting short-term outcome after ACS through the inclusion of additional prognostic factors critical for long-term prognosis. (pulsus.com)
  • Prognostic value of each RS (SIMPLE, TIMI-STEMI, TIMI-UA/NSTEMI, GRACE in-hospital, GRACE post-discharge, ZWOLLE, LLOYD-JONES) with additional risk factors was evaluated with the area under receiver operating characteristics (ROC) curve. (pulsus.com)
  • Taking these factors into consideration may improve risk stratification of ACS patients. (pulsus.com)
  • Long-term clinical outcomes in patients with acute coronary syndromes (ACS) are dependent on various factors such as the demographic profile of the patient, the extent of myocyte necrosis, and the development of arrhythmic and hemodynamic complications [ 1 ]. (pulsus.com)
  • biology and prognostic factors]. (liverpool.ac.uk)
  • A prospective, 12-month, multicentre study was carried out to assess the clinical characteristics, aetiology, evolution and prognostic factors of elderly patients (≥65 yrs) admitted to hospital for CAP. (ersjournals.com)
  • The results of this study may aid in the management of empiric antibiotic treatment in elderly patients with community-acquired pneumonia and the patients who have a greater probability of bad evolution may be identified based on the risk factors. (ersjournals.com)
  • Mortality also appears to be increased in this group of patients with CAP, with values ranging 15-35% 15 and there are few reports on the prognostic factors associated with the evolution of this disease 8 , 11 , 13 . (ersjournals.com)
  • Since the number of elderly persons in Spain represents an important population, ∼15% of the overall population 16 , a prospective, multicentre study was undertaken by the current authors' group (Area de Tuberculosis e Infecciones Respiratorias) in elderly patients admitted to hospital for CAP, with the aim of determining the clinical characteristics, aetiology, evolution and prognostic factors of this disease in Spain. (ersjournals.com)
  • Dahl M, Aurit SJ, Silberstein PT, Gootee J. Primary Site and Other Prognostic Factors for Fibrosarcoma: An Analysis of the National Cancer Database. (creighton.edu)
  • In developing countries, majority of the lymphoma patients had high prevalence of anemia with bone marrow involvement as one of the causative factors and most of them were diagnosed with advanced stages of disease [3]. (waocp.com)
  • High preoperative and postoperative NLRs, and especially the persistent elevation of preoperative to postoperative NLR, were significant poor prognostic factors for OS in patients with gastric cancer. (biomedcentral.com)
  • however, as patients with the same tumor stage have a heterogeneous prognosis, additional reliable prognostic factors are needed. (biomedcentral.com)
  • We sought to determine risk factors for MDR AB bacteremia in patients colonized with MDR AB in the ICU. (biomedcentral.com)
  • We conducted a retrospective, observational study among patients colonized with MDR AB admitted to our ICU to assess risk factors associated with the development of MDR AB nosocomial bacteremia. (biomedcentral.com)
  • Knowledge of these risk factors will allow recommendations for preventive and therapeutic guidelines for the patients colonized with MDR AB. (biomedcentral.com)
  • While not a curative option, ruxolitinib offers great palliative potential and results in significant reduction in splenomegaly and improvement in constitutional symptoms in the majority of treated patients, thus improving their quality of life and performance status. (cancernetwork.com)
  • Generally, chronic phase is characterized by leukocytosis, anemia and splenomegaly with detection of BCR-ABL fusion gene [6]. (waocp.com)
  • A 39 year-old man was referred to our department because of leukocytosis, mild anemia, and thrombocytopenia (WBC 180000/mmc, Hb 11.8 g/dl, PLT 130000/mmc) associated with splenomegaly. (biomedcentral.com)
  • Patients with massive splenomegaly are particularly prone to thrombotic events because the associated increase in plasma volume masks the true extent of the red cell mass elevation measured by the hematocrit or hemoglobin level. (basicmedicalkey.com)
  • A "normal" hematocrit or hemoglobin level in a PV patient with massive splenomegaly should be considered indicative of an elevated red cell mass until proven otherwise. (basicmedicalkey.com)
