• We conducted a nationwide, multicenter, prospective registry study for newly diagnosed patients with peripheral T-cell lymphoma (PTCL) to better define the clinical characteristics, treatment patterns, survival outcomes, and the role of upfront autologous stem cell transplantation (ASCT) in these patients. (e-crt.org)
  • Pre-emptive treatment with rituximab of molecular relapse after autologous stem cell transplantation in mantle cell lymphoma. (smw.ch)
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
  • Orelabrutinib has been also approved in China for the treatment of r/r chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and r/r mantle cell lymphoma (MCL). (businesswire.com)
  • On Dec. 25, 2020, orelabrutinib received conditional approval from the China National Medical Products Administration (NMPA) in two indications: the treatment of patients with relapsed/refractory chronic lymphocytic leukemia (CLL) /small lymphocytic lymphoma (SLL), and the treatment of patients with relapsed/refractory mantle cell lymphoma (MCL). (businesswire.com)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • 20% lymphoblasts in marrow), a diagnosis of lymphoblastic lymphoma is made. (medscape.com)
  • Fine-needle aspirate is sufficient for lymphoma diagnosis but rarely adequate for subtyping, thus excisional or incisional biopsy is considered mandatory[5]. (oncolink.org)
  • The subtypes are based on how developed the cancer cells are when you get your diagnosis and how different they are from normal cells. (medlineplus.gov)
  • Doctors sometimes value prognostic scores more than the staging of a cancer diagnosis. (cmlalliance.com)
  • Therefore, the paper outlines the relevant immune signatures for the prognostic diagnosis of breast cancer. (techscience.com)
  • Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
  • [9] If enlarged lymph nodes are caused by infiltrating CLL-type cells, a diagnosis of small lymphocytic lymphoma (SLL) is made. (wikipedia.org)
  • A doctor will carry out several tests to confirm a non-Hodgkin's lymphoma diagnosis. (healthline.com)
  • A lymphoma diagnosis often includes imaging tests. (healthline.com)
  • Reliability of flow-cytometry in diagnosis and prognostic stratification of myelodysplastic syndromes: correlations with morphology and mutational profile. (cdc.gov)
  • Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: analysis of 490 cases. (medscape.com)
  • Socioeconomic status, access to care, risk factor patterns, and stage at diagnosis for head and neck cancer among black and white patients. (who.int)
  • In addition to the approved indications, multi-center, multi-indication clinical trials are underway in the US and China with orelabrutinib as monotherapy or in combination therapies, such as first line treatment of MCD subtype of diffuse large B-cell lymphoma (DLBCL). (businesswire.com)
  • Malignant blast cells (i.e. diffuse large B-cell lymphoma) are fast-growing and result in aggressive disease, whereas malignant mature lymphocytes (i.e. follicular lymphoma) behave indolently. (oncolink.org)
  • HGBL, not otherwise specified (NOS) is a heterogeneous, aggressive, mature B-cell lymphoma that does not meet criteria for BL, DHL, or diffuse large B-cell lymphoma NOS. (cancernetwork.com)
  • SummaryDiffuse large B‑cell lymphoma (DLBCL) comprises 30-40% of non-Hodgkin's lymphoma. (deepdyve.com)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • Abstract Objective To explore the prognostic factors of primary mediastinal large B-cell lymphoma (PMBCL) and the effects of chemoradiotherapy versus chemotherapy alone on patients' prognosis before and after rituximab era. (zlfzyj.com)
  • Effects of Chemoradiotherapy Versus Chemotherapy Alone on Survival of Patients with Primary Mediastinal Large B-cell Lymphoma[J]. Cancer Research on Prevention and Treatment, 2022, 49(03): 205-212. (zlfzyj.com)
  • Prognostic factors, therapeutic approaches, and distinct immunobiologic features in patients with primary mediastinal large B-cell lymphoma on longterm follow-up[J]. Blood Cancer J, 2020, 10(5): 49. (zlfzyj.com)
  • Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B-cell lymphoma with analysis of outcome by molecular subtype[J]. Haematologica, 2012, 97(5): 758-765. (zlfzyj.com)
  • Treatment patterns and comparative effectiveness in elderly diffuse large B-cell lymphoma patients: a surveillance, epidemiology, and end resultsmedicare analysis[J]. Oncologist, 2014, 19(12): 1249-1257. (zlfzyj.com)
  • Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial[J]. Lancet Oncol, 2019, 20(1): 31-42. (zlfzyj.com)
  • This study aimed to assess haematopoietic stem cell transplantation (HSCT) safety and efficacy while exploring strategies for optimising outcomes in patients with hepatitis-associated aplastic anaemia (HAAA). (bvsalud.org)
  • I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
  • Newer treatment therapies, progress in stem cell transplantation, better supportive care and studies of new drugs in clinical trials are all contributing to improved outcomes and quality of life for people diagnosed with blood cancers. (schoolandyouth.org)
  • Hematopoietic stem cell transplantation rates and long-term survival in acute myeloid and lymphoblastic leukemia: Real-World Population-Based Data From the Swedish Acute Leukemia Registry 1997-2006. (sfhem.se)
  • In a multicentre, single-arm, open-label phase 2 study, we enrolled adult patients with Philadelphia-chromosome-negative, primary refractory or relapsed (first relapse within 12 months of first remission, relapse within 12 months after allogeneic haemopoietic stem-cell transplantation [HSCT], or no response to or relapse after first salvage therapy or beyond) leukaemia. (nih.gov)
  • Allogeneic stem cell transplantation is the only known curative therapy for CLL. (medscape.com)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • In patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), however, EFS and OS were not significantly different between FHL2 or iASPP high- and low-expression groups. (nature.com)
  • Aoki J, Kimura K, Kakihana K, Ohashi K, Sakamaki H: Efficacy and tolerability of Entecavir for hepatitis B virus infection after hematopoietic stem cell transplantation. (ycuhri.com)
  • Aoki J, Tsubokura M, Kakihana K, Oshikawa G, Kobayashi T, Doki N, Sakamaki H, Ohashi K: The predictive value for pulmonary infection by area over the neutrophil curve (D-index) in patients who underwent reduced intensity hematopoietic stem cell transplantation. (ycuhri.com)
  • Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation. (cdc.gov)
  • Successful use of allogeneic stem cell transplantation for treatment-refractory mycosis fungoides]. (medscape.com)
  • Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)
  • Hence, with its novel mechanism of action and convenient oral once-daily regimen, venetoclax monotherapy or fixed 24-month combination therapy with rituximab represents an important option for treating RR CLL, including in patients with del(17p) or TP53 mutation and those failing a B cell receptor (BCR) inhibitor and/or chemotherapy. (sagepub.com)
  • Juliusson G. Older patients with acute myeloid leukemia benefit from intensive chemotherapy: an update from the Swedish Acute Leukemia Registry. (sfhem.se)
  • Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
  • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
  • High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • Among patients with solid cancers or lymphomas, up to half develop anemia following chemotherapy. (cancernetwork.com)
  • Several salvage chemotherapy regimens may be considered before ASCT in adult patients. (guidelinecentral.com)
  • Oncogene iASPP enhances self-renewal of hematopoietic stem cells and facilitates their resistance to chemotherapy and irradiation. (nature.com)
  • Multivariate Cox regression analysis showed that age, stage and chemotherapy were independent prognostic factors. (zlfzyj.com)
  • Survival rates vary depending on the type of leukemia, but may be as high as 90% in ALL. (wikipedia.org)
  • Key factors of the pentose phosphate pathway and linoleic acid metabolism, G6PD and CYP2C8/9/18/19, respectively, are related to the survival of PC patients according to our tissue microarray. (aging-us.com)
  • Moreover, recurrence and metastasis are major factors that reduce the survival rate of PC patients [ 3 ]. (aging-us.com)
  • Gene expression-based prognostic signatures have a significant effect on predicting the survival of patients with malignant tumors, such as non-small cell lung cancer [ 7 ] and pediatric acute myeloid leukemia [ 8 ]. (aging-us.com)
  • Still, despite high remission rates, relapses still commonly occur in adults and survival rates for adult patients remain at approximately 20 to 40 percent. (schoolandyouth.org)
