Progenitor cells quiescent satellite cell. Medical search. Frequent questions

In order to distinguish the rate of proliferation between different PHM clones, a comparative index (CI) was established using the cell cycle and total RNA data of the two PHM clones. (sun.ac.za)
Finally, FGF6 and FGF2, both individually and sequentially, were used to treat quiescent myoblasts to determine their involvement in activation and proliferation with the use of cell cycle analysis and mRNA assessment of ki67, p21, myf5, and MyoD. (sun.ac.za)
However, FGF2 did impede the cell cycle inhibition factor p21, indirectly influencing proliferation. (sun.ac.za)
The inverse sequential treatment order did not demonstrate any significant effect on both activation and proliferation of the quiescent cells. (sun.ac.za)
Researchers at the Fujian Provincial Research Institution of Traditional Chinese Medicine conclude that acupuncture reduces muscle cell death while promoting the proliferation and differentiation of muscle satellite cells. (acupunctureofiowa.com)
However, diprotin A, a positive modulator of CXCR4-SDF-1 binding, significantly enhanced engraftment and stimulated sustained proliferation of donor cells in vivo . (biomedcentral.com)
Diprotin A stimulation of CXCR4, however, significantly increased the number of canine dystrophin-positive muscle fibers and canine-derived satellite cells by enhancing donor cell proliferation. (biomedcentral.com)
Proliferating, BrdU-positive cells in muscle sections were detected with immunohistochemistry indicating different cell types and decreasing proliferation with age. (nature.com)
Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
Collectively, our experiments suggest that the IRE1α-mediated signaling promotes muscle regeneration through augmenting the proliferation of satellite cells in a cell non-autonomous manner. (elifesciences.org)
Here, we demonstrate that a systemic factor found in the circulation of young mice is able to increase the proliferation rate of old pancreatic β-cells. (diabetesjournals.org)
In some cases, the decline in proliferation reaches an irreversible state called cellular senescence, which is characterized by a total lack of cell divisions and altered cellular morphology, gene expression profile, and chromatin organization ( 3 ). (diabetesjournals.org)
Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiation of cellular signaling. (biomedcentral.com)
Cell proliferation is a very important physiological effect for low power laser irradiation (LPLI) used in clinical practice. (biomedcentral.com)
However, the mechanisms of cell proliferation induced by LPLI are poorly understood. (biomedcentral.com)
Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
Combined treatment with selumetinib and a dose of palbociclib sufficient to reinforce G1 arrest in selumetinib-sensitive cells, but not to impair proliferation of resistant cells, delays the emergence of resistant colonies, meaning that escape from G1 arrest is critical in the formation of resistant clones. (babraham.ac.uk)
6 These manipulations result in satellite cell activation and proliferation, which in turn are responsible for muscle repair and regeneration. (arvojournals.org)
A sufficient supply of progenitor stem cells to facilitate epithelial cell proliferation is important for the cornea. (medscape.com)

Embryonic myogenic progenitor cells express CXCR4, G-protein coupled cell surface receptor, and migrate towards regions of SDF-1 expression during limb muscle development, suggesting that CXCR4/SDF-1 plays a role in muscle cell homing. (biomedcentral.com)
The study uses a specific derivative of Human Pluripotent stem cells (hiPSC) called myogenic progenitor cells (MPC). (visikol.com)

We have also been able to show that there are a greater number of precursor cells within the EOM than limb. (umn.edu)
Our hypothesis is that the EOM are spared from the degenerative effects of Duchenne muscular dystrophy (DMD) due to the presence of higher numbers of a unique precursor cell capable of maintaining a normal phenotype under conditions that normally result in atrophy. (umn.edu)
Sparing of extraocular muscle in aging and muscular dystrophies: a myogenic precursor cell hypothesis.Exp Cell Res. (umn.edu)
Myogenic precursor cells in craniofacial muscles. (umn.edu)
CD34 is expressed on early precursor cells of myeloid and B-cell lineages, and CD15 is expressed on immature monocytic lineage cells and highly expressed on granulocytic lineage cells.31 As diseased muscle contains many myeloid cells such as neutrophils, monocytes, and macrophages, a more specific marker for mesenchymal cells with adipogenic potential is AAF-CMK required for detailed characterization of these cells in human diseased muscle. (phytid.org)
Postnatal growth and repair of skeletal muscle relies upon a population of quiescent muscle precursor cells, called satellite cells that can be activated to proliferate and differentiate into new myofibers, as well as self-renew to replenish the satellite cell population. (biomedcentral.com)