  • For patient education information, see the Blood Cancer Directory , as well as Anemia . (medscape.com)
  • For patient education information, see the Cancer Center, as well as Anemia. (medscape.com)
  • Anemia is common in subacute endocarditis, and leukocytosis is a hallmark of acute endocarditis. (medscape.com)
  • Statistical analysis was done to observe the difference in any parameters between patients with anemia and non-anemia. (waocp.com)
  • Six hundred eleven (611) lymphoma patients were involved in this study, 296 (48.5%) had anemia and 314 (51.5%) did not. (waocp.com)
  • Anemia commonly occurs in Indonesian lymphoma patients. (waocp.com)
  • There is an association and increased risk to develop anemia in male, Ann Arbor stage III-IV, underweight, elevated LDH, abnormal platelet, leukocytosis, and high total prognostic score. (waocp.com)
  • Apparently, more than half of lymphoma patients had anemia before diagnosis [2]. (waocp.com)
  • Anemia may cause shortness of breath, cardiovascular complication, poor performance status, impairment of cognitive, and fatigue in lymphoma patients [3]. (waocp.com)
  • The most common type of anemia in patients with lymphoma is anemia of chronic disease, followed with secondary anemia due to marrow involvement, iron deficiency anemia (IDA), vitamin B-12 deficiency, and hemolytic anemia [3]. (waocp.com)
  • Different from prognostic score in Non Hodgkin Lymphoma (NHL), anemia is included in the prognostic score component of HL and is almost found in all HL patients. (waocp.com)
  • Generally, anemia is more frequent in patients with higher stage of lymphoma due to the possible bone marrow involvement. (waocp.com)
  • Anemia in NHL patients without bone marrow involvement may be caused by the production of tumor necrosis factor (TNF) alpha [7]. (waocp.com)
  • Of course, in patients with associated acid-peptic disease, occult gastrointestinal bleeding may lead to a presentation with hypochromic, microcytic anemia, masking the presence of PV. (basicmedicalkey.com)
  • The JAK2V617F mutation is particularly common in the classic MPNs, although it is also found in approximately half of patients with the uncommon myelodysplastic (MDS)/MPN, refractory anemia with ringed sideroblasts and marked thrombocytosis, and at lower frequencies in AML, other myeloproliferative, and myelodysplastic disorders. (oncohemakey.com)
  • To analyze the clinical and epidemiological characteristics of patients with invasive meningococcal infection hospitalized in a reference hospital center. (una.py)
  • A descriptive, observational and retrospective study based in the review of clinical records of patients admitted between 2005 and 2018 in the Institute of Tropical Medicine in whom Neisseria meningitidis was isolated o detected by PCR in blood or CSF. (una.py)
  • However, data on long-term prediction differs depending on the duration of the follow-up periods in the clinical trials and registries and there is no appropriate score for post-discharge risk stratification for patients after ACS. (pulsus.com)
  • In this study, we examined the association of clinical outcome with the Controlling Nutritional Status (CONUT) score during hospitalization in aSAH patients. (nature.com)
  • Here, we retrospectively analyzed the relationship between clinical outcomes and the CONUT score in aSAH patients during hospitalization. (nature.com)
  • This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as the influx of investigational approaches and novel drugs into the pipeline of clinical trials that target pathogenetic mechanisms of the disease. (ashpublications.org)
  • clinical effects of hyperthermia in patients with carcinoma of the esophagus--a multi-institutional cooperative study]. (liverpool.ac.uk)
  • However, in some reports 7 , 8 the clinical picture has been fundamentally acute with few variations with respect to younger patients. (ersjournals.com)
  • Ganti AK, Subbiah SP, Kessinger A, Gonsalves WI, Silberstein PT, Lobriza FR Jr. Association between Race and Survival of Patients with Non-Small Cell Lung Cancer in The United States Veterans Affairs Population:Clinical Lung Cancer-2014 Mar;15(2):152-8. (creighton.edu)
  • In a multivariable logistic regression, adjusting for clinical variables the odds ratios for new onset AF was 1.93 (95% confidence interval 1.0-3.59, P = 0.04) for patients in the third CRPv tertile. (ima.org.il)
  • There is limited clinical information on coronavirus disease-19 (COVID-19) patients in Israel. (ima.org.il)
