DifferentiationHematopoietic progenitor cellMultipotentEndothelialLineageHaematopoieticThymusPrecursorsHSCsHemopoieticMonocytesCommon lymphoidAdaptive immuneCellTumorsSourced from bone marrowVitroDendriticReceptorSelectivelyProliferationAssaysPhenotypePathwaysPluripotentPathwayCord bloodInvadesImmune systemMiceInfusionChronicCells derivedReceptorsGenerateHumanLeukemiaCountsInfantsBlood
Differentiation7
- Notch signaling activates T lineage differentiation from hemopoietic progenitors, but relatively few regulators that initiate this program have been identified, e.g. (caltech.edu)
- The other daughters of HSCs (myeloid and lymphoid progenitor cells) can follow any of the other differentiation pathways that lead to the production of one or more specific types of blood cell, but cannot renew themselves. (wikipedia.org)
- The IL-3R plays an important role in hematopoietic progenitor cell growth and differentiation. (bdbiosciences.com)
- It regulates the homeostasis and differentiation of neural, pancreatic, and myogenic progenitor cells, T and B lymphocytes. (rndsystems.com)
- Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells. (dadamo.com)
- A research team in Japan has linked a developmental checkpoint in the differentiation of hematopoietic progenitors into specific T cell lineages to the activity of a single gene encoding a transcription factor. (riken.jp)
- The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)
Hematopoietic progenitor cell1
- STUDY DESIGN AND METHODS: The hematopoietic progenitor cell (HPC) and lymphocyte subset (LS) content of approximately 8000 CB units were characterized, and these results were correlated with donor ethnicity, birth weight, gestational age, sex, and type of delivery. (emmes.com)
Multipotent3
- To a remarkable extent, however, expression of these T lineage-enriched genes, including zinc finger transcription factor, helicase, and signaling adaptor genes, was also shared by stem cells (Lin^−Sca-1^+Kit^+CD27^−) and multipotent progenitors (Lin^−Sca-1^+Kit^+CD27^+), although down-regulated in other lineages. (caltech.edu)
- The few genes sharply up-regulated between multipotent progenitors and Pro-T cell stages included those encoding transcription factors Bcl11b, TCF-1 (Tcf7), and HEBalt, Notch target Deltex1, Deltex3L, Fkbp5, Eva1, and Tmem131. (caltech.edu)
- During regular hematopoiesis, multipotent progenitors (myeloid-T-B progenitors) first lose the potential to generate B cells. (riken.jp)
Endothelial9
- Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
- Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
- Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
- However, the features initially ascribed to endothelial progenitor cells, i.e ., phenotype, expression of endothelial markers, and ability to form tube-like structures on Matrigel, can be mimicked by blood monocytes [ 3 ]. (hindawi.com)
- Cells previously known as endothelial progenitor cells are considered now to be rather myeloid angiogenic cells than endothelial precursors [ 4 ]. (hindawi.com)
- Endothelial progenitors should be devoid of hematopoietic markers and able to form vessels both in vitro and in vivo . (hindawi.com)
- Endothelial progenitor cells (EPCs) are bone marrow-derived haematopoietic progenitor cells that have been implicated in vasculogenesis. (scirp.org)
- Nishiwaki, Y., Yoshida, M., Masuda, H. and Isobe, M. (2004) Recruitment of bone marrow-derived endothelial progenitor cells to vascular endothelium involves E-selectin dependent mechanism. (scirp.org)
- The microenvironment, consisting of lymphocytes, macrophages, fibroblasts, endothelial elements, and stroma in which hematopoietic cells reside, creates a regulatory niche that determines the local area network. (medscape.com)
Lineage7
- The clonal origin of myeloid and B lymphocyte lineage cells was further confirmed by the generation of both myeloid and B lymphoid cells in the same well following FACS clone-sorting of IL-3 induced blast cells. (elsevierpure.com)
- Cells of the myeloid lineage, which include granulocytes, megakaryocytes, monocytes and macrophages, are derived from common myeloid progenitors, and are involved in such diverse roles as innate immunity and blood clotting. (wikipedia.org)
- While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
- Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)
- A malignancy in the lymphoid lineage that includes white blood cells such as T lymphocytes and B lymphocytes. (medgadget.com)
