• Epidermal growth factor (EGF) and fibroblast growth factor (FGF) are mitogens that promote neural progenitor and stem cell growth in vitro, though other factors synthesized by the neural progenitor and stem cell populations are also required for optimal growth. (wikipedia.org)
  • Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates [2] "Better understanding of the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. (edu.au)
  • Here, we use RNA sequencing, cell imaging, and lineage tracing of mouse and human in vitro NSCs and monkey brain sections to model the generation of cortical neuronal fates. (edu.au)
  • The requirements for the successful culture of organoids in vitro differ significantly from those of traditional monolayer cell cultures. (mdpi.com)
  • In the present study, our aim was to establish an in vitro cell model based on patient-specific human neurons to study the pathomechanism of sporadic AD. (biomedcentral.com)
  • In the adult CB, neurotransmitters and vascular cytokines released by glomus cells upon exposure to chronic hypoxia act as paracrine signals that induce proliferation and differentiation of pluripotent stem cells, neuronal and vascular progenitors. (bvsalud.org)
  • In 2016, Axiogenesis AG and Metrion Biosciences Ltd., joined forces with the aim to validate, optimize, and commercialize induced pluripotent stem cell-derived cells and tissues to speed up research in drug discovery. (medgadget.com)
  • Evaluation of the cardiotoxicity of mitragynine and its analogues using human induced pluripotent stem cell-derived cardiomyocytes. (1library.org)
  • Comparative analysis of human induced pluripotent stem cell-derived mesenchymal stem cells and umbilical cord mesenchymal stem cells. (reprocell.com)
  • This research is the first to produce induced pluripotent stem cell-derived inner ear sensory neurons in the Neurog1 +/− heterozygote mouse using blastocyst complementation. (biomedcentral.com)
  • Mouse utricle sensory epithelial cellCderived progenitor cells (MUCs), which possess locks cell progenitor and mesenchymal features via epithelial-to-mesenchymal changeover (EMT) seeing that previously described, provide a potential strategy for locks cell regeneration via cell transplantation. (forgetmenotinitiative.org)
  • Hiroshi Kawamoto interconnects Cell, Gene rearrangement, Gene and Transplantation in the investigation of issues within Molecular biology. (research.com)
  • WO 2001/046401 discloses embryonic or stem-like cells produced by cross species nuclear transplantation. (justia.com)
  • To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
  • Impact of Diabetes Mellitus on Human Mesenchymal Stromal Cell Biology and Functionality: Implications for Autologous Transplantation. (shengsci.com)
  • Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination. (1library.org)
  • BC is the only current method for making fully functional, three-dimensional organs from pluripotent cells and generating human organs in large mammalian hosts may be able to address the critical worldwide problem of organ shortages for transplantation [ 16 ]. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) the most significant stem cells for cell therapy were first isolated and characterized in 1974 and have been used in the clinic since 2004. (mastercellbank.com)
  • Human iPSC derived cardiovascular and neuronal cells are being used in preclinical studies and will find use in clinical application as cell therapies. (mastercellbank.com)
  • Tra 1-60+ iPSC colonies were picked and re-plated on matrigel coated 12-well plates and maintained in mTeSR 1 (Stemcell Technologies, 85850). (nih.gov)
  • Our in vivo analysis also confirmed the expression of synemins H/M in multipotent neural stem cells in the subventricular zone of the adult brain, a neurogenic germinal niche of the mice. (biomedcentral.com)
  • Rossant, J. & Lis, W. T. Potential of isolated mouse inner cell masses to form trophectoderm derivatives in vivo . (nature.com)
  • Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
  • We demonstrate an in vivo electroporation protocol for transfecting single or small clusters of retinal ganglion cells (RGCs) and other retinal cell types in postnatal mice over a wide range of ages. (jove.com)
  • The robustness and efficacy of the retrodifferentiation process in generating unprecedented quantities of stem cells belonging to the three germ layers will enable organ and tissue reconstruction ex vivo, using bio-printing and various scaffold materials. (eurekaselect.com)
  • Restitution of miR122 in BCLC9 cells, decreases cell proliferation rate and reduces significantly tumor size in vivo . (oncotarget.com)
  • allogenic natural killer cells (NK-cells) generated ex vivo from umbilical cord blood progenitor cells in cancer immunotherapy. (mastercellbank.com)
  • With growth, these proliferate and, in a remarkably articulated manner, progressively differentiate into multipotent stem cells (Type B), progenitor cells (Type C), mature body somatic cells (Type E), and many eventually become senescent cells (Type E). (anti-agingfirewalls.com)
