Progenitor strain. Medical search. Frequent questions

This shows that the differences between Zika and dengue are not at the level of being able to infect neural progenitors, but more about the harm Zika causes when it does infect those cells,' says senior author Peng Jin, PhD, professor of human genetics at Emory University School of Medicine. (infectioncontroltoday.com)
Neural progenitors were derived by depleting feeder cells and culturing cells in suspension in neural differentiation basal medium (DFNB) for 2 days followed by 500nM all-trans retinoic acid treatment in DFNB. (nih.gov)
Zika virus (green) infects human neural progenitors and leads to cell death (red). (the-scientist.com)
Partnering with scientists at Florida State University who study Zika virus, Ming's team inoculated the neural progenitors as well as human iPSCs, embryonic stem cells and immature neurons and compared the extent of the resulting infections. (the-scientist.com)
While less than 20 percent of the iPSCs, embryonic stem cells and neurons became infected, the infection of the neural progenitors was "really striking," said Ming. (the-scientist.com)
Neural progenitors "give rise to the larger population of neurons and glial cells of the brain," Ming said. (the-scientist.com)

Furthermore, we identify the transcription factor Gli1, expressed in medial IZ cells, as an antagonist of E(Spl) and Gsk3β/PKA, and demonstrate that the neurogenesis-promoting activity of Gli1 accounts for the reduced sensitivity of medial IZ progenitors to neurogenesis inhibitors and their increased propensity to differentiate. (biologists.com)
Neural Progenitor Cells Derived from XCL-1 DCXp-GFP are a neuronal lineage reporter cell line that can be used in neuronal differentiation and drug screening. (atcc.org)
To download a certificate of analysis for Neural Progenitor Cells Derived from XCL-1 DCXp-GFP ( ACS-5005 ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
The certificate of analysis for that lot of Neural Progenitor Cells Derived from XCL-1 DCXp-GFP ( ACS-5005 ) is not currently available online. (atcc.org)
In adult mouse hippocampus, Tbr2 protein and Tbr2-GFP (green fluorescent protein) transgene expression were specifically localized to intermediate-stage progenitor cells (IPCs), a type of transit amplifying cells. (jneurosci.org)
suggesting that progenitor cells in the embryonic and adult brain may share similar molecular phenotypes. (jneurosci.org)
Furthermore, neural progenitor cells (those self-renewing cellular factories responsible for the development and maintenance of many of the cell types in the brain) were less able to form balls of cells called neurospheres -- a laboratory test that reflects the number and robustness of nerve stem cells in a culture. (sciencedaily.com)
Conversely, reducing Usp16 expression in skin and nerve-progenitor cells from people with Down syndrome allowed the cells, which usually proliferate slowly, to assume normal growth patterns. (sciencedaily.com)
STEMdiff™ Neural Progenitor Medium is a defined and serum-free medium for the expansion of neural progenitor cells (NPCs) derived from human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells using STEMdiff™ Neural Induction Medium (Catalog #05835). (stemcell.com)
Scientists have revealed molecular differences between how the African and Asian strains of Zika virus infect neural progenitor cells. (infectioncontroltoday.com)
The overlap in gene expression changes when neural progenitor cells are infected by African or Asian strains of Zika virus. (infectioncontroltoday.com)
The findings, from the Emory/Johns Hopkins/Florida State team that showed this spring that neural progenitor cells are particularly vulnerable to Zika infection, were published in Nucleic Acid Research. (infectioncontroltoday.com)
The research team catalogued and compared genes turned on and off by Asian and African strains of Zika virus, as well as dengue virus, in human neural progenitor cells. (infectioncontroltoday.com)
Although they show that dengue can infect neural progenitor cells like Zika can, dengue infection does not stunt the cells' growth or lead to cell death. (infectioncontroltoday.com)
In comparison with African strains, infection by the Asian strain of Zika virus more potently affected the p53 gene and genes connected with cells' responses to viral infection, such as interferons. (infectioncontroltoday.com)
Both Zika strains were able to infect and cause cell death in neural progenitor cells. (infectioncontroltoday.com)
The neural progenitor cells used were derived from iPSCs (induced pluripotent stem cells), which were in turn derived from donor skin cells. (infectioncontroltoday.com)
The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. (nature.com)
SARAH C. OGDEN Laboratory-grown human neural progenitor cells, which can give rise to the kind of neurons and glia found in the brain, can be infected and killed by a strain of Zika virus, according to a report published today (March 4) in Cell Stem Cell . (the-scientist.com)
Because analyzing actual human brain development is practically impossible, she uses human neural progenitor cells derived from induced pluripotent stem cells (iPSCs) as a model system. (the-scientist.com)
On hearing about the Zika-microcephaly crisis in Brazil, Ming realized she had a unique opportunity to examine whether human neural progenitor cells might be susceptible to infection. (the-scientist.com)
Up to 90 percent of the cells contained the virus and "what is a bit scary to us," she said, "is that we found these progenitor cells can actually spit out more virus"-with the potential to infect yet more progenitor cells. (the-scientist.com)
Ming and colleagues showed that infection of the progenitors either killed the cells or slowed their proliferation significantly. (the-scientist.com)
To gain a better understanding of potential disease mechanism, Ming's team plans to examine whether the infected neural progenitor cells lead to abnormal development of brain organoids-cultured mini brains derived from human iPSCs. (the-scientist.com)
V6.5 ES cells were differentiated into neural progenitor cells (NPCs) using established techniques (Meissner et al. (nih.gov)
Next-generation vaccines that utilize T cells could potentially overcome the limitations of current influenza vaccines that rely on antibodies to provide narrow subtype-specific protection and are prone to antigenic mismatch with circulating strains. (mdpi.com)
Fine mapping of the epiblast in the posterior region of the early-streak stage embryo reveals that although the early-gastrula organizer contains cells that give rise to the axial mesoderm, the bulk of the progenitors of the head process and the notochord are localized outside the early gastrula organizer. (silverchair.com)
In the mid-gastrula organizer, early gastrula organizer derived cells that are fated for the prechordal mesoderm are joined by the progenitors of the head process that are recruited from the epiblast previously anterior to the early gastrula organizer. (silverchair.com)
Like their progenitor, they have mutations in the region of the virus that binds to cells that make them extremely transmissible. (rt.com)
Recently, a subpopulation of stem/progenitor cells has been identi ed within the auricular cartilage tissue, with similarities to MSCs in terms of proliferative capacity and cell surface biomarkers, but their potential for tissue engineering has not yet been explored. (swan.ac.uk)
This study compared the in vitro cartilage-forming ability of equine auricular cartilage progenitor cells (AuCPCs), bone marrow-derived MSCs and auricular chondrocytes in gelatin methacryloyl (gelMA)-based hydrogels over a period of 56 d, by assessing their ability to undergo chondrogenic di erentiation. (swan.ac.uk)
The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells by: William Webb, et al. (swan.ac.uk)
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. (jax.org)
Victoria Ptasinski defended her Ph.D. thesis 'Alveolar Progenitor Cells in Lung Damage and Regeneration in Pulmonary Fibrosis' on Monday, November 27, 2023. (lu.se)
The project is about studying lung regeneration of lung progenitor cells in COPD (Chronic Obstructive Pulmonary Disease) using exercise-mimicking stretching. (lu.se)