  • 6 Comorbidity determined by the hematopoietic cell transplantation-comorbidity index (HCT-CI), 7 predicts for worse survival, generally through higher TRM. (haematologica.org)
  • Attitude Towards Remission Induction for Elderly Patients with Acute Myeloid Leukemia Influences Survival. (sfhem.se)
  • Survival analysis and time receiver operating characteristic curves indicate that the prognostic signature has strong predictive performance. (techscience.com)
  • Survival of patients with chronic myeloid leukemia (CML) has improved significantly since the introduction of tyrosine kinase inhibitors (TKI) in 2001. (haematologica.org)
  • The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)
  • Risk factors and outcomes in hematological patients who acquire invasive fungal sinusitis (IFS) are infrequently reported in the modern medical era. (biomedcentral.com)
  • As a health services researcher, her program primarily concerns evaluating patient outcomes related to healthcare access and cancer late effects, and developing interventions for childhood, adolescent and young adult cancer survivors, with a focus on addressing the social and financial consequences of cancer. (utah.edu)
  • Successful outcomes following allogeneic hematopoietic cell transplant (HCT) may be offset by risks of transplant-related morbidity and mortality. (haematologica.org)
  • Which factors at relapse predict poor outcomes? (guidelinecentral.com)
  • Which pre-ASCT factors predict better outcomes? (guidelinecentral.com)
  • Japan Adult Leukemia Study Group (JALSG): Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group. (ycuhri.com)
  • Prognosis of children and young adults with newly diagnosed rhabdomyosarcoma metastatic to bone marrow treated on Children's Oncology Group studies. (stanfordchildrens.org)
  • Leukemia research 2023 9 134 107390. (cdc.gov)
  • The American Cancer Society estimates that in the United States in 2023 there will be about 20,000 new cases of acute myeloid leukemia (AML) and about 11,300 deaths , almost all in adults. (msdmanuals.com)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • Many investigators have suggested that both lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) may be part of one clinical spectrum of a single malignant lymphoproliferative disorder . (medscape.com)
  • Clinical investigation as well as the mouse model of experimental HCT have consistently shown that timely reconstitution of antiviral CD8 T cells is critical for preventing CMV disease in HCT recipients. (bvsalud.org)
  • Leukemia Society of America, Clinical Scholar Award. (rochester.edu)
  • In this study, clinical characteristics were retrospectively reviewed and their correlation with outcome was evaluated to identify prognostic factors in patients with hematological disorders and IFS. (biomedcentral.com)
  • This is not surprising as there are well-accepted clinical and morphologic differences between pediatric and adult MDS (e.g., bone marrow hypocellularity is more common in children) leading the World Health Organization (WHO) to classify MDS differently in adults and in children 10 . (nature.com)
  • Venetoclax monotherapy or combination therapy with rituximab was an effective treatment, provided durable responses, and had a manageable safety profile in pivotal clinical trials in adults with RR CLL, including in patients with adverse prognostic factors. (sagepub.com)
  • Originally mutation of the epidermal growth factor receptor (EGFR) was the only actionable molecular alteration, now there are more than 10 driver mutations known, and more are detected, and clinical studies are performed. (deepdyve.com)
  • Clinical factors such as a high International Prognostic Index (IPI) or molecular factors as cell of origin (COO) have an influence on the clinical outcome after conventional immunochemotherapy. (deepdyve.com)
  • They may suffer from a cancer type that received less research funding yielding smaller prognostic statistical information and fewer if any clinical trials. (cmlalliance.com)
  • Prognostic models based on immune-related genes help to improve the prognosis prediction and clinical treatment of breast cancer patients. (techscience.com)
  • The translation of research findings into clinical trials is facilitated by the Clinical Trials Unit and by early clinical trial units (ECTU) for adults and for children. (uniklinik-freiburg.de)
  • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? (nature.com)
  • We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
  • Epidemiology and clinical manifestations of cutaneous T-cell lymphoma. (medscape.com)
  • 2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)
  • Although several subtypes of T-cell lymphoblastic leukemia/lymphoma exist, early T-cell precursor lymphoblastic leukemia (ETP-ALL) is the only subtype recognized as an entity in the revised 2016 WHO tumor classification. (medscape.com)
  • Non-ETP subtypes of T-cell lymphoblastic leukemia/lymphoma, in contrast, are associated with activating NOTCH1 mutations in over half of all patients and an additional 10% to 15% of cases have FBXW7 mutations, which also result in increased NOTCH signaling. (medscape.com)
  • High response rates were consistent among patients with different MZL subtypes and those with negative disease prognostic factors at baseline. (businesswire.com)
  • 1 A significant minority of these cases were the especially aggressive B-cell lymphomas Burkitt lymphoma (BL) and high-grade B-cell lymphoma (HGBL), the latter of which includes the histologic subtypes HGBL with MYC and BCL2 and/or BCL6 translocations (conventionally referred to as double-hit lymphoma [DHL]) and HGBL, not otherwise specified (NOS). (cancernetwork.com)
  • Acute myeloid leukemia has a number of subtypes and precursor neoplasms that are distinguished from each other by morphology, immunophenotype, cytochemistry, and genetic abnormalities (see also The 2016 World Health Organization [WHO] Classification of myeloid neoplasms ) all of which have important implications for prognosis and treatment. (msdmanuals.com)
  • Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. (who.int)
  • We sought to confirm the prognostic importance of simple clinically available biomarkers of C-reactive protein, serum albumin, and ferritin prior to allogeneic hematopoietic cell transplantation. (haematologica.org)
  • Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)
  • The nature of disease (indolent vs. aggressive) is correlated to the stage of lymphocytic differentiation of the malignant cells. (oncolink.org)
  • Risk Factors and Trends for HPV-Associated Subsequent Malignant Neoplasms among Adolescent and Young Adult Cancer Survivors. (utah.edu)
  • Minimal residual disease (MRD) refers to the small number of malignant cells that remain after therapy when the patient is in remission and shows no symptoms or overt signs of disease. (smw.ch)
  • Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
  • In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
  • Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
  • Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
  • BEIJING--( BUSINESS WIRE )--American Journal of Hematology recently published the study result of BTK (Bruton Tyrosine Kinase) inhibitor orelabrutinib in patients with relapsed or refractory (r/r) Marginal Zone Lymphoma (MZL), which investigated the efficacy and safety of orelabrutinib in r/r MZL. (businesswire.com)
  • Adults with relapsed or refractory B-precursor acute lymphoblastic leukaemia have an unfavourable prognosis. (nih.gov)
  • Single-agent blinatumomab showed antileukaemia activity in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia characterised by negative prognostic factors. (nih.gov)
  • Amgen, Inc.) for treatment of Philadelphia chromosome-negative relapsed or refractory precursor B-cell acute lymphoblastic leukemia (R/R ALL). (aacrjournals.org)
  • In our practice, hematologic neoplasms are mainly lymphoproliferative syndromes and the most common varieties are non-Burkitt non Hodgkin lymphoma, high grade lymphomas, chronic lymphocytic lymphoma and multiple myeloma. (bvsalud.org)
  • Childhood leukemia is the most common childhood cancer, accounting for 29% of cancers in children aged 0-14 in 2018. (wikipedia.org)
  • This method has excellent performance in identifying prognostic factors for a variety of cancers [ 13 - 15 ]. (aging-us.com)
  • They account for about 4% of newly diagnosed adult cancers and are among the leading causes of cancer mortality. (oncolink.org)
  • Leukemia is a term for cancers of the blood cells. (medlineplus.gov)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • Burkitt lymphoma (BL), in spite of its low incidence throughout most of the world, has had a major impact upon the understanding and treatment of lymphomas and doubtless upon many other cancers. (hindawi.com)