  • Phase I and II clinical trials) for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) based on the underlying mutational drivers of each disease. (moffitt.org)
  • He has published significantly on this topic including recently in highly regarded journals including Leukemia and Haematologica and these work form the foundation of the clinical trials that he is bringing to patients in order to improve their quality of life and survival. (moffitt.org)
  • As an example, Dr. Sallman has focused research and clinical trial efforts on patients who have TP53 mutation (often associated with complex genes/cytogenetics) given their high risk of transformation to acute leukemia and poor survival. (moffitt.org)
  • Twenty-five percent of patients with staphylococcal bacteremia and 23% of those with catheters as the primary focus have evidence of IE on the basis of transesophageal echocardiography (TEE) findings, in the absence of clinical and transthoracic echocardiography (TTE) findings. (medscape.com)
  • The clinical setting (CoNS are significant in patients with prosthetic valves but not in those with native valves. (medscape.com)
  • The Cotswolds modification maintains the original 4-stage clinical and pathologic staging framework of the Ann Arbor staging system but also adds information regarding the prognostic significance of bulky disease (denoted by an X designation) and regions of lymph node involvement (denoted by an E designation). (medscape.com)
  • Therefore, in this study, we examined the clinical utility of postoperative NLR, and its preoperative to postoperative changes, as prognostic indicators of gastric cancer. (biomedcentral.com)
  • A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia. (cancerindex.org)
  • In this study, we recruited 93 women with PE and 94 normal pregnant women matched for both maternal age and gestastional age as controls to assess the clinical, hemodynamic, and neurohormonal status of patients. (jcgo.org)
  • Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options. (cornell.edu)
  • BACKGROUND: Despite the availability of several acute coronary syndrome (ACS) prognostic risk scores (RSs), there is no appropriate score for post-discharge risk stratification for patients after ACS. (pulsus.com)
  • Despite the availability of several acute coronary syndrome (ACS) prognostic risk scores, the majority of them have mostly been validated with respect to in-hospital and short-term (30-day) use [ 2 - 8 ]. (pulsus.com)
  • These findings indicate that CONUT score during hospitalization may be a useful daily marker for predicting poor outcomes in aSAH patients. (nature.com)
  • Thus, it is important to identify a useful marker of the nutritional status of SAH patients during hospitalization. (nature.com)
  • However, it is unclear whether the CONUT score during hospitalization influences the functional outcomes of aSAH patients. (nature.com)
  • We analyzed the hematological and coagulation parameters of hospitalized patients with COVID-19 at admission, and two and three weeks during hospitalization. (bvsalud.org)
  • New-onset AF during hospitalization occurred in 3.4%, 4.5 %, and 9.1% of patients in the first, second and third CRPv tertiles, respectively ( P for trend = 0.006). (ima.org.il)
  • One such result can lead to 4 days of unnecessary patient hospitalization. (medscape.com)
  • The patient was intubated because of increased ily Picornaviridae ), induces mostly asymptomatic or oxygen dependence. (cdc.gov)
  • didemnin b--an immunosuppressive cyclic peptide that stimulates murine hemagglutinating antibody responses and induces leukocytosis in vivo. (liverpool.ac.uk)
  • METHODS: Blood biomarkers associated with NETs and neutrophil activation (nucleosomal citrullinated histone H3 [H3Cit-DNA], cell-free DNA, and neutrophil elastase) were quantified in patients with VTE. (bvsalud.org)
  • METHODS: Observational prospective single-center study included 672 consecutive patients admitted for ACS and discharged alive between 2002 and 2004. (pulsus.com)
  • Studies using refined methods of X-linked DNA analysis have demonstrated polyclonal hematopoiesis in some patients with essential thrombocythemia and monoclonal hematopoiesis in healthy elderly women [ 11 ]. (medilib.ir)
  • The 30-day and 6-month mortality rate is 39% and 49%, respectively, and only 23% of patients have a favorable outcome, as evaluated using a modified Rankin scale (mRS) score of 0-2 2 . (nature.com)