Most studies investigating satellite cells in vitro use already activated satellite cells, called myoblasts. (sun.ac.za)
When overexpressed in the murine myoblast cell line C2C12 or in primary myoblasts, C/EBPβ reduced MyoD and other myogenic protein levels during differentiation, in addition to reducing myoblast fusion. (biomedcentral.com)

Satellite cells from your trunk and the limb are derived from an embryonic populace of progenitor cells in the somites transient mesodermal constructions that develop on either part of the neural tube [1]. (healthyguide.info)
Interestingly recent data indicated that although MyoD is not indicated in quiescent satellite cells in the adult it is transiently indicated in satellite cell progenitors in the embryo suggesting that satellite cells are derived from committed embryonic precursors of myogenic lineage [4] [5]. (healthyguide.info)
In Drosophila , a population of muscle-committed stem-like cells called adult muscle precursors (AMPs) keeps an undifferentiated and quiescent state during embryonic life. (biologists.com)
The embryonic AMPs are at the origin of all adult fly muscles and, as we demonstrate here, they express repressors of myogenic differentiation and targets of the Notch pathway known to be involved in muscle cell stemness. (biologists.com)

From pioneering research on the in vivo expression, structure and regulation of muscle genes, she and her lab went on to study the myogenic regulatory factors, showing that Myf5 is present before MyoD in the embryo and that in the absence of Myf5 and Mrf4, cells fail to form skeletal muscle and acquire other mesodermal cell fates. (wikipedia.org)
I will perform the following experiments: 1) examine the phenotype and differentiation potential of these cells, 2) determine the mechanism for their resiliency to injury, and 3) examine their ability to repair or regenerate muscle in vivo . (umn.edu)
Ultimately, we hope to transplant our EOM-derived progenitor cells into injured limb muscle of mdx mice in order to determine the regenerative capabilities in vivo . (umn.edu)
Defining the heterogeneity of skeletal muscle-derived side and main population cells isolated immediately ex vivo. (umn.edu)
In vivo , the identification of macrophage phenotype is complicated since macrophages are obviously exposed to a microenvironment that is more complex respect to cell culture conditions, and they display characteristics that do not conform to the in vitro defined phenotypic categories. (hindawi.com)
Ex vivo cultures of myofiber explants demonstrate that ablation of IRE1α reduces the proliferative capacity of myofiber-associated satellite cells. (elifesciences.org)
In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)

They identified genes, including Pitx2/3, that affect the behaviour of these cells and showed that Myf5 mRNA, present in quiescent satellite cells is sequestered until these cells are activated after injury. (wikipedia.org)
Quantifying the exact expression levels of the mRNA isoforms encoding these myogenic transcription factors is therefore key to understanding how MuSCs switch between cell states. (biomed.news)
We demonstrate that mdPCR can give exact molecule counts per cell for mRNA isoforms encoding the myogenic transcription factor Pax3. (biomed.news)

The prevalence of replicating pancreatic β-cells declines dramatically with age in both rodents and humans ( 4 , 5 ). (diabetesjournals.org)

identification of cells equivalent to these mesenchymal progenitors in humans has considerable clinical implication. (phytid.org)
In this study, we use PDGFRas a marker for mesenchymal progenitors. (phytid.org)
The use of mesenchymal stem cells (MSCs) as a regenerative therapy holds the promise of regrowing injured vasculature, helping DM patients live healthier and longer lives. (thno.org)