- Subsequently, myeloid potential is terminated and the progenitors become committed to the T cell lineage. (riken.jp)
- CD25 is expressed by early progenitors of T and B lineage as well as by activated mature T and B lymphocytes. (thermofisher.com)
Haematopoietic1
- The in vitro effect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. (bmj.com)
Thymus7
- Our findings were subsequently tested by in vitro experiments, where putative early and later-stage DN1 progenitors from the thymus were purified and their pro- gression into DN2 was measured. (lu.se)
- thymus from marrow-derived progenitors circulating in the blood. (lu.se)
- In detail, thymus-settling progenitors enter the thymus and generate early T-cell progeni- tors (ETP/DN1 stage), which in turn give rise to DN2, DN3 and DN4 cells. (lu.se)
- T lymphocyte development occurs mostly in the thymus from progenitors of bone marrow origin in a process that involves high cellular turnover. (gulbenkian.pt)
- Consistently, when no progenitors seed the thymus, i.e., if no cell competition took place, old precursors persisted in the thymus, self-renewed, and for some time gave rise to T lymphocytes. (gulbenkian.pt)
- The Lymphocyte development and Leukemogenesis Laboratory focuses on the identification of the cellular and molecular mechanisms governing cell competition in normal thymus turnover, and on the changes associated with the malignant transformation of T lymphocyte precursors as a consequence of impaired cell competition. (gulbenkian.pt)
- Placing the final piece in the puzzle, the researchers discovered that T cell progenitors in the thymus from mice deficient in the gene Bcl11b exhibited the same halted development and self-renewal cycle, while further experiments connected up-regulation of the transcription factor encoded by this gene to IL-7 levels. (riken.jp)
Precursors1
- To identify additional regulators of T cell specification, a cDNA library from mouse Pro-T cells was screened for genes that are specifically up-regulated in intrathymic T cell precursors as compared with myeloid progenitors. (caltech.edu)
HSCs5
- Besides producing daughter HSCs after cell division, HSCs also produce different progenitor cell types that, in turn, divide to produce specific types of mature blood cells. (medicalnewstoday.com)
- Besides housing hematopoietic stem cells and their progeny, the endosteum and the central marrow also contain distinct cell populations that express molecules or secrete proteins, such as cytokines that regulate the formation, development, and function of HSCs and progenitor cells. (medicalnewstoday.com)
- In textbook theory, HSCs branch early on into two progenitor cell types, one of which, known as the common lymphoid progenitor (CLP), later differentiates into T and B cells. (riken.jp)
- In experiments with mouse HSCs cultured on immobilized delta-like 4 proteins, the researchers found that progenitors developing toward T cells were arrested in the absence of so-called feeder cells, which support survival and growth. (riken.jp)
- Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
Hemopoietic2
- The first stages of the pathway by which lymphocytes differentiate from hemopoietic stem cells were studied at a clonal level. (elsevierpure.com)
- Currently, little is known concerning regulation of IL-5Ralpha expression in the context of commitment of hemopoietic progenitor cells to the eosinophil and basophil lineages. (dadamo.com)
Monocytes2
- The non-restricted CD45 epitope is present on the surface of all human leucocytes, lymphocytes, eosinophils monocytes, basophils and neutrophils by order of decreasing level of expression. (beckman.com)
- It is produced by activated monocytes and T lymphocytes. (peprotech.com)
Common lymphoid1
- They are derived from common lymphoid progenitors. (wikipedia.org)
Adaptive immune4
- Lymphocytes are the cornerstone of the adaptive immune system. (wikipedia.org)
- The two main types of lymphocytes are T cells and B cells , which function in the adaptive immune system . (newworldencyclopedia.org)
- The two main categories of lymphocytes are the B lymphocytes ( B cells ) and T lymphocytes ( T cell ), both of which are involved in the adaptive immune system (Alberts 1989). (newworldencyclopedia.org)
- The adaptive immune system is based on dedicated lymphocytes. (newworldencyclopedia.org)
Cell19