  • 4 at admission independently predicted patients' functional outcome status at 3 months after aSAH 7 . (nature.com)
  • Acute myeloid leukemia (AML) patients with a high allelic burden of an internal tandem duplication ( ITD )-mutated FMS - like Tyrosine Kinase - 3 ( FLT3 ) have a dismal outcome. (biomedcentral.com)
  • Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. (cancerindex.org)
  • Dr. Sallman's research focuses on the development of novel, targeted therapeutic strategies for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). (moffitt.org)
  • Nevertheless, the identification of novel additional molecular alterations is of great interest, opening to new prognostic and therapeutic strategies for such heterogeneous hematological disease. (cancerindex.org)
  • This study investigated the association between ten clinicopathological characteristics and cancer-specific survival (CSS) in patients with bladder cancer. (biomedcentral.com)
  • RESULTS: This study included 460 patients with VTE, of which 221 (48%) had isolated deep vein thrombosis. (bvsalud.org)
  • Recent results reported that 17% of the patients had primary resistance or loss of response (secondary resistance). (waocp.com)
  • 5 4 In addition to increased disease-related morbidity, MF results in early death with the median survival of affected patients being approximately 6 years. (haematologica.org)
  • Proper patient preparation, accurate blood drawing techniques, and precise measurement are crucial for reliable results. (carepatron.com)
  • We aimed to investigate the correlation between levels of these three biomarkers and neutrophil granulocyte and lymphocyte count in patients with moderate to very severe COPD stratified by use of systemic glucocorticoids. (biomedcentral.com)
  • We included 801 STEMI patients who underwent PCI between 200 7 and 2017 and had their CRP measured with a wide range assay (wr-CRP) at least twice during the 24 hours after admission. (ima.org.il)
  • From 2009 to 2012, 1227 consecutive patients who underwent curative surgery for gastric cancer were enrolled in this study. (biomedcentral.com)
  • Prospectively collected data on 1943 patients with gastric adenocarcinoma who underwent gastrectomy at Seoul St. Mary's Hospital between 2009 and 2012 were reviewed. (biomedcentral.com)
  • Of these patients, 1612 patients underwent curative surgery (R0) for gastric cancer. (biomedcentral.com)
  • Four months after diagnosis the patient underwent unsuccessful bone marrow transplantation from a HLA haploidentical brother. (biomedcentral.com)
  • To investigate the role of certain new inflammatory biomarkers in the diagnosis of patients with FMS. (ima.org.il)
  • In this study data were collected from FMS patients who were admitted to Ziv Medical Center during the period 2013 to 2019 in an attempt to find a connection between inflammatory markers detectable by a traditional complete blood count (CBC) tests such as neutrophil-lymphocytes ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet value (MPV), red cell distribution width (RDW), and C-reactive protein (CRP) and FMS. (ima.org.il)
  • Neutrophil-to-lymphocyte ratio (NLR), YKL-40 and calprotectin are biomarkers of inflammation and predict mortality in patients with different inflammatory diseases. (biomedcentral.com)
  • Inflammatory biomarkers may help to identify a subgroup of COPD patients with a higher level of basal inflammation and with a more rapid disease progression [ 5 ]. (biomedcentral.com)
  • Additionally, ruxolitinib is the only agent that has demonstrated a survival benefit in patients with MF. (cancernetwork.com)
  • Although these predictive variables have contributed to estimating the BCa recurrence risk and survival outcomes, additional variables that can integrate with well-established prognostic models and provide accurate risk grading for BCa patients after RC are critical. (biomedcentral.com)
  • Treatment patterns, and survival of patients with metastatic undifferentiated pleomorphic sarcoma: A National Cancer Database (NCDB) study. (creighton.edu)
  • There is increasing evidence that the local immune response and systemic inflammation support tumor progression in patients with established cancer, adversely affecting their survival [ 3 ]. (biomedcentral.com)
