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Bone Marrow TransplantationBone MarrowTransplantation, HomologousBone Marrow CellsGraft vs Host DiseaseTransplantation, AutologousWhole-Body IrradiationBone and BonesAnemia, AplasticHematopoietic Stem Cell TransplantationTransplantation ConditioningHematopoietic Stem CellsLeukemiaLiver TransplantationTransplantation ChimeraGraft SurvivalTissue DonorsBone Marrow PurgingBusulfanHistocompatibility TestingHematopoiesisHistocompatibilityCyclophosphamideTransplantation, IsogeneicBone Marrow DiseasesMice, Inbred C57BLKidney TransplantationRadiation ChimeraRecurrenceCombined Modality TherapyLeukemia, Myelogenous, Chronic, BCR-ABL PositiveStem CellsLeukemia, Myeloid, AcuteCell DifferentiationColony-Forming Units AssayBone Marrow ExaminationTime FactorsStem Cell TransplantationImmunosuppressive AgentsRemission InductionHematologic NeoplasmsTreatment OutcomeGraft RejectionPrecursor Cell Lymphoblastic Leukemia-LymphomaBone RemodelingHepatic Veno-Occlusive DiseaseLeukemia, MyeloidBone Marrow NeoplasmsTransplantation ImmunologyGraft vs Host ReactionLymphocyte DepletionImmunosuppressionLymphoma, Non-HodgkinAcute DiseaseLeukocyte TransfusionHeart TransplantationT-LymphocytesChimeraAntigens, CD34Severe Combined ImmunodeficiencyMyelodysplastic SyndromesHLA AntigensSurvival AnalysisCells, CulturedRetrospective StudiesLung TransplantationHematologic DiseasesCyclosporineFlow CytometryBone DensityActuarial AnalysisGranulocyte Colony-Stimulating FactorCell LineageLymphocyte TransfusionAntineoplastic Combined Chemotherapy ProtocolsCarmustineNuclear FamilyPancytopeniaOrgan TransplantationLeukocyte CountSpleenGraft vs Tumor EffectCytarabineMice, Inbred BALB CGraft vs Leukemia EffectFollow-Up StudiesMice, KnockoutSurvival RateCytomegalovirus InfectionsGranulocytesBone ResorptionMelphalanCell SeparationEtoposideDisease-Free SurvivalLymphomaMultiple MyelomaMice, TransgenicCell TransplantationImmunophenotyping
Regimen prior to allogeneic hematopoietic progenitorDerived progenitor cellsUmbilicalStromal cellsAllogeneic bone marrowMultipotentHematopoiesisReconstitutionTissuesReconstitute bone marrowPeripheral blood progenitorHematopoietic progenitor cellStem cellPatientsAutologous bone marrowDifferentiationEngraftmentLineagesDifferentiatePatient'sChemotherapyAspirationInfusionHSCTDonorComplicationsCell TherapyCurative treatmentMSCsHematologicalHeterogeneous cellBloodRegenerativeEtiologyVitroTyrosineSubsetsUndergoProliferationDefectiveOrganSpleenSyngeneicDisordersAdultOrgansRegenerationDonorsMice
Regimen prior to allogeneic hematopoietic progenitor1
  • The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (nih.gov)
Derived progenitor cells1
  • For over 30 years, bone marrow derived progenitor cells have been used to treat a variety of conditions because they have remarkable healing and regenerative properties. (futuremedicalgroup.com)
Umbilical4
  • In Dr. Moise's article about umbilical cord blood, it was found that there is approximately 10% less stem cells in cord blood than there is in bone marrow. (wikipedia.org)
  • The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
  • To enrich for analogous human progenitor cells, we purified human umbilical cord blood (UCB) and BM based on high aldehyde dehydrogenase activity (ALDHhl), a conserved function in multiple progenitor lineages. (uwo.ca)
  • MSCs can be isolated from different locations, such as bone marrow, umbilical cord, placenta, adipose and dental tissues. (bvsalud.org)
Stromal cells7
  • Multipotent mesenchymal stromal cells (MSCs) were first isolated from bone marrow and then from various adult tissues including placenta, cord blood, deciduous teeth, and amniotic fluid. (embrapa.br)
  • However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
  • Nowadays, experts agree that MSCs may generate upon appropriate stimulation quite different mature cells including osteoblasts, chondrocytes, tenocytes, adipocytes, smooth muscle cells, and stromal cells of the bone marrow [ 9 ]. (hindawi.com)
  • Transplantation of ALDHhl mixed progenitor cells or culture- expanded multipotent stromal cells (MSC) into streptozotocin-treated NOD/SCID mice revealed endogenous islet regeneration occurred via distinct mechanisms. (uwo.ca)
  • It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
  • These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
  • Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
Allogeneic bone marrow5
Multipotent3
  • Endothelial progenitor cells and multipotent unrestricted adult stem cells can also be found in cord blood. (wikipedia.org)
  • They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)
  • Hematopoietic stem cells (HSCs) are a type of multipotent stem cell found primarily in the bone marrow and, to a lesser extent, in peripheral blood. (thenoveldifference.com)
Hematopoiesis3
Reconstitution3
