Progenitor cells modulate vascular. Medical search. Frequent questions

Thus, conserved endocytic functions may control blood cell progenitor quiescence and differentiation. (nih.gov)
We examined the influence of variable hemodynamic conditions on progenitor cell localization and differentiation in experimental AAAs.Murine AAAs were created via porcine pancreatic elastase (PPE) infusion. (stanfordhealthcare.org)
Increased granulocyte-macrophage colony-stimulating factor (GM-CSF) expression was also present in LF-AAAs.Hemodynamic conditions influence CD34+ cell localization and differentiation in experimental AAA. (stanfordhealthcare.org)
Modulating cell lineage differentiation of mature progenitor cells may represent a novel therapeutic strategy to maintain medial cellularity and extracellular matrix integrity in AAA disease. (stanfordhealthcare.org)
microRNAs have emerged as master regulators of stem cell lineage differentiation and angiogenesis [ 14 ]. (biomedcentral.com)
The production of terminally differentiated cells from such cells, therefore, requires successive changes of cell fates, meaning that genes relevant for the next stage of differentiation must be switched on and genes not relevant anymore must be switched off. (amegroups.org)
The development of the hematopoietic system has long served as model to understand how changes in gene regulatory networks drive the differentiation of the various blood cell types. (amegroups.org)
These secreted factors may stimulate vascular growth and redesigning, attenuate fibrosis, modulate swelling, regulate cell differentiation and survival, and sponsor resident come or progenitor cells.12,13 Activation of these pathways may blunt reperfusion injury or attenuate adverse remodeling in individuals suffering from acute myocardial infarction (AMI) or HF, respectively. (bioinf.org)
Our laboratory is specifically interested in the regulation of vascular cell commitment, differentiation and cell cycle progression, and defining signaling pathways that modulate these processes. (virginia.edu)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
Afterwards, she worked in Janet Rossant's lab at SickKids elucidating the trajectories of trophoblast stem cell differentiation in the mouse. (ho-lab.org)
DSpace at KIST: BMP9 Induces Cord Blood-Derived Endothelial Progenitor Cell Differentiation and Ischemic Neovascularization via ALK1. (kist.re.kr)
Approach and Results We evaluated gene expression profiles of cord blood-derived EPCs and endothelial cells to identify the key factors in EPCendothelial cell differentiation and to show that transforming growth factor- family members contribute to EPC differentiation. (kist.re.kr)
The expression levels of activin receptor-like kinase 1 (ALK1) and its high-affinity ligand, bone morphogenetic protein 9 (BMP9) were markedly changed in EPCendothelial cell differentiation. (kist.re.kr)
Interestingly, BMP9 induced EPCendothelial cell differentiation and EPC incorporation into vessel-like structures by acting on ALK1 expressed on EPCs in vitro. (kist.re.kr)
Many people of Wnt protein have been determined to regulate proliferation, differentiation, and loss of life of varied cells. (ipa2014.org)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)
Autophagy also regulates cell proliferation, differentiation, survival, and apoptosis, highlighting its role in maintaining cellular homeostasis [ 1 ]. (hindawi.com)

These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
Cells for vascular therapy must be able to home to ischaemic or damaged tissue and engage in vessel formation alone or in unison with resident vasculature to achieve a controlled and functional reperfusion event, without causing pathological angiogenesis (for example, proliferative retinopathy in the vitreous of the eye). (biomedcentral.com)
CD47 is a high affinity receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis, and in this later capacity the TSP1-CD47 interaction inhibits nitric oxide signaling at multiple levels in vascular cells. (wikidoc.org)
[8] Binding of TSP-1 to CD47 influences several fundamental cellular functions including cell migration and adhesion, cell proliferation or apoptosis, and plays a role in the regulation of angiogenesis and inflammation. (wikidoc.org)
Moreover, knockdown of METTL3 significantly affected angiogenesis of the human endothelial cells. (biomedcentral.com)
Ultimately, the up-regulated downstream genes of Notch signaling pathway dramatically affected the angiogenesis of endothelial cells. (biomedcentral.com)
contraction shear stress skeletal muscle stretch vascular endothelial growth factor ( VEGF ) MMPs induce proteolytic degradation of the extracellular matrix, which is an essential step in sprouting angiogenesis that allows the endothelial sprout to protrude from the existing capillary. (silverchair.com)
Results Our findings indicate that the platelets in HD are dysfunctional with respect to the release of angiogenic factors and functions including thrombosis, angiogenesis and vascular haemostasis. (bmj.com)
Objective Modulating endothelial progenitor cells (EPCs) is essential for therapeutic angiogenesis, and thus various clinical trials involving EPCs are ongoing. (kist.re.kr)
Engineered mesenchymal cell-based patches as controlled VEGF delivery systems to induce extrinsic angiogenesis. (unibas.ch)

