• Objectives: This quasi-experimental study examined the efficacy of targeted exercise training on gross motor performance and neuromuscular impairments in survivors of childhood acute lymphoblastic leukemia (ALL CCS). (bvsalud.org)
  • It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
  • As noted earlier, patients with acute lymphoblastic leukemia (ALL) may present with fever without any other evidence of infection. (medscape.com)
  • Value of immunophenotype in intensively treated adult acute lymphoblastic leukemia: cancer and leukemia Group B study 8364. (medscape.com)
  • Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: associations with physical performance and chemotherapy doses. (medscape.com)
  • Guideline] NCCN Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia, Version 2:2015. (medscape.com)
  • Treatment of adult acute lymphoblastic leukemia. (medscape.com)
  • Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. (medscape.com)
  • The value of high-dose systemic chemotherapy and intrathecal therapy for central nervous system prophylaxis in different risk groups of adult acute lymphoblastic leukemia. (medscape.com)
  • Short course high dose mitoxantrone with high dose cytarabine is effective therapy for adult lymphoblastic leukemia. (medscape.com)
  • Cytarabine with high-dose mitoxantrone induces rapid complete remissions in adult acute lymphoblastic leukemia without the use of vincristine or prednisone. (medscape.com)
  • Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. (wikipedia.org)
  • Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
  • Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)
  • As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
  • There was a significant improvement in survival of Acute Myeloid Leukemia, Chronic Lymphoid leukemia, CML and ALL, the latter approximately with 90% cure rate in children. (sld.cu)
  • Myeloid markers in adult acute lymphocytic leukemia. (medscape.com)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. (medscape.com)
  • Since its establishment in 2010, the Adult AML Working Group within the JSHCT has been using this registry data to complete several studies focusing on various aspects of HCT in adults with AML, with particular attention paid to patient-, disease-, and transplantation-related factors. (apbmt.org)
  • Various factors including age, sex, performance status (PS), disease status, cytogenetic risk, donor type, graft source, sex mismatch between the donor and the recipient, and year of transplantation were all shown to impact OS 2 . (apbmt.org)
  • 2010) and has been identified as a poor prognostic factor associated with high risk disease with an increased risk of relapse (Cario et al. (atlasgeneticsoncology.org)
  • 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
  • Risk factors include having a family history of the disease, with 10% of those who develop CLL having a family history of the disease. (wikipedia.org)
  • Risk factors include smoking, previous chemotherapy or radiation therapy, myelodysplastic syndrome, and exposure to the chemical benzene. (wikipedia.org)
  • Most people with leukemia are treated with chemotherapy. (healthline.com)
  • Leukemia and other cancers are often treated with chemotherapy and radiation therapy . (healthline.com)
  • Other conditions that should be considered in the evaluation of suspected acute ALL include acute biphenotypic leukemia and natural killer (NK)-cell leukemia. (medscape.com)
  • The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
  • In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
  • The gene is composed of 4 exons and the promoter region contains the regulatory transcription factor binding sites for CREB, POU3F1 and deltaCREB. (atlasgeneticsoncology.org)
  • reviewed in Roll and Reuther, 2010), as well as mutations of the lymphoid transcription factor gene IKZF1 (IKAROS) (Harvey et al. (atlasgeneticsoncology.org)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • Once the cause is determined, prompt treatment is a major factor ensuring a good outcome. (healthline.com)
  • Chronic leukemia showed higher treatment duration. (sld.cu)
  • Treatment of 218 adult acute lymphoblastic leukemias. (medscape.com)
  • Intensification of treatment for adults with acute lymphoblastic leukaemia: results of U.K. Medical Research Council randomized trial UKALL XA. (medscape.com)
  • Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. (medscape.com)
  • The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. (wikipedia.org)
  • Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
  • As an acute leukemia, AML progresses rapidly, and is typically fatal within weeks or months if left untreated. (wikipedia.org)
  • Leukemia is grouped according to how aggressive the cancer is and the type of cells that are affected. (healthline.com)
  • Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
  • 2010). Although P2RY8-CRLF2 fusions have been confirmed as a clear clinical risk factor in paediatric ALL, their precise role in the leukemic process remains to be elucidated with studies supporting involvement in the cellular transformation process but suggesting they function as a secondary capacity in driving the entire leukemic process (Morak et al. (atlasgeneticsoncology.org)
  • Leukemia is the name for a group of cancers of the blood cells. (healthline.com)
  • Lymph node swelling is rare in most types of AML, except for acute myelomonocytic leukemia (AMML). (wikipedia.org)
  • Most cases of AML do not have exposure to any identified risk factors. (wikipedia.org)
  • However, a number of risk factors for developing AML have been identified. (wikipedia.org)
  • [2] [9] Exposure to Agent Orange , certain insecticides , sun exposure , exposure to hepatitis C virus , and common infections are also considered risk factors. (wikipedia.org)
  • As P2RY8-CRLF2 fusion in B-acute lymphoblastic leukaemia (B-ALL) and Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) (Mullighan et al. (atlasgeneticsoncology.org)
  • 17. CD34 expression is associated with major adverse prognostic factors in adult acute lymphoblastic leukemia. (nih.gov)
  • Value of immunophenotype in intensively treated adult acute lymphoblastic leukemia: cancer and leukemia Group B study 8364. (medscape.com)
  • Greaves M. A causal mechanism for childhood acute lymphoblastic leukaemia. (medscape.com)
  • Andersen MK, Christiansen DH, Jensen BA, Ernst P, Hauge G, Pedersen-Bjergaard J. Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992. (medscape.com)
  • The presence of Philadelphia chromosome does not confer poor prognosis in adult pre-B acute lymphoblastic leukaemia in the tyrosine kinase inhibitor era - a surveillance, epidemiology, and end results database analysis. (medscape.com)
  • 50% of Down syndrome-associated acute lymphoblastic leukaemia (Mullighan et al. (atlasgeneticsoncology.org)
  • As P2RY8-CRLF2 fusion in B-acute lymphoblastic leukaemia (B-ALL) and Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) (Mullighan et al. (atlasgeneticsoncology.org)
  • Using retroviral expression screening for transforming genes in biphenotypic acute leukaemia, P2RY8 has been confirmed to have oncogenic potential (Fujiwara et al. (atlasgeneticsoncology.org)
  • There are two subtypes recognized: erythroleukemia and pure erythroid leukemia. (nih.gov)
  • Acute leukemias are due to an anomaly of the stem cell characterized among other things by the expression of CD34(+) CD38(-) surface markers. (nih.gov)
  • We therefore proposed to investigate the prognostic value of the expression of CD34(+) CD38(-) markers in acute leukemias in Abidjan. (nih.gov)
  • 11. B-lineage antigens that are useful to substitute CD19 for minimal residual disease monitoring in B cell precursor acute lymphoblastic leukemia after CD19 targeting. (nih.gov)
  • This CD34(+) CD38(-) phenotype as well as other factors such as tumor syndrome, high leukocytosis and blasts are considered as important factors of poor prognosis. (nih.gov)
  • 16. Biphenotypic leukemic lymphocyte precursors in CD2+CD19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues. (nih.gov)
  • 2010). Although P2RY8-CRLF2 fusions have been confirmed as a clear clinical risk factor in paediatric ALL, their precise role in the leukemic process remains to be elucidated with studies supporting involvement in the cellular transformation process but suggesting they function as a secondary capacity in driving the entire leukemic process (Morak et al. (atlasgeneticsoncology.org)
  • 9. Prognostic significance of the CD10+CD19+CD34+ B-progenitor immunophenotype in children with acute lymphoblastic leukemia: a report from the Children's Cancer Group. (nih.gov)
  • Secondary acute lymphoblastic leukemia is a distinct clinical entity with prognostic significance. (medscape.com)
  • To determine the prevalence and prognostic significance of molecular abnormalities of WT1, runt-related transcription factor (RUNX)1, mixed-lineage leukemia (MLL)-partial tandem duplication (PTD), tet methylcytosine dioxygenase 2 (TET2), Cbl proto-oncogene, E3 ubiquitin protein ligase (c-CBL), v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), and other novel AML-associated genes in pediatric AML. (ucbraid.org)