  • Autologous hematopoietic stem cell transplantation and reconstitution: Different species and including primates and humans for studies are being used for development, localization, and therapeutic strategies. (hoajonline.com)
  • The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)
  • We collected large numbers of peripheral blood (PB) progenitors after CSF administration using either G- CSF or GM-CSF and tested their ability to affect hematopoietic reconstitution and resource utilization in patients undergoing high-dose chemotherapy and autologous BM support. (johnshopkins.edu)
Tissues13
  • Transplantation of GFP+Lin-BM into lethally-irradiated mice showed engraftment of hematopoietic cells into non-hematopoietic tissues, including the brain and spinal cord. (uni-goettingen.de)
  • But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
  • Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
  • Progenitor cells are often located within specific tissues, close to where they will ultimately function. (thenoveldifference.com)
  • At 16 weeks after implantation surgery, full‑thickness osteochondral defects with a diameter of 5 mm and a depth of 4 mm were well‑filled with newly regenerated tissues, exhibiting the simultaneous regeneration of avascular articular cartilage and well‑vascularized subchondral bone, as proven through macroscopic and microscopic observations in PRF‑treated groups compared with that in the untreated group. (spandidos-publications.com)
  • The application of L‑PRF and F‑PRF for osteochondral defects in rabbits contributed to massive host remodeling and reconstruction of osteochondral tissues, thus offering a prospective bioactive scaffold for the simultaneous reconstruction of articular cartilage and subchondral bone tissue. (spandidos-publications.com)
  • Moreover, to produce acceptable structural and functional repair, all three kinds of tissues involved in osteochondral lesions, including subchondral bone, the osteochondral interface and articular cartilage, need to be reconstructed simultaneously ( 3 ). (spandidos-publications.com)
  • img class='aligncenter' src='https://scx1.b-cdn.net/csz/news/800a/2023/pitt-study-reframes-un.jpg' alt='Pitt study reframes understanding of graft-versus-host disease' title='A new model of graft-versus-host-disease (GVHD): Early post transplant (left side), GVHD is initiated by progenitor T cells that seed affected tissues from the spleen and lymph nodes via the blood. (awebfind.biz)
  • In the later phases of GVHD (right side), hoodia diet drink costco the disease is maintained locally in the tissues by these long-lived progenitor cells, which differentiate into disease-causing cells. (awebfind.biz)
  • While often lifesaving for patients with leukemia and other blood disorders, the treatment also comes with a risk of developing GVHD, a life-threatening disease that occurs when donor alloreactive T cells attack the recipient's healthy tissues. (awebfind.biz)
  • Led by co-senior author Thomas Höfer, Ph.D., division head of the German Cancer Research Center and professor of theoretical systems biology at the University of Heidelberg, the team used mathematical models to predict that progenitor T cells seed out into recipient tissues early after transplant, differentiating there into disease-causing cells. (awebfind.biz)
  • We think that progenitor T cells are long-lived in target tissues and are critical for maintaining GVHD," said Sacirbegovic. (awebfind.biz)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Reconstitute bone marrow1
Peripheral blood progenitor2
  • Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
  • or BM with G-CSF or GM-CSF and G-CSF or GM-CSF primed peripheral blood progenitor cells (PBPC). (johnshopkins.edu)
Hematopoietic progenitor cell1
  • CML ensues when an abnormal pluripotent hematopoietic progenitor cell initiates excessive production of all myeloid lineage cells, primarily in the bone marrow but also in extramedullary sites (eg, spleen, liver). (msdmanuals.com)
Stem cell23
Patients12
  • Patients who undergo HSCT experience a sequential suppression of host defenses, resulting in varying infectious risk at different phases of the transplantation process. (medscape.com)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • Patients typically have recurrent infections and presentation and complications can vary depending upon where the defect has occurred in B-cell development or the degree of functional impairment. (medscape.com)
  • Thirty-eight patients (4.83%) had pathologic findings before transplantation. (slideshare.net)
  • Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
  • The objectives of the present study were to observe the biological characteristics of MSCs from CML patients and to determine if MSCs originate in part from donors in CML patients after bone marrow transplantation (BMT). (embrapa.br)
  • Patients should not receive Sargramostim until the post marrow infusion ANC is less than 500 cells/mm3. (wikidoc.org)