Her main contribution to cardiogenesis is the identification of the second heart field (SHF) as a major source of cardiac progenitor cells that form specific regions of the heart. (wikipedia.org)
Vascular therapy of the cardiac muscle could be modulated by endothelial progenitors cells derived from embryonic or stem cells from different sources. (rsc.org)
Effective medical translation, however, remains demanding due to inconclusive study results concerning come cell regenerative capacity and their ability to improve cardiac function.2C6 Here we will evaluate the proposed mechanisms of action for originate cell regenerative therapy, review various originate cell sources, and discuss the merits and limitations of recently published adult originate cell clinical tests. (bioinf.org)
Despite this imperfect knowledge, sufficient medical encounter offers been accumulated from the several medical tests using numerous adult come cell populations, including bone tissue marrow-derived mononuclear cells (BMMNCs), mesenchymal come cells (MSCs), and come cells separated from cardiac cells (Number 1). (bioinf.org)
We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. (frontiersin.org)
Oddly enough, these mobile cascades from the Wnt-Frizzled pathways can take part in many neurodegenerative, vascular, and cardiac disorders and could end up being integrated using the function of trophic factors closely. (ipa2014.org)
During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac development by undergoing endothelial-to-mesenchymal transition (EndoMT). (surrey.ac.uk)
They are secreted by a wide array of cells, including cardiac myocytes, mature and progenitor endothelial cells, mesenchymal stem cells, immune cells like antigen-presenting cells (APCs), and malignant cells 5 , 6 . (bmrat.org)

OPC architecture, proliferation and oligodendro-/myelino-genesis are finely regulated by the interplay of cell-intrinsic and extrinsic factors. (nature.com)
Our results unveil a novel player in the complex regulation of OPC biology, on the one hand showing that JNK1 ablation cell-autonomously determines alterations of OPC proliferation and branching architecture and, on the other hand, suggesting that JNK1 signaling in OLs participates in myelination in vivo. (nature.com)
Both a cell-intrinsic program and environmental factors participate in the regulation of OPC architecture, proliferation and oligodendro-/myelino-genesis. (nature.com)
indicated that ATMs colocalized with T cells in lymphoid clusters within adipose tissue and may act as APCs, which express high levels of MHCII and also costimulatory molecules and process and present antigens to induce CD4+ T-cell proliferation and activation in adipose tissue of obese mice (29, 68, 105). (exposed-skin-care.net)
showed that adipose tissue from obese mice induced proliferation of splenic CD8+ T cells, indicating a CD8+ T cell-activating environment in obese adipose tissue (31). (exposed-skin-care.net)
The role of CD47 in promoting cell proliferation is heavily dependent on cell type as both activation and loss of CD47 can result in enhanced proliferation. (wikidoc.org)
Activation of CD47 with TSP-1 increases proliferation of human U87 and U373 astrocytoma cells but not normal astrocytes . (wikidoc.org)
Additionally, CD47 blocking antibodies inhibit proliferation of unstimulated astrocytoma cells but not normal astrocytes. (wikidoc.org)
Though the exact mechanism is unclear, it is likely that CD47 promotes proliferation via the PI3K/Akt pathway in cancerous cells but not normal cells. (wikidoc.org)
Loss of CD47 allows sustained proliferation of primary murine endothelial cells and enables these cells to spontaneously reprogram to form multipotent embryoid body-like clusters. (wikidoc.org)
Activation of CD47 with TSP-1 in wild-type cells inhibits proliferation and reduces expression of stem cell transcription factors. (wikidoc.org)
The intracellular roles of NPM include a wide range of metabolic processes such as ribosome biogenesis, proliferation, cell cycle control, migration, DNA repair, non-programmed cell death, stress sensor ( 3 , 4 ). (frontiersin.org)
Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)
BNP also stimulated the proliferation of WT1 + epicardium-derived cells but only in the hypoxic area of infarcted hearts. (elifesciences.org)
The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)

They discovered a population of Pax3/Pax7-positive progenitors that are essential for foetal muscle development and showed that Pax-positive satellite cells associated with adult fibres constitute stem cells for muscle regeneration. (wikipedia.org)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Vitamin D supplement for CKD patients provides a protective role in vascular calcification on the endothelium by (1) renin-angiotensin-aldosterone system inactivation, (2) alleviating insulin resistance, (3) reduction of cholesterol and inhibition of foam cell and cholesterol efflux in macrophages, and (4) modulating vascular regeneration. (tmu.edu.tw)
EPCs are currently being tested in different clinical settings including repair of damaged microcirculation, regeneration of ischemic tissues, and bioengineering of vascular grafts ( http://www.clinicaltrials.gov/ ). (biomedcentral.com)
The use of cell therapy for vascular regeneration offers an exciting new prospect in regenerative medicine. (biomedcentral.com)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
However, vascular regeneration is a promising treatment for cardiovascular disease. (medicalxpress.com)
During the endothelialization process of native blood vessels, vascular endothelial cells and progenitor cells are first recruited to regeneration sites. (medicalxpress.com)