In the absence of patient zero, a Temple University research team may have found the next best thing: the progenitor or "mother" of all SARS-CoV-2 genomes and its early offspring strains, which have subsequently mutated and spread to dominate the world pandemic. (isaaa.org)
Kumar's team uncovered a predicted sequence of the progenitor (mother) genome of all SARS-CoV-2 genomes (proCoV2). (isaaa.org)
Genomes of individuals strains typically incorporate 45-55 recombinations between parental chromosomes. (nervenet.org)
The present study reports the identification and structural and expression analysis of the AQPs found in the diploid progenitor genomes of A. hypogea i.e. (biomedcentral.com)

Here we demonstrate that interstitial mesenchymal progenitors respond to mechanical load and stimulate MuSC proliferation in a surgical mouse model of increased muscle load. (mdc-berlin.de)
Mechanistically, transcriptional activation of Yes-associated protein 1 (Yap1)/transcriptional coactivator with PDZ-binding motif (Taz) in mesenchymal progenitors results in local production of thrombospondin-1 (Thbs1), which, in turn, drives MuSC proliferation through CD47 signaling. (mdc-berlin.de)

Neuronal production in the midbrain-hindbrain domain (MH) of the vertebrate embryonic neural tube depends on a progenitor pool called the `intervening zone' (IZ), located at the midbrain-hindbrain boundary. (biologists.com)

This has provided hope for the design of a universal vaccine able to prime against diverse influenza virus strains and subtypes. (mdpi.com)
The potential exists for coinfection of multiple subtypes of influenza virus and with genetic reassortment and the creation of possible new strains of influenza virus. (cdc.gov)

