Progenitor mouse homeobox gene. Medical search. Frequent questions

Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration. (biomedcentral.com)

We report that haploinsufficiency for the forkhead transcription factor Foxo1 reverses beta cell failure in Irs2(-/-) mice through partial restoration of beta cell proliferation and increased expression of the pancreatic transcription factor pancreas/duodenum homeobox gene-1 (Pdx1). (nih.gov)
The phenotype of iPS-HSCs, including gene and protein expression profiles and vitamin A storage, resembled that of hepatic stellate cells. (ca.gov)
Expression analysis of several Hox genes in human embryos. (cnr.it)
Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development. (cnr.it)
Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)
Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)
Expression of this gene is restricted to the node and the posterior notochord during gastrulation [embryonic day 7.5 (E7.5)-E12.5]. (bepress.com)
2003). Expression of vesicular glutamate transporter 1 in the mouse retina reveals temporal ordering in development of rod vs. cone and ON vs. OFF circuits. (uh.edu)
2003). Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina. (uh.edu)
In an early step, the Dorsocross genes act in parallel with tinman to activate the expression of pannier , a cardiogenic gene encoding a Gata factor. (biologists.com)
Our loss- and gain-of-function studies, as well as the observed genetic interactions among Dorsocross, tinman and pannier , suggest that co-expression of these three genes in the cardiac mesoderm, which also involves cross-regulation, plays a major role in the specification of cardiac progenitors. (biologists.com)
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. (nature.com)
Co-expression of these genes in X. tropicalis early gastrula embryos was shown with in situ hybridization using hemisections. (xenbase.org)
GSE30419 gene microarray data of BMSCs and GSE72088 gene microarray data of primary hepatocytes were obtained from the Gene Expression Omnibus database. (aging-us.com)
The expression of the hub genes in the BMSCs and hepatocytes was verified by reverse transcription-quantitative PCR (RT-qPCR). (aging-us.com)
Here we show that downregulation of Zeb1 expression in embryonic cortical neural progenitor cells (NPCs) is necessary for proper neuronal differentiation and migration. (stanford.edu)
In agreement with these observations, expression of dominant-negative Smads in the developing basal ganglia phenocopies the cell migration defects observed in Dlx1/2 -deficient mice. (biomedcentral.com)
Within this region, their expression overlaps with that of Gad65 and Gad67 , genes encoding different forms of the rate-limiting enzyme required for production of GABA from glutamate. (biomedcentral.com)
On days 3 and 7 of culture, islets were assessed for recovery, insulin content, viability, cellular composition, GLUT2 expression in beta cells, differentia‐ tion of pancreatic endocrine progenitor cells, function, and oxygen consumption rate. (crenolanibinhibitor.com)
Chemically induced gene expression changes were characterized by qRT-PCR, global run-on sequencing (GRO-seq) and immunoblotting, and the network of cooperative proteins of GATA4 and NKX2-5 were further explored by the examination of the GATA4 and NKX2-5 interactome by BioID. (biomedcentral.com)
Reporter gene assays were conducted to examine combinatorial effects of GATA-targeted compounds and bromodomain and extraterminal domain (BET) inhibition on chamber-specific gene expression. (biomedcentral.com)
GATA4-targeted compounds 3i-1000 and 3i-1103 were identified as differential modulators of atrial and ventricular gene expression. (biomedcentral.com)
In this line, reporter gene assays with combinatorial treatment of 3i-1000 and the BET bromodomain inhibitor (+)-JQ1 demonstrated the cooperative role of GATA4 and BRD4 in the modulation of chamber-specific cardiac gene expression. (biomedcentral.com)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
Results Primary B cells exogenously expressing Bcl2 , Myc and Ccnd1 showed factor-independent growth ability, enhanced colony-forming capability and aggressive oncogenicity, unlike the cases observed with the expression of any combination of only two of the genes. (haematologica.org)
7 Importantly, it is believed that other hitherto unknown genes also play important roles in lymphomagenesis in addition to the synergistic effects of the aforementioned two oncogenes since human B-cell lymphomas often show a variety of genes subject to alterations and/or deregulated expression. (haematologica.org)
Adenoviral mediated overexpression of HOXB4 in human primitive hematopoietic cells in vitro generates very high levels of HOXB4 within 24 hours of transduction, leading to an increased differentiation towards myeloid lineages, and to a reduction of primitive hematopoietic progenitors, suggesting that the level of HOXB4 expression may determine the fate options following gene transfer. (dissertations.se)
These transcription factors bind promoters and distant regulatory regions, including E-box elements, of genes whose expression is restricted to muscle cells. (unipv.it)
We show that Zeb2 over-expression has a positive impact on skeletal muscle differentiation in pluripotent stem cells and adult myogenic progenitors. (unipv.it)
We have examined the expression profile of synemin isoforms in mouse pluripotent ES cells and during their neural differentiation induced by retinoic acid. (biomedcentral.com)
Our in vivo analysis also confirmed the expression of synemins H/M in multipotent neural stem cells in the subventricular zone of the adult brain, a neurogenic germinal niche of the mice. (biomedcentral.com)
The different expression of isoforms H, M and L of synemin in the nervous system raises several questions about the regulation of synemin gene expression during the determination of glial and neuronal cell lineages in the central and the peripheral nervous system (CNS and PNS). (biomedcentral.com)
These findings attribute a novel biological role to expressed pseudogenes, as they can regulate coding gene expression, and reveal a non-coding function for mRNAs. (uncommondescent.com)
Mechanistically, EBF2 uniformly activates Pparγ-expression in pancreatic cancer cells and limits cell proliferation, whereas oncogenic drivers are expressed differentially in the progenitor cell subsets. (amegroups.org)
Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in the chick. (geneticsmr.com)
MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes. (geneticsmr.com)
Gene expression signatures have been commonly used as diagnostic and prognostic markers for cancer subtyping. (biomedcentral.com)
Notably, these TFs were selected solely from inferred regulatory links using gene expression profiles and included many TFs regulating tumorigenic processes such as proliferation, metastasis, and differentiation. (biomedcentral.com)
With advances in genome-wide gene expression technologies, classification of cancer subtypes based on expression signatures is widespread and results in many biomarkers for various cancers. (biomedcentral.com)
applied a reverse engineering method for context-specific transcriptional regulatory networks to 176 gene expression profiles from high-grade glioblastoma (HGG) patients. (biomedcentral.com)
This was accompanied by reductions in hepatocyte sirtuin 3 (SIRT3) deacetylase activity, gene expression and protein levels as well as in superoxide dismutase enzyme activity. (emory.edu)
Vasoactive intestinal peptides (VIP) expression and secretion by EN were assessed by RT-PCR and ELISA, respectively. (emory.edu)
1 In particular, morpholino oligonucleotides (MOs) have been used to block the expression of targeted genes in several invertebrate and vertebrate models. (cdc.gov)

