Progenitor stem cells can differentiate. Medical search. Frequent questions

BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a DeltaNp63+ cytotrophoblast stem cell state. (ca.gov)
Using this knowledge, we have determined that human embryonic stem cells, when treated with the chemical BMP4, undergo this 'cytotrophoblast stem cell state' before becoming fully functional placental cells. (ca.gov)
Remarkably, the progenitors derived from embryonic stem cells by dual inhibition efficiently differentiate into cardiac and skeletal muscle cells. (ncbs.res.in)
BDNF acts as a survival factor for human embryonic stem cells when plated on either feeder cells or Corning® Matrigel® (Pyle et al. (stemcell.com)
XI - embryonic stem cells: embryonic cells that are capable of modifying the cells of any organism tissue. (hinxtongroup.org)
Cell replacement using human embryonic stem cells (hESCs) derivatives may offer new therapeutic opportunities to replace degenerated neurons and repair damaged circuits. (lu.se)

Boundary cap neural crest stem cells promote survival of mutant SOD1 motor neurons. (wikipedia.org)
Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
Since neurosphere-forming cells can self-renew and differentiate into neurons and glia, the ability of cells to form neurospheres has generally been taken as evidence that they are stem cells. (elifesciences.org)
Prior to this research, creating pure neuronal cells from ES cells had been problematic as the cells did not always differentiate into neurons. (science20.com)
Sometimes they became glial cells, which lack many of the neurons' desirable properties. (science20.com)
As a result, we were able to produce neuronal progenitor cells that differentiate into a virtually pure population of neurons and survive inside the brain. (science20.com)
D: Coronal view showing the adult mouse subgranular zone (SGZ) and the newborn neurons (red) being integrated in the granular cell layer (gr). (wjgnet.com)
hiPSCs and hESCs were differentiated into functional neurons following a modified version of published step-wise differentiation protocol(s). hESC- as well as hiPSC-derived neural stem/progenitor cell (NSC/NPC) colonies formed rosettes and expressed neural precursor markers Nestin and Sox2. (nih.gov)
These robust, rapidly dividing cells are poised to travel down a committed path of differentiation to yield new brain cells of several different types including neurons. (neurosciencenews.com)
ReNcell CX Immortalized Cells (SCC007): ReNcell CX is an immortalized human neural progenitor cell line with the ability to readily differentiate into neurons and glial cells. (thomassci.com)
It also has a role in neurogenesis by promoting survival and growth of dorsal root ganglion cells, and hippocampal and cortical neurons (Binder & Scharfman). (stemcell.com)
BDNF, together with glial cell line-derived neurotrophic factor (GDNF) and other supplements, is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Brafman). (stemcell.com)
Conclusions: The data support the long-term therapeutic potential of ESC-derived human striatal progenitor grafts for the replacement of degenerated striatal neurons in HD and suggest that EE can effectively accelerate the maturation and promote the integration of human striatal cells. (lu.se)
Stem Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease? (lu.se)
Our current focus is to learn how to direct and efficiently drive controlled differentiation of human stem cells into subtype-specific neurons. (lu.se)

Pushing mature cells into other lineages may offer a new way to replace cells involved in blood diseases and neurodegenerative disorders such as Alzheimer s disease. (innovations-report.com)
Our results show for the first time the feasibility of using a physical stimulus to afford the expression of pluripotentiality in human adult somatic cells up to the attainment of three major target lineages for regenerative medicine. (nih.gov)
Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and adipogenic) after suitable stimulation. (scirp.org)
Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. (cun.es)
HSPCs are multipotent cells that can self-renew and differentiate to give rise to all blood cell lineages. (go.jp)
In response to morphogens, the hONPs differentiate along several neural lineages. (scirp.org)
The findings also help explain why the process of differentiating stem cells into specific lineages in the laboratory has been highly inefficient. (sciencedaily.com)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