  • 5. Immunophenotype predicts radiation resistance in T-lineage acute lymphoblastic leukemia and T-lineage non-Hodgkin's lymphoma. (nih.gov)
  • 12. Immunophenotype of acute lymphoblastic leukemia cells: the experience of the Italian Cooperative Group (Gimema). (nih.gov)
  • 1. Lack of CD24 antigen expression in B-lineage acute lymphoblastic leukemia is associated with intrinsic radiation resistance of primary clonogenic blasts. (nih.gov)
  • 2. Radiation resistance of primary clonogenic blasts from children with acute lymphoblastic leukemia. (nih.gov)
  • 3. Intrinsic radiation resistance of primary clonogenic blasts from children with newly diagnosed B-cell precursor acute lymphoblastic leukemia. (nih.gov)
  • 6. Radiation damage repair capacity of primary clonogenic blasts in acute lymphoblastic leukemia. (nih.gov)
  • 10. Sensitivity of primary clonogenic blasts from acute lymphoblastic leukemia patients to an activated cyclophosphamide, viz. (nih.gov)
  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. (cancerindex.org)
  • This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. (cancerindex.org)
  • The gene is composed of 4 exons and the promoter region contains the regulatory transcription factor binding sites for CREB, POU3F1 and deltaCREB. (atlasgeneticsoncology.org)
  • reviewed in Roll and Reuther, 2010), as well as mutations of the lymphoid transcription factor gene IKZF1 (IKAROS) (Harvey et al. (atlasgeneticsoncology.org)
  • The FAB classification system can be useful, but it doesn't take into account many of the factors that are now known to affect prognosis (outlook). (cancer.org)
  • Contribution of Matrix Metalloproteinase-7 Genotypes to the Risk of Non-solid Tumor, Childhood Leukemia. (medscape.com)
  • 4. In vitro and in vivo radiation resistance associated with CD3 surface antigen expression in T-lineage acute lymphoblastic leukemia. (nih.gov)
  • 7. Engagement of the CD19 receptor on human B-lineage leukemia cells activates LCK tyrosine kinase and facilitates radiation-induced apoptosis. (nih.gov)
  • 8. Autologous bone marrow transplantation in high-risk remission B-lineage acute lymphoblastic leukemia using a cocktail of three monoclonal antibodies (BA-1/CD24, BA-2/CD9, and BA-3/CD10) plus complement and 4-hydroperoxycyclophosphamide for ex vivo bone marrow purging. (nih.gov)
  • 13. Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells. (nih.gov)
  • 15. Demonstration of functional CD40 in B-lineage acute lymphoblastic leukemia cells in response to T-cell CD40 ligand. (nih.gov)
  • Prognostic impact of pretreatment cytogenetics in adult Philadelphia chromosome-negative acute lymphoblastic leukemia in the era of minimal residual disease. (medscape.com)
  • Acute lymphoblastic leukemia represents a malignant proliferation of lymphoid cells blocked at an early stage of cell differentiation. (bvsalud.org)
  • For example, the acute promyelocytic leukemia (APL) subtype is often treated using drugs that are different from those used for other subtypes of AML. (cancer.org)
  • In the 1970s, a group of French, American, and British leukemia experts divided AML into subtypes, M0 through M7, based on the type of cell the leukemia develops from and how mature the cells are. (cancer.org)
  • The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. (wikipedia.org)
  • This was based largely on how the leukemia cells looked under the microscope after routine staining. (cancer.org)
  • The World Health Organization (WHO) system, most recently updated in 2016, includes some of these factors to try to better classify AML. (cancer.org)
  • In Côte d'Ivoire, acute leukemias account for 12.5% of hematological malignancies. (nih.gov)
  • Lymph node swelling is rare in most types of AML, except for acute myelomonocytic leukemia (AMML). (wikipedia.org)
  • Most cases of AML do not have exposure to any identified risk factors. (wikipedia.org)
  • However, a number of risk factors for developing AML have been identified. (wikipedia.org)
  • A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. (medscape.com)
  • We retrospectively analyzed the data of 40 children with AML-pCT, treated from 2005 to 2020 within the Polish Pediatric Leukemia and Lymphoma Study Group. (bvsalud.org)
  • Acute leukemias were then identified and distributed using the score proposed by the European Group for the Immunological characterization of Leukemias. (nih.gov)