In zebrafish, Blimp1 promotes differentiation from the embryonic sluggish muscle tissue lineage (9) and specifies neural crest and sensory neuron progenitors (10). (immune-source.com)
2004). Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1. (uh.edu)
Han Y , He X , Lee S , Mao Y , Liu X , Sun H , Jin M , Kwon T , . Network analysis for the identification of hub genes and related molecules as potential biomarkers associated with the differentiation of bone marrow-derived stem cells into hepatocytes. (aging-us.com)
Herein, we screened differentially expressed genes between hepatocytes and untreated BMSCs to identify the genes responsible for the differentiation of BMSCs into hepatocytes. (aging-us.com)
Hub genes were analyzed using the STRING and Cytoscape v 3.8.2, revealing that twenty-four hub genes, play a pivotal role in the differentiation of BMSCs into hepatocytes. (aging-us.com)
In-vitro studies with isolated SA progenitor cells had suggested that chromaffin cell differentiation depends crucially on glucocorticoids provided by adrenal cortical cells. (silverchair.com)
Adult ependyma-specific deletion of Ccn1 transiently enhanced NSC proliferation and reduced neuronal differentiation in mice, increasing the numbers of NSCs and NSC units. (stanford.edu)
ZEB1 regulates a cohort of genes involved in cell differentiation and migration, including Neurod1 and Pard6b. (stanford.edu)
Thus, small molecules capable of influencing the fate decisions and differentiation programs of multipotent progenitor cells could facilitate therapeutic regeneration of lost myocardium. (biomedcentral.com)
We investigate the role of Zeb2 in skeletal muscle differentiation using genetic tools and transgenic mouse embryonic stem cells, together with single-cell RNA-sequencing and in vivo muscle engraftment capability. (unipv.it)
However, both synemin H and M were restricted to the progenitor line during the neural differentiation program. (biomedcentral.com)
His research in Athens focused on the regulation of neuronal differentiation and specification, studying the role of genes that coordinate cell cycle exit and differentiation of neural stem cells during embryonic development. (bioacademy.gr)
Cells were transfected with the early B-cell factor-2 (EBF2) to activate progenitor cell differentiation and gauged the tumorigenic potentials of the derived cell subsets. (amegroups.org)
Here we show that the brown adipose differentiation gene, EBF2, activates differentiation-associated signals in the cancer progenitor cells in culture and CSC transplantation models. (amegroups.org)
This study reveals a previously unrecognized function of EBF2 in regulating PDAC progenitor cell differentiation and tumor suppression. (amegroups.org)
MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells. (geneticsmr.com)

