INTRODUCTION: Transcatheter arterial chemoembolization (TACE) is the first-line treatment for intermediate stage hepatocellular carcinoma (HCC) and prolongs survival in HCC patients. (bvsalud.org)
However, repeated TACE results in diminished therapeutic response. (bvsalud.org)
To evaluate the effectiveness of transarterial chemoembolization (TACE) combined with lenvatinib and sintilimab in treating patients with midstage hepatocellular carcinoma (HCC). (hindawi.com)
At present, both the European Association for the Study of the Liver (EASL) [ 2 ] and the American Association for the Study of Liver Diseases (AASLD) [ 3 ] recommend transarterial chemoembolization (TACE) as the standard treatment option for patients with intermediate-stage (BCLC stage B) HCC. (hindawi.com)
Primary aim of our analysis was to evaluate the role of transarterial chemoembolization, either with lipiodol (traditional TACE) or drug-eluting microspheres (precision TACE, pTACE), in terms of response rate (RR), time to progression (TTP) and overall survival (OS), in patients with advanced HCC. (biomedcentral.com)
Combined SBRT and immunotherapy resulted in significantly superior survival and less toxicity compared with transcatheter arterial chemoembolization (TACE) [ 14 ]. (biomedcentral.com)
Finding a feeding vessel with diameter greater than 0.9 mm during transarterial chemoembolization (TACE) for hepatocellular cancer (HCC) has been shown to predict tumor necrosis on subsequent pathology. (thieme-connect.de)
We conducted a cohort study to investigate the prognostic significance of vascular endothelial growth factor (VEGF) polymorphisms in hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). (geneticsmr.com)
2,3 However, most HCC patients are beyond these stages at the time of diagnosis, 3 and transarterial chemoembolization (TACE) is the standard of care in a palliative manner in the BCLC intermediate stage. (dirjournal.org)
To clarify the hemodynamic changes under balloon occlusion of the hepatic artery and to identify predictors of the short-term therapeutic effect (TE) after balloon-occluded transcatheter arterial chemoembolization using miriplatin (B-TACE) for hepatocellular carcinoma (HCC). (springeropen.com)
Unfortunately less than half of individuals with advanced-stage HCC benefit from these therapies and the benefits are transient.6 Finally aggressive anti-vascular therapies are available for unresectable HCC-hepatic artery ligation (HAL) and transcatheter arterial chemoembolization (TACE). (researchatlanta.org)
A single-centre cohort study was performed to identify the independent factors associated with the overall survival (OS) of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization with drug-eluting beads (DEB-TACE). (biomedcentral.com)
According to the European and American guidelines [ 3 , 4 ], transarterial chemoembolization (TACE) is the first-line treatment for asymptomatic patients with Barcelona Clinic Liver Cancer (BCLC) B stage disease (which includes multinodular HCC beyond the Milan criteria, without portal invasion or extrahepatic disease) and compensated liver function. (biomedcentral.com)
Transarterial chemoembolization (TACE) is another option for palliative therapy since most of the blood supply to the metastatic site comes from the arteries. (cancertreatmentjournal.com)
AIM: To evaluate and compare the effect of combined transarterial chemoembolization (TACE) and arterial administration of Bletilla striata (a Chinese traditional medicine against liver tumor) versus TACE alone for the treatment of hepatocellular carcinoma (HCC) in ACI rats. (uni-frankfurt.de)
Hepatocellular8
Sorafenib remains one major first-line therapeutic options for advanced hepatocellular carcinoma (aHCC), with modest efficacy. (nature.com)
Hepatocellular carcinoma (HCC) is a vascular tumour with poor prognosis. (nature.com)
In this study, we developed a novel prognostic model for hepatocellular carcinoma based on cuproptosis-related genes that can effectively predict the prognosis of LIHC patients. (biomedcentral.com)
Chemoembolization for hepatocellular carcinoma: multivariate analysis of predicting factors for tumor response and survival in a 362-patient cohort. (thieme-connect.de)
However, the role of miR‑197‑3p in the progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. (spandidos-publications.com)
We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC). (geneticsmr.com)
Intro Despite many treatment options for individuals with early-stage hepatocellular carcinoma (HCC) the mortality rate remains high making HCC the third leading cause of cancer-related death worldwide.1 This high mortality rate reflects the poor prognosis for individuals with advanced-stage HCC the pattern of demonstration and the poor outcome associated with cirrhosis. (researchatlanta.org)