12 Bang and colleagues reported the safety and feasibility of intravenous infusion of autologous mesenchymal stem cells (MSCs) with no reported adverse effects in five patients treated with intravenous MSCs. (bmj.com)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)

The aim of this study was to identify early diabetes-related changes in the expression of genes that have been reported to be closely involved in endothelial progenitor cell migration and function. (biomedcentral.com)
Based on review of current literature, this study examined the expression level of 35 genes that are known to be involved in endothelial progenitor cell migration and function in magnetically sorted Lin - /VEGF-R2 + endothelial progenitor cells obtained from the bone marrow of Akita mice in the early stages of diabetes (18 weeks) using RT-PCR and Western blotting. (biomedcentral.com)
Knocking down miR-31 levels in CB-EPCs suppressed cell migration and microtubule formation, while overexpressing miR-31 in PB-EPCs helped to recapitulate some of CB-EPC functions. (biomedcentral.com)
studies indicated that RANTES is Purpureaside C an adipokine that can be produced by adipocytes and takes on an important part in T cell migration, suggesting a potential part of the RANTES/CCR5 axis in adipose T cell build up in obesity (24). (exposed-skin-care.net)
These interactions result in CD47/integrin complexes that affect a range of cell functions including adhesion, spreading and migration. (wikidoc.org)
This topography can significantly direct cell polarization and thereby enhance the collective migration of vascular endothelial cells," said Zhao Qilong, first author of the study. (medicalxpress.com)
The formation of new vessels in the hypoxic area restores blood flow, provides oxygen and nutriments to the surviving cells, and promotes the migration and engraftment of new cells. (elifesciences.org)
Soluble factors in conditioned media from E 2 treated breast cancer cells also lead to migration and tube formation of human umbilical vein endothelial cells (HUVEC) in vitro . (biomedcentral.com)

She joined the the EPL in 2018 with an interest in deciphering the roles of endogenous peptides in the vascular endothelium. (ho-lab.org)
Remodeling the endothelium-i.e., forming a confluent vascular endothelial cell monolayer on the lumen-plays a vital role in this process. (medicalxpress.com)
Such materials cannot offer dynamic, on-demand means for manipulating specific vascular endothelial cell functions at different stages of endothelium remodeling. (medicalxpress.com)
A joint research group led by Dr. Du Xuemin at the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences recently demonstrated a remote-controlled "smart" platform that effectively directs programmed vascular endothelium remodeling in a temporally controllable manner. (medicalxpress.com)
The bilayer platform allowed on-demand manipulation of vascular endothelial cell functions, thus meeting the requirements of endothelium remodeling. (medicalxpress.com)
Normally, the endothelium forms an integral cellular barrier to regulate vascular homeostasis. (surrey.ac.uk)

We have shown that chronic inflammatory disease impacts endothelial progenitor cell (EPC) biology, through reducing their circulating numbers and by impairing their function. (rug.nl)
In vitro experiments revealed that dglycin inhibited inflammatory cytokine secretion from aortic endothelial cells via the inhibition of NF-κB signaling. (bvsalud.org)
Interestingly, NPM interacts with Toll-like receptor (TLR)4 in these cells and activates an NF-kB-dependent inflammatory pathway upregulating interleukin IL-6 and COX-2 gene expression. (frontiersin.org)
To this end, she leads the effort to discover and characterize inflammatory SEPs, with a focus on those that modulate metabolism. (ho-lab.org)
She is currently deciperhing how MOCCI modulates inflammatory outcomes. (ho-lab.org)
These include macrophage and smooth muscle cell (SMC) phenotypic switching and various inflammatory signaling, such as IL-33/suppression of tumorigenesis 2 (ST2), Ras-Raf-MEK-ERK pathways, and JAK-STAT signaling pathways 14 , 15 , 16 , 17 . (bmrat.org)
Mast cells play an important role in a variety of biological processes and actively participate in the inflammatory response. (bvsalud.org)
In this investigation we sought to answer the question concerning the presence of mast cells in human and rat dental pulp tissues, under normal and inflammatory conditions. (bvsalud.org)
The role of mast cells in the inflammatory dental pulp response is not clear. (bvsalud.org)
Since mast cells are active during inflammatory responses it becomes crucial to find out if these cells are actually present and play a role in dental pulp under normal and inflammatory conditions either in humans or in rats. (bvsalud.org)