They discovered a population of Pax3/Pax7-positive progenitors that are essential for foetal muscle development and showed that Pax-positive satellite cells associated with adult fibres constitute stem cells for muscle regeneration. (wikipedia.org)
Muscle satellite cells make up a stem cell populace that is capable of differentiating into myocytes and contributing to muscle mass regeneration upon injury. (healthyguide.info)
ENGLISH ABSTRACT: Introduction: Adult mammalian tissue regeneration recruits progenitor stem cells. (sun.ac.za)
A portion of these satellite cells stays behind post-injury to maintain and self-renew the cell pool allowing future regeneration of damaged tissue. (visikol.com)
Using genetic tools to conditionally abrogate C/EBPβ expression in Pax7 + cells, we examined the role of C/EBPβ in self-renewal of satellite cells during muscle regeneration. (biomedcentral.com)
After a single muscle injury, C/EBPβ-deficient satellite cells fail to self-renew resulting in a reduction of satellite cells available for future rounds of regeneration. (biomedcentral.com)
These findings demonstrate that C/EBPβ is a novel regulator of satellite cell self-renewal during muscle regeneration acting at least in part through Notch2. (biomedcentral.com)
Myofiber-specific ablation of IRE1α or XBP1 in mice diminishes skeletal muscle regeneration that is accompanied with reduced number of satellite cells. (elifesciences.org)
Finally, targeted ablation of IRE1α also reduces Notch signaling, abundance of satellite cells, and skeletal muscle regeneration in the mdx mice, a model of Duchenne muscular dystrophy. (elifesciences.org)
The findings shed new light on mechanisms of regeneration of healthy myofibers after severe tissue injury and suggest interplay between these fibers and muscle satellite cells though mechanisms remain to be elucidated. (elifesciences.org)
Aging lowers the replicative potential of most cells and the capacity for tissue regeneration ( 1 , 2 ). (diabetesjournals.org)
Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)
1 2 Residing outside the sarcolemma but within the basal lamina of individual myofibers is a population of cells that are responsible for muscle repair and regeneration, the satellite cells. (arvojournals.org)
Skeletal muscle growth and regeneration involves the activity of resident adult stem cells, namely satellite cells (SC). (sdbonline.org)

Thus, these markers in combination with basal lamina staining were useful for the identification of human satellite cells. (phytid.org)
These cells are located beneath the basal lamina of myofiber in a dormant state. (elifesciences.org)
Basal and limbal stem cells contribute to mitosis. (medscape.com)
For example, muscle stem cells (MuSCs), located beneath the basal lamina, exist in the quiescent state but can transition to an activated, proliferative state upon injury. (biomed.news)

Finally we found that in an mouse model of fracture healing where muscle mass progenitor cells were lineage-traced Nkx3.2 and Sox9 are significantly upregulated while Pax3 is significantly downregulated in the muscle mass progenitor cells that give rise to chondrocytes during fracture restoration. (healthyguide.info)
Therefore our and analyses suggest that the balance of Pax3 Nkx3.2 and Sox9 may act as a molecular Talniflumate switch during the chondrogenic differentiation of muscle mass progenitor cells which may be important for fracture healing. (healthyguide.info)
We found that in the descendents of muscle mass progenitors that contributed to cartilage formation Nkx3.2 and Sox9 were strongly induced while Pax3 manifestation was strongly repressed. (healthyguide.info)
Collectively our data suggest that the balance of Nkx3.2 Sox9 and Pax3 can act as a molecular switch during the chondrogenic differentiation of satellite cells which may play an important part in the healing process experiments were normalized to GAPDH. (healthyguide.info)

Our experiments will use in vitro cell culture including activated caspase and stress-induced death assays. (umn.edu)
To assess the differentiation capabilities of these cells, we will use flow cytometry to sort the CD34+ population, followed by in vitro differentiation assays using various growth factors and serum deprivation. (umn.edu)
Methods: Isolated satellite cells from human muscle biopsies were expanded in vitro creating primary human myoblast (PHM) clones. (sun.ac.za)
These cells were expanded in vitro for seven days with around a 30 percent MPC retention rate, while a portion of the others differentiated into other cells. (visikol.com)
The engrafted cells often had smaller RNA sequences than their in vitro counterparts suggesting they are in a quiescent state. (visikol.com)
Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
10 Even more compelling is a recent study that subjected individual quiescent satellite cells isolated from adult limb muscle to stretching in vitro, and showed that direct stretching of the satellite cells themselves results in activation and bromodeoxyuridine (BrdU) incorporation. (arvojournals.org)

This is unlike the satellite cells of limb muscles, which remain quiescent unless injury is sustained. (umn.edu)
These cells from EOM are more resistant to apoptosis than similar cells from limb muscles. (umn.edu)
7 8 9 In fact, passive stretching alone can activate limb muscle satellite cells. (arvojournals.org)

a reverse function mutant Talniflumate of Nkx3.2 blocks the ability of Sox9 to both inhibit myogenesis and induce chondrogenesis suggesting that Nkx3.2 is required for Sox9 to promote chondrogenic differentiation in satellite cells. (healthyguide.info)
The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)