Cao studies how tissues and organs maintain stable populations of cells-a hallmark of health-so he and his team wanted to investigate how different cellular populations develop, and whether these varied neuronal cells decline in the same way or forge different paths. (scitechdaily.com)
In theory, transplanting neuronal brain cells could restore at least some brain function, just as heart transplants restore blood flow. (science20.com)
Even when the neuronal cells were created successfully, they often died in the brain following transplant-a process called programmed cell death or apoptosis. (science20.com)
Using MEF2C, the researchers created colonies of pure neuronal progenitor cells, a stage of development that occurs before becoming a nerve cell, with no tumors. (science20.com)
F: Confocal images showing immunostaining in the DG for the astrocyte marker GFAP in green, for the progenitor precursor marker T-box brain protein 2 (TBR2) in red and for the neuronal precursor marker Doublecortin (DCX) in red. (wjgnet.com)
Rapid conversion of hESC and hiPSC into functional induced neuronal (iN) cells could be achieved in less than two weeks by overexpression of exogenous Ngn2 or ASCL1/DLX2. (nih.gov)
This study suggests that specific transcription factors and treatment with morphogens can restrict human adult olfactory-derived progenitors to a dopaminergic neuronal lineage. (scirp.org)
The focus of my research is to understand cell fate specification in the developing brain and in human neural progenitor cells, using cell-based models of neuronal differentiation. (lu.se)

They are "midway" between stem cells and fully differentiated cells. (wikipedia.org)
Aerosolized nano-zinc oxide (nZnO) exposure alters the cellular composition of the fully differentiated human airway epithelium. (cdc.gov)
Fully differentiated cells were exposed to aerosolized nZnO for 6 minutes, at the indicated doses, using the VitroCell® Cloud Alpha 12 system. (cdc.gov)
The presence of all four major cell types at protein level was confirmed by IF staining of the fully differentiated airway epithelium. (cdc.gov)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)

Some research found that progenitor cells were mobile and that these progenitor cells could move through the body and migrate towards the tissue where they are needed. (wikipedia.org)
Some of these transit amplifying neural progenitors migrate via rostral migratory stream to the olfactory bulb and differentiate further into specific types of neural cells. (wikipedia.org)
transit amplyfing progenitors (TAP) or type C cells (green) express the achaete-scute homolog 1 (ASCL1) transcription factor and give rise to type A cells (red) that migrate through the rostral migratory stream (rms). (wjgnet.com)
The stratified organization of the epithelium restricts proliferative cells to the basal layer, and these cells must migrate toward the lumen as they differentiate. (jci.org)
The crypts generate a constant stream of new cells that differentiate and migrate upward into the villi. (wjgnet.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)

In this point of view, they can compare to adult stem cells, but progenitors are said to be in a further stage of cell differentiation. (wikipedia.org)
Many properties are shared by adult stem cells and progenitor cells. (wikipedia.org)
Li, L. & Clevers, H. Coexistence of quiescent and active adult stem cells in mammals. (nature.com)
Together with other published results, these observations blur the concept of fixed cell types and provide new insights concerning potential uses for adult stem cells. (innovations-report.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
They develop from progenitor cells-descendants of adult stem cells that differentiate into specialized cell types. (scitechdaily.com)
Do NPCs of adult stem cells lack Nup133 as protection against inadvertent responses to differentiation signals, while derivative progenitor cells express Nup133 to facilitate differentiation? (ny.gov)

Endothelial progenitor cells (EPCs) are one of the main focuses of this field. (wikipedia.org)
Angioblasts or endothelial progenitor cells (EPC). (wikipedia.org)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)

The REAC action bypassed a persistent reprogramming toward an induced pluripotent stem cell-like state and involved the transcriptional induction of the NADPH oxidase subunit Nox4. (nih.gov)
Here we generated high quality human induced pluripotent stem cell (iPSC) lines carrying two of the most recurrent germline GATA2 mutations (R389W and R396Q) associated with MDS, using CRISPR/Cas9. (nih.gov)
Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)

Sites of loosely packed extracellular matrix (ECM) also offer stem and progenitor cell optimal space to proliferate and differentiate. (europa.eu)

after that period, progenitor cells produce only dissimilar mesenchymal stem cell daughters. (wikipedia.org)
A particular stem cell type in the adult human-being is the 'Mesenchymal stem cell' (MSC). (europa.eu)
Hart, D.A. (2014) Why Mesenchymal Stem Cell/Progenitor Cell Heterogeneity in Specific Environments? (scirp.org)
Wu, Y. and Zhao, R.C. (2012) The Role of Chemokines in Mesenchymal Stem Cell Homing to the Myocardium. (scirp.org)
Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
Fehrer, C. and Lepperdinger, G. (2005) Mesenchymal Stem Cell Aging. (scirp.org)