Kondziolka and colleagues used N-Tera 2 cells derived from a lung metastasis of a human testicular germ cell tumour that when treated with retinoic acid generate postmitotic neurons that maintain a fetal neuronal phenotype indefinitely in vitro (LBS neurons). (bmj.com)
The correct cell must be chosen for its phenotype, cell characteristics and biological functions. (biomedcentral.com)
In addition, Methylated RNA Immunoprecipitation Sequencing technology (MeRIP-seq) was performed to screen downstream targets of METTL3 in endothelial cells and to fully clarify the specific underlying molecular mechanisms affecting the phenotype of cerebral AVM. (biomedcentral.com)
In addition, we demonstrated that blocking Notch pathway with DAPT could restore the phenotype of METTL3 deficient endothelial cells. (biomedcentral.com)
Deep RNA-DNA, RNA-protein interaction studies, and phenotype rescue analyses reveal that LETR1 is a nuclear trans-acting lncRNA modulating, via key epigenetic factors, the expression of essential target genes, including KLF4 and SEMA3C , governing the growth and migratory ability of LECs. (nature.com)
The construction of the blood-brain barrier (BBB), which is a natural barrier for maintaining brain homeostasis, is the result of a meticulous organisation in space and time of cell-cell communication processes between the endothelial cells that carry the BBB phenotype, the brain pericytes, the glial cells (mainly the astrocytes), and the neurons. (mdpi.com)
The review focuses on the role of APC-derived EVs in regulating the transformation of macrophage phenotype, shaping foam cells, driving autophagy and/or inhibiting apoptosis of Th4 + cells, T regulatory cells, endothelial and smooth muscle cells (SMCs), as well as in facilitating oxidative stress in vasculature. (bmrat.org)
Notochordal cell conditioned medium (NCCM) regenerates end-stage human osteoarthritic articular chondrocytes and promotes a healthy phenotype. (unibas.ch)

Shen K, Scheiffele P Genetics and cell biology of building specific synaptic connectivity. (co.ke)

This co-relates with fewer Col+ cells in the hematopoietic stem cell niche of asrij mutants. (nih.gov)
A. Lesman and S. Levenberg, in Stem Cell-Based Tissue Repair, ed. (rsc.org)
Blood-derived endothelial progenitor cells (EPCs) represent the "promoters" of vascular repair providing the rationale for autologous stem cell therapy [ 2 ]. (biomedcentral.com)
Expression of several stem cell markers , including c-Myc , is elevated in CD47-null endothelial cells and a human T cell line lacking CD47. (wikidoc.org)
The purpose of this evaluate is to provide an outline of the preclinical basis for angiogenic and stem cell therapies evaluate the clinical study that has been carried out summarize the lessons learned identify gaps in knowledge and suggest a program toward successfully dealing with an unmet medical need in a large and growing patient population. (bioerc-iend.org)

It is well established that endothelial cells (EC) play a crucial role in vascular physiology. (rug.nl)

Lena trained with Gerald Crabtree during her PhD at Stanford University, where she studied the function and mechanism of chromatin remodeling proteins in the epigenetic regulation of embryonic, hematopoietic and cancer stem cells. (ho-lab.org)

0.05), more medial smooth muscle cells, fewer infiltrative macrophages, and a smaller diameter than LF-AAA. (stanfordhealthcare.org)
On the other hand, dglycin prevented the uptake of oxidized LDL by macrophages via suppressing the expression of scavenger receptor class A1, which suggested that dglycin prevented foam cell formation. (bvsalud.org)
Another statement showed the preadipocyte- and endothelial cell-derived stromal-derived element-1 (CXCL12), mediated early infiltration of CD4+ T lymphocytes in obesity, which preceded the increase of macrophages in adipose cells of mice on HFD (101). (exposed-skin-care.net)
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumor-associated macrophages. (tcd.ie)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Bone marrow-derived progenitor cell (BMPC) therapy has been shown to promote neovascularization, decrease infarct area and attenuate left ventricular (LV) dysfunction after MI. (indexindex.com)
We observed a significant increase in the number of Lin - /VEGF-R2 + endothelial progenitor cells within the bone marrow in diabetic mice compared with non-diabetic mice. (biomedcentral.com)
Low SDF-1 expression may contribute to the dysfunctional mobilization of bone marrow Lin - /VEGF-R2 + endothelial progenitor cells, which may contribute to microvascular injury in early diabetes. (biomedcentral.com)
Bone marrow-derived vascular progenitor cells (CD34+) are present in human and animal models of abdominal aortic aneurysm (AAA) disease. (stanfordhealthcare.org)
Previously we found that estrogen aided in this neovasculogenesis via recruitment of bone marrow derived endothelial progenitor cells (BM-EPCs), leading to increased vessel formation and vascular endothelial growth factor (VEGF) production in vivo . (biomedcentral.com)
Spontaneous In Vivo Chondrogenesis of Bone Marrow-Derived Mesenchymal Progenitor Cells by Blocking Vascular Endothelial Growth Factor Signaling. (unibas.ch)