Prediction of Early Treatment Response to Initial Conventional Transarterial Chemoembolization Therapy for Hepatocellular Carcinoma by Machine-Learning Model Based on Computed Tomography. (cdc.gov)
Radiofrequency ablation3
9 Options for treating localized renal cell carcinoma include nephrectomy (open or laparoscopic, total or partial), laparoscopic and percutaneous ablation (for example, radiofrequency ablation, cryotherapy), and minimally invasive catheter techniques such as superselective chemoembolization. (diagnosticimaging.com)
In these patients, local ablative therapies, including radiofrequency ablation (RFA), chemoembolization, and potentially novel chemotherapeutic agents, may extend life and provide palliation. (medscape.com)
Further advances can be expected by new multimodal therapy regimes such as downsizing (chemotherapy, chemoembolization) and therapeutic splitting (surgery and radiofrequency ablation). (thieme-connect.com)
Trans-arterial chemoembolization2
Intra-arterial transcatheter embolotherapies are recommended for non-surgical patients in the intermediate HCC stage, while sorafenib is the standard systemic herapy for patients with advanced HCC and well-preserved liver function and those with intermediate-stage HCC who progress following trans-arterial chemoembolization (TACE). (biomedcentral.com)
Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
Embolization4
These patients are therefore candidates treatment including transarterial embolization and chemoembolization and systemic treatments including chemotherapy, immunotherapy and hormonal therapy [ 6 ]. (biomedcentral.com)
It is unclear whether chemotherapy, arte- rial embolization, or arterial chemoembolization improve survival advantage enough to justify their high toxicity. (pinestreetfoundation.org)
Arterial embolization, chemoembolization, and arterial chemotherapy are the major procedures in chemotherapy. (pinestreetfoundation.org)
Arterial embolization or chemoembolization includes procedures such as transcatheter arterial chemo- embolization, transarterial embolization, hepatic arterial chemoembolization, and hepatic arterial embolization. (pinestreetfoundation.org)
Tumors4
Application of anti-PD-1/PD-L1 antibodies as checkpoint inhibitors is rapidly becoming a promising therapeutic approach in treating tumors, and some of them have successfully been commercialized in the past few years [ 10 ]. (hindawi.com)
Therapeutic options in patients with progressive and disseminated metastatic neuroendocrine gastroenteropancreatic (GEP) tumors are often limited, and prognosis is often poor ( 1 , 2 ). (snmjournals.org)
In this review, we have summarized the therapeutic options for non-colorectal cancer liver metastases in neuroendocrine tumors, gastrointestinal stromal tumors, pancreatic cancer, kidney cancer, and breast cancer. (cancertreatmentjournal.com)
Tumor7
Prognosis and outcome of renal cell carcinoma are influenced by tumor stage and grade at the time of diagnosis. (diagnosticimaging.com)
Current staging systems such as Barcelona Clinic Liver Cancer (BCLC) and 7th American Joint Committee on Cancer (AJCC) cannot accurately predict recurrence and survival, because the individual prognosis is affected by various risk factors including patients' general condition and their tumor characteristics whereas these systems only considered limited variables. (e-crt.org)
The prognosis of HCC patients is influenced by many factors, the most important of which lie in the tumor itself and the underlying liver condition. (xiahepublishing.com)
8 Understanding tumor occurrence and development is of great help in determining their prognosis. (xiahepublishing.com)
Therapy-induced necrosis or vascular normalization may not lead to tumor shrinkage in HCC and may mask the restorative effects of antiangiogenic providers.12 13 As a result establishing techniques that can measure and/or predict the antitumor effects of antiangiogenics will be critical for screening future therapeutic strategies. (researchatlanta.org)
Similar to colorectal cancer, liver metastases of neuroendocrine cancer, gastrointestinal stromal tumor, and pancreatic cancer also determine patient prognosis to some extent. (cancertreatmentjournal.com)
A retrospective analysis of surgery and loco-regional therapy showed that the 5-year survival rate was 71% in partial hepatectomy compared to 31% in liver chemoembolization 4,5 . (cancertreatmentjournal.com)
The cure rate could be further increased through timely identification of patients at risk who might benefit from surgical techniques, such as intra-arterial chemoembolization and/or liver transplantation, which must be carried out in institutions with specific expertise. (biomedcentral.com)
Patients12
The treatment of patients in this stage is more complex than that in the early stage, and their prognosis is better than that in the advanced stage, so special attention should be paid to it. (hindawi.com)