GRPs are progenitor cells that differentiate into astrocytes and oligodendrocytes following transplantation. (reprocell.com)
We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
The research, an important step toward developing new treatments for stroke, Alzheimer's, Parkinson's and other neurological conditions showed that mice afflicted by stroke showed tangible therapeutic improvement following transplantation of these cells. (science20.com)
None of the mice formed tumors, which had been a major setback in prior attempts at stem cell transplantation. (science20.com)
To move forward with stem cell-based therapies, we need to have a reliable source of nerve cells that can be easily grown, differentiate in the way that we want them to and remain viable after transplantation," said Dr. Lipton. (science20.com)
Results: Human striatal progenitors survived up to 6 months after transplantation and showed morphological and neurochemical features typical of human MSNs. (lu.se)
My projects investigated whether patient-derived cells are more prone to develop disease phenotypes and what can be done to protect these cells after transplantation," explained Fredrik. (lu.se)
Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)
Allogeneic hematopoietic stem cell transplantation is curative but it requires a histocompatible donor and is associated with significant morbidity and mortality, so it is reserved for severe cases of PNH with aplastic anemia or transformation to leukemia. (medscape.com)
Watch the lecture where Malin Parmar tells about the long history of transplantation trials in Lund and how they have been able to differentiate stem cells into specific dopaminergic cells in vitro. (lu.se)

B-cells arise from a lymphoid progenitor, while macrophages come from a myeloid progenitor. (innovations-report.com)
In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)

It appears there is at least a small window where terminally differentiated cells vacillate on which identity to adopt. (innovations-report.com)
Results: qPCR analysis of the differentiation time-course shows a steady increase in markers of terminally differentiated cells, such as club (SCGB1A1), goblet (MUC5AC) and ciliated cells (FoxJ1). (cdc.gov)

02:47 and red blood cells in vitro. (yale.edu)
Investigating astrocyte maturation in a cell culture model revealed that in vitro-differentiated astrocytes lack expression of many mature astrocyte-specific genes, including genes for the transcription factors Rorb, Dbx2, Lhx2 and Fezf2. (nature.com)
To gain insights into the mechanisms driving astrocyte maturation, we have characterised acutely isolated murine astrocytes at both postnatal and adult stages, as well as in vitro differentiated astrocytes. (nature.com)
These hiPSCs represent an in vitro model to study the molecular and cellular mechanisms underlying GATA2 deficiency, when differentiated into blood progenitors. (nih.gov)
We examined the effects of sustained exposure of hESC\derived mesenchymal\like progenitors to recombinant Wnt5a or BMP\2 in vitro. (woofahs.com)
ReNcell NSC Maintenance Medium (SCM005): ReNcell Neural Stem Cell (NSC) Maintenance Medium is a defined serum-free, growth factor-free medium that has been optimized for the growth and in vitro differentiation of ReNcell immortalized human neural progenitor cells. (thomassci.com)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)

The common stem cell produces 2 other stem cells, the myeloid stem cell and the lymphoid stem cell. (medscape.com)
Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)

Radial glial cells found in developing regions of the brain, most notably the cortex. (wikipedia.org)
Astrocytes are the most abundant glial cells in the mammalian central nervous system and they serve essential functions in brain development and homoeostasis. (nature.com)
Myelin-a membrane produced by specialized glial cells-plays a critical role in protecting the fibers that help carry messages throughout the body. (technologynetworks.com)

Based on their transcriptional profile, we identified changes in the proportions of progenitor compartments during aging, and differences in their functionality, as evidenced by gene set enrichment analysis. (cun.es)
Transcriptional profiling demonstrated that Krt15 + basal cells are molecularly distinct from Krt15 - basal cells. (jci.org)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)
We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)

Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. (scirp.org)