Mechanisms that modulate and integrate these signals are poorly understood. (nih.gov)
Unlike vascular effects, the anti-fibrosis mechanisms of BMPC, specifically under diabetic conditions, are poorly understood. (indexindex.com)
EPCs from human umbilical cord and adult peripheral blood activate different mechanisms upon high-dose x-ray radiation treatment: CB-EPCs undergo p53 stabilization, Bax-dependent apoptosis and p21-dependent G 1 and G 2 /M cell cycle checkpoints, while PB-EPCs undergo only radiation-induced senescence [ 13 ], indicating unique gene expression patterns in EPCs of different sources. (biomedcentral.com)
Proposed Mechanisms of Action to Improve Heart Function Over the last decade, investigators possess proposed three fundamental mechanisms to support the assertion that come cell therapy can become used as an effective treatment for HF (Number 1). (bioinf.org)
Cheryl joined the EPL in 2017 with an interest in dissecting the mechanisms of vascular inflammation, the underlying cause of many major cardiovascular diseases. (ho-lab.org)
Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G and Jansen F: Vascular pathologies in chronic kidney disease: Pathophysiological mechanisms and novel therapeutic approaches. (spandidos-publications.com)
This condition happens regularly but transiently in Tie2 kinase inhibitor healthy humans when they begin to exercise.4 In response to work out homeostatic mechanisms are activated so that vascular supply raises to match metabolic demand.5 Specifically the cells requirements for oxygen and nutrients are matched from the inflow of oxygenated blood. (bioerc-iend.org)
With physical exertion such as operating on a treadmill machine blood flow to the lower limbs may boost 5-fold to match metabolic demand.5 This vascular response is tightly controlled by neuronal hormonal endothelial and metabolic mechanisms. (bioerc-iend.org)

Sheryl obtained a masters in Cadiovascular Science from University College London where she investigated the anti-proliferative role of nitric oxide in vascular smooth muscle cells under the supervision of Professor Lucie Clapp. (ho-lab.org)
The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)

VEGF therapy biomarker neuropilin receptor tyrosine kinase (RTK) vascular endothelial growth factor ( VEGF ) The mammalian VEGF (vascular endothelial growth factor) family consists of five homodimeric polypeptides of 40 kDa: VEGF-A, -B, -C and -D and PlGF (placental growth factor). (silverchair.com)
Vascular Response to Metabolic Demand Ischemia defines a state in which blood flow is definitely insufficient to meet metabolic Tie2 kinase inhibitor demands. (bioerc-iend.org)
Functional Tie2 kinase inhibitor Reactions to Metabolic Demand In the exercising lower leg muscle mass the arterioles dilate reducing vascular resistance. (bioerc-iend.org)

Therefore, dglycin alleviated the early-stage of atherosclerosis via depressing inflammation, lipid deposition, protecting aortic endothelial cells and preventing foam cell formation. (bvsalud.org)
NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
The development of the disease is associated with microvascular inflammation and altered immune reaction due to strong infiltration of intima and sub-intima by oxidized lipids, oxidative stress, proliferative responses from cellular components of intima and media, accumulation of extracellular components with the shaping of atherosclerotic plaques, impaired vasomotion ability, endothelial dysfunction, and thrombosis, ultimately resulting in vascular remodeling and artery obstruction 11 , 12 . (bmrat.org)
Mast cells play an important role in a variety of biological processes including allergic reactions, atherosclerosis and inflammation 7,8 . (bvsalud.org)

Recently, adventitial progenitor cell has been linked to be involved in the vascular calcification. (tmu.edu.tw)
Vitamin D may provide a role in modulating adventitial progenitor cells. (tmu.edu.tw)

Two genes, SDF-1 and SELE, were significantly differentially expressed in diabetic Lin - /VEGF-R2 + endothelial progenitor cells and six other genes, CAV1, eNOS, CLDN5, NANOG, OCLN and BDNF, showed very low levels of expression in diabetic Lin - /VEGF-R2 + progenitor cells. (biomedcentral.com)
Vascular endothelial (VEGF) and platelet-derived growth factor (PDGF) expression varied directly with capillary density between groups. (stanfordhealthcare.org)
The vascular endothelial growth factor ( VEGF ) signalling axis remains the most widely studied, with biological and small-molecule therapeutics now registered for clinical use. (silverchair.com)
Both genetic and drug targeting experiments have demonstrated the requirement for the vascular endothelial growth factor ( VEGF ) system, the Delta-like-Notch system and the transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP. (silverchair.com)
2004 351 2805 2816 19 Schrijvers B.F. Flyvbjerg A. De Vriese A.S. The role of vascular endothelial growth factor ( VEGF ) in renal pathophysiology Kidney Int. 2004 65 2003 2017 20 Marrelli A. Cipriani P. Liakouli V. (silverchair.com)
Estrogen treated TG1-1 cells secreted higher levels of VEGF which were comparable to secreted levels from cells grown under hypoxic conditions. (biomedcentral.com)

And finally, how hemodynamic forces modulate EndMT both through inhibition, and stimulation of this process. (rug.nl)
The CD47/SIRPα interaction leads to bidirectional signaling, resulting in different cell-to-cell responses including inhibition of phagocytosis , stimulation of cell-cell fusion, and T-cell activation . (wikidoc.org)