  • In essence, early-on the body sets up pools of stem and progenitor cells to replace lost somatic cells. (anti-agingfirewalls.com)
  • A dedifferentiation program was suggested for inducing differentiated somatic cells to become pluripotent embryonic-like stem cells (Halley-Stott et al. (forgetmenotinitiative.org)
  • Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. (biorxiv.org)
  • One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)
  • A new cell therapy, donor lymphocyte infusion, emerged in the 1990s to ensure that the donor stem cells remain engrafted whereby lymphocytes from the blood of a donor are given to a patient who has already received a hematopoietic stem cells from the same donor. (mastercellbank.com)
  • Hematopoietic stem cells (HSCs) used in the treatment of cancers and other immune system disorders are found in the red bone marrow in the central part of most bones but principally in the pelvis, femur, and sternum. (mastercellbank.com)
  • The mature glomus cells express numerous trophic and growth factors, and their corresponding receptors, which act on CB cell populations in autocrine or paracrine ways. (bvsalud.org)
  • Therefore, the therapeutic use of appropriate populations derived from stem and progenitor cells has been considered for cell-based therapies for neurodegenerative diseases, primarily Parkinson's disease, and brain injuries. (ehu.eus)
  • As a stem cell biologist, I aim to understand the mechanisms through which stem cells differentiate into progressively specialized cell types and to harness this knowledge to artificially generate pure populations of desired cell types from stem cells. (stanford.edu)
  • Current differentiation strategies typically generate heterogeneous cell populations unsuitable for basic research or clinical applications. (stanford.edu)
  • Revealing cell populations catching the early stages of the human embryo development in naïve pluripotent stem cells. (axonmedchem.com)
  • These findings can be integrated in a new unified framework that regards the early mammalian embryo as a self-organizing system. (nature.com)
  • The early mammalian embryo consists of the extra-embryonic cell layers-the trophoblast and a body of cells called the inner cell mass (ICM), which eventually become the embryo proper. (thefutureofthings.com)
  • The different expression of isoforms H, M and L of synemin in the nervous system raises several questions about the regulation of synemin gene expression during the determination of glial and neuronal cell lineages in the central and the peripheral nervous system (CNS and PNS). (biomedcentral.com)
  • The CB structural plasticity depends on the existence of a population of multipotent neural crest-derived stem cells, which are activated during hypoxia to proliferate and differentiate into new both neuronal (glomus) and vascular cell types. (bvsalud.org)
  • My laboratory investigates transcriptional and post-transcriptional mechanisms that regulate mammalian neural stem cells and neuronal development. (winstepforward.org)
  • His postdoctoral work focused on the role of post-transcriptional mechanisms in mammalian cell fate. (distefano-lab.com)
  • In latest years, regeneration of locks cells offers produced guaranteeing outcomes (Groves et al. (forgetmenotinitiative.org)
  • Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration. (biomedcentral.com)
  • Thus, small molecules capable of influencing the fate decisions and differentiation programs of multipotent progenitor cells could facilitate therapeutic regeneration of lost myocardium. (biomedcentral.com)
  • Cell fate decisions, including events that occur naturally (e.g., development, differentiation, regeneration, and homeostasis) and experimentally (e.g., reprogramming to induced pluripotent stem (iPS) cells, directed differentiation, transdifferentiation), are typically mediated by transcription factors in concert with epigenetic modifications. (distefano-lab.com)
  • His research integrates issues of Molecular biology, Human leukocyte antigen and Regeneration in his study of Induced pluripotent stem cell. (research.com)
  • During limb epimorphic regeneration: committed mesenchymal cells at the stump site dedifferentiate, forming a cluster of heterogeneous population of stem cells, known as the blastema. (eurekaselect.com)
  • Epimorphic regeneration and retrodifferentiation both have the capacity to recreate and reconstruct tissue with precise positional integration of cells in such a way that will enable us to heal without scars and to understand how to maintain tissue integrity and architecture in the face of a hostile environment. (eurekaselect.com)
  • These cells play a critical role in the regeneration and restoration of injured sites. (shengsci.com)
  • This review considers the genetic and epigenetic control of nephrogenesis, together with the epigenetic mechanisms that accompany kidney development and recent advances in induced reprogramming and kidney cell regeneration in the context of DN. (emjreviews.com)