  • In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • Earlier studies described persistent residual spasticity and hyperactive tendon reflexes (descending motor tracts) and ataxia (spinocerebellar tracts) occurred in hexane-intoxicated patients after recovery from PNS symptoms [ 7 , 8 ]. (biomedcentral.com)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
Autologous bone marrow3
  • Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. (futuremedicalgroup.com)
  • A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. (futuremedicalgroup.com)
  • Two hematopoietic colony-stimulating factors, granulocyte colony- stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF), have been shown to accelerate leukocyte and neutrophil recovery after high-dose chemotherapy and autologous bone marrow (BM) support. (johnshopkins.edu)
Differentiation7
  • This reduced differentiation of CD34+ hematopoietic progenitor stem cells could occur due to both infectious and non-communicable diseases and also due to their drug induced treatments. (hoajonline.com)
  • Transcription factors and cellular signaling pathways play an important role in their self-renewal process.Self-renewal is abrogated when the terminal differentiation occurs. (hoajonline.com)
  • Progenitor cells, also known as precursor cells, are a type of cell that falls somewhere between stem cells and fully differentiated, specialized cells in terms of their differentiation potential. (thenoveldifference.com)
  • They have already committed to a particular differentiation pathway, meaning they are destined to become a specific type of cell, such as a red blood cell, white blood cell, or platelet in the case of hematopoietic progenitor cells. (thenoveldifference.com)
  • The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)
  • [ 18 ] Arylsulfatase A deficiency leads to defective glial and neuronal differentiation from neural progenitor cells. (medscape.com)
  • Cultured oligodendrocyte progenitor cells (OPCs) were incubated with HD ± BMSC-derived conditional medium (BMSC-CM). OPC differentiation was studied by immunostaining and morphometric analysis. (biomedcentral.com)
Engraftment6
  • Although engraftment of irradiated C.B-17 scid/scid (SCID) mice with human progenitor cells occurred after infusion with human pediatric bone marrow cells, significant engraftment of the mouse bone marrow with human cells was dependent upon continuous treatment with exogenous human cytokines. (elsevierpure.com)
  • Since engraftment occurs in the absence of exogenous cytokine treatment, the BM- SCID-hu mouse model described should provide a useful in vivo system for studying factors important in the maturation of human myeloid and lymphoid cells in the bone marrow and the behavior of the mature human cells after dissemination into the peripheral lymphoid tissue. (elsevierpure.com)
  • Studies have reported the migration of hematopoietic progenitor cells past the BBB and their engraftment into the CNS suggesting their potential as anatural vehicle to transport therapeutic agents past this barrier. (uni-goettingen.de)
  • This migration was correlated with disease severity, with higher engraftment occurring after administration at higher clinical scores. (uni-goettingen.de)
  • Engraftment was only observed in the spleen and bone marrow of healthy mice. (uni-goettingen.de)
  • The dose can be repeated after 7 days off therapy if engraftment has not occurred. (wikidoc.org)
Lineages1
Differentiate3
  • Bone marrow is the place for the production of the hematopoietic cells which differentiate in to three groups: red blood cells, white blood cells and platelets. (longdom.org)
  • Progenitor cells take several weeks to months to differentiate. (futuremedicalgroup.com)
  • Figure 10.22 shows the stages of blood cell develop-ment in which characteristic cell types can be identified in thelight microscope in a tissue section or bone marrow smear.Hemopoiesis is initiated in an apparently random mannerwhen individual HSCs begin to differentiate into one ofthe lineage-restricted progenitor cells. (childpsychiatryassociates.com)
Patient's3
  • Autologous transplantation is feasible when the patient's bone marrow is normal and there are no relevant genetic conditions. (medscape.com)
  • These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
  • Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
Chemotherapy4
  • For subjects with recent chemotherapy or experimental therapy the first dose of study drug must occur after 5 times the half-life of the agent(s). (astrazenecaclinicaltrials.com)
  • The recommended dose is 250 mcg/m2/day administered IV over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. (wikidoc.org)
  • After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
  • The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
Aspiration3