TARE may compete with systemic chemotherapy, sorafenib, in intermediate stage patients with prior chemoembolization failure or advanced patients with tumoral macrovascular invasion with no extra-hepatic spread and good liver function. (biomedcentral.com)
In order to guide the therapeutic approach and to predict the prognosis of patients with HCC, different staging systems are used. (biomedcentral.com)
Nomograms with non-TLV/ICG predicted the prognosis of single large HCC patients accurately and effectively. (xiahepublishing.com)
Besides, patients are in the terminal stages of HCC when diagnosed, unsuitable for surgical resection, and often have other liver diseases, resulting in a poor prognosis. (xiahepublishing.com)
Prognosis of patients with HCC is poor, with a ratio of mortality to incidence of 0.95 [ 2 ]. (oncotarget.com)
Therefore, the miR‑197‑3p/ZIK1 axis may serve as a novel therapeutic target in patients with HCC. (spandidos-publications.com)
This study aimed to evaluate the association between RRM1 and BRCA1 expressions and the therapeutic efficacy of platinum-based chemotherapy in non-small cell lung cancer patients in terms of their response and prognosis. (geneticsmr.com)
Therefore, early detection, professional treatment, and regular follow-up are especially important to achieve positive prognoses for the patients. (biomedcentral.com)
In recent years, major progress has been made in interventional radiology which has allowed the development of minimally invasive therapeutic alternatives with fewer complications for patients not eligible for conventional treatments. (mdpi.com)
Metastases3
Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
With the development of surgical techniques, pharmaceutical research, and perioperative treatment, therapeutic strategies for non-colorectal cancer liver metastases have improved greatly during the last two decades, inevitably leading to some controversies. (cancertreatmentjournal.com)
A systematic review of the therapeutic approaches for various cancer-related liver metastases would provide a better understanding of the latest progression and controversies regarding the surgical options, systematic chemotherapy, and palliative treatment. (cancertreatmentjournal.com)
Synchronous1
The prognosis of synchronous occurrence of double hepatic cancer was poorer than for either HCC or ICC, and the origin of it needs further study. (biomedcentral.com)
Pancreatic cancer1
Pancreatic cancer as a general term usually refers to pancreatic adenocarcinoma, an aggressive malignant cancer with a poor prognosis. (rarediseases.org)
Novel therapeutic1
The combination of RT with anti-PD1 may, therefore, be a novel therapeutic strategy for HCC. (biomedcentral.com)
Approaches1
In fact radical surgery and liver transplantation, the most radical therapeutic approaches, are indicated only in case of early diagnosis. (wjgnet.com)
Poor2
Partial or complete perfusion defect on BO-CTHA was an independent factor associated with poor therapeutic effect. (springeropen.com)
G3 neuroendocrine carcinomas have a similar poor prognosis as pancreatic adenocarinomas. (rarediseases.org)
Survival2
The Cdk5-AMT signal pathway involved in regulation of DDR by TIGAR defines a new role of TIGAR in cancer cell survival and it suggests that TIGAR may be a therapeutic target for cancers. (nature.com)
LTx has shown an improvement in the prognosis and survival with severe cases of ALF. (wikipedia.org)
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (rochester.edu)
Treatment3
The prognosis of HCC has many variables and, thus, the effect of a specific treatment is difficult to evaluate. (bvsalud.org)
Despite the spread of HCC, its treatment it's still a hard challenge, due to high rate of late diagnosis and to lack of therapeutic options for advanced disease. (wjgnet.com)
My philosophy of patient care is based on a personalized approach, providing each patient with comprehensive information regarding his or her diagnosis, treatment options and prognosis. (rochester.edu)
Characteristics1
Two distinct subtypes of LIHC were identified based on cuproptosis-related genes, with different prognosis and immune characteristics. (biomedcentral.com)
Cancer1
Skin Electrical Resistance as a Diagnostic and Therapeutic Biomarker of Breast Cancer Measuring Lymphatic Regions. (cdc.gov)
Targets1
Therefore, it is essential to identify novel biomarkers that simultaneously serve as prognostic predictive markers and therapeutic targets for LIHC. (biomedcentral.com)
Effect1
Debulking surgery has also been reported to enhance the effect of subsequent chemoembolization 4 . (cancertreatmentjournal.com)
Strategy1
Imaging can play an important role in choosing the most appropriate therapeutic strategy. (diagnosticimaging.com)