  • In the adult, stem cells exist in many tissues throughout life and may play critical roles in physiological functions and tissue regeneration. (winstepforward.org)
  • Here we identified which architectural principles of functional connectome organization are initiated prior to birth , and contrast those with topological characteristics observed in the mature adult brain. (edu.au)
  • We identified efficient network attributes, common functional modules and high overlap between the fetal and adult brain network. (edu.au)
  • Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
  • Recently, RNAs have been shown to be selectively sequestered in cytoplasmic condensates, however, the functional role and composition of RNA condensates during cell fate specification remain unknown. (distefano-lab.com)
  • The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
  • The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
  • Very few studies have addressed the functional roles of the bimodal heterogeneity of Nanog expression in the differentiation and specification process of stem cells. (biomedcentral.com)
  • Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. (lww.com)
  • Efficient commitment to functional CD34+ progenitor cells from human bone marrow mesenchymal stem-cell-derived induced pluripotent stem cells. (1library.org)
  • Cord blood is now being enriched with functional stem and progenitor cells and also immune modulatory cells. (mastercellbank.com)
  • Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. (reprocell.com)
  • Using exogenous stem cells to replace lost inner ear neurons is a potential strategy if stem cell-derived neurons can form central and peripheral connections, form synapses on hair cells and cochlear nucleus neurons, and re-establish functional and tonotopic circuits [ 6 ]. (biomedcentral.com)
  • The idea to use transplants of dopa- ment of protocols that allow generation of fully functional mine-producing cells to substitute for the lost midbrain and safe midbrain dopamine neurons from stem cells. (lu.se)
  • Differences in the size of the central nervous system are among the most important distinctions between the species and thus mutations in the genes that regulate the size of the neural stem cell compartment are among the most important drivers of vertebrate evolution. (wikipedia.org)
  • In this study, we maintained mesenchymal-like MUCs in adherent cultures to test new methods that were able to guide MUCs to buy SB-649868 become a number of epithelial cells expressing epithelial genes such as in MUCs. (forgetmenotinitiative.org)
  • Cells become cancerous by accumulating, stepwise, a series of several mutations that alter the function of genes important for cell growth. (agemed.org)
  • The mtDNA contains only 37 genes, thus most of the gene products in the mammalian body are encoded by nuclear DNA. (justia.com)
  • In terms of the gene regulatory network defining cellular potency, Nanog has direct mutual interactions with two other core stem cell specific genes Oct4 and Sox2. (biomedcentral.com)
  • BCLC9-miR122 cells down-regulate expression of MYC, KLF4, FOXM1, AKT2 and AKT3 genes and up-regulate FOXO1 and FOXO3A gene expression. (oncotarget.com)
  • Variation of DNA methylation on the IRX1/2 genes is responsible for the neural differentiation propensity in human induced pluripotent stem cells. (reprocell.com)
  • This work validates the use of blastocyst complementation as a tool to create novel insight into the function of developmental genes and highlights blastocyst complementation as a potential platform for generating chimeric inner ear cell types that can be transplanted into damaged inner ears to improve hearing. (biomedcentral.com)
  • The current research activity focuses at unravelling the genetic and the molecular basis of embryo development, with particular emphasis on the early stages of mammalian embryogenesis as well as on muscular, cardiovascular and neural differentiation. (cnr.it)
  • The contributors describe how the first cell lineages arise in the mammalian embryo, stem cell dynamics during the development and homeostasis of specific tissues (e.g., epithelia and brain), and what happens when stem cell integrity is compromised (e.g., by DNA mutations). (cshlpress.com)
  • According to a simplified model of this theory a newly-conceived human embryo consists of pluripotent stem cells (Type A), ones that can potentially divide into any body cells. (anti-agingfirewalls.com)
  • At conception, the embryo is all Type A cells. (anti-agingfirewalls.com)
  • The mechanisms underlying the appearance of asymmetry between cells in the early embryo and consequently the specification of distinct cell lineages during mammalian development remain elusive. (nature.com)
  • Louvet-Vallee, S., Vinot, S. & Maro, B. Mitotic spindles and cleavage planes are oriented randomly in the two-cell mouse embryo. (nature.com)
