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  • patients
  • In immunocompromised patients, B19 infection may persist for months, leading to chronic anemia with B19 viremia due to chronic marrow suppression. (wikipedia.org)
  • mice
  • citation needed] G-CSF is used clinically (see Neutropenia) but tests in mice suggest it may lead to bone loss. (wikipedia.org)
  • clinical
  • In-vitro colony forming cell (CFC) assays using normal human bone marrow grown in appropriate semi-solid media such as ColonyGEL have been shown to be useful in predicting the level of clinical myelotoxicity a certain compound might cause if administered to humans. (wikipedia.org)
  • vitro
  • These predictive in-vitro assays reveal effects the administered compounds have on the bone marrow progenitor cells that produce the various mature cells in the blood and can be used to test the effects of single drugs or the effects of drugs administered in combination with others. (wikipedia.org)
  • transplants
  • Bone marrow suppression due to azathioprine can be treated by changing to another medication such as mycophenolate mofetil (for organ transplants) or other disease-modifying drugs in rheumatoid arthritis or Crohn's disease. (wikipedia.org)
  • precursors
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • murine
  • Working under the supervision of Bruce (AACR Award), and in association with Till and McCulloch and a vibrant group of graduate students and post-doctoral fellows, Eaves completed his PhD in Medical Biophysics at the University of Toronto with a thesis entitled Studies on the Control of Murine Bone Marrow Function (1974). (wikipedia.org)
  • ablation
  • Techniques of bone-marrow ablation have been superseded by safer conditioning regimens, with occasional complete remission and partial remission in some patients. (icr.ac.uk)
  • blood
  • The harvested bone marrow is then processed to remove blood and bone fragments. (brightkite.com)
  • This crosses the bone marrow barrier to the blood and is consumed in the lung by alveolar macrophages. (wikipedia.org)
  • Symptoms caused by bone marrow damage Bruising, spotting: the reason is lack of platelets, it is very common in BAL patients, most of patients die due to the Anemia: Because the decline of hematopoietic function, need blood transfusion therapy Persistent fever, infection prolonged healing: Diffuse hemorrhage: also called Septicemia, which is dangerous and might lead to death. (wikipedia.org)
  • Following observation of the symptoms, the patients need to get complete blood counts and a bone marrow examination. (wikipedia.org)