Current research on progenitor cells focuses on two different applications: regenerative medicine and cancer biology. (wikipedia.org)
Research on cancer biology focuses on the impact of progenitor cells on cancer responses, and the way that these cells tie into the immune response. (wikipedia.org)
Scientists at the University of Pennsylvania School of Veterinary Medicine have found a new wrinkle in the developmental biology dogma that cell differentiation occurs irreversibly as stem cells give rise to increasingly specialized types of offspring cells. (innovations-report.com)
Measurements of cell mixtures can hide differences between cells that might be important in biology or disease studies. (acs.org)
Researchers are putting single-cell proteomics to work in fields like developmental biology, cell biology, cancer biology, and neuroscience. (acs.org)
This is an important step in placental biology, because it provides a reproducible cell culture model for the study of human placental development and disease. (ca.gov)
Understanding what's causing the prostate to grow with age helps us to consider strategies to prevent the expansion of these cells and possibly reduce a person's risk for prostate growth or disease," said Andrew Goldstein, member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and a UCLA assistant professor of urology and of molecular, cell, and developmental biology. (ucla.edu)
Led by Sui Huang, MD, PhD, a Visiting Associate Professor in the Children's Hospital Boston Vascular Biology Program (now also on the faculty of the University of Calgary), and Hannah Chang, an MD/PhD student in Children's Vascular Biology Program, the researchers examined how blood stem cells "decide" to become white blood cell progenitors or red blood cell progenitors. (sciencedaily.com)
These results establish the presence of a long-lived and indispensable Krt15 + progenitor cell population that provides additional perspective on esophageal epithelial biology and the widely prevalent diseases that afflict this epithelium. (jci.org)
We were able to show that when PRMT5 is present, the progenitor cells are able to differentiate and become myelin-producing cells," said Patrizia Casaccia, director of the ASRC's Neuroscience Initiative and the Einstein Professor of Biology at Hunter College and at The Graduate Center, CUNY. (technologynetworks.com)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
During a biology course, we had a guest speaker from Lund Stem Cell Center who talked about stem cells and their potential to become any type of cell in the body. (lu.se)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)
My group works with translational stem cell biology. (lu.se)

Thomas-Tikhonenko and colleagues found that when the cells are returned to the animal, they generate spherical B-cell lymphomas, indicating that they have changed their identity yet again. (innovations-report.com)
We thought it was a real possibility that older cells would have a reduced capacity to generate prostate tissue when we took them out of the prostate," said Goldstein, who is also a member of the UCLA Jonsson Comprehensive Cancer Center . (ucla.edu)
Genetic in vivo lineage tracing revealed that the Krt15 promoter marks a long-lived basal cell population able to self-renew, proliferate, and generate differentiated cells, consistent with a progenitor/stem cell population. (jci.org)
that is, they have the ability to generate other stem cells and perpetuate themselves. (bvsalud.org)

In this study, we used single cell RNA sequencing (scRNAseq) to characterize an enriched population of human hematopoietic stem and progenitor cells (HSPCs) obtained from young and elderly healthy individuals. (cun.es)
Endothelial cells (ECs) line blood vessels and can serve as specialized vascular niches for hematopoietic stem and progenitor cells (HSPCs), a special environment where HSPCs reside and self-renew. (go.jp)
Throughout our lives, a small pool of hematopoietic stem/progenitor cells (HSPCs) ensures the stable production of a wide range of blood and immune cells in our bodies. (phys.org)
Cells in the blood such as immune cells, red blood cells and other vital cell types are constantly renewed from stem cells, the so-called hematopoietic stem and progenitor cells (HSPCs). (phys.org)

In primary polycythemia, the disorder results from a mutation expressed within the hematopoietic stem cell or progenitor cells, which drives the eventual accumulation of red blood cells. (medscape.com)
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell (HSC) disease. (medscape.com)

These islet1 -expressing cells surprisingly originate not from the mesoderm, the germ layer classically defined to give rise to ECs, but from the endoderm. (go.jp)
C) We have identified that islet1 + endothelial progenitors originate from endoderm and finally differentiate into posterior venous ECs in a process dependent on Bmp-Smad signaling, requiring Npas4l-Etsrp function. (go.jp)
Mature epithelial cells originate from the crypt and move up toward the villus tip. (wjgnet.com)