  • This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)
  • Many chapters illustrate how single-cell profiling, stem-cell-derived organoids, intravital microscopy, lineage tracing, quantitative modeling, and other modern approaches have offered important insights. (cshlpress.com)
  • In addition, the authors consider the potential of stem-cell-based therapies in the clinic (e.g., for treating retinal diseases and skin disorders) and the innovations that are facilitating the development of those therapies, including various lineage reprogramming strategies and new biomaterials that modulate stem cell properties. (cshlpress.com)
  • During development and lineage specification, pluripotent and adult stem cells generate the diverse arrays of specialized cells of the adult body. (distefano-lab.com)
  • He has included themes like Lineage, Haematopoiesis and B cell in his Progenitor cell study. (research.com)
  • or movements in a free energy landscape such that lineage choices are paths between stable cell states. (lu.se)
  • In response to ligation of monomorphic regions of MHC class II antigens with monoclonal antibody CR3/43, human leukocytes retrodifferentiate into a variety of heterogeneous stem cell types belonging to the mesoderm, ectoderm or endoderm lineage, depending on culture media and conditions. (eurekaselect.com)
  • During this process, leukocytes lose lineage-associated markers home and undergo homocytic aggregation, upregulate expression of stem cell antigens, and subsequently redifferentiate to give rise original tissue or, transdifferentiate into a different tissue altogether. (eurekaselect.com)
  • However, more recent data have revealed that the majority of the newly formed glomus cells is derived from the glomus cell lineage itself. (bvsalud.org)
  • miR122 is the prevalent miRNA in adult healthy liver and it is responsible for liver stem cell differentiation towards hepatocyte lineage. (oncotarget.com)
  • To address this challenge, I mapped the cascade of branching lineage choices through which PSCs differentiate into various endodermal and mesodermal cell types. (stanford.edu)
  • BC is a technique in which deletion of a key gene for the development of a specific lineage creates a vacant niche (organogenesis-disabled phenotype) that can be complemented by the progeny of wild type pluripotent stem cells injected into embryos at the blastocyst stage of development. (biomedcentral.com)
  • Because FOX proteins regulate neural stem cell homeostasis, FOX proteins have been used to protect neural stem cells by inhibiting Wnt signaling. (wikipedia.org)
  • Moreover, my lab is testing the hypothesis that RNA sequestration is critical to maintaining adult tissue homeostasis. (distefano-lab.com)
  • Besides the well-known role of miR122 in favoring hepatitis C virus replication in hepatocytes [ 4 ], its function in the normal adult liver is related to cholesterol and lipid homeostasis [ 5 ]. (oncotarget.com)
  • The interest of the Institute in developmental biology is rooted back at the time when IGB researchers pioneered mouse genetics using gene targeting techniques to study mammalian embryonic development. (cnr.it)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines recent progress in our understanding of stem cell biology and how the properties of stem cells can be manipulated for therapeutic purposes, emphasizing the roles that cutting-edge technologies and interdisciplinary approaches have played in this work. (cshlpress.com)
  • Thus, uncovering and understanding new molecular and cellular pathways that govern HSPC cell fate is critical for basic biology and to develop new therapeutic strategies for hematologic disorders. (distefano-lab.com)
  • Hiroshi Kawamoto mostly deals with Immunology, Cell biology, Progenitor cell, Population and T cell. (research.com)
  • His Cell biology research incorporates themes from Cellular differentiation, Interleukin-7 receptor, Lymphocyte, Cytotoxic T cell and Cell type. (research.com)
  • Hiroshi Kawamoto works mostly in the field of T cell, limiting it down to topics relating to Molecular biology and, in certain cases, T-cell receptor. (research.com)
  • Hiroshi Kawamoto focuses on Cell biology, Immunology, Progenitor cell, T cell and Molecular biology. (research.com)
  • His Cell biology study combines topics from a wide range of disciplines, such as Cellular differentiation, Enhancer, Transcription factor, Cell fate determination and Regulation of gene expression. (research.com)
  • The scientist's investigation covers issues in Cancer research, Cell biology, T-cell receptor, Induced pluripotent stem cell and Cytotoxic T cell. (research.com)
  • Hiroshi Kawamoto specializes in Cell biology, namely Progenitor cell. (research.com)
  • Hiroshi Kawamoto spends much of his time researching Cancer research, Cell biology, Molecular biology, Cellular differentiation and Progenitor cell. (research.com)
  • His studies deal with areas such as Endothelial stem cell, Adult stem cell and Enhancer, Transcription factor, Cell fate determination as well as Cell biology. (research.com)