Furthermore, it inhibited reactive oxygen species generation, subsequently enhanced cell viability, and protected aortic endothelial cells from necrosis and apoptosis via mitochondrial function improvement. (bvsalud.org)
CD47 ligation leads to cell death in many normal and tumor cell lines via apoptosis or autophagy . (wikidoc.org)
The activation of CD47 induces rapid apoptosis of T cells. (wikidoc.org)
Jurkat cells and peripheral blood mononuclear cells ( PBMC ) incubated with the monoclonal antibody Ad22 results in apoptosis within 3 hours. (wikidoc.org)
Similarly, CD47 ligation rapidly induces apoptosis in B-cell chronic lymphocytic leukemia (CLL) cells. (wikidoc.org)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)

Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Endothelial progenitor cells (EPCs) play a fundamental role in post-natal vascular repair, yet EPCs from different anatomic locations possess unique biological properties. (biomedcentral.com)
EPCs from CB expressed abundant genes involved in cell cycle, hypoxia signalling and blood vessel development, correlating with the phenotypes that CB-EPCs proliferated more rapidly, migrated faster, and formed tubule structure more efficiently. (biomedcentral.com)
Thus, umbilical cord blood EPCs hold great therapeutic potential for cell therapy and vascular engineering. (biomedcentral.com)

Accumulation of low-density lipoproteins (LDL), formation of foam cells, and endothelial dysfunction within the arterial intima contribute to atherosclerotic plaque formation. (bvsalud.org)
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)

hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)

There is a therapeutic window in which to deliver the cells, to avoid extensive tissue damage, fibrosis and necrosis. (biomedcentral.com)

From pioneering research on the in vivo expression, structure and regulation of muscle genes, she and her lab went on to study the myogenic regulatory factors, showing that Myf5 is present before MyoD in the embryo and that in the absence of Myf5 and Mrf4, cells fail to form skeletal muscle and acquire other mesodermal cell fates. (wikipedia.org)
Additional factors which accumulate with active metabolism and which can also induce a direct vasodilation of the vascular clean muscle include extracellular potassium hydrogen ions and lactic acid.7 Humoral endothelial and anxious regulation enjoy much less of a job in regulating microvascular tone during training. (bioerc-iend.org)
Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
Using the murine mammary cell line TG1-1 we observed estrogen (E 2 ) lead to an up regulation of hypoxia inducible factor-1 (HIF-1), an effect abrogated by the anti-estrogen Fulvestrant and the HIF-1 inhibitor YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole) suggesting the interchangeability of hypoxia and estrogen mediated effects. (biomedcentral.com)

These cells initially amplify and colonize the entire CNS and maintain the proliferating ability even during adult life 5 . (nature.com)
In vascular medicine, various stem cells and adult progenitors have been highlighted as having a vasoreparative role in ischaemic tissues. (biomedcentral.com)
Come Cells Utilized in Clinical Tests For Heart Diseases 329045-45-6 Although animal studies support the idea that the beneficial effects observed from treatment with adult come cells are attributable to paracrine effect,13,16,17, the precise mechanism of action in humans remains ambiguous. (bioinf.org)
Engineering Small-Scale and Scaffold-Based Bone Organs via Endochondral Ossification Using Adult Progenitor Cells. (unibas.ch)

Margaret Buckingham is a developmental biologist who is interested in how naïve multipotent cells acquire tissue specificity during embryogenesis. (wikipedia.org)
If the underlying ischaemia is not sufficiently resolved it can lead to tissue damage, with subsequent cell death. (biomedcentral.com)
This review will examine the clinical potential of several stem and progenitor cells that may be utilised to regenerate defunct or damaged vasculature and restore blood flow to the ischaemic tissue. (biomedcentral.com)
This leads to hypoxia and tissue damage as a consequence of the build up of waste metabolites and may result in cell death [ 1 ]. (biomedcentral.com)
A cell therapy approach should be aimed at promoting revascularisation of ischaemic tissue. (biomedcentral.com)
However, its role in aging-related adipose tissue CD4+ T cell activation remains to be investigated. (exposed-skin-care.net)
CD8+ T Cell Activation Compared to CD4+ T cells, CD8+ T cells show a greater increase in adipose tissue in obesity and in aging (31, 43, 106). (exposed-skin-care.net)
Similar to CD4+ T cells, CD8+ T cells exhibit effector memory or effector phenotypes expressing elevated levels of IFN- in obese adipose tissue (31, 44). (exposed-skin-care.net)
The mechanism for CD8+ T cell activation in adipose tissue is not fully understood. (exposed-skin-care.net)
Indeed, CD8+ T cells from mouse adipose tissue respond to cytokines and become activated and proliferate under stimulation of IL-12 and IL-18, which are mainly produced by APCs and are elevated in obese adipose tissue (44). (exposed-skin-care.net)
Traditionally, biomaterials and tissue engineering scaffolds offer suitable platforms to support cell attachment and ingrowth. (medicalxpress.com)
As the cells becomes more metabolically active arterial inflow and venous/lymphatic outflow increase.6 For example at rest the skeletal muscle tissue of the lower leg require a blood flow of ≈5 mL/min per milligram of cells. (bioerc-iend.org)
The activation of these cells leads to the release of chemical mediators such as histamine and arachidonic acid metabolites, which increase vascular permeability and tissue swelling 9 . (bvsalud.org)