One such alternative cell fate is the adipogenic fate as Pax7(+) satellite cells isolated from solitary myofibers used adipogenic fate in addition ARHGAP1 to muscle mass fate significance of these factors we used a mouse fracture healing model inside a genetically altered reporter mouse where muscle mass progenitors were lineage-traced. (healthyguide.info)

These satellite cells must then remain dormant until muscle degeneration is detected, and, in that case, they would repair the damaged myofibers. (visikol.com)
After successful transplantation, researchers then needed to determine if these MPCs could occupy the satellite cell space and regenerate myofibers. (visikol.com)
Antibody markers were used to determine if regenerated myofibers or satellite cells were, in fact, from the MPCs. (visikol.com)
engrafted hPSC-MPCs were able to occupy the satellite cell space and regenerate myofibers when damaged. (visikol.com)
In the resected muscle and in the passively stretched antagonist muscle, there was a dramatic increase in the number of myofibers positive for neonatal MyHC and in the number of BrdU- and MyoD-positive satellite cells. (arvojournals.org)
Both active and passive stretch of the rectus muscles produced by strabismus surgery dramatically upregulated the processes of satellite cell activation, integration of new myonuclei into existing myofibers, and concomitant upregulation of immature myosin heavy chain isoforms. (arvojournals.org)
3 When a muscle is injured, this specialized cell population becomes activated, divides, and either repairs damaged fibers or forms new myofibers. (arvojournals.org)

Upon activation satellite cells rapidly initiate MyoD expression which leads to the activation of myogenin and terminally differentiated structural muscle mass genes such as myosin heavy chain (MHC) [1] [3]. (healthyguide.info)

Her main contribution to cardiogenesis is the identification of the second heart field (SHF) as a major source of cardiac progenitor cells that form specific regions of the heart. (wikipedia.org)

Despite this, clinical responses are typically transient as tumour cells develop resistance. (babraham.ac.uk)
Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)

The international journal of biochemistry & cell biology 35, no. 8 (2003): 1151-1156. (acupunctureofiowa.com)
This team, which brings together expertise in stem cell biology, cell biology, developmental signalling pathways, and genetic screens, aims at improving methods to achieve generation of HSC. (utoronto.ca)

The premise behind this manuscript is important and timely for muscle biologists and for stem cell biologists. (sciety.org)
The generation of HSCs has been a long-standing goal of stem cell biologists working in the field of developmental hematopoiesis. (utoronto.ca)

However, both markers are expressed on many different cell types, including myeloid cells of hematopoietic lineage. (phytid.org)
We used a clinically acceptable regimen of hematopoietic stem cell transplantation to establish mixed donor/host blood cell chimerism and immune tolerance in a canine model of Duchenne muscular dystrophy ( cxmd ) [ 9 ]. (biomedcentral.com)
Worldwide, 50,000 hematopoietic stem cell transplant (HSCT) procedures are undertaken annually to replace a person's blood-forming cells - hematopoietic stem cells (HSCs) - to treat blood disorders and cancers, yet two-thirds of patients who need HSCT lack matched donor tissue. (utoronto.ca)
Thus, alternative sources of patient-specific hematopoietic stem cells (HSCs) are required. (utoronto.ca)
The methods proposed are cutting-edge and no other team in the world has this combination of technologies, approaches and expertise to make advances in hematopoietic cell therapies. (utoronto.ca)

Metalloproteinases are secreted as proenzymes by neutrophils infiltrating the wound, injured epithelial cells, and keratocytes. (medscape.com)

Almost all PDGFRsingle-positive state, and so did CD56+ cells in our culture condition (Figures 2c and d). (phytid.org)
Secondly, the quiescent state is an integral part of stem cell regulation, therefore choosing the right protocol for inducing quiescence is important. (sun.ac.za)
These cells were examined using RNA sequencing to determine if they could reach a quiescent state. (visikol.com)

Skeletal muscle, the most abundant tissue of the body, has remarkable regenerative capacity mainly due to its resident muscle stem cells, also known as satellite cells. (elifesciences.org)

Both miRNAs and siRNAs need to be delivered into the target tissue or cell in order to activate the desired therapeutic effect," Muthiah Manoharan, Ph.D., senior vp, drug discovery, Alnylam Pharmaceuticals, explained. (genengnews.com)
Unlike FGF2, individual treatment with FGF6 was adequate to activate the quiescent PHMs and aid their re-entry into cell cycle with consistency in all three PHM clones by upregulating ki67 expression. (sun.ac.za)