  • His work in Molecular biology addresses issues such as Induced pluripotent stem cell, which are connected to fields such as Human leukocyte antigen, CTL*, T cell and T-Cell Receptor Gene. (research.com)
  • In February 2018, the Institute of Integrative Biology collaborated with Anika Therapeutics, Inc., to develop an injectable mesenchymal stem cell (MSC) therapy for the treatment of osteoarthritis. (medgadget.com)
  • Development: For advances in developmental biology and stem cells. (lu.se)
  • Stem cell technologies have opened up new avenues in the study of human biology and disease. (ehu.eus)
  • They therefore represent a more realistic cellular environment for modeling the cell biology and pathology of the nervous system. (ehu.eus)
  • I then moved my laboratory to Stanford University as a Siebel Investigator and Instructor at the Stanford Institute for Stem Cell Biology & Regenerative Medicine. (stanford.edu)
  • His study in Immunology is interdisciplinary in nature, drawing from both CD34, Haematopoiesis, Stromal cell and Green fluorescent protein. (research.com)
  • Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and immunomodulatory properties to restore and repair injured tissues, making them attractive candidates for cell-based therapies. (shengsci.com)
  • MSCs are multipotent stromal cells that make and restore skeletal tissue and can differentiate into diverse cell types: bone, cartilage, muscle and fat. (mastercellbank.com)
  • They play critical roles during embryonic development and in the maintenance and repair of adult tissues. (cshlpress.com)
  • In addition to their ability to supply cells at the turnover rate of their respective tissues, they can be stimulated to repair injured tissue caused by liver damage, skin abrasions and blood loss. (thefutureofthings.com)
  • The ability of our body to regenerate some of its tissues is largely owed to the reserves of adult stem cells. (thefutureofthings.com)
  • Stem cells represent a small fraction of cells located in different tissues. (shengsci.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • During development, stem cells and resulting progenitor cells are responsible for generating all the tissues and cells of an organism. (winstepforward.org)
  • WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)
  • Johnson, M. H. & Ziomek, C. A. The foundation of two distinct cell lineages within the mouse morula. (nature.com)
  • Communication between dermal papilla cells and the overlying epithelium is essential for differentiation of the hair follicle lineages. (biologists.com)
  • Specifically, we study the genetic, epigenetic and metabolic control of pluripotent and adult stem cells, and the molecular circuitries governing the decision between self-renewal and commitment to differentiation, both in physiology and disease. (cnr.it)
  • Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
  • To explore VHL as a regulator defining nephron progenitor self-renewal versus differentiation, we bred Six2-TGC tg mice with VHL lox/lox mice to generate mice with a conditional deletion of VHL from Six2 + nephron progenitors. (lww.com)
  • The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. (axonmedchem.com)
  • Stem cells have two fundamental properties: self-renewal and multipotency. (winstepforward.org)
  • Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
  • We have examined the expression profile of synemin isoforms in mouse pluripotent ES cells and during their neural differentiation induced by retinoic acid. (biomedcentral.com)
  • However, both synemin H and M were restricted to the progenitor line during the neural differentiation program. (biomedcentral.com)
  • Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
  • A number of large biotech companies and scientists are looking toward stem cells as the basis for a therapeutic solution to cure such illnesses as blindness, diabetes and spinal cord injuries. (thefutureofthings.com)
  • Our current research aims to understand the post-transcriptional & epigenetic mechanisms that govern stem cell potency and cell fate decisions, and determine how to exploit these mechanisms to develop new therapeutic strategies. (distefano-lab.com)
  • The lymphoma application segment leads the global stem cell banking market, owing to rising prevalence of these disorders and higher number of successful therapeutic procedures carried out to treat the condition using stem cells. (medgadget.com)
  • In particular, due to the limited regenerative capacity of the adult nervous system, the therapeutic potential of stem cells has opened up new perspectives for development of treatment strategies for brain repair after injury or disease. (ehu.eus)
  • Once a cell type is specified, the mechanisms that restrict and maintain cell fate are important in ensuring tissue integrity, and their dysregulation often results in disease, particularly cancer. (distefano-lab.com)