A special form of Y pseudotuberculosis infection called Far East scarlet-like fever (FESLF) has been described in association with specific strains[7] of Y pseudotuberculosis in Russia and Japan that demonstrate mitogen A, which acts as a superantigen. (medscape.com)
Thus while surviving infection with BA.2, BA.4 and BA.5 appears to give some protection against the BQ-type strains, neither infection nor vaccination offers protection against XBB. (rt.com)
0.001), compared with infection with other strains within sublineage IIb. (barfblog.com)
In order to better understand differences in the outcome of infectious bursal disease virus (IBDV) infection, we inoculated a very virulent (vv) strain into White Leghorn chickens of inbred line W that was previously reported to experience over 24% flock mortality, and three inbred lines (15I, C.B4 and 0) that were previously reported to display no mortality. (imperial.ac.uk)

2017. Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem. (sun.ac.za)

Recombinant inbred strain, progenitor cross: (A/J female X C57BL/6J male). (jax.org)
Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. (nervenet.org)
Recombinant inbred (RI) strains have been used to map a wide range of Mendelian loci and quantitative traits (Taylor, 1989). (nervenet.org)

In this study we have increased the density of microsatellite markers 2- to 5-fold in each of several major RI sets that share C57BL/6 as a parental strain (AXB, BXA, BXD, BXH, and CXB). (nervenet.org)

B-D) NPCs maintained in STEMdiff™ Neural Progenitor Medium express the CNS-type NPC markers PAX6 (B, D, red), SOX1 (C, red) and NESTIN (C, green), but not the neural crest marker SOX10 (D, green, single channel shown in inset). (stemcell.com)

It also correlates with a lower sensitivity of medial versus lateral IZ progenitors to the neurogenesis inhibition process that maintains the IZ pool. (biologists.com)
Neurogenesis in the adult hippocampus is a highly regulated process that originates from multipotent progenitors in the subgranular zone (SGZ). (jneurosci.org)

HuNoV outbreaks are frequently associated with recombination between circulating strains. (harvard.edu)
The final consensus maps are based on 1578 microsatellite loci and these maps have a cumulative length of approximately 1400 cM after adjustment for recombination frequencies of RI strains. (nervenet.org)

The authors describe dengue as inducing more robust changes in gene expression than either strain of Zika. (infectioncontroltoday.com)

The progenitors of hard rock gave sound and shape to a divergent and ultimately diverse strain of rock and roll. (guitarplayer.com)
Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence by: Christopher Fellows, et al. (swan.ac.uk)

Genetic analysis also showed that only snippets of DNA from the new strain, called PoxSib, remained and that no intact viral particles had survived. (latimes.com)
According to the research report, the virus "could be a direct progenitor of modern viral strains or a member of an ancient lineage that did not cause outbreaks in the 20th century. (latimes.com)

We used whole-genome sequencing to investigate the evolutionary context of an emerging highly pathogenic strain of Shiga toxin-producing Escherichia coli (STEC) O157:H7 in England and Wales . (barfblog.com)
Uropathogenic Escherichia coli strains isolated from these patients, as well as the archetypal E. coli strain UTI89, were found to produce colibactin. (bvsalud.org)

The strains currently circulating in the Western Hemisphere, which have been linked to microcephaly in infants and Guillain Barre syndrome in adults, are more closely related to the Asian lineage. (infectioncontroltoday.com)
The isolated strains belong to the Asian lineage and are more closely related to French Polynesia 10-12 . (bvsalud.org)

Sudhir Kumar, director of the Institute for Genomics and Evolutionary Medicine at Temple University said that they have now reconstructed the progenitor genome and mapped where and when the earliest mutations happened. (isaaa.org)

The applicant and other colleagues in the group have studied lung progenitors in ex vivo lung models. (lu.se)

Concurring in the denial of rehearing en banc, Judge Christen, joined by Judge D.W. Nelson, wrote that the panel's opinion affirmed the district court's summary judgment ruling because Kennedy spoke as a public employee, because BSD did not demonstrate a hint of hostility or bias toward religion or non-religion, and because BSD had a compelling interest in avoiding an Establishment Clause violation. (justia.com)

A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain. (jax.org)
[ 9 ] More optimistically, a specific strain of Y pseudotuberculosis, IP32953, has been modified into a potentially promising vaccine against bubonic and pneumonic plague. (medscape.com)