- A lymphocyte is a type of white blood cell (leukocyte) in the vertebrate immune system . (newworldencyclopedia.org)
- In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
- DN1 stage) T-cell progenitors. (lu.se)
- Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)
- A scanning electron micrograph of a human T lymphocyte (or T cell) from the immune system of a healthy person. (britannica.com)
- T lymphocytes are responsible for cell-mediated immunity , so named because the T cells themselves latch onto the antigens of the invader and then initiate reactions that lead to the destruction of the nonself matter. (britannica.com)
- EBV can also be transmitted from EBV-infected B cells or epithelial cells to T/NK lymphocytes by cell-to-cell infection. (selfgrowth.com)
- Studies have shown that EBV-infected T/NK lymphocytes often express cytotoxic molecules, such as perforin, granzyme B, and T cell intracytoplasmic antigen (TIA-1). (selfgrowth.com)
- White blood cell, eosinophil, CD4- and CD8-positive lymphocyte counts, and serum interleukin-5 (IL-5) and IgE levels were determined before, 2 and 4 weeks after switching to vitamin E-bonded dialyzers. (dadamo.com)
- In the current research, the researchers sought to substantiate this theory by pinpointing the moment at which T cell progenitors lose the potential to develop into myeloid cells, a key step in determining cell fate. (riken.jp)
- 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
- 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
- Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
- In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
- Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
- We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
- The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (nih.gov)
- Although antilymphocyte serum was used in the treatment of chronic lymphocytic leukemia and in T-cell and B-cell lymphomas, resulting in temporary decreases in lymphocyte counts or lymph node size, newer humoral immunotherapeutic modalities have been developed. (msdmanuals.com)
- Inherited bone marrow failure syndromes (IBMFS) are usually the result of intrinsic stem cell/progenitor defects. (medscape.com)
Tumors2
- NK cells, CD8+ T cells, and γδ T cells observed in EBV-associated T/NK lymphocyte tumors are typical of EBV-infected cells and belong to the type of killer cells that attempt to kill EBV-infected B cells or epithelial cells. (selfgrowth.com)
- Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors. (msdmanuals.com)
Sourced from bone marrow1
- It is also intended for use in testing pools of human plasma and pools of human serum composed of equal aliquots of not more than 16 individual specimens from donors of whole blood, blood components, hematopoietic stem/progenitor cells sourced from bone marrow, peripheral blood or cord blood, and from donors of donor lymphocytes for infusion. (fda.gov)
Vitro2
- As a first step toward the goal of defining the effects of DP treatment on haematopoiesis of preterm infants, we designed this in vitro study to determine whether DP affects the clonal growth of erythroid or granulocyte-macrophage progenitor cells in preterm infants, and if the preterm infant's progenitors respond to DP in a different manner from those of adults. (bmj.com)
- Additionally, ethylene oxide is genotoxic and mutagenic in many in-vitro tests and in-vivo studies in animals, and its cytogenetic effects in lymphocytes of exposed workers provided strong support for its classification in Group 1. (cdc.gov)
Dendritic1
- Z200459The chemokine MIP-3 beta is a chemoattractant for T and B lymphocytes, dendritic cells, macrophage progenitor cells, and natural killer cells. (topsan.org)
Receptor2
- Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. (nature.com)
- CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. (thermofisher.com)
Selectively1
- Exodus-2 selectively stimulates the chemotaxis of adult T-lymphocytes and is. (topsan.org)
Proliferation2
- Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. (peprotech.com)
- CD25 plays a role in lymphocyte differentiating and activation/proliferation. (thermofisher.com)
Assays1
- The effects of DP on the clonal growth of erythroid and granulocyte-macrophage progenitors were investigated using clonogenic assays according to procedures previously tested in our laboratory. (bmj.com)
Phenotype1
- The lymphoid cells were proved to be B lymphocytes by phenotype and immunoglobulin gene rearrangement analyses and by demonstration of surface expression of IgM. (elsevierpure.com)