The gradual decrease in the rate of cell division seen already in early postnatal life, before any evidence of senescence, is even less well-understood. (diabetesjournals.org)

These cells are also present in the EOM of mdx mice and mdx/utrophin -/- mice, models for DMD. (umn.edu)
In murine-to-murine transplantation experiments, CXCR4 expression marks a population of adult murine satellite cells with robust engraftment potential in mdx mice, and CXCR4-positive murine muscle-derived SP cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice. (biomedcentral.com)
Indeed, CXCR4-positive muscle-derived side population (SP) cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice [ 10 ]. (biomedcentral.com)
Immunodeficient mice had their tibialis anterior muscles depleted of host satellite cells for the engrafting experiment. (visikol.com)
Old mice parabiosed to young mice have increased β-cell replication compared with unjoined old mice or old mice parabiosed to old mice. (diabetesjournals.org)
conversely, young β-cells transplanted into old mice decrease their replication rate compared with young cells transplanted into young recipients. (diabetesjournals.org)
however, we have recently found that a residual replicative potential is retained even in β-cells of very old mice ( 8 ). (diabetesjournals.org)

Interest in ALMS1 is heightened by the recent discovery of its involvement in neonatal cardiomyocyte cell cycle arrest, a process with potential relevance to regenerative medicine. (springer.com)

In the beginning satellite cells were considered to Talniflumate be unipotent stem cells with the ability of generating a unique specialized phenotype the skeletal muscle mass cells. (healthyguide.info)
The cell surface phenotype of PDGFRand CD56 expression. (phytid.org)

Upon injury or when challenged with a variety of mechanical or biochemical stimuli satellite cells re-enter the cell cycle and give rise to Talniflumate differentiated myocytes which form new muscle mass materials or fuse with existing materials and contribute to muscle mass growth and restoration [1]. (healthyguide.info)

Previous studies have shown the involvement of cell-autonomous factors in this phenomenon, particularly the decline of polycomb genes and accumulation of p16/INK4A. (diabetesjournals.org)

She has studied both the formation of skeletal muscle and of the heart, using the tools of mouse molecular genetics to characterise cell behaviour and to identify the genes that govern cell fate choices. (wikipedia.org)
Selumetinib causes long-term G1 arrest accompanied by reduced expression of DNA replication and repair genes, but cells stochastically re-enter the cell cycle during treatment despite continued repression of pERK1/2. (babraham.ac.uk)
The group plans to identify better markers to track and purify key cell intermediates as well as uncover key genes/pathways that lead to HSC development. (utoronto.ca)

Therefore, these results establish the efficacy of diprotin A in stimulating muscle cell engraftment, and highlight the pre-clinical utility of a xenotransplantation model in assessing the relative efficacy of muscle stem cell populations. (biomedcentral.com)

In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

Muscle fibers formed by donated cells were labeled with human-specific antibody dystrophin, and the secreted extracellular matrix was labeled with laminin. (visikol.com)
Semaphorins are a wide family of extracellular regulatory signals with a multifaceted role in cell-cell communication. (biomed.news)

The quiescent muscle stem cell (QSC) pool is heterogeneous and generally characterized by the presence and levels of intrinsic myogenic transcription factors. (sciety.org)

Primary satellite cells can be harvested from muscle tissue to investigate or even use as potential therapeutic application. (sun.ac.za)
In conclusion, using clones that were distinctly different as assessed by the comparative index, this thesis illuminates that the two FGF family members investigated, act on cell cycle in different ways, thus would influence their utilization in experimental or therapeutic applications. (sun.ac.za)
Intramuscular injection of donor muscle-derived cells into chimeric cxmd recipients restored dystrophin expression for at least 24 weeks in the absence of post-transplant immunosuppression, indicating that cell transplantation may be a viable therapeutic option for muscular dystrophy. (biomedcentral.com)

Specifically, the muscle progenitor cells, called satellite cells, are activated in the apparent absence of injury. (umn.edu)
In Drosophila with depleted RACK1 in all muscle cells or, specifically, in SC lineage resulted in a delayed recovery of skeletal muscle after physical damage as well as the low presence of active SC in the wound area. (sdbonline.org)

03/01/2011 [-] IgG4 plasma cells in inflammatory myofibroblastic tumor inflammatory marker or pathogenic link? (infopig.com)