Homeobox protein DBX2, also known as developing brain homeobox protein 2, is a protein that in humans is encoded by the DBX2 gene. (wikipedia.org)
2003). Differential distribution of vesicle associated membrane protein isoforms in the mouse retina. (uh.edu)
Regulatory network inference revealed novel transcription factors including Prospero homeobox protein 1 (PROX1) may act jointly with NEUROG3. (figshare.com)
We identified both gene and protein markers for three temporally distinct ProSG cell subsets, including a migratory cell population with a transcriptome distinct from the previously defined T1- and T2-ProSG stages. (biologists.com)
Four members of the mouse Dlx protein family (Dlx1, 2, 5 and 6), part of the Antennapedia class of non-Hox homeodomain transcription factors, are expressed in the embryonic subpallium (Panganiban and Rubenstein 2002 ). (biomedcentral.com)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

Role of Otx2 in dopaminergic neurogenesis: dose-dependent, anterior -posterior and dorsal-ventral integrated control by Otx2 regulates proliferation, number and neurotransmitter phenotype of dopaminergic progenitors. (cnr.it)
2005). Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina. (uh.edu)
Although proliferation of NSCs and neurogenesis seen in Ccn1 knockout mice eventually returned to normal, the expanded NSC pool was maintained in the V-SVZ until old age. (stanford.edu)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Comparing HESC controls with HESCs deficient in SRC-3, gene enrichment analysis of the differentially expressed gene set revealed an overrepresentation of genes involved in chromatin remodeling, cell proliferation/motility, and programmed cell death. (frontiersin.org)

NEUROGENIN3+ (NEUROG3+) cells are considered to be pancreatic endocrine progenitors. (figshare.com)

