The recent cloning and sequencing of a gene coding for a membranous progesterone receptor [ 5 ] in African clawed frog ( Xenopus laevis ) brought evidence for the existence of both intracellular and membrane progestin receptors [ 6 ]. (biomedcentral.com)
Specific1
There was, however, a specific, significant inhibition of progesterone-induced FSH but not LH release when the 5α-reductase inhibition was sustained throughout the afternoon of the gonadotropin surge. (elsevierpure.com)
Significant1
These results indicate a biologically significant role for the irreversible 5α-reduction of progesterone in the modulation of the release of FSH. (elsevierpure.com)
5alpha-dihydroprogesterone2
17. The anti-aromatase effect of progesterone and of its natural metabolites 20alpha- and 5alpha-dihydroprogesterone in the MCF-7aro breast cancer cell line. (nih.gov)
Uptake of (3H)progesterone and (3H)5alpha-dihydroprogesterone by rat tissues in vivo and analysis of accumulated radioactivity: accumulation of 5alpha-dihydroprogesterone by pituitary and hypothalamic tissues. (nih.gov)
Placenta3
5-Alpha-dihydroprogesterone formation in human placenta from 5alpha-pregnan-3beta/alpha-ol-20-ones and 5-pregnan-3beta-yl-20-one sulfate. (nih.gov)
Se convierte de progesterona en 20-alfa-hidroxipregn-4-en-3-ona por acción de la 20-ALFA-HIDROXIESTEROIDE DESHIDROGENASA en el CUERPO LÚTEO y la PLACENTA. (bvsalud.org)
Pregnenolone3
Coupling high performance liquid chromatography with gas chromatography- mass fragmentography has made it possible to simultaneously measure subpicomolar concentrations of allopregnanolone and its precursors, pregnenolone, progesterone and 5 alpha-dihydroprogesterone (5 alpha- DHP) in various brain areas. (jneurosci.org)
Infusion of pregnenolone sulfate in ADX/CX rats elicited a fourfold increase in 5 alpha-DHP and progesterone content and a seven- to eightfold increase in the content of allopregnanolone in brain but not in liver or plasma. (jneurosci.org)
The 5 alpha-reductase inhibitor, (17 beta)17[[bis(1- methylethyl)amino]carbonyl] androstane-3,5-diene-3-carboxylic acid (SKF 105111), reduced the brain content of allopregnanolone and blocked the increased formation of allopregnanolone in brain following pregnenolone sulfate infusion. (jneurosci.org)
Estradiol3
20. Estradiol as an anti-aromatase agent in human breast cancer cells. (nih.gov)
The specificity of the effect of progesterone treatment of the nuclei or cytosol in depleting nuclear estradiol receptors in vitro will be studied by examining the effects of cholesterol, corticosterone and 5 Alpha-dihydrotestosterone. (elsevierpure.com)
In these studies, cytoplasmic and nuclear estradiol and progesterone receptors will be measured after treatment of castrated rats with various estrogen and progesterone regimens. (elsevierpure.com)
Hypothalamic1
The effect of progesterone metabolites on hypothalamic LHRH secretion will be evaluated by measuring medial basal hypothalamic, preoptic area, and plasma LHRH levels along with serum LH and FSH levels at 15 min intervals after injecting the progestin in estrogen-primed castrated rats. (elsevierpure.com)
Metabolites3
and 3 Beta, 5 Alpha-reduced metabolites of progesterone on FSH and LH secretion. (elsevierpure.com)
The direct effect of progesterone and its metabolites on the pituitary will be determined by studying the effect of the steroids on cellular content and basal and LHRH stimulated release of LH and FSH in dispersed pituitary monolayer cell cultures. (elsevierpure.com)
The time course of progesterone effects on anterior pituitary nuclear estrogen receptors will be studied at 1, 2, 3, 4, 8 and 12 hrs after the progesterone injection in vivo and the effects of progesterone metabolites on estrogen receptor dynamics will be evaluated. (elsevierpure.com)
Vivo1
however, the AED effect was independent of TNF-alpha suppression, both in vivo and in vitro. (lookformedical.com)
Estrogen4
9. Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor alpha. (nih.gov)
Whether transcription and/or protein synthesis is involved in the action of progesterone in the reduction of occupied nuclear estrogen receptors will be determined by using actinomycin-D and cycloheximide. (elsevierpure.com)
Experiments will be done to determine the interactive effects of progesterone on estrogen receptors and estrogens on progesterone receptors and to determine if progesterone modulates its own receptors. (elsevierpure.com)
Emphasis is given to preclinical studies that examined genomic and rapid membrane effects of estrogen, progesterone, glucocorticoids, and GABAergic neurosteroids for their effects on alcohol drinking and models of relapse. (nih.gov)
Selective1
The selective release of FSH by 5 Alpha-dihydroprogesterone and selective release of LH by 3 Alpha-hydroxy-5 Alpha-pregnant-20-one will be confirmed in the 21-day-old rat injected with pregnant mare's serum gonadotropin. (elsevierpure.com)
Inhibitor1
The requirement for 5 Alpha-reduction of progesterone for FSH release will be tested by using a 5 Alpha-reductase inhibitor. (elsevierpure.com)
Lactation1
The treatment (4 µg/kg body weight/day) started the day 0 of pregnancy and continued throughout pregnancy, lactation, and lasted for a total of 20 weeks. (bvsalud.org)
Effects1
Antinociceptive effects of the neuroactive steroid, 3alpha-hydroxy-5alpha-pregnan-20-one and progesterone in the land snail, Cepaea nemoralis. (nih.gov)
Effect1
DHEA appears to mediate its protective effect by a mechanism that blocks the toxin-induced production of pathophysiological levels of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1. (lookformedical.com)
Similar1
The incidence of headache is between 12 and 20%, which is similar to the incidence of headache found in patients taking placebos in the studies that lead to zafirlukast's approval. (mdwiki.org)