  • Our current goal is to elucidate molecular mechanisms regulating establishment and maintenance of mammalian cell identity. (distefano-lab.com)
  • There his work focused on the mechanisms that control transcription factor-induced cell fate change. (distefano-lab.com)
  • A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)
  • However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
  • Because of their specific niche and a limited number of stem cells, the key question is whether there are different anti-viral mechanisms against viral infection notably COVID-19. (shengsci.com)
  • These data could help us to understand the possible viral infections in different stem cells and the activation of specific molecular mechanisms upon viral entrance. (shengsci.com)
  • Quiescent stem cells are Type B that are able to remain in the quiescent state due to the renewable tissue provided by the specific niches composed of blood vessels, astrocytes, microglia, ependymal cells, and extracellular matrix present within the brain. (wikipedia.org)
  • Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
  • The global stem cell banking market growth has gained a major momentum in the recent years, due to the rising awareness of the use of cord blood and cord tissue stem cells in therapeutics, and the extensive application of stem cells in the treatment of autism, lymphoma, anemia, etc. (medgadget.com)
  • An organoid is a 3D organization of cells that can recapitulate some of the structure and function of native tissue. (mdpi.com)
  • The organ consists of "glomera" composed of two cell types, glomus and sustentacular cells, interspersed by blood vessels and nerve bundles and separated by connective tissue. (bvsalud.org)
  • Conversely, aging results in a reduction in the number and volume of glomus cells with progressive cellular degeneration and an apparent increase in the surrounding connective tissue. (bvsalud.org)
  • ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)
  • Biostór / Master Cell Bank is a leading EU-licensed Tissue Establishment (TE) storing life-saving cell therapies, GMP Cell Banks and Clinical Trial samples since 2007. (mastercellbank.com)
  • Serving global markets, it provides cell and tissue biostorage and cold chain logistics solutions to many leading medical and biotechnology research organisations world-wide. (mastercellbank.com)
  • In particular, the advent of human embryonic stem cells followed by reprograming technologies for generation of induced pluripotent stem cells have instigated studies into modeling human brain development and disease by providing a means to simulate a human tissue otherwise completely or largely inaccessible to researchers. (ehu.eus)
  • Organogenesis is a complex developmental process requiring hierarchical cell and tissue differentiation, coordinated in time and space in response to changes in local and distant signaling cues. (biomedcentral.com)
  • They also explore specialized niches in which stem cells reside (e.g., in the testis and lung) and how the extracellular cues in those microenvironments regulate stem cell behavior. (cshlpress.com)
  • It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
  • His Transcription factor research is multidisciplinary, relying on both Cellular differentiation and B cell. (research.com)
  • Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)
  • Heterogeneous gene expressions of cells are widely observed in self-renewing pluripotent stem cells, suggesting possible coexistence of multiple cellular states with distinct characteristics. (biomedcentral.com)
  • These results suggest the co-existence of two cellular "sub-states" within the pluripotent stem cell state: high-Nanog sub-state and low-Nanog sub-state, rather than one well-defined, homogenous pluripotent cellular state. (biomedcentral.com)
  • Hardly a day goes by without hearing of some new cell involved in a new disease treatment: Numerous cellular immunotherapies are currently in clinical development, using natural killer cells, dendritic cells (DCs), macrophages, polyclonal or antigen-specific T cells and lymphokine-activated killer cells. (mastercellbank.com)
  • We thus efficiently generate artery and vein cells, introduce stem-cell-based toolkits for biosafety-level-4 virology, and explore the arterial tropism and cellular effects of Nipah and Hendra viruses. (stanford.edu)
  • The interplay between all these layers of epigenetic regulation finally controls the transcriptional output of the conversion process, thus determining the final cell fate. (distefano-lab.com)
  • In addition, the authors also review future strategies in DN treatment such as transcriptional reprogramming of mature adult kidney cells into uncommitted induced pluripotent stem cells for renal repair and therapeutics. (emjreviews.com)
  • Genetic background drives transcriptional variation in human induced pluripotent stem cells. (1library.org)