The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)
Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
For the last four years, Fredrik has explored the use of patient-specific cells in cell replacement therapy for Parkinson's disease to identify strategies to safeguard these transplanted cells from disease-related degeneration. (lu.se)
My Ph.D. studies revolved around cell replacement therapy for Parkinson's disease. (lu.se)
My thesis cover illustrates the workflow of generating patient-specific cells for cell replacement therapy for Parkinson's Disease. (lu.se)
The ultimate aim is to develop these cells and technologies for use in brain repair, with a focus on Parkinson's disease. (lu.se)
Develop a stem cell-based therapy for Parkinson's Disease. (lu.se)

Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into forebrain neural progenitor cells. (lu.se)

Somatic cells can be directly reprogrammed to alternative differentiated fates without first becoming stem/progenitor cells. (nih.gov)
The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
ReNcell CX was developed by the ReNeuron Group plc, a biotech company that specializes in using human somatic stem cells for therapeutics. (thomassci.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
Clinical manifestations of PNH occur when a HSC clone carrying somatic PIGA mutations acquires a growth advantage and differentiates, generating mature blood cells that are deficient of GPI-anchored proteins. (medscape.com)
Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)

However, since the patient-derived cells have a disease background it could be so that they develop disease-associated phenotypes and degenerate over time. (lu.se)

Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. (nature.com)
We were able to quantify cellular proliferation and differentiation rates of many cell types across the entire brain in a single experiment, which wasn't possible using conventional approaches," Cao says. (scitechdaily.com)
performed in vivo lineage tracing studies to determine that expression of the keratin 15 promoter distinguishes a distinct basal stem cell population that is capable of self-renewal, proliferation, and differentiation into squamous-lineage cells. (jci.org)
Depletion of Krt15 -derived cells resulted in decreased proliferation, thereby leading to atrophy of the esophageal epithelium. (jci.org)
When used in conjunction with FGF and EGF, the maintenance medium will allow for the proliferation of ReNcell immortalized VM and CX neural stem cells. (thomassci.com)
The signaling network in the niche establishes the baseline for self-renewal, fate determination, proliferation, and differentiation of intestinal stem cells. (wjgnet.com)
A) The biological activity of Human Recombinant BDNF was tested by its ability to promote the proliferation of a neuroblastoma cell line stably expressing TrkB (BR6). (stemcell.com)
Cell proliferation was measured using a colorimetric assay method. (stemcell.com)
Malignant transformation and uncontrolled proliferation of an abnormally differentiated. (msdmanuals.com)
Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)

Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)

Jensen, K. B. & Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. (nature.com)
Human cervix cells under magnification. (acs.org)
STEMdiff™ Neural Progenitor Medium is a defined and serum-free medium for the expansion of neural progenitor cells (NPCs) derived from human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells using STEMdiff™ Neural Induction Medium (Catalog #05835). (stemcell.com)
Gimble, J.M., Bunnell, B.A. and Guilak, F. (2012) Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation. (scirp.org)
The molecular study of fat cell development in the human body is essential for our understanding of obesity and related diseases. (mdpi.com)
REPROCELL's iPSC-GRPs are the first and only human glial-restricted progenitor (GRP) cell therapeutic. (reprocell.com)
Here, we show that BMP4-treated hESCs differentiate into bona fide CTB by direct comparison with primary human placental tissues and isolated CTB through gene expression profiling. (ca.gov)
Taken together, our results establish that BMP4-treated hESCs are an excellent model of human trophoblast differentiation, closely mimicking the in vivo progression from p63+ CTB stem cells to terminally differentiated trophoblast subtypes. (ca.gov)
The adult human airway epithelium is comprised of four major cell types, basal, club, goblet, and ciliated cells. (cdc.gov)
Thus, the aim of this study was to investigate if aerosolized nZnO exposure leads to changes in the cellular composition of the airway epithelium, using air-liquid interface (ALI)-differentiated primary human bronchial epithelial cells. (cdc.gov)
Methods: Normal human bronchial epithelial cells (NHBEpC) (at ≥ 90% viability) were seeded on 12-well porous 0.4 µm- cell culture inserts in basal cell culture medium. (cdc.gov)
Transcription factors (nurr1, pitx3 and lmx1a) that promote embryonic mouse or chicken dopaminergic development were employed to determine if they would modulate lineage restriction of these adult human progenitors. (scirp.org)
ReNcell CX Human Neural Progenitor Cell Line & Culture Media Kit ReNcell CX Kit contains human neural progenitor cells, optimized maintenance media & freezing media for culture of human neural stem cells. (thomassci.com)
ReNcell NSC Freezing Medium (SCM007): ReNcell NSC Freezing Medium is qualified for use with ReNcell immortalized human neural progenitor cell lines, CX (CHEMICON Catalog No. SCC007) and VM (CHEMICON Catalog No. SCC008) cultured in serum-free conditions with ReNcell NSC Maintenance Medium (CHEMICON Catalog No. SCM005). (thomassci.com)
From infancy through adolescence, myelinating oligodendrocytes are generated in abundance in the human brain by progenitor cells in a process that is highly sensitive to hormones, nutrients and environmental conditions. (technologynetworks.com)
… "embryo" means a human organism during the first 56 days of its development following fertilization or creation, excluding any time during which its development has been suspended, and includes any cell derived from such an organism that is used for the purpose of creating a human being. (hinxtongroup.org)
To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. (lu.se)
Sozzi E, Nilsson F, Kajtez J, Parmar M, Fiorenzano A. Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells . (lu.se)
Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)

Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
They are derived from induced pluripotent stem cells (iPSCs) which provide an unlimited source of robust GRPs for therapeutic use. (reprocell.com)
The work also suggests a much more efficient way of differentiating stem cells for therapeutic purposes. (sciencedaily.com)

Normal erythropoiesis begins with multipotent hematopoietic stem cells, which differentiate into erythroid progenitors, eventually to develop into the mature red blood cells. (medscape.com)
Using previous findings in healthy cells as a reference, we analyzed scRNA-seq data obtained from patients with myelodysplastic syndrome (MDS) and detected specific alterations of the expression dynamics of genes involved in erythroid differentiation in all patients with MDS such as TRIB2. (cun.es)

The most important difference between stem cells and progenitor cells is that stem cells can replicate indefinitely, whereas progenitor cells can divide only a limited number of times. (wikipedia.org)
Undifferentiated spermatogonia divide mitotically to both repopulate the testicular stem cell population and provide progenitor cells that undergo spermatogenesis. (jci.org)
The secondary stem cell pool also generates progenitor cells which divide and differentiate to become sperm. (lesswrong.com)
These stem cells divide to eventually give rise to red blood cells, platelets, and most white blood cells in the red marrow. (medscape.com)

B-D) NPCs maintained in STEMdiff™ Neural Progenitor Medium express the CNS-type NPC markers PAX6 (B, D, red), SOX1 (C, red) and NESTIN (C, green), but not the neural crest marker SOX10 (D, green, single channel shown in inset). (stemcell.com)
Do NPCs of differentiated cells lack Nup133 to stabilize their gene expression profile? (ny.gov)
Far more common are their immediate progeny, which are called neural progenitor cells, or NPCs. (neurosciencenews.com)

To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

Stem cells are essential for regeneration and repair of worn-out or injured tissue. (europa.eu)
There, MSC differentiate and regenerate tissue integrity. (europa.eu)
Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)
They also serve as specialized vascular niches that provide instructive signals to tissue-specific stem cells or parenchymal cells for tissue formation and repair. (go.jp)
Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
The prostates of older mice contain more luminal progenitor cells - cells capable of generating new prostate tissue - than the prostates of younger mice, UCLA researchers have discovered. (ucla.edu)
For instance, prostate progenitor cells can only form prostate tissue. (ucla.edu)
So it was a surprising and important finding that there's really no difference between old cells and young cells in their ability to form prostate tissue. (ucla.edu)
The higher concentration of luminal progenitors, coupled with their maintained ability to form new tissue, helps explain why the prostate grows with age and why the risk of prostate cancer and benign prostatic hyperplasia increase: Both are associated with the growth of cells. (ucla.edu)
Many researchers believe that these cells may be able to regenerate damaged brain tissue by integrating into circuits that have been eroded by neurodegenerative disease or destroyed by injury. (neurosciencenews.com)
This week in the JCI , a study led by Anil Rustgi at the University of Pennsylvania identifies keratin 15 as a marker for a subpopulation of proliferative stem cells in the esophagus that are indispensible for maintaining homeostasis as well as regenerating tissue following injury. (jci.org)
Although wild-type mice displayed normal morphology 15 days after injury, tissue regeneration remained incomplete in mice lacking keratin 15 + cells. (jci.org)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)