The mechanisms governing replication of terminally differentiated beta cells and neogenesis from progenitor cells are unclear. (nih.gov)
Furthermore, titration of hhex with a dexamethasone-inducible hhex -VP16GR fusion construct suggested that endogenous hhex activity during gastrulation is essential for the formation of ventral pancreatic progenitor cells. (xenbase.org)
Fine mapping of the epiblast in the posterior region of the early-streak stage embryo reveals that although the early-gastrula organizer contains cells that give rise to the axial mesoderm, the bulk of the progenitors of the head process and the notochord are localized outside the early gastrula organizer. (silverchair.com)
In the mid-gastrula organizer, early gastrula organizer derived cells that are fated for the prechordal mesoderm are joined by the progenitors of the head process that are recruited from the epiblast previously anterior to the early gastrula organizer. (silverchair.com)
LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. (ca.gov)
Here, we identify genes regulating the generation and maturation of liver cells from iPSCs. (ca.gov)
In this study, we developed a model system for improving interactions between human iPS-derived hepatic progenitor cells (iPS-HPCs) and human iPS-derived hepatic stellate cell-like cells (iPS-HSCs). (ca.gov)
proven to recruit the histone methyltransferase G9a towards the promoter of knockout mice shows that Blimp1 can be a crucial determinant from the germ cell lineage (7, 8), which is important for constant repression of homeobox genes that normally accompany standards of primordial germ cells (PGCs) (7). (immune-source.com)
Latest research of Blimp1 in T cells show that mice missing Blimp1 develop inflammatory disease and display a reduction in success of T cells in thymocytes (11, 12). (immune-source.com)
Under anterior sensory induction and neurogenic circumstances in vitro, the Atoh7-Cre/ROSA-YFP iPS cells differentiate into neurons that co-express different RGC guns and YFP, suggesting that these neurons are extracted from Atoh7-articulating progenitors. (baxkyardgardener.com)
The older retina is composed of specific neuronal cell types extracted from a common pool of sensory progenitor cells during advancement [1]C[3]. (baxkyardgardener.com)
The homeobox gene Pax6, which participates in eyes primordium perseverance and handles the pluripotency of retinal progenitor cells, regulates Atoh7 transcription [17]C[19] positively. (baxkyardgardener.com)
Cell family tree looking up research have got proven that the progeny of Atoh7-showing progenitors also provide rise to a subset of early blessed cone photoreceptor cells [22], [23]. (baxkyardgardener.com)
Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development. (bepress.com)
The aim of this study was to determine the developmental origins of nucleus pulposus cells within the intervertebral disc using a novel notochord-specific Cre mouse. (bepress.com)
To trace the fate of notochordal cells within the intervertebral disc, we derived a notochord-specific Cre mouse line by targeting the homeobox gene Noto. (bepress.com)
This suggests that notochordal cells might serve as tissue-specific progenitor cells within the disc and establishes the Noto-cre mouse as a unique tool to interrogate the contribution of notochordal cells to both intervertebral disc development and disc degeneration. (bepress.com)
Our current knowledge on the molecular program of NEUROG3+ cells in humans is largely extrapolated from studies in mice. (figshare.com)
Here we report that activation of a humanized Npm1c knock-in allele in mouse hemopoietic stem cells causes Hox gene overexpression, enhanced self renewal and expanded myelopoiesis. (nature.com)
Using single-cell RNA sequencing (RNAseq), we studied the development of ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice. (biologists.com)
It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
However, stem cells are difficult to distinguish from multipotential progenitors, which may look and act like them. (karger.com)
The diversification of neural-crest-derived sympathoadrenal (SA) progenitor cells into sympathetic neurons and neuroendocrine adrenal chromaffin cells was thought to be largely understood. (silverchair.com)
However, analysis of mice lacking the glucocorticoid receptor gene had revealed that adrenal chromaffin cells develop mostly normally in these mice. (silverchair.com)
Neurotransmitter subtype specification in the developing forebrain depends in part on the temporal and spatial coordinates of local neuronal progenitor/precursor cells. (biomedcentral.com)
Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
Design and Methods Growth in culture, colony formation and oncogenicity in vivo were assessed in mouse primary B cells exogenously expressing various combinations of Bcl2 , Myc and Ccnd1 . (haematologica.org)
Conclusions Bcl2 , Myc and Ccnd1 or Bcl2 , Myc and CCND3 synergistically transformed mouse primary B cells into aggressive malignant cells. (haematologica.org)
These findings represent the first evidence that synemins could potentially be useful markers for distinguishing multipotent ES cells from undifferentiated neural stem cells and more committed progenitor cells. (biomedcentral.com)
This selectivity suggests that the commitment of CNS precursor cells to form glia or neuron involves the direct regulation of the single synemin gene. (biomedcentral.com)
2013). Corticotropin-releasing hormone exerts direct effects on neuronal progenitor cells: implications for neuroprotection. (bioacademy.gr)
Cancer stem cells (CSCs) and poorly differentiated progenitor cells in pancreatic ductal adenocarcinoma (PDAC) exacerbate hierarchical tissue organization contributing to cell hyperproliferation and therapy resistance. (amegroups.org)
We used a previously established model of mouse primary enteric neuronal cells and an enteric neuronal cell line treated with palmitate (PA) and lipopolysaccharide (LPS) to induce mitochondrial dysfunction and enteric neuronal cell death. (emory.edu)
Methods: Primary mouse enteric neurons (EN) were exposed to a conditioned medium from ACE2-expressing Caco-2 colonic epithelial cells infected with SARS-CoV-2 or treated with tunicamycin (ER stress inducer). (emory.edu)
BC is a technique in which deletion of a key gene for the development of a specific lineage creates a vacant niche (organogenesis-disabled phenotype) that can be complemented by the progeny of wild type pluripotent stem cells injected into embryos at the blastocyst stage of development. (biomedcentral.com)