  • We also retrospectively analyzed the overall survival of AML patients with different NFATC1 expression status. (biomedcentral.com)
  • because continued production of mature leukocytes by bone marrow and an intact antibody response are crucial to defense against infection in immunosuppressed patients, we have evaluated the effects of db on these processes as well. (liverpool.ac.uk)
  • Here we review the pathogenesis, biological consequences, and prognostic impact of bone marrow fibrosis. (haematologica.org)
  • Furthermore, the platelet-to-neutrophil ratio (PNR) and platelet-to-WBC ratio (PWR) have been introduced as prognostic markers in patients with AIS [ 4 , 20 ]. (the-jcen.org)
  • Recently, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR), which can be derived from the complete blood count (CBC), have been studied as novel markers of prognosis in patients with PE [ 4 , 5 ]. (jcgo.org)
  • Accurate prognostic indicators would improve the early management of gastric cancer patients, especially those with a poor prognosis. (biomedcentral.com)
  • The presence of FLT3 ITD mutation in young patients with AML and normal cytogenetics is thought to be associated with a poor prognosis. (cornell.edu)
  • Historically, patients with this debilitating disease have had limited treatment options, and disease-modifying agents were not available. (cancernetwork.com)
  • Most of the patients exhibit BCR-ABL protein which forms the target to tyrosine kinase inhibitors that are the main stay of treatment in CML [4]. (waocp.com)
  • Therefore, cytogenetic analysis is not only essential to establish the diagnosis of CML and to assess treatment response but also has prognostic significance if additional cytogenetic abnormalities are detected [5]. (waocp.com)
  • Dr. Tallman focuses on the molecular genetics of APL, current curative treatment strategies and approaches for patients with relapsed and refractory disease. (ashpublications.org)
  • In this study, we wish to learn if there are differences in the treatment effectiveness or in the quality of life of patients based on their type of treatment (e.g. (stanford.edu)
  • Physicians and researchers work close together to provide innovative treatment options for patients. (moffitt.org)
  • Dr. Sallman studies the genetic drivers of myeloid diseases in order to improve prognostication for patients and also to allow for more personalized treatment. (moffitt.org)
  • Rheumatoid factor (ie, "poor man's circulating immune complex") becomes positive in 50% of patients with subacute disease and resolves after successful treatment. (medscape.com)
  • The patient received no further treatment. (biomedcentral.com)
  • Laboratory investigations revelaed white blood cell (WBC) count of 13.6 to 17.9 × 10 9 /L, neutrophils 8.2 to 10.9 × 10 9 /L, and eosinophils 1.8 to 1.9 × 10 9 /L (reference range WBC 3.3 to 10.7 × 10 9 /L, neutrophils 1.6 to 7.2 × 10 9 /L, eosinophils 0.0 to 0.5 × 10 9 /L). The patient received no further treatment and was discharged. (biomedcentral.com)
  • Therefore, identification of potentially severe cases of CDI could provide evidence for appropriate treatment and lead to better patient outcomes. (biomedcentral.com)
  • Gastrectomy with lymph node dissection remains the mainstay treatment for gastric cancer [ 2 ] but the prognosis differs among patients. (biomedcentral.com)
  • Our findings suggest cooperative mechanisms of MSI2 over-expression driven by HOXA proteins and strongly supports MSI2 as a prognostic marker and a candidate in target treatment of CML. (biomedcentral.com)
  • Another sizable contingent of investigators and practitioners favor a different approach (originally published in 2011, newly termed here as "consensus-2"), resembling "consensus-1" in some respects but differing in others, leading to substantial differences between these proposals in the numbers of patients qualifying for diagnosis (and thus treatment). (degruyter.com)
  • Overdiagnosis by "consensus-2" criteria has potential to be problematic, but underdiagnosis by "consensus-1" criteria seems the far larger problem given (1) increasing appreciation that MCAS is prevalent (up to 17% of the general population), and (2) most MCAS patients, regardless of illness duration prior to diagnosis, can eventually identify treatment yielding sustained improvement. (degruyter.com)
