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  • cellular
  • and it has remained unsettled whether adult newts possess a cellular population that is equal to mammalian satellite cells. (rupress.org)
  • Thus, the understanding of the role of mitochondria in regulating cellular Ca2+ homeostasis has become crucial for the understanding of a series of cell functions. (unipd.it)
  • The cellular targets for myostatin and activin A in muscle and the role of satellite cells in mediating muscle hypertrophy induced by inhibition of this signaling pathway have not been fully elucidated. (pnas.org)
  • Inhibition of Notch signaling induces myotube hypertrophy by recruiting a subpopulation of reserve cells," Journal of Cellular Physiology , vol. 208, no. 3, pp. 538-548, 2006. (hindawi.com)
  • regulation
  • The regulation of Notch signaling by its inhibitor Numb appears to determine lineage progression and cell fate determination. (stanford.edu)
  • We are currently exploring further the regulation of the Notch and Wnt signaling pathways during satellite cell activation, the mechanisms underlying the transcriptional control of Delta expression, and epigenetic processes that may account for age-related changes in these pathways. (stanford.edu)
  • Current studies are focused on the role of post-transcriptional regulation of stem cell quiescence and activation. (stanford.edu)
  • Exercise positively affects muscle fiber composition via regulation of satellite cells to improve muscle performance. (hindawi.com)
  • Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy," The FASEB Journal , vol. 28, no. 4, pp. 1654-1665, 2014. (hindawi.com)
  • fibers
  • New fiber synthesis and/or increased growth of preexisting fibers via satellite cell fusion or increased protein synthesis is ultimately responsible for muscle hypertrophy observed following repeated eccentric contractions ( 9 , 13 , 22 , 23 ). (physiology.org)
  • Growth and repair of skeletal muscle are normally mediated by the satellite cells that surround muscle fibers. (sciencemag.org)
  • Specifically they needed "well-developed contractile muscle fibers" included in the mix with the immature cells. (tgnreview.com)
  • Once the cells grew into mature fibers themselves, they were grafted into mice where the new muscle adapted function and strength. (tgnreview.com)
  • These cells are located between the basal lamina and plasma membrane of skeletal muscle fibers in which they represent 2.5%-6% of all nuclei and remain in a quiescent state under normal physiological conditions [ 2 ]. (hindawi.com)
  • transplantation
  • Furthermore, pharmacological manipulation of C/EBPβ expression with the phosphodiesterase inhibitor, isobutylmethylxanthine (IBMX), increased the number of cells available for transplantation into dystrophic muscle and enhanced the expression of stem cell markers in a C/EBPβ-dependent fashion. (uottawa.ca)
  • Pharmacological
  • Together, these results demonstrate that C/EBPβ is an important regulator of SC function and that pharmacological manipulation of C/EBPβ improves culture conditions for the expansion and selection of SCs available for cell therapy for the treatment of muscular dystrophies. (uottawa.ca)
  • tissues
  • Dedifferentiation of stump tissues, such as skeletal muscle, precedes blastema formation, but it was not known whether dedifferentiation involves stem cell activation. (rupress.org)
  • We demonstrate that skeletal muscle dedifferentiation involves satellite cell activation and that these cells can contribute to new limb tissues. (rupress.org)
  • It is unclear to what extent differentiated cells reverse mature phenotypes and to what extent undifferentiated cells, such as stem cells, residing within differentiated tissues become activated, followed by their incorporation into the blastema. (rupress.org)