Pathways2
- The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. (nih.gov)
- Figure 2: Pathways involved in nutrient signaling in some lymphocytes. (nature.com)
Pluripotent1
- CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
Pathway1
- Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway. (uchicago.edu)
Cord blood1
- METHODS: Progenitor cells were obtained from bone marrow aspirates and cord blood samples. (dadamo.com)
Invades2
- EBV can also infect T/NK lymphocytes, but the mechanism by which EBV attaches and invades T/NK lymphocytes has not been elucidated. (selfgrowth.com)
- The next step is to evoke a more powerful response called adaptive immune response (after pathogen invades) which causes T and B lymphocyte response. (freezingblue.com)
Immune system3
- Other lymphocyte-like cells are commonly known as natural killer cells, or NK cells, and are part of the innate immune system . (newworldencyclopedia.org)
- In addition, lymphocyte-like cells called natural killer (NK) cells are involved in the immune system, albeit part of the innate immune system . (newworldencyclopedia.org)
- The key cells of the immune system are the white blood cells known as lymphocytes. (britannica.com)
Mice1
- 1984. Depression in B- and T-lymphocyte mitogen- induced blastogenesis in mice exposed to low concentrations of benzene. (cdc.gov)
Infusion1
- For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
Chronic2
- The double infection of T lymphocytes and NK cells in patients with chronic active EBV infection (CAEBV) has been reported in the literature, further supporting that EBV may infect the common progenitor cells of T cells and NK cells. (selfgrowth.com)
- Chronic lymphocytic leukemia (CLL) is a form of leukemia where the B lymphocytes are affected. (differencebetween.net)
Cells derived1
- In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
Receptors1
- T/NK lymphocytes neither express CD21 nor HLA class II, but T/NK lymphocytes express some integrins, which increase when stimulated and can act as receptors for T/NK lymphocytes. (selfgrowth.com)
Generate2
- This population includes Lin - CD122 + CD49a + progenitors that can generate liver ILC1s but not conventional natural killer cells. (nih.gov)
- In a model put forth nearly ten years ago, the researchers proposed a radically different picture in which progenitor cells retain the potential to generate myeloid cells across all branches of development. (riken.jp)
Human1
- A scanning electron microscope (SEM) image of a single human lymphocyte. (newworldencyclopedia.org)
Leukemia3
- Research in the Lymphocyte development and Leukemogenesis Laboratory focuses on T lymphocyte development, both under steady state, physiological conditions, as well as in leukemia. (gulbenkian.pt)
- Acute lymphoblastic leukemia affects progenitor stem cells in the bone marrow. (differencebetween.net)
- Acute lymphoblastic leukemia (ALL) is a type of leukemia that develops rapidly and affects the progenitor cells of either B lymphocytes or T lymphocytes. (differencebetween.net)
Counts2
- RESULTS: Eosinophil and CD4-positive lymphocyte counts and serum IL-5 were significantly (P = 0.003, 0.003 and 0.031, respectively) decreased after switching to vitamin E-bonded dialyzers. (dadamo.com)
- CD8-positive lymphocyte counts and serum IgE levels were unaltered. (dadamo.com)
Infants1
- The concentrations of erythropoietin (Epo) used to promote the growth of erythroid colonies ranged from 0.2 U/ml to 20 U/ml, based on the possibility that very high Epo concentrations might mask the effects of DP on progenitors of preterm infants. (bmj.com)
Blood4
- A stained lymphocyte surrounded by red blood cells viewed using a light microscope. (newworldencyclopedia.org)
- These changes in the hematopoietic system include a decline in the ability of HSC to produce new HSC and progenitor cells, especially those that produce white blood cells. (medicalnewstoday.com)
- 5 In this study we started with a highly enriched population of CD34+ progenitor cells 6 obtained by incubating the mononuclear fraction of blood and bone marrow with biotinylated anti-CD34 antibodies and running the CD34 labelled cells over an avidin column (Cellpro, Inc., Bothell, Washington, USA). (bmj.com)
- While varying widely in function, all blood cells share a common origin in progenitors known as hematopoietic stem cells (HSC). (riken.jp)