  • Calprotectin was related to neutrophil granulocyte count and NLR in patients with moderate to very severe COPD in stable phase and not in treatment with systemic glucocorticoids. (biomedcentral.com)
  • These guidelines for the treatment of patients with sexually transmitted diseases (STDs) were developed by staff members of CDC after consultation with a group of invited experts who met in Atlanta on January 19-21, 1993. (cdc.gov)
  • These recommendations were developed in consultation with experts whose experience is primarily with the treatment of patients in public STD clinics. (cdc.gov)
  • Forty-three patients had active cancer at inclusion and were excluded from the primary analysis Cancer during follow-up was diagnosed in 29 of 417 (7.0%) patients. (bvsalud.org)
  • In patients, primary or acquired resistance to chemotherapy is associated with the expression of P-gp. (ashpublications.org)
  • Lee HG, Aurit S, Silberstein P, Gootee J. Primary anatomical site as a prognostic factor for pleomorphic liposarcoma. (creighton.edu)
  • To evaluate the relation between the change in CRP over time (CRP velocity [CRPv]) and new-onset AF among STEMI patients treated with primary PCI. (ima.org.il)
  • CRPv might be an independent and rapidly measurable biomarker for new-onset AF following primary PCI in STEMI patients. (ima.org.il)
  • These recommendations also should be applicable to other patient-care settings, including family planning clinics, private doctor's offices, and other primary-care facilities. (cdc.gov)
  • CONCLUSIONS: H3Cit-DNA is an independent predictor for occult cancer in patients with VTE and elevated in cancer-associated VTE, suggesting that H3Cit-DNA is potentially a useful diagnostic marker for cancer in patients with VTE and that elevated NET formation is a hallmark of cancer-associated VTE. (bvsalud.org)
  • Clonal evolution occurs in approximately 30% of CML patients in AP and upto 80% in blastic phase. (waocp.com)
  • The clonal process may develop at different progenitor cell levels in individual patients, and the clonal progenitor cell may or may not involve T and B lymphocytes [ 10 ]. (medilib.ir)
  • A total of 503 consecutive patients, ≥65 yrs in age, admitted to 16 Spanish hospitals for CAP from January 1 1997 to December 31 1997, were studied prospectively. (ersjournals.com)
  • 386 patients with moderate to very severe COPD were followed prospectively for 10 years. (biomedcentral.com)
  • These researchers also showed in a prospective observational study of 229 SAH patients that a negative nitrogen balance during the first 14 post-bleed days is a risk factor for infectious complications and is associated with poor outcomes (mRS ≥ 4) at 3 months 11 . (nature.com)
  • We conducted a retrospective, observational study of 200 patients colonized with MDR AB in the ICU at Severance Hospital, South Korea during the outbreak period between January 2008 and December 2009. (biomedcentral.com)
  • This was a retrospective, observational study of 200 patients colonized with MDR AB, admitted to the medical ICUs of Severance Hospital, Seoul, South Korea (a university, tertiary, referral hospital with two 15-bed medical ICUs) from January 2008 to December 2009. (biomedcentral.com)
  • This is a retrospective chart review of all patients who were diagnosed with CML in chronic phase (CP) with additional chromosomal abnormalities (ACAs) over a period of 5 years from 2010 to 2015 at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. (waocp.com)
  • The controlling nutritional status (CONUT) score, which is calculated based on patients' serum albumin, total lymphocytes and total cholesterol, is associated with Full Nutritional Assessment (FNA) and was recently introduced as a nutritional screening tool 12 . (nature.com)
  • 31 patients out of these were found to have additional chromosomal abnormalities at the time of diagnosis in addition to BCR-ABL fusion gene or Philadelphia chromosome detection. (waocp.com)
  • Conventional cytogenetic analysis performed for each patient at the time of diagnosis revealed that 11 (35.5%) of patients had variant Philadelphia chromosome followed by 7 patients (22.6%) with trisomy 8. (waocp.com)
  • It has been reported that around 10% to 12% of patients with CML in chronic phase have ACAs at the time of diagnosis [9]. (waocp.com)
  • An important difference between these proposals is the number of patients who would qualify for an MCAS diagnosis. (degruyter.com)
