Point MutationMutation, MissenseMutationFrameshift MutationPrognosisGerm-Line MutationCyclin-Dependent KinasesSurvival AnalysisTumor Markers, BiologicalPedigreeSurvival RateNeoplasm StagingCyclin-Dependent Kinase 5Cyclin-Dependent Kinase 2Mutation RateCyclin-Dependent Kinase 4Base SequenceExonsPolymerase Chain ReactionPredictive Value of TestsDisease-Free SurvivalMolecular Sequence DataRetrospective StudiesAmino Acid SubstitutionHeterozygoteDNA Mutational AnalysisMultivariate AnalysisKaplan-Meier EstimateImmunohistochemistryAllelesBreast NeoplasmsProportional Hazards ModelsPolymorphism, Single-Stranded ConformationalFollow-Up StudiesAmino Acid SequenceTreatment OutcomeMutagenesis, Site-DirectedGenotypeCDC2-CDC28 KinasesTime FactorsHomozygoteSequence Analysis, DNAMutagenesisCodon, NonsenseLymphatic MetastasisCyclin-Dependent Kinase 6PhenotypeDNA-Binding ProteinsCell Cycle ProteinsCDC2 Protein KinaseGene Expression Regulation, NeoplasticDNA PrimersCyclinsCell LineProtein Structure, TertiaryPhosphorylationLung NeoplasmsGenes, RecessiveSequence DeletionNuclear ProteinsTumor Suppressor Protein p53Proto-Oncogene ProteinsTranscription FactorsGenetic TestingAdenocarcinomaGenes, p53Neoplasm Recurrence, LocalDNA, NeoplasmProspective StudiesCell CycleRNA, MessengerProtein BindingProtein-Serine-Threonine KinasesRisk FactorsCohort StudiesDisease ProgressionGenes, DominantBinding SitesNeoplasm ProteinsGene DeletionModels, MolecularChromosome MappingEscherichia coliSuppression, GeneticTumor Suppressor ProteinsCell Line, TumorCodonReverse Transcriptase Polymerase Chain ReactionSequence Homology, Amino AcidCyclin-Dependent Kinase Inhibitor p27Colorectal NeoplasmsKi-67 AntigenDNANeoplasm InvasivenessTransfectionSyndromeCyclin EMembrane ProteinsGenetic Predisposition to DiseaseCarrier Proteins