The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)
These findings indicate that keratin 15 + progenitors give rise to a population of squamous epithelial cells that are critical to recovery from injury and disease. (jci.org)
Rapid epithelial renewal occurs, but the specific cell of origin that supports this high proliferative demand remains unknown. (jci.org)
Further, Krt15 + cells were radioresistant and contributed to esophageal epithelial regeneration following radiation-induced injury. (jci.org)
Above the stem cell zone is the lineage-committed progenitor cells, also known as the transit amplifying zone, divided to fuel the rapid epithelial cell turnover. (wjgnet.com)

They demonstrated that transferring functional mitochondria of bone marrow-derived stem cells to defective parenchymal cells increases the aerobic respiration capacity of recipient mitochondria ( 7 ). (frontiersin.org)

Scientists have long had the tools to identify the genes being transcribed in a single cell. (acs.org)
In this study, single-cell RNA-sequencing analyses show that islet1 + -derived ECs express a set of genes that reflects their unique origin even as they become heterogeneous. (go.jp)
MEF2C is a transcription factor that turns on specific genes which then drive stem cells to become nerve cells. (science20.com)
MEF2C helps this process first by turning on the genes that, when expressed, make stem cells into nerve cells. (science20.com)
It then turns on other genes that keep those new nerve cells from dying. (science20.com)
Instead, it supports the idea that cells differentiate through the collective behavior of multiple genes in a network that ultimately leads to just a few endpoints -- just as a marble on a hilltop can travel a nearly infinite number of downward paths, only to arrive in the same valley. (sciencedaily.com)
Again, they found tremendous variability within the apparently uniform cell population: more than 3,900 genes were differentially expressed (turned "on" or "off") between the low- and high-Sca-1 cells. (sciencedaily.com)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
En route to the patient we can also remove disease-associated genes that might compromise the transplanted cells and eventually the clinical benefit of the graft over time," described Fredrik. (lu.se)

Research on regenerative medicine has focused on progenitor cells, and stem cells, because their cellular senescence contributes largely to the process of aging. (wikipedia.org)
Increased circulation of progenitor cells in the body has also positively correlated to increased longevity and regenerative processes. (wikipedia.org)
The Tisch Multiple Sclerosis Research Center of New York ( click here ) recently published the Phase 1 results of the first-ever FDA approved multiple sclerosis regenerative stem cell study ( click here ). (wheelchairkamikaze.com)
The next installment will include an overview of the upcoming FDA approved Phase 2 trial, as well as a discussion of how regenerative stem cells might work and their possible impact on the treatment landscape of multiple sclerosis. (wheelchairkamikaze.com)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

We have previously shown that p63, a member of the p53 family of nuclear proteins, is expressed in proliferative cytotrophoblast (CTB), precursors to terminally differentiated syncytiotrophoblast (STB) in chorionic villi and extravillous trophoblast (EVT) at the implantation site. (ca.gov)

The natural aging of cells, called their cellular senescence, is one of the main contributors to aging on an organismal level. (wikipedia.org)
A major component outside of the cells, which notably is distinctly involved in controlling and guiding many cellular processes, is the polysaccharide hyaluronan (HA). (europa.eu)
Our results now suggest that 4-MU treatment of MSC not only affects the formation of SG via increased levels of O-linked glycosylation of cellular proteins but also that MSC cultivated under osteogenic stimulation develop SG, which in turn support MSC differentiation into osteogenic precursor cells. (europa.eu)
TrackerSci is a new tool for tracking brain cell development and aging, offering fresh insights into cellular changes over a lifetime and potential applications in various organ studies. (scitechdaily.com)
In summary, we demonstrate that the combination of single cell technologies with computational analysis tools enable the study of a variety of cellular mechanisms involved in complex biological systems such as early hematopoiesis and can be used to dissect perturbed differentiation trajectories associated with perturbations such as aging and malignant transformation. (cun.es)
Within these activated cells, internal garbage disposals called lysosomes form in large numbers and start whirring, ready to make mincemeat out of pathogens or cellular debris. (neurosciencenews.com)