  • Myelodysplastic syndromes (MDS) are a group of blood cancers in which your bone marrow doesn't make enough healthy blood cells. (healthline.com)
  • The estimated overall incidence of acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma in Europe is 1.28 per 100 000 individuals annually, with significant age-related variations (0.53 at 45-54 years, ∼1.0 at 55-74 years and 1.45 at 75-99 years). (medscape.com)
  • Black adults have a threefold to fivefold higher overall incidence of bacteremia (49-58 cases per 100,000 population) than whites (5-8). (cdc.gov)
  • At the end of 2021, orelabrutinib was included into National Reimbursement Drug list to benefit more lymphoma patients. (businesswire.com)
  • Cost of Cancer in Adolescents and Young Adults in the United States: Results of the 2021 Report by Deloitte Access Economics, Commissioned by Teen Cancer America. (utah.edu)
  • We aimed to assess the patterns of local recurrence (LR) in patients with STS treated with surgery with or without RT.We performed a retrospective analysis of adults with STSs evaluated at our institution between 2007-2021. (stanfordchildrens.org)
  • Transplant Cell Ther 2021. (harvard.edu)
  • Lymphoblastic leukemias/lymphomas are neoplasms of precursor T cells and B cells or lymphoblasts. (medscape.com)
  • however, because lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) are known to represent the same disease entity, the World Health Organization (WHO) classification has unified these entities as precursor B-cell and T-cell lymphoblastic leukemia/lymphoma. (medscape.com)
  • U2AF1 pathogenic variants in myeloid neoplasms and precursor states: distribution of co-mutations and prognostic heterogeneity. (cdc.gov)
  • 7/10) was an independent prognostic factor associated with better OS and GFFS. (bvsalud.org)
  • However, these rates can vary significantly, depending on the patient's ALL subtype and other prognostic factors. (schoolandyouth.org)
  • [18] CLLs are, in virtually all cases, preceded by a particular subtype of monoclonal B-cell lymphocytosis (MBL). (wikipedia.org)
  • Acute promyelocytic leukemia (APL) is a subtype of AML with recurrent genetic abnormalities. (msdmanuals.com)
  • Age 10years, alveolar histology, FOXO1 fusion presence, unfavorable primary location, higher Oberlin score, and lack of radiation were identified as poor prognostic/predictive characteristics.This study represents the largest analysis of RMS metastatic to bone marrow, defining the poor prognostic outcome for these patients. (stanfordchildrens.org)
  • Our results suggested that high expressions of FHL2 and iASPP were poor prognostic factors for AML, but the prognostic effect might be overcome by allo-HSCT. (nature.com)
  • The belief that T-cell lymphomas have a worse prognosis than B-cell lymphomas remains controversial. (oncolink.org)
  • Several risk factors and pathologies, including ageing, smoking, obesity and diabetes have been associated with poor prognosis in colorectal cancer patients. (frontiersin.org)
  • The journal has been included in SCIE and SCI databases, with an impact factor of 13.268 in 2022. (businesswire.com)
  • Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
  • Similarly, the miRNA signature shows predictive value in adults with T-cell lymphoblastic lymphoma [ 9 ], and long noncoding RNA shows predictive value in adults with localized clear cell renal cell carcinoma [ 10 ]. (aging-us.com)
  • The most common form childhood leukemia is acute lymphocytic (or lymphoblastic) leukemia (ALL), which makes up 75-80% of childhood leukemia diagnoses. (wikipedia.org)
  • Chronic lymphocytic leukemia (CLL) is another form of chronic leukemia, but is extremely rare in children. (wikipedia.org)
  • Venetoclax for patients with chronic lymphocytic leukemia who progressed during or after idelalisib therapy. (sagepub.com)
  • Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial. (sagepub.com)
  • Chronic lymphocytic leukemia (CLL) is a monoclonal disorder characterized by a progressive proliferation and accumulation of mature yet functionally incompetent lymphocytes. (medscape.com)
  • Peripheral smear from a patient with chronic lymphocytic leukemia, small lymphocytic variety. (medscape.com)
  • Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
  • Among the 16 patients with chronic lymphocytic leukemia, 6 (37.5%) received Rituximab. (bvsalud.org)
