Loading...
  • adult
  • Lhx2 is expressed in the liver associated st mesenchymal cells that become integrated in the liver and contribute to a subpopulation of hepatic stellate cells in adult liver. (diva-portal.org)
  • Recently, it was shown that islet and ductal cells in adult pancreas expressed Sca-1 [ 14 ]. (hindawi.com)
  • The outlook on stem cell (SC) biology is shifting from a rigid hierarchical to a more flexible model in which the identity and the behavior of adult SCs, far from being fixed, are determined by the dynamic integration of cell autonomous and non-autonomous mechanisms. (frontiersin.org)
  • Such a role of ncRNAs has been investigated in embryonic and induced pluripotent SCs, and in numerous types of adult SCs and progenitors, including those of the breast, which will be the topic of this review. (frontiersin.org)
  • generate
  • A type I neuroblast expresses Deadpan (Dpn) and Asense (Ase) and divides asymmetrically to self-renew and to generate a progenitor cell called a ganglion mother cell (GMC). (biologists.org)
  • We believe that these iPSCs can be potentially used in the future to generate sufficient number of cells to be implanted in the damaged heart to regenerate the lost tissue post heart attack. (ca.gov)
  • In summary, we report a rapid and efficient strategy to generate an enriched population of OSPCs from hiPSCs, thereby establishing the value of this approach for disease modeling and cell-based therapies of the inner ear. (frontiersin.org)
  • HSPCs
  • We have therefore examined the BM homing properties of human induced pluripotent stem cell-derived HSPCs (hiPS-HSPCs). (jci.org)
  • However, glycoengineered hiPS-HSPCs did not engraft long-term, indicating that additional functional deficiencies exist in these cells. (jci.org)
  • sensory
  • Development of stem cell-based therapy requires a better understanding of factors and signals that drive stem cells into otic sensory progenitor cells (OSPCs) to replace lost HCs. (frontiersin.org)
  • Almost all cell types of the inner ear, including neurosensory, non-sensory and secretory cells derive from the otic vesicle, an epithelial structure that emerged through invagination of the otic placode (OP) during early organogenesis. (frontiersin.org)
  • induce
  • Hemodynamic forces such as fluid shear stress increase the percentage of cells in the S and G2-M phases, and induce decondensation of chromatin for gene transcription. (eurekaselect.com)
  • Furthermore, specific depletion of CD169 (+) MΦ, which spares BM MOs, was sufficient to induce HSC/ progenitor egress. (nih.gov)
  • fluorescent protein
  • Method and Result] BM cells of mice constitutively expressing green fluorescent protein (GFP) was intravenously injected into irradiated syngeneic newborn C57BL/6 mouse within 48hours after the birth. (ahajournals.org)
  • B) TF-1 cells were infected with lentiviruses encoding doxycycline (DOX)-inducible cohesin WT or mutant variants and green fluorescent protein (GFP). (nih.gov)
  • therapies
  • Our lab has studied how these cardiac progenitors evolve in the developing heart and applied our finding to iPSCs to recapitulate the cardiac progenitors to ultimately use in clinical therapies. (ca.gov)
  • genes
  • The differentiated cells can be analyzed by real-time PCR and flow cytometry to confirm enrichment of EC-specific genes and proteins. (pubmedcentralcanada.ca)
  • Furthermore
  • Furthermore, the expression of ncRNAs is often tissue- or even cell type-specific, emphasizing their involvement in defining space, time and developmental stages in gene regulation. (frontiersin.org)
  • tissues
  • Growing and developing tissues are particularly vulnerable to alcohol's influence, suggesting that stem- and progenitor-cell function could be affected. (springer.com)
  • Accordingly, recent studies have revealed the possible relevance of alcohol exposure in impairing stem-cell properties, consequently affecting organ development and injury response in different tissues. (springer.com)
  • regulate
  • Our findings establish distinct kinase-dependent and -independent activities of FAK that differentially regulate luminal progenitors and basal MaSCs. (aacrjournals.org)
  • Regenerative Medicine
  • 3 Center for Stem Cell and Regenerative Medicine, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, USA. (jci.org)
  • Address correspondence to: Brian R. Davis, Center for Stem Cell and Regenerative Medicine Brown Foundation, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA. (jci.org)
  • devoid
  • However, this application is limited because of the inability to prospectively identify a pure population of cardiovascular progenitors (CVPs) that is devoid of residual, undifferentiated cells capable of teratoma formation. (ahajournals.org)
  • fate
  • Asymmetric stem cell division balances maintenance of the stem cell pool and generation of diverse cell types by simultaneously allowing one daughter progeny to maintain a stem cell fate and its sibling to acquire a progenitor cell identity. (biologists.org)
  • Via the secretion of soluble molecules one type of cells affect the fate of their neighboring cells. (diva-portal.org)
  • A central issue in organogenesis is how a cell interprets such extrinsic signals and adopts a specific fate, and how the cell in response to this signal establishes reciprocal signaling. (diva-portal.org)
  • Within this framework, the recent discovery of thousands of non-coding RNAs (ncRNAs) with regulatory function is redefining the landscape of transcriptome regulation, highlighting the interplay of epigenetic, transcriptional, and post-transcriptional mechanisms in the specification of cell fate and in the regulation of developmental processes. (frontiersin.org)