HOXB4 is one of 39 members of the homeobox (HOX) family, a family of transcription factors involved in embryonic development. (dissertations.se)
Our analysis of mouse development from embryonic day 5 to 15 (E5 to E15) has demonstrated that synemin M mRNA is produced at E5 as early as nestin and vimentin mRNA, prior to the appearance of the H isoform. (biomedcentral.com)

ventral pancreatic precursor 1 ( vpp1 ) is a marker gene that is differentially expressed in a cell population within the dorsal endoderm in a pattern partially overlapping with that of hematopoietically expressed homeobox ( hhex ) during gastrulation. (xenbase.org)

We identified three undifferentiated SG subsets at postnatal day 7, each of which expresses distinct genes, including transcription factor and signaling genes. (biologists.com)
NKX2-5 is a gene which encodes a homeobox-containing transcription factor. (city-made.com)
Here, we show that the transcription factor zinc finger E-box-binding homeobox 2 (Zeb2, Sip-1, Zfhx1b) is present in skeletal muscle tissues. (unipv.it)

This research is the first to produce induced pluripotent stem cell-derived inner ear sensory neurons in the Neurog1 +/− heterozygote mouse using blastocyst complementation. (biomedcentral.com)

p53 regulates the manifestation of downstream focus on genes, which serve as mediators of p53 features (17C19). (immune-source.com)
p53 binds to and regulates mRNA and proteins are significantly elevated after BLIMP1 depletion favorably, which is normally accompanied with the induction of p53 focus on genes. (immune-source.com)

tumor suppressor genes. (upstate.edu)
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

Improvement of sensory deficits in Fragile X mice by boosting cortical interneuron activity after the critical period. (ucla.edu)
Dendritic Spines in Early Postnatal Fragile X Mice Are Insensitive to Novel Sensory Experience. (ucla.edu)

2014). Prospero-related homeobox 1 (Prox1) at the crossroads of diverse pathways during adult neural fate specification. (bioacademy.gr)

In all these organisms, cardiac induction in the lateral mesoderm involves the concerted action of signals mediated by Bmp, Wnt and Fgf family members, which act upon cardiogenic genes encoding NK homeodomain, Gata and T-box transcription factors (reviewed by Zaffran and Frasch, 2002 ). (biologists.com)
hence,the cardiac progenitors are generated in bilateral, segmentally repeated areas of the dorsal mesoderm of the early embryo. (biologists.com)
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. (geneticsmr.com)

Mice lacking insulin receptor substrate-2 (Irs2) develop beta cell failure, suggesting that insulin signaling is required to maintain an adequate beta cell mass. (nih.gov)
This cell population can therefore be regarded as the mid-gastrula organizer and, together with the early-gastrula organizer and the node, constitute the organizer of the mouse embryo at successive stages of development. (silverchair.com)
Next, we generated iPS cell lines overexpressing LIM homeobox 2 (LHX2), which suppresses myofibroblastic changes in HSCs in mice. (ca.gov)
Otx2 cell-autonomous control of thalamic glutamatergic progenitors. (cnr.it)
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. (umassmed.edu)
Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. (biomedcentral.com)
These genes are transcriptionally deregulated as the partner genes of IgH translocation, and are thus thought to perform crucial roles in human B-cell lymphomagenesis. (haematologica.org)
2 A synergistic effect resulting from a combination of two genes from BCL2 , MYC and CCND1 has been implicated in human B-cell lymphomagenesis. (haematologica.org)
The objective of this study was to identify additional cooperative gene(s) associated with BCL2 and MYC or MYC and CCND1 in human B-cell lymphomagenesis. (haematologica.org)
Clinical and cell-based studies as well as investigations on mice have demonstrated pivotal roles for each SRC in numerous physiological and pathophysiological contexts, underscoring their functional pleiotropy. (frontiersin.org)
In this study we investigated the mechanisms involved in the induction of oxidative stress and impairment of mitochondrial quality control and mitophagy in hepatocytes by the saturated fatty acid palmitate and Western diet feeding in mice and if their harmful effects could be reversed by the neurotrophic factor glial cell derived neurotrophic factor (GDNF). (emory.edu)
This work validates the use of blastocyst complementation as a tool to create novel insight into the function of developmental genes and highlights blastocyst complementation as a potential platform for generating chimeric inner ear cell types that can be transplanted into damaged inner ears to improve hearing. (biomedcentral.com)
In combination with transgenic organisms, such enzyme-actuated antisense tools will enable gene silencing in specific cell types, including tissues that are not amenable to optical targeting. (cdc.gov)
11 , 12 Light-dependent gene silencing can be achieved through whole-organism irradiation or the targeted illumination of specific cell populations. (cdc.gov)

Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible. (ucla.edu)

Studies in our knockout mice reveal that deficiency of HOXB4 leads to a hypocellularity in hematopoietic organs and impaired proliferative capacity. (dissertations.se)

The Noto-cre mice were crossed with a conditional lacZ reporter for visualization of notochord fate in whole-mount embryos. (bepress.com)

Role of Otx1 and Otx2 in brain evolution: functional equivalence between the invertebrate Orthodenticle and the murine OTX1 and OTX2 gene products supports a conserved genetic program of brain development between insects and mammals. (cnr.it)

In vivo dissection of Otx1 and Otx2 roles in brain development by using reciprocal knock-in mouse models: definition of extended functional equivalence between OTX1 and OTX2 proteins and the relevance of the Otx1 and Otx2 differential transcriptional control. (cnr.it)
We also show that Dlx and Smad proteins localize to promoters/enhancers of a number of common telencephalic genes in vivo and that Smad proteins co-activate transcription with Dlx family members, except with certain mutated human DLX proteins identified in autistic individuals. (biomedcentral.com)

Due to cellular heterogeneity in the heart, the activation of gene programs representing specific atrial and ventricular cardiomyocyte subtypes would be highly desirable. (biomedcentral.com)

To identify genes, signaling pathways and networks that are controlled by SRC-3 and potentially important for hormone-dependent decidualization, we performed RNA-sequencing on HESCs in which SRC-3 levels were significantly reduced at the time of administering the deciduogenic stimulus. (frontiersin.org)

Role of Orthopedia in migration of diencephalic progenitors fated to populate the telencephalic amygdala. (cnr.it)

Studies in several vertebrate models and Drosophila have uncovered a surprising degree of evolutionary conservation of regulatory mechanisms and genes that control early cardiogenesis. (biologists.com)
Together, these signaling and transcriptional pathways set up complex and only partially defined regulatory networks that result in the progressive delineation and specification of heart progenitors. (biologists.com)
Our network approach leads to the identification of the upstream transcription factors for prognostic signature genes to provide leads to their regulatory mechanisms. (biomedcentral.com)
Then, the regulatory TFs for the mesenchymal signature genes were inferred from the use of master regulator analysis (MRA) together with or without stepwise linear regression method (SLR). (biomedcentral.com)

Figure 2: Hematopoietic changes and incidence of AML in Npm1 cA/+ mice. (nature.com)

In the developing telencephalon, the majority of gamma-aminobutyric acid (GABA)-ergic interneurons arise from progenitor zones [ventricular (VZ) and subventricular (SVZ) zones] within the lateral, medial and caudal ganglionic eminences (LGE, MGE and CGE, respectively) of the basal ganglia anlage (subpallium). (biomedcentral.com)

These data indicate that the inhibition of autophagy promotes apoptosis as described for herpes simplex computer virus 1 and mouse herpesvirus 68 [41]. (immune-source.com)

Nuclear receptor NR5A2 is involved in the calreticulin gene regulation during renal fibrosis. (bioacademy.gr)

Critical Period Inhibition of NKCC1 Rectifies Synapse Development and Restores Adult Tactile Response Maps in Fragile X Mice. (ucla.edu)

Inhibition of EGFR signaling prevented expansion of the NSC population observed in CCN1 deficient mice. (stanford.edu)
Tumors that developed in mice deficient in INK4A were enhanced by the topical application of carcinogens and ultraviolet light. (medscape.com)

Phosphorodiamidate morpholino oligonucleotides are widely used to interrogate gene function in whole organisms, and light-activatable derivatives can reveal spatial and temporal differences in gene activity. (cdc.gov)

