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  • embryonic
  • While it is commonly accepted as an aging-related phenomenon, senescence might happen also during the embryonic development with the biological meaning of replacing transient structures or specific cell types with other ones [ 3 - 5 ]. (hindawi.com)
  • BioTime, Inc announced the launch of a beta version of Embryonic.AI, an artificially intelligent system for analyzing the embryonic state of human cell samples using gene expression data. (neuralcellnews.com)
  • The mouse embryonic gonad provides an outstanding model to study the complