ProgeriaWerner SyndromeAging, PrematureLamin Type ASyndromeSkin AbnormalitiesCockayne SyndromeFarnesyltranstransferaseLipodystrophyMutationProtein PrecursorsPoint MutationMutation, MissensePedigreePhenotypeFrameshift MutationTrichothiodystrophy SyndromesEhlers-Danlos SyndromeDNA Mutational AnalysisRecQ HelicasesAbnormalities, MultipleHeterozygoteGerm-Line MutationExonsBase SequenceGenetic TestingCell AgingGenotypeDown SyndromeMolecular Sequence DataPolymerase Chain ReactionNuclear ProteinsMetabolic Syndrome XGalactosyltransferasesAllelesHomozygoteSequence Analysis, DNALongevityAgingAmino Acid SubstitutionPolymorphism, Single-Stranded ConformationalExodeoxyribonucleasesDisease Models, AnimalGenetic Predisposition to DiseaseCodon, NonsenseMembrane ProteinsMetalloendopeptidasesGenes, RecessiveFibroblastsEndonucleasesDNA-Binding ProteinsMutation RateDNA RepairAmino Acid SequenceNephrotic SyndromeMice, KnockoutFructose-1,6-Diphosphatase DeficiencyDNA PrimersFamily HealthSjogren's SyndromeCells, CulturedAtaxia TelangiectasiaCell LineGenes, p53Protein Structure, TertiarySignal TransductionChromosome Mapping