  • Bone marrow aspiration is carried out by a puncture on the level of the sternum or the posterior iliac peaks under local anesthesia by the doctor. (longdom.org)
  • In this setting, immediately perform a bone marrow aspiration and obtain a biopsy from the posterior iliac crest. (medscape.com)
  • For the bone marrow aspiration, an EZIO-10 drill with 28mm bone marrow needle was used. (caringmedical.com)
Infusion1
  • In the present study, after infusion of irradiated SCID mice with pre-cultured human fetal bone marrow cells (BM-SCID-hu mice), their bone marrow became significantly engrafted with human precursor cells and their peripheral lymphoid compartment became populated with human B cells and monocytes independently of the administration of extraneous human cytokines. (elsevierpure.com)
HSCT2
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
Donor5
  • In autologous transplantation, the donor and recipient is the same individual. (medscape.com)
  • When the donor is someone other than the recipient, the procedure is described as allogeneic transplantation. (medscape.com)
  • Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
  • Kidney transplantation is a surgical process encompassing the amputation of a healthy and operational kidney from a donor and inserting it in a patient without any appropriately working kidney. (articleted.com)
  • The only curative treatment for ALF is liver transplantation, but there are many restrictions on the application of liver transplantation because of financial considerations, a shortage of donor livers, and immunosuppression-related complications [ 3 ]. (springer.com)
Complications2
  • If one of the brothers and sisters is compatible, we speak about geno-identical allogeneic transplantation having the advantage of reducing the complications post-transplantation. (longdom.org)
  • Despite their use, a prolonged period of absolute leukopenia persists during which infections and other complications of transplantation occur. (johnshopkins.edu)
Cell Therapy3
  • In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
  • Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
  • We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
Curative treatment1
MSCs2
  • The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
  • Therefore, MSCs may help resolve issues restricting the application of hepatocyte transplantation. (springer.com)
Hematological1
Heterogeneous cell1
  • Bone marrow is a heterogeneous cell population which includes hematopoietic and mesenchymal progenitor cells. (embrapa.br)
Blood11
  • However, the interest in cord blood is mostly driven by the observation that cord blood also contains various types of stem and progenitor cells, mostly hematopoietic stem cells. (wikipedia.org)
  • Collected cord blood is cryopreserved and then stored in a cord blood bank for future transplantation. (wikipedia.org)
  • For example, hematopoietic progenitor cells are found in the bone marrow, as this is where blood cell production occurs. (thenoveldifference.com)
  • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
  • The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
  • The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
  • The use of CSF-primed PBPC led to a highly significant reduction in the duration of leukopenia with a white blood cell (WBC) count under 100 and 200 cells/mL, and neutrophil count under 100 and 200 cells/mL with both GM- and G-CSF primed PB progenitor cells, compared with the use of the CSF with BM or with historical controls using BM alone. (johnshopkins.edu)
  • Often, analysis of blood occurs in a nonterminal manner. (harvard.edu)
  • In this study, we report significant alterations in blood parameters, particularly of total white blood cells, specific populations of dendritic cells and myeloid-derived suppressor cells, and hematopoietic progenitor cells, as a result of site and manner of sampling. (harvard.edu)
  • Peripheral blood smear, bone marrow aspirate, and demonstration of the Philadelphia chromosome are diagnostic. (msdmanuals.com)
  • thymus from marrow-derived progenitors circulating in the blood. (lu.se)
Regenerative2
  • Progenitor cells are being explored for various therapeutic applications, including tissue engineering and regenerative medicine. (thenoveldifference.com)
  • After more than 50 years of research, airway transplantation remains a major challenge in the fields of thoracic surgery and regenerative medicine. (biomedcentral.com)
Etiology1
  • The etiology of bone marrow failure (BMF) includes defective stem/progenitor cells and/or stroma/accessory cells/growth factors, as well as deficient nonspecific nutrients or, as in the case of acquired aplastic anemia, immune-mediated abnormalities. (medscape.com)
Vitro2
  • Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
  • Our findings were subsequently tested by in vitro experiments, where putative early and later-stage DN1 progenitors from the thymus were purified and their pro- gression into DN2 was measured. (lu.se)
