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  • Expression
  • In this context, it has been demonstrated that high PC4 expression in osteosarcoma correlates with poor prognosis, and suppression of PC4 blocked the pulmonary metastasis by reducing malignancy phenotype through transcriptional level depression of MMP9. (oncotarget.com)
  • brain
  • Astrocytomas that occur in the brain can cause seizures, headaches and nausea. (mayoclinic.org)
  • Your brain surgeon (neursurgeon) will work to remove as much of the astrocytoma as possible. (mayoclinic.org)
  • Since the tumour types look different and have different prognoses it has been assumed that they arise from different cells of origin in the brain, but the fact is that the exact cell of origin has not been determined for any glioma. (eurekalert.org)
  • aggressive
  • Some astrocytomas grow very slowly and others can be aggressive cancers that grow quickly. (mayoclinic.org)
  • It is well established that the deregulation of AKT-mTOR (mammalian target of rapamycin) signaling is involved in carcinogenesis and plays a major role in the development of an aggressive phenotype influencing prognosis and determining response to therapies. (hindawi.com)
  • common
  • The absence of 11 amino acids in the shorter isoform, which seems to be common in astrocytomas, may affect the normal quaternary structure and biological function of CA XII. (pubmedcentralcanada.ca)
  • type
  • Using tumour models for both astrocytoma and oligodendroglioma, which are very similar to human tumours, they could show that one and the same cell type, called oligodendrocyte precursor cells, could give rise to both tumour forms. (eurekalert.org)
  • conclude
  • By analysing gene activity in a large number of human astrocytoma and oligodendroglioma they could also conclude that the tumours are more similar to one another than was previously believed. (eurekalert.org)