  • The distribution of the patients with chronic lymphocytic leukemia was as follows: COP 31.25%, CHOP 31.25%, RCVP 12.5% and R-CHOP 25% and 68.75% had full response. (bvsalud.org)
  • Lymphoblastic lymphoma is associated with exposure to radiation or pesticides and congenital or acquired immunosuppression and is more common in children and young adults. (medscape.com)
  • Lymphoblastic lymphoma is aggressive and progresses rapidly, presenting as stage IV disease in more than 70% of patients (see Staging). (medscape.com)
  • In the United States, lymphoblastic lymphoma is relatively rare, comprising only 2% of all non-Hodgkin lymphomas (NHLs). (medscape.com)
  • T-lymphoblastic lymphoma (T-LBL) accounts for 25-30% of childhood NHL and is closely related to T-lymphoblastic leukemia (T-ALL). (medscape.com)
  • Therefore, we aimed to compare the differential expressions of PD-1, PD-L1 and PD-L2 between the primary and metastatic sites of renal cell carcinoma (RCC). (biomedcentral.com)
  • Renal cell carcinoma (RCC) is originated from the epithelium of renal tubules. (biomedcentral.com)
  • The relationship between blood pressure and risk of renal cell carcinoma. (who.int)
  • Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
  • E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)
  • This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
  • The study population consisted of 784 adults with acute myeloid leukemia in remission or myelodysplastic syndromes undergoing unrelated donor transplant reported to the Center for International Blood and Marrow Transplant Research. (haematologica.org)
  • Molecular markers have shown excellent prognostic performance with the development of genome sequencing technology. (techscience.com)
  • Molecular classification of primary mediastinallarge B-cell lymphoma using routinely available tissue specimens[J]. Blood, 2018, 132(22): 2401-2405. (zlfzyj.com)
  • Childhood leukemia is leukemia that occurs in a child and is a type of childhood cancer. (wikipedia.org)
  • Leukemia is a hematological malignancy or a cancer of the blood. (wikipedia.org)
  • AML is cancer of the blood in which too many myeloblasts (immature white blood cells) are produced in the bone marrow. (wikipedia.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • RATIONALE: Human T-cell lymphotropic virus type 1 can cause cancer. (druglib.com)
  • Giving zidovudine, interferon alfa-2b, and PEG-interferon alfa-2b together may stimulate the immune system and slow down or keep the cancer cell from growing. (druglib.com)
  • The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against cancer. (schoolandyouth.org)
  • The wide applicability of AI approach with enthusiastic commitment from Department of Bioinformatics at MD Anderson Cancer Center, in addition to Department of Leukemia, will ensure the success of the development of AI for this purpose, and allow for the future broad application of the AI project to acute myeloid leukemia and other hematologic malignancies. (mdanderson.org)
  • Non-Hodgkin lymphoma (NHL) is the seventh most common cancer in the United States, with approximately 77,000 new cases and 20,000 deaths in 2020. (cancernetwork.com)
  • Dr. Kirchhoff has a strong history of funding as a Principal Investigator from both institutional grant support and external funding via the NIH and foundations, including an NCI R01 to develop and test insurance educational materials for adolescents and young adults with cancer. (utah.edu)
  • Caring for Children in Relation to Financial Hardship, Advance Care Planning, and Genetic Testing Among Adolescent and Young Adults with Cancer. (utah.edu)
  • COVID-19-Related Employment Disruptions and Increased Financial Burden Among Survivors of Adolescent and Young Adult Cancer. (utah.edu)
  • Hospitalizations in long-term survivors of childhood AML treated with allogeneic HCT-An Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study. (cancercentrum.se)
  • Study protocol for the Fex-Can Childhood project: An observational study and a randomized controlled trial focusing on sexual dysfunction and fertility-related distress in young adult survivors of childhood cancer. (cancercentrum.se)
  • At a recent Leukemia & Lymphoma Society Educational Event, I was reminded that some people may be dispositioned to alcoholism and cancer due to genetic mutations, community dynamics and environmental factors. (cmlalliance.com)