Together, these data suggest that CXCR4 plays an important role in donor cell engraftment. (biomedcentral.com)
Therefore, we sought to translate these results to a clinically relevant canine-to-canine allogeneic transplant model for Duchenne muscular dystrophy (DMD) and determine if CXCR4 is important for donor cell engraftment. (biomedcentral.com)
In this study, we used a canine-to-murine xenotransplantation model to quantitatively compare canine muscle cell engraftment, and test the most effective cell population and modulating factor in a canine model of DMD using allogeneic transplantation experiments. (biomedcentral.com)
We show that CXCR4 expressing cells are important for donor muscle cell engraftment, yet FACS sorted CXCR4-positive cells display decreased engraftment efficiency. (biomedcentral.com)
We used the xenotransplant model to show that CXCR4 expression on canine donor muscle cells is also important for cell engraftment, but FACS sorting for CXCR4-positive cells decreased their engraftment efficiency. (biomedcentral.com)
The first process outlined in the study was the process of cell engraftment. (visikol.com)

Yet, it remains unclear from murine transplantation experiments which cell population most effectively engrafts into diseased skeletal muscle. (biomedcentral.com)
Irradiation treatment, which eliminates satellite cells from these muscles, prevents the compensatory hypertrophy in these types of experiments. (arvojournals.org)

LPLI-induced cell cycle progression can be regulated by the activation or elevated expressions of cell cycle-specific proteins. (biomedcentral.com)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)

Two transplantation strategies were tested to engraft the cells, one without FACS (fluorescence-activated cell sorting) and one with FACS. (visikol.com)

The light must be absorbed by the endogenous chromophores of cells or tissues for actions. (biomedcentral.com)

These cells, theoretically, would not require transfection of dystrophin, and could potentially provide an autologous source of cells for transplant therapies. (umn.edu)
The hope is that this study will be used as a "proof of principle" for future cell therapies using pluripotent stem cells and their derivatives. (visikol.com)
For these therapies to work, the MPCs must differentiate into what is known as a satellite cell. (visikol.com)

However satellite cells have since been shown to have the ability to adopt option cell fates. (healthyguide.info)

We hope to identify a new source of cells for use in myoblast transfer therapy. (umn.edu)
By describing a means for EOM sparing in DMD, we may advance our understanding of the disease and identify a new source of cells for myoblast transfer therapy. (umn.edu)

They have proinflammatory functions: they produce effector molecules (reactive oxygen and nitrogen intermediates) and inflammatory cytokines (IL-1 β , TNF α , and IL-6) and participate as inducer and effector cells in polarized Th1 responses. (hindawi.com)

Satellite cells help to repair and regenerate muscle fibers. (acupunctureofiowa.com)

Researchers at Johns Hopkins University's neurology department conducted a study recently involving human pluripotent stem cells and their potential use as a treatment for degenerative muscle disorders. (visikol.com)
Our parameter study explores variations in collision speed, magnetic field inclination (with respect to the collisional axis), and resolution, as defined by the number of cells per Jeans length. (klessen.org)
This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)

I have found a CD34+ group of cells in EOM that is negative for other lineage-specific markers. (umn.edu)
These cells were isolated using CD3426, 30 or CD1527, 28 as markers. (phytid.org)
Human-specific antibodies were used for marking so recovered cells could then be tested using a PCR for their human-specific markers to prove they were not of mouse origin. (visikol.com)

Anatomy21

Organisms5

Diseases2

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes16

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science2

Health Care1

Proliferation20

Myogenic progenitor cells2

Precursor6

Myoblasts2

Embryonic4

Vivo7

MRNA3

Rodents and humans1

Mesenchymal3

Regeneration14

Basal4

Pax34

Vitro7

Limb3

Differentiation2

Pax71

Myofibers7

MyoD1

Cardiac1

Transient2

Biology2

Stem cell biologists2

Hematopoietic5

Epithelial cells1

State3

Muscle stem cells1

Activate2

Postnatal1

Mice7

Regenerative1

Phenotype2

Stimuli1

Involvement1

Genes3

Clinical1

Fibroblasts1

Extracellular2

Heterogeneous1

Therapeutic3

Specifically2

Marker1

Engraftment6

Experiments2

Proteins2

FACS1

Endogenous1

Therapies3

Fates1

Myoblast2

Effector1

Regenerate1

Study3

Markers3