  • Furthermore, MAG Pharmaceuticals, Inc. acquired Cord Blood Registry (CBR) - an umbilical cord blood stem cell collection and storage company - for US$ 700 million in order to expand and diversify its maternal health business in 2015. (medgadget.com)
  • At the top of the list comes the zygote-a fertilized egg, which of course has the ability to divide and differentiate into all cell types in the body and create a new organism. (thefutureofthings.com)
  • The first three divisions of the zygote give birth to eight totipotent cells, each of which also has the ability to become an entire organism. (thefutureofthings.com)
  • Internal signals producing apoptosis depend on interactions of several proteins and may serve to protect the organism from cancer by killing cells that have pre-cancerous changes. (agemed.org)
  • On the other hand, a chimera is defined as an organism in which cells from two or more different organisms have contributed. (frontiersin.org)
  • As a graduate student at Cornell University, she employed the invertebrate model organism C. elegans, and made significant contributions to the discovery of RNA interference (RNAi) as well as understanding of asymmetric cell divisions. (ucsf.edu)
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • The method involves microinjecting heterologous mitochondria into an oocyte or embryonic cell wherein the heterologous mitochondria are capable of achieving at least normal levels of mitochondrial membrane potential in the oocyte or embryonic cell. (justia.com)
  • SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. (axonmedchem.com)
  • Adult stem cells can be used to accelerate bone or tendon healing , and they can induce cartilage progenitor cells to produce a better matrix and repair cartilage damage . (thefutureofthings.com)
  • The clinical application cells began in 1956 with the first successful bone marrow transplant, performed between twins, with bone marrow taken from the healthy identical twin, and given to the other, who had leukaemia. (mastercellbank.com)
  • Its clinical introduction in 1986 replaced bone marrow (BM) as a stem cell source to almost 100% in the and to autologous approximately 75% in the allogeneic transplant setting. (mastercellbank.com)
  • Hematopoietic stem and progenitor cells (HSPCs) have the capacity to self-renew and commit to fully mature specialized blood cell types. (distefano-lab.com)
  • There are two basic types of stem cell: adult stem cells, which are limited in their ability to differentiate, and embryonic stem cells (ESCs), which are pluripotent and have the capability of differentiating into any cell type. (wikipedia.org)
  • At an advanced age, the pools of Type B and Type C cells become depleted in part because of replicative senescence and the cells remaining in the pools lose their ability to differentiate as necessary to replace Type D cells. (anti-agingfirewalls.com)
  • These adult stem cells are considered multipotent, having the ability to differentiate into different cell types, albeit with a more limited repertoire than embryonic stem cells. (thefutureofthings.com)
  • Here, we employed a human pancreatic differentiation platform complemented with an shRNA screen in human pluripotent stem cells (PSCs) to identify potential drivers of early endoderm and pancreatic development. (mdpi.com)
  • My work over the past ten years has centered on pluripotent stem cells (PSCs, which include embryonic and pluripotent stem cells), which can generate any of the hundreds of diverse cell types in the body. (stanford.edu)
  • However, it has been notoriously challenging to guide PSCs to differentiate into a pure population of a given cell type. (stanford.edu)
  • Cell Stem Cell) from PSCs. (stanford.edu)
  • My laboratory currently focuses on differentiating human PSCs into liver progenitors (Ang et al. (stanford.edu)
  • Chemistry of RNA and DNA base methylation The addition of the methyl-group to DNA and RNA bases (Fig.?2) is catalyzed by DNA- and RNA-methyltransferases that use DNMTs, which methylate canonical dC bases.26 In contrast, DNMT1 maintains the methylation status Actinomycin D biological activity during cell division. (thebiotechdictionary.com)
  • DNA methylation dynamics in human induced pluripotent stem cells over time. (1library.org)
  • Review - Time for Radical Changes in Brain Stem Nomenclature - Applying the Lessons From Developmental Gene Patterns [1] "The traditional subdivision of the brain stem into midbrain , pons , and medulla oblongata is based purely on the external appearance of the human brain stem. (edu.au)
  • Our study shows a developmental stage specific regulation of synemin isoforms in ES cells and its neural derivatives. (biomedcentral.com)
  • Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. (biomedcentral.com)
  • The ICM continues to differentiate into three germ layers-ectoderm, mesoderm and endoderm, each of which follows a specific developmental destiny that takes them along an ever-specifying path at which end the daughter cells will make up the different organs of the human body. (thefutureofthings.com)