  • Lymphoma occurs if cancer forms in the lymphatic system. (healthline.com)
  • High levels in the blood may be a sign of cancer, including lymphoma, but could also be due to other sources of inflammation. (healthline.com)
  • Kreso A, Dick J. Evolution of the cancer stem cell model. (nature.com)
  • And although pancreatic cancer does have a genetic component, we're also trying to increase the community's awareness of other risk factors such as obesity, smoking and recent onset of diabetes. (evms.edu)
  • Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). (medscape.com)
  • 1991. Alcohol, smoking, and occupational factors in cancer of the larynx: A case control study. (cdc.gov)
  • Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
  • Cancer Prev Res (Phila), factor 1. (who.int)
  • 99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)
  • [ 1 ] ETP-ALL frequently has mutations in RUNX1 and/or ETV6 in addition to genes that are more commonly associated with myeloid neoplasms and are otherwise rare in T-cell lymphoblastic leukemia/lymphoma (such as FLT3 , IDH1/2 , TET2 , and DNMT3A mutations). (medscape.com)
  • Hematologic neoplasms are abnormal and anarchic proliferations of hematopoietic cells with a medullary or peripheral starting point. (bvsalud.org)
  • complete response or partial response) to zidovudine, recombinant interferon alfa-2b, and PEG-interferon alfa-2b therapy in patients with human T-cell lymphotropic virus type 1-associated adult T-cell leukemia/lymphoma (ATLL). (druglib.com)
  • Safe administration of CAR-T cell therapy requires thorough patient selection and patient care in qualified CAR-T cell centers. (deepdyve.com)
  • Prospective minimal residual disease monitoring to predict relapse of acute promyelocytic leukemia and to direct pre-emptive arsenic trioxide therapy. (smw.ch)
  • Acute lymphoblastic leukemia and down syndrome: 6-mercaptopurine and methotrexate metabolites during maintenance therapy. (cancercentrum.se)
  • What are common regimens of salvage therapy before ASCT in adult patients? (guidelinecentral.com)
  • Fatigue is a common side effect of tyrosine kinase inhibitor (TKI) therapy in chronic myeloid leukemia (CML) patients. (haematologica.org)
  • iASPP is a negative regulator of the apoptotic function of p53, and it can enhance the ability of hematopoietic stem cells to self-renew and resist chemo- and radiation therapy. (nature.com)
  • Hata M, Kaneko A, Tomita N, Inoue T: Severe retinopathy following radiation therapy with a moderate dose for orbital mucosa-associated lymphoid tissue lymphoma. (ycuhri.com)
  • Dose-adjusted EPOCH rituximab therapy in primary mediastinal B-cell lymphoma[J]. N Engl J Med, 2013, 368(15): 1408-1416. (zlfzyj.com)
  • My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
  • The spectrum of cutaneous T-cell lymphomas: new insights into biology and therapy. (medscape.com)
  • Sézary syndrome: immunopathogenesis, literature review of therapeutic options, and recommendations for therapy by the United States Cutaneous Lymphoma Consortium (USCLC). (medscape.com)
  • Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)
  • We provide epidemiologic findings and HTLV-1 proviral load (HTLV-1 DNA copies/100 peripheral blood mononuclear cells) for this case-patient and 9 other asymptomatic HTLV-1 carriers of similar demography who reported a history of self-flagellation in Iraq, Pakistan, India, or the United Kingdom ( Table ). (cdc.gov)
  • Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia. (smw.ch)
  • Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease caused by human T-cell lymphotropic virus type 1 that predominantly affects Japanese and Caribbean populations. (oncotarget.com)
  • The aggressive B-cell lymphomas BL, DHL, and HGBL, NOS are unique diseases with specific pathogenesis and biology. (cancernetwork.com)
  • In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. (nature.com)
  • Our data show that, in contrast to adult MDS, Ras/MAPK pathway mutations are common in pediatric MDS (45% of primary cohort), while mutations in RNA splicing genes are rare (2% of primary cohort). (nature.com)
  • Our data confirm that adult and pediatric MDS are separate diseases with disparate mechanisms, and that SAMD9/SAMD9L mutations represent a new class of MDS predisposition. (nature.com)