Tyrosine2
  • Following B-cell receptor activation, 2 waves of tyrosine kinase phosphorylation occur. (medscape.com)
  • The bcr-abl oncoprotein has uncontrolled tyrosine kinase activity, which deregulates cellular proliferation, decreases adherence of leukemia cells to the bone marrow stroma, and protects leukemic cells from normal programmed cell death (apoptosis). (msdmanuals.com)
Subsets1
  • Further understanding of these endogenous angiogenic or putative neogenic programs activated by distinct human progenitor subsets may provide new approaches for combinatorial cellular therapies to treat diabetes. (uwo.ca)
Undergo1
  • Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)
Proliferation3
  • While progenitor cells can divide and replicate, their proliferation potential is more restricted compared to stem cells. (thenoveldifference.com)
  • Transplanted murine bone marrow (BM) progenitor cells stimulate endogenous beta cell proliferation and insulin production. (uwo.ca)
  • Transplantation of ALDHhl cells improved systemic hyperglycemia via increased islet vascularization and proliferation resulting in increased islet size, but not islet number. (uwo.ca)
Defective1
  • They demonstrated that transferring functional mitochondria of bone marrow-derived stem cells to defective parenchymal cells increases the aerobic respiration capacity of recipient mitochondria ( 7 ). (frontiersin.org)
Organ3
  • When specific tissue or organ damage occurs, these cells can rapidly generate new cells of the desired type to facilitate the healing process. (thenoveldifference.com)
  • In countries with established transplant programs, organ transplantation is highly regulated. (britannica.com)
  • Of particular concern is organ donation , with legal , medical, and social issues surrounding the procurement of organs, without compensation, for transplantation. (britannica.com)
Spleen1
Syngeneic3
  • GVHD has been reported after syngeneic and autologous transplantation but is rare. (medscape.com)
  • Intramyocardial Syngeneic Cardiomyocyte Transplantation Improves Cardiac Pump Function Cardiac morphology and function were assessed four weeks after MI/thoracotomy using MRI. (cell-signaling-pathways.com)
  • Open in a separate Retigabine dihydrochloride window Figure 3 Syngeneic cardiomyocyte transplantation after MI leads to improved cardiac pump function and macrophage infiltration with no improvement in fibrosis and capillary density. (cell-signaling-pathways.com)
Disorders5
  • Therapies for these disorders (eg, intravenous immunoglobulin [IVIG], bone marrow transplantation, gene therapy) are very costly and require highly advanced facilities. (medscape.com)
  • Defects occurring at the CLP stage or those affecting processes common to B- and T-cell development result in combined immunodeficiency involving B, T, and NK cells (see Combined B-Cell and T-Cell Disorders ). (medscape.com)
  • Thus homeostasis of T regulatory cells is an overbearing requirement for prevention of autoimmune disorders arising from uncontrolled self-tolerance which also permits malignancies to occur. (hoajonline.com)
  • Bone marrow failure syndrome (BMFS) is a group of disorders that may manifest as single cytopenia (eg, erythroid, myeloid, or megakaryocytic) or as pancytopenia. (medscape.com)
  • We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
Adult2
  • Hematopoietic stem cells (HSCs) are very rare cells, representing approximately one in 100,000 bone marrow (BM) cells in the adult. (longdom.org)
  • Four types of MLD occur with varying ages at onset and courses (ie, late infantile, early juvenile, late juvenile, and adult). (medscape.com)
Organs1
  • Secondary B lymphopoiesis is an antigen-dependent process and occurs in the germinal center of peripheral lymphoid organs with specific antibody production. (medscape.com)
Regeneration3
Donors2
  • If the geno-identical transplantation is impossible, we will direct ourselves towards the national and international register donors of bone marrow. (longdom.org)
  • Transplantation raises important ethical considerations concerning the diagnosis of death of potential donors, and, particularly, how far resuscitation should be continued. (britannica.com)
Mice3
  • Examination of the bone marrow of the BM-SCID-hu mice for human cytokine mRNA gene expression demonstrated human leukemia inhibitory factor mRNA and interleukin 7 mRNA in nine of nine BM-SCID-hu mice and macrophage-colony-stimulating factor mRNA in seven of eight BM-SCID-hu mice. (elsevierpure.com)
  • Hematopoietic progenitor cells (Lin-BM) were isolated from the bone marrow of β-actin green fluorescent protein (GFP)-transgenic mice. (uni-goettingen.de)
  • Cardiomyocyte Transplantation Alters the Dynamics of the Immune Response in the Heart after MI in C57BL/6J Mice Mice underwent permanent MI through ligation of the LAD. (cell-signaling-pathways.com)