  • In the adult mammalian brain, the subgranular zone in the hippocampal dentate gyrus, the subventricular zone around the lateral ventricles, and the hypothalamus (precisely in the dorsal α1, α2 region and the "hypothalamic proliferative region", located in the adjacent median eminence) have been reported to contain neural stem cells. (wikipedia.org)
  • Adult NSCs differentiate into new neurons within the adult subventricular zone (SVZ), a remnant of the embryonic germinal neuroepithelium, as well as the dentate gyrus of the hippocampus. (wikipedia.org)
  • To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
  • In addition to identifying VHL as a critical regulator of nephron progenitors' metabolic switching, the authors' findings demonstrate that this switch also plays a large role in the differentiation process, and suggest that VHL is required for normal kidney development. (lww.com)
  • Our findings identify a novel role for VHL in mediating nephron progenitor differentiation through metabolic regulation, and suggest that VHL is required for normal kidney development. (lww.com)
  • The mammalian carotid body (CB) exhibits considerable plasticity of its structure during development and aging and as a consequence of environmental, metabolic and inflammatory stimuli. (bvsalud.org)
  • MSCs were cultured in defined, MesenCult-ACF media (StemCell Technologies, Cat. (nih.gov)
  • VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)
  • The cells of the ICM are no longer omnipotent, because they no longer share the fate of the trophoblast, and they have committed themselves to an embryonic fate with the ability to become any cell in the body (but not the trophoblast). (thefutureofthings.com)
  • The localization of RNAs in the cell can influence their folding, editing, splicing, translation, degradation, and even the fate of the proteins they encode. (distefano-lab.com)
  • Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions. (axonmedchem.com)
  • It is hypothesized that neurogenesis in the adult brain originates from NSCs. (wikipedia.org)
  • The glial-like sustentacular or type II cells are regarded to be supporting cells although they sustain physiologic neurogenesis in the adult CB and are thus supposed to be progenitor cells as well. (bvsalud.org)
  • By embryonic day 15.5, kidneys of nephron progenitor cell-specific VHL knockout mice begin to exhibit reduced maturation of nephron progenitors. (lww.com)
  • Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
  • the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)
  • 2007). Some research possess recommended that assisting cells had been the most likely resource of progenitors (Kelley et al. (forgetmenotinitiative.org)
  • 2006). Latest research possess discovered that a subpopulation of assisting cells, such as Sox2- and Lgr5-positive assisting cells, have the capacity to become new hair cells (Chai et al. (forgetmenotinitiative.org)
  • Recently, cell reprogramming technology has been used in stem cell research. (forgetmenotinitiative.org)
  • Stem cells are at the forefront of medical research and incite some of the most controversial ethical and religious debates worldwide. (thefutureofthings.com)
  • While regarded by many top scientists as the Holy Grail of medicine, others consider embryonic stem-cell research sacrilegious. (thefutureofthings.com)
  • Recent advances in the field of stem-cell research are giving hope to millions. (thefutureofthings.com)
  • A particular field encouraged by the foundation is stem-cell research, with the great hope that it will result in the ability to get cells to differentiate into neurons and support cells to bridge the gap of a spinal cord injury. (thefutureofthings.com)
  • His Progenitor cell research integrates issues from Endothelial stem cell, Embryonic stem cell and B cell. (research.com)
  • In his study, which falls under the umbrella issue of T cell, T-cell receptor, Cancer research and Antigen is strongly linked to Cytotoxic T cell. (research.com)
  • His Cancer research research is multidisciplinary, incorporating perspectives in Protein kinase B, Thymocyte, CD8, Cytotoxic T cell and Antibody. (research.com)
  • His Progenitor cell research is within the category of Stem cell. (research.com)
  • 1 Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, Cambridge CB2 1QR, UK. (biologists.com)
  • The ease by which various stem cell types can be generated from human peripheral blood has allowed the design of various kits to guarantee the specificity, sterility and efficacy of stem cells production for various clinical and research applications. (eurekaselect.com)
  • Innovations in Training: Toward Mitigating "Eternal post-docdum" in Stem Cell Research. (shengsci.com)
  • Stem cell research endeavors to generate specific subtypes of classically defined "cell types. (stanford.edu)
  • We use mouse genetics, primary neural stem cells, and human patient-derived pluripotent stem cells as model systems in our research. (winstepforward.org)