Intense efforts to examine genetic alterations in human cancer have provided a catalogue of cancer-causing genes. (haematologica.org)
pointed out that additional genetic alterations were involved in lymphoma development in an Emu mouse model ectopically expressing Myc and Bcl2 . (haematologica.org)

Our present study identifies the Dorsocross T-box genes as key mediators of combined Dpp and Wg signals during this process. (biologists.com)

The Dorsocross genes are induced within the segmental areas of the dorsal mesoderm that receive intersecting Dpp and Wg inputs. (biologists.com)

Identification of transcription and processing signals of ribosomal genes of D. melanogaster. (cnr.it)

Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. (umassmed.edu)

After cardioblast specification, the Dorsocross genes are re-expressed in a segmental subset of cardioblasts, which in the heart region develop into inflow valves (ostia). (biologists.com)
Head specification by the head -selector gene, orthodenticle (otx), is highly conserved among bilaterian lineages. (xenbase.org)
An underlying principle is that Otx marks target genes for head specification to be regulated positively or negatively by partner TFs through specific types of CRMs. (xenbase.org)

We demonstrate that our approach could identify upstream biomarkers for a given set of signature genes with markedly smaller size and comparable performances. (biomedcentral.com)

We and others have synthesized light-activatable cMOs that allow spatiotemporal control of RNA splicing or translation, complementing the use of conditional knockouts to study stage- and tissue-specific differences in gene function. (cdc.gov)
18 , 19 We surmised that cyclic cMOs containing an NfsB-cleavable linker could be used with analogous lines to knock down gene function in a tissue-specific manner (Figure 1 a). (cdc.gov)

These reductions were reversed in the liver of Western diet fed GDNF transgenic mice and in hepatocytes exposed to palmitate in the presence of GDNF. (emory.edu)

Western diet (WD)-feeding increased hepatic lipid peroxidation in control mice and, in vitro palmitate induced oxidative stress and impaired the mitophagic clearance of damaged mitochondria in hepatocytes. (emory.edu)

Transcriptome Analysis Console software showed that 1896 genes were upregulated and 2506 were downregulated in hepatocytes as compared with BMSCs. (aging-us.com)

In Dlx1/2 −/− double mutant mice, the tangential migration of GABAergic interneurons into pallial structures is nearly extinguished and neuronal precursors accumulate in the SVZ of the MGE and CGE (Anderson et al. (biomedcentral.com)

Thus, SMADs both transmit the signal into the nucleus and execute the downstream effects by directly regulating target-gene transcription. (nature.com)

Conventional MOs are typically used to constitutively disrupt targeted genes in an organism-wide manner. (cdc.gov)

Isolation and identification of the structural organization of the human homeobox gene family (HOX Complex). (cnr.it)
Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)
7 That multiple genes are involved in human lymphoma formation has also been suggested by experimental mouse models. (haematologica.org)
13 The identification and clarification of the multiple cooperative genes implicated in human lymphoma formation is important, although our present understanding of such genes remains scant. (haematologica.org)
Studies have also identified other contender genes and genomic disruptions in human pancreatic exocrine tumors classified patients into different subclasses based on tumor histotypes and cancer-specific chromosomal rearrangements ( 7 - 9 ). (amegroups.org)
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. (geneticsmr.com)

More than 30 mammalian genes comprise the TGFβ superfamily of growth factors. (nature.com)

Anatomy2

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes5

Information Science2

Delivered progenitor cells1

Expression44

Differentiation16

Protein8

Proliferation5

Pancreatic endocrine1

Cells38

Embryonic2

Differentially expressed1

Transcription factor3

Neurons1

Regulates2

Tumor suppr4

Sensory2

PROX11

Cardiac3

Cell15

Neuron1

Knockout1

Embryos1

Murine1

Vivo2

Cardiomyocyte1

Identify genes1

Telencephalic1

Regulatory4

Hematopoietic1

Ventricular1

Apoptosis1

Regulation1

Adult1

Deficient2

Spatial1

Alterations2

Mediators1

Mesoderm1

Signals1

Mechanisms1

Specification3

Markedly1

Tissue-specific2

Transgenic1

Vitro1

Hepatocytes1

Migration1

Downstream1

Disrupt1

Human6

Superfamily1