This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)

Some studies have shown that vitamin D deficiency is highly prevalent among women suffering from preeclampsia, influencing immune modulation and vascular function. (ac.ir)
In the human body , such a process is implemented through extracellular matrix (ECM)-mediated stepwise modulation of vascular endothelial cell functions at different stages. (medicalxpress.com)
Estrogen modulation of HIF-1 and subsequent effects on endothelial cells is dependent on the Akt/PI3K pathway and protein synthesis as validated by the use of the inhibitors wortmannin and cycloheximide which abrogated estrogen's effects respectively. (biomedcentral.com)

However, all developmental processes originate from pluripotent precursor cell types. (amegroups.org)
The stimulus for the change of cell fate originates from extrinsic signals which set a cascade of intracellular processes in motion that eventually terminate at the genome leading to changes in gene expression and the development of alternate gene regulatory networks. (amegroups.org)
In the developing embryo, TFs regulating the assembly/disassembly of transcriptional complexes and ultimately gene expression, are directed by complex extrinsic signalling processes which connect all cells within a multi-cellular organism to their environment. (amegroups.org)

However, the main element substances that mediate T cell infiltration into adipose tissues in maturing remain to become discovered. (exposed-skin-care.net)

We also aim to understand how some vascular cells acquire specialized functions, such as the generation and/or maintenance of multi-lineage stem/progenitor cells. (virginia.edu)
We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
Together, our study provides several lines of evidence supporting the intriguing concept that every cell type expresses precise lncRNA signatures to control lineage-specific regulatory programs. (nature.com)

This upsurge in stream causes a rise in vascular shear tension. (bioerc-iend.org)

Recently, there has been growing interest in the therapeutic potential of using a cell-based approach to treat vasodegenerative disorders. (biomedcentral.com)
In particular, we focus on the therapeutic potential of endothelial progenitor cells as an exciting new option for the treatment of ischaemic diseases. (biomedcentral.com)

Vascular calcification, common in patients with CKD, is a predictor of cardiovascular mortality. (tmu.edu.tw)
Vitamin D deficiency, another complication of CKD, is associated with vascular calcification in patients with CKD. (tmu.edu.tw)
In summary, vitamin D supplement may provide an ancillary role for ameliorating uremic vascular calcification. (tmu.edu.tw)
Vascular calcification is commonly observed in chronic kidney disease. (spandidos-publications.com)
Ren SC, Mao N, Yi S, Ma X, Zou JQ, Tang X and Fan JM: Vascular calcification in chronic kidney disease: An update and perspective. (spandidos-publications.com)
Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM and Roe MT: Targeting vascular calcification in chronic kidney disease. (spandidos-publications.com)
Yamada S and Giachelli CM: Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho. (spandidos-publications.com)

Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)

In addition venous and lymphatic outflow balance the arterial inflow so as to remove metabolites from active cells. (bioerc-iend.org)

The behaviour of these cells is controlled by gene regulatory networks and signalling pathways, exemplified by the FGF10 gene. (wikipedia.org)
We also highlight recent studies identifying the cis -regulatory elements such as enhancers at the global level and explain how their developmental activity is regulated by the cooperation of cell-type specific and ubiquitous transcription factors with extrinsic signals. (amegroups.org)
CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells . (wikidoc.org)
Oddly enough, recent studies possess demonstrated that these factors may become clustered into extracellular membrane vesicles, including exosomes and microsomes, which can then transfer proteins, lipids, RNA, and microRNAs to mediate cardioprotection.14,15 Although further studies are needed to confirm that these vesicles can substitute for originate cell therapy, delivering these vesicles rather than cells themselves may present a clinically attractive therapeutic option from a regulatory and commercial perspective. (bioinf.org)
New insights into IL-10 dependent and IL-10 independent regulatory B cell immune suppression. (tcd.ie)
Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells. (tcd.ie)
Earlier studies suggested that certain chemotherapeutic providers, including gemcitabine, 5-fluoro-uracil (5-FU) and a metronomic dose of cyclophosphamide, as well as irradiation, may activate the sponsor immunity or inhibit suppressors of sponsor responses, such as regulatory T cells (Tregs) and myeloid-derived suppressor cells, enhancing the Rabbit Polyclonal to ERI1 effect of malignancy immunotherapy (9-11). (opioid-receptors.com)

This vasodilation is largely because of build up of cells metabolites in the active muscle mass. (bioerc-iend.org)

The blood and lymphatic vascular systems are essential for the efficient transport of oxygen, nutrients, signaling molecules, and leukocytes to and from peripheral tissues, the removal of waste products, and the preservation of fluid homeostasis. (nature.com)
Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