  • The spectrum of genes harboring germline variants in pediatric MDS has also recently begun to expand beyond transcription factors, including ANKRD26 17 and SRP72 18 . (nature.com)
  • These data suggest that pediatric MDS is separate from adult MDS with disparate underlying mechanisms. (nature.com)
  • Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
  • The key procedure of anti-tumor respond is the activation of T cell and tumor cells can inhibit this process through binding its immune checkpoints to receptors expressed on T-cell, thus leading to immune escape. (biomedcentral.com)
  • However, neither the amount of genomic 5-hmc in ATLL tumor cells nor TET2 expression has been studied yet. (oncotarget.com)
  • By employing a direct in situ approach, we documented that tumor T cells infiltrating lymph nodes exhibit low level of 5-hmc compared to residual normal T cells. (oncotarget.com)
  • Furthermore, this 5-hmc defect was more pronounced in tumor T cells from acute patients than from chronic ones and correlated with reduced expression of TET2 protein. (oncotarget.com)
  • Surprisingly, germline variants in SAMD9 or SAMD9L were present in 17% of primary MDS patients, and these variants were routinely lost in the tumor cells by chromosomal deletions (e.g., monosomy 7) or copy number neutral loss of heterozygosity (CN-LOH). (nature.com)
  • CIBERSORT and TIMER algorithms confirmed that there are significant differences in tumor-infiltrating immune cells in different risk groups. (techscience.com)
  • Although related treatment has improved, there are still challenges in combating tumor heterogeneity due to prognostic prediction difficulty ( Eisenstein, 2015 ). (techscience.com)
  • These changes can be inherited and are, therefore, found in every cell, but more often, they are somatically acquired and restricted to tumor cells. (medscape.com)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
  • Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
  • Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
  • Mycosis fungoides is the most common type, accounting for 60% of CTCLs and almost half of all primary cutaneous lymphomas. (medscape.com)
  • WHO-EORTC classification for cutaneous lymphomas. (medscape.com)
  • Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. (medscape.com)
  • Rook AH, Yoo EK, Grossman DJ, Kao DM, Fox FE, Niu Z. Use of biological response modifiers in the treatment of cutaneous T-cell lymphoma. (medscape.com)
  • Emerging new therapies for cutaneous T-cell lymphoma. (medscape.com)
  • Herrmann JJ, Roenigk HH Jr, Hönigsmann H. Ultraviolet radiation for treatment of cutaneous T-cell lymphoma. (medscape.com)
  • Cutaneous T cell lymphoma: update of treatment. (medscape.com)
  • Sinha AA, Heald P. Advances in the management of cutaneous T-cell lymphoma. (medscape.com)
  • Topical treatment of early cutaneous T-cell lymphoma. (medscape.com)
  • Russell-Jones R. Extracorporeal photopheresis in cutaneous T-cell lymphoma. (medscape.com)
  • Immune escape is mainly caused by histocompatibility complex (MHC) class I, abnormal antigen signaling mechanism, immunosuppressive components (such as HLA-G), Fas and its ligands to activate apoptosis and overexpression of other immunosuppressive molecules, such as lymphocyte activation gene 3 (LAG-3), T cell immunoglobulin and mucin domain 3 (TIM-3) ( Steven and Seliger, 2018 ). (techscience.com)
  • Il s'agissait d'une étude rétrospective descriptive d'une durée de 2 ans 3 mois allant du 1er janvier 2018 au 31 Mars 2020 portant sur 80 dossiers de malades porteurs d'hémopathies malignes et prise en charge dans le centre. (bvsalud.org)
  • ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)
  • However, whether they have prognostic significance in acute myeloid leukemia (AML) is unknown. (nature.com)
  • Hulegårdh E, Hägglund H, Ahlberg L, Karlsson K, Karbach H, Markuszewska A, Persson I, Åström M, Hallböök H. Outcome after HSCT in Philadelphia chromosome positive acute lymphoblastic leukemia in Sweden: a population-based study. (sfhem.se)
  • Favorable outcome of primary mediastinallarge B-cell lymphoma patients treated with sequential RCHOP-RICE regimen without radiotherapy[J]. (zlfzyj.com)
  • and a "sporadic" variant, which most frequently occurs in young adults. (cancernetwork.com)
  • REAL/WHO- [6] - classification includes leukemias and lymphomas, with 3 categories based on lineage and morphology (Hodgkin, B cell, and T/NK cell). (oncolink.org)