  • The discovery of an activating point mutation in the Janus kinase 2 gene ( JAK2 V617F) in a significant portion of patients with MPNs led to improved understanding of the pathobiology of these disorders and prompted rapid development of JAK inhibitors. (cancernetwork.com)
  • However, JAK2 V617F mutation analysis has revealed that patients with "polyclonal" essential thrombocythemia might also display the mutation [ 12 ]. (medilib.ir)
  • however, the FLT3 D835 mutation or other mutations in the A-loop(eg, D839, Y842) may occur as an acquired resistance mutation in the setting of patients with FLT3 ITD mutations being treated with targeted therapy. (cornell.edu)
  • With sensitive detection techniques, this mutation is detectable in more than 95% of patients with PV and in 50% to 60% of those with ET or PMF. (oncohemakey.com)
  • The symptoms of hepatic encephalopathy may range from mild to severe and may be observed in as many as 70% of patients with cirrhosis. (medscape.com)
  • If a patient presents with symptoms of conditions like rheumatoid arthritis or systemic lupus erythematosus, this form becomes essential. (carepatron.com)
  • Some of the central nervous system symptoms observed in patients with PV, such as ocular migraine, appear to represent a variant of erythromelalgia. (basicmedicalkey.com)
  • The use of salicylates as a tonic against thrombosis in PV patients is not only potentially harmful if the red cell mass is not controlled by phlebotomy, but is also an unproven remedy. (basicmedicalkey.com)
  • We aimed to assess neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) levels in patients with preeclampsia (PE) compared with matched normal pregnant women and evaluate whether there is an association of PE severity with hematological paramaters. (jcgo.org)
  • We compared NLR and PLR levels in patients with PE with matched normal pregnant women and evaluated whether there is an association of PE severity with hematological paramaters. (jcgo.org)
  • Moreover, in subgroup analysis, patients with severe PE had similar NLR but lower PLR levels compared to women with mild PE. (jcgo.org)
  • To determine the mechanisms underlying MSI2 over-expression in our patient we performed Chromatin Immunoprecipitation and found that NUP98/HOXA13 fusion protein deregulates MSI2 gene by binding its promoter. (biomedcentral.com)
  • OBJECTIVES: To investigate the association between NET formation and occult cancer in patients with VTE. (bvsalud.org)
  • Forty-three percent of the patients required admission to the ICU. (una.py)
  • A total of 432 patients was included, PLR and PNR were calculated from laboratory data on admission. (the-jcen.org)
  • however, death occurs in approximately 15-20% of patients over 5-6 years. (medscape.com)
  • Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)
  • Allogeneic stem cell transplantation is potentially curative and should be considered for patients at high risk. (medscape.com)
  • Do cytokines affect development of fatigue in rheumatoid arthritis patients? (rsu.lv)
  • The following patients were excluded from the study: those who had been previously admitted within the last month, immunosuppressed patients, those with acquired immunodeficiency syndrome or patients receiving chemotherapy or corticosteroids (equivalent doses of prednisone ≥20 mg·day −1 ). (ersjournals.com)
  • Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • Radical cystectomy (RC) with bilateral pelvic lymph node dissection is the gold standard for patients with localized muscle-invasive tumors. (biomedcentral.com)
  • Forty-four patients with invasive meningococcal disease were recruited during the period studied (3 ± 2 cases/year). (una.py)
  • Patients in the ICU, colonized with MDR AB, should be considered for minimizing invasive procedures and early removal of the invasive devices to prevent development of MDR AB bacteremia. (biomedcentral.com)
  • Some patients with cirrhosis are completely asymptomatic and have a reasonably normal life expectancy. (medscape.com)
  • Electroencephalography may be helpful in the initial workup of a patient with cirrhosis and altered mental status, when ruling out seizure activity may be necessary. (medscape.com)
  • may also develop in patients with cirrhosis, especially if iron accumulation coexists. (merckmanuals.com)
  • Approximately one year after resection, the patient was readmitted with metastatic disease to her lungs. (biomedcentral.com)