In addition to a role in adaptive immunity, memory CD8+ T cells are involved in innate immunity, being able to become activated and to proliferate under cytokine stimulation (107, 108). (exposed-skin-care.net)

further defined that mostly huge adipocytes from obese adipose tissues exhibited an increased expression degree of MHCII substances and acted as APCs to activate Compact disc4+ T cells to secrete IFN- (103). (exposed-skin-care.net)
Due to the ubiquitous expression of CD47, signaling differs according to cell type. (wikidoc.org)
During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
Scaffold Composition Determines the Angiogenic Outcome of Cell-Based Vascular Endothelial Growth Factor Expression by Modulating Its Microenvironmental Distribution. (unibas.ch)

During Central Nervous System ontogenesis, myelinating oligodendrocytes (OLs) arise from highly ramified and proliferative precursors called oligodendrocyte progenitor cells (OPCs). (nature.com)
Myelinating OLs originate from parenchymal precursors expressing the neuron-glia antigen 2 (NG2) chondroitin sulphate proteoglycan and the platelet derived growth factor receptor alpha (PDGFRα), commonly referred to as oligodendrocyte progenitor cells (OPCs) 4 . (nature.com)

She has studied both the formation of skeletal muscle and of the heart, using the tools of mouse molecular genetics to characterise cell behaviour and to identify the genes that govern cell fate choices. (wikipedia.org)

Identification from the important components that modulate the Wnt-Frizzled signaling pathway should continue steadily to unlock the potential of Wnt pathway for the introduction of new therapeutic choices against neurodegenerative and vascular illnesses. (ipa2014.org)

These strategies include administration of angiogenic cytokines either as recombinant protein or as gene therapy and more recently to investigations of stem/progenitor cell therapy. (bioerc-iend.org)
We will discuss what has been learned from your clinical tests of cell therapy and angiogenic factors for PAD. (bioerc-iend.org)

In this study, we wanted to determine whether NPM was similarly modulated in the skin and plasma of psoriatic patients (Pso). (frontiersin.org)
Further, hypoxia and estrogen are interchangeable as both similarly modulate epithelial-endothelial cell interaction. (biomedcentral.com)

We have recently reported that HD brains are also characterised by vascular abnormalities, which include changes in blood vessel density/diameter as well as increased blood-brain barrier (BBB) leakage. (bmj.com)

A dendritic cell (DC)-based vaccine was coupled with intensity-modulated radiotherapy (IMRT) or other conformal radiotherapy (RT), assuming minimal immunosuppression by such RT modalities. (opioid-receptors.com)

This is followed by the adhesion and spreading of the vascular endothelial cells to form a confluent vascular endothelial cell monolayer. (medicalxpress.com)
The focal adhesion and spreading of vascular endothelial cells were subsequently promoted at the later stage of endothelialization by the platform after the topographies were changed. (medicalxpress.com)

Indeed, the principal adipocytes isolated from obese mice could induce antigen-specific Compact disc4+ T cell activation (58). (exposed-skin-care.net)
with tumor-associated antigens, the DCs induce antigen-specific cytotoxic T lymphocytes (CTLs), which assault cancer cells. (opioid-receptors.com)
using this method, DCs were expected to determine and capture apoptotic tumor cells as antigens and induce antigen-specific CTLs thereafter. (opioid-receptors.com)

The aberrant metabolism of H 2 S is involved in the pathogenesis of several skin diseases, such as vascular disorders, psoriasis, ulcers, pigment disorders, and melanoma. (hindawi.com)
She joined the EPL in 2021 with an interest to identify and study SEPs involved in mitochondrial translation and cell metabolism. (ho-lab.org)
In this article, we review the current studies evaluating the association between maternal vitamin D status and vascular health, metabolism, placental immune function and the risk of preeclampsia. (ac.ir)

Anatomy70

Organisms16

Diseases7

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes52

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science2

Differentiation19

Angiogenesis11

Cardiac8

Proliferation15

Regeneration8

Mesenchymal stem2

Migration8

Endothelium6

Inflammatory10

Phenotype8

Biology1

Stem cell5

Role in vascular1

Embryonic1

Macrophages4

Bone marrow7

Mechanisms8

Smooth muscl2

Kinase3

Inflammation4

Adventitial2

VEGF6

Inhibition2

Apoptosis6

EPCs4

Dysfunction2

Blood vessels2

Fibrosis1

Regulation4

Adult4

Tissue13

Epigenetic1

Modulation3

Processes3

Infiltration1

Lineage3

Shear1

Therapeutic potential2

Calcification7

Willebrand1

Arterial1

Regulatory7

Metabolites1

Lymphatic3

Stimulation1

Expression4

Precursors2

Skeletal muscle1

Pathway1

Angiogenic2

Similarly2

Vessel1

Dendritic1

Adhesion2

Induce3

Metabolism3