Intermediate progenitor cells formed in the subventricular zone. (wikipedia.org)
We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast mid EGFR high PlexinB2 high CD24 −/low O4/PSA-NCAM −/low Ter119/CD45 − (GEPCOT) cells. (elifesciences.org)
A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)
When cells from the subventricular zone are cultured in a way that allows the cells to freely float around (rather than growing on a surface), a few percent form spherical colonies called neurospheres. (elifesciences.org)
have used a technique called flow cytometry to identify and isolate neural stem cells and neurosphere-forming cells directly from the subventricular zone. (elifesciences.org)

We also establish that, similar to in vivo events, hESC differentiation into trophoblast is characterized by a p63+/KRT7+ CTB stem cell state, followed by formation of functional KLF4+ STB and HLA-G+ EVT. (ca.gov)
The cell is the basic functional unit of our body, so changes to the cell essentially underlie virtually every disease and the aging process," says Cao, head of the Laboratory of Single-Cell Genomics and Population Dynamics. (scitechdaily.com)
The present results clearly demonstrate that ECs originating from the endoderm via islet1 + endothelial progenitors play a specialized role in forming a functional vascular HSPC niche (Figure 1C). (go.jp)
In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury. (frontiersin.org)

Skin cells are taken from a patient, reprogrammed to induced pluripotent stem cells (iPSCs), differentiated into dopaminergic progenitors, and put back in the patient. (lu.se)

New cells are continuously produced in the adult mammalian brain, a critical process associated with memory, learning, and stress. (scitechdaily.com)
Neural stem cells can endure essentially unchanged for decades in two places in the mammalian brain, replicating just enough to meet the routine needs of those regions. (neurosciencenews.com)

Astrocytes are generated from neural stem cells (NSCs) during late embryonic and early postnatal stages. (nature.com)
Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. (elifesciences.org)
A: Schematic of DNA methylation and histone modifications in neural stem cells (NSCs). (wjgnet.com)

Pre-GEPCOT cells could not form neurospheres but expressed the stem cell markers Slc1a3-CreER T , GFAP-CreER T2 , Sox2 CreERT2 , and Gli1 CreERT2 and were long-lived in vivo. (elifesciences.org)
term pre-GEPCOT cells (based on an acronym of the markers used to isolate the cells), were long-lived and quiescent, but they lacked the ability to form colonies in culture. (elifesciences.org)
Herein, we have described a long-lived progenitor cell population in the mouse esophageal epithelium that is characterized by expression of keratin 15 ( Krt15 ). (jci.org)

hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
The true opportunity of this work lies in the potential to deliver patient-specific treatments as well as curative stem cell-based therapies to patients globally. (lu.se)
My work focus on cell repair and cell models which is central to these aims both for developing new therapies and for understanding and diagnosis disease. (lu.se)

Anatomy67

Organisms17

Diseases9

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes53

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science2

Health Care1

Embryonic stem6

Neurons16

Lineages8

Neuronal8

Fully differentiated5

Migrate6

Adult stem7

Endothelial progenitor cells3

Pluripotent stem3

Proliferate and differentiate1

Mesenchymal stem6

Transplantation10

Myeloid progenitor2

Terminally differentiated cells2

Vitro7

Lymphoid2

Glial cells3

Transcriptional4

Neural progenitors1

Biology15

Generate4

HSPCs4

Hematopoietic stem2

Originate3

Parkinson's Disease7

Differentiation of human1

Somatic9

Phenotypes1

Proliferation10

Self-renew1

Human19

Therapeutic3

Erythroid2

Divide4

NPCs3

Immediate progeny1

Tissue18

Epithelial5

Bone Marrow-Derived Stem Cells1

Genes9

Regenerative5

Precursors1

Cellular6

Subventricular zone5

Functional4

IPSCs1

Mammalian brain2

NSCs3

Long-lived3

Therapies4