We have determined the crystal structure of M type Progenitor complex of botulinum neurotoxin E [PTC-E(M)], a heterodimer of BoNT and NTNH. (nature.com)
B ) Results of PCR with primers external to all three nrd operons in ΔRNR compared with the wild-type progenitor strain (REL606). (elifesciences.org)

One possible explanation for patients' improvement due to exercise is that lung progenitors regain their physiological stretching from healthy conditions and activate molecular pathways favouring lung regeneration. (lu.se)

In this project, we aim to study the molecular pathways in lung regeneration induced by stretching on lung progenitors in COPD. (lu.se)

A timed phylogeny of sublineage IIb revealed that the emerging clone evolved from a STEC O157:H7 stx-negative ancestor ≈10 years ago after acquisition of a bacteriophage encoding Shiga toxin (stx) 2a, which in turn had evolved from a stx2c progenitor ≈20 years ago. (barfblog.com)

It is known that progenitor toxin complex protects the neurotoxin during exposure to harsh conditions found in the stomach and small intestines where it is exposed to acidic pH (2.0) and peptidases like pepsin. (nature.com)
It can be associated with postinfectious complications such as erythema nodosum and reactive arthritis , and strains of Y pseudotuberculosis found in Asia appear to produce a superantigen-associated toxic erythema illness suggestive of scarlet fever. (medscape.com)
They found the proCoV2 virus and its initial descendants arose in China and that a population of strains with as many as six mutational differences from proCoV2 existed at the time of the first detection of COVID-19 cases in China . (isaaa.org)
Ho's study, which has not been published or peer reviewed, found that patients who received the two initial mRNA vaccines plus a booster had 37- and 55-fold lower immune neutralization against BQ.1 and BQ.1.1 than they did against the strain of the virus they were inoculated against, and 70-fold lower neutralization against XBB and XBB.1. (rt.com)
The Columbia University study did not compare unvaccinated patients who had been infected with any of the strains, though several earlier studies found natural immunity alone was more effective in neutralizing the Delta variant of the coronavirus than vaccine-derived immunity alone. (rt.com)

For one thing, he said, the virus strain used in the study differs to the one responsible for the ongoing outbreak in Latin America. (the-scientist.com)

The institute's director, David Ho, called for vaccines against the new, increasingly common, strains before it is too late to tackle their potential spread. (rt.com)

We provide two-locus correlograms that can be used to detect and correct for non-syntenic association and to reduce error rates in QTL mapping studies that exploit RI strains. (nervenet.org)

A progenitor of modern wheat, this wild relative contributed the D-genome pillar in bread wheat. (phys.org)

It has been 24 years since Slim Cessna parted ways with The Denver Gentlemen, that grand progenitor of the peculiar strain of Gothic Americana unique to the Mile High City, to form Slim Cessna's Auto Club with a group of talented peers. (towerrecords.com)

The idea that they play an important role is also based on data that suggest drastically-enhanced oral toxicity of the progenitor toxin compared to the purified BoNT 10 . (nature.com)

Clostridium botulinum neurotoxin (BoNT) is released as a progenitor complex, in association with a non-toxic-non-hemagglutinin protein (NTNH) and other associated proteins. (nature.com)

People who received the Omicron shot as their second booster did slightly better against all four strains, and individuals who had received the original booster and been infected with the BA.2 variant performed better than any of the other groups against BQ.1 and BQ.1.1 even as they did much worse against XBB and XBB.1. (rt.com)

The progressive recruitment of IZ progenitors along the mediolateral (future dorsoventral)axis prefigures the earlier maturation of the MH basal plate. (biologists.com)
In this way, hard rock began to evolve, securing its future and laying new paths from which other strains, like glam rock and prog, would eventually emerge. (guitarplayer.com)

Recently, RI strains have also been used to map QTLs that that are responsible for biometric variation in the architecture of the mouse CNS (Belknap et al. (nervenet.org)

Our results suggest that relayed signaling between mesenchymal progenitors and MuSCs through a Yap1/Taz-Thbs1-CD47 pathway is critical to establish the supply of MuSCs during muscle hypertrophy. (mdc-berlin.de)

Analysis of strain, sex, and diet-dependent modulation of gut microbiota reveals candidate keystone organisms driving microbial diversity in response to American and ketogenic diets. (usda.gov)

Current therapeutic interventions rarely result in a cure and the associated lifelong treatment places a considerable strain on an overburdened health sector. (bvsalud.org)

To test the method the team collected a diversity panel of 151 strains of a grass called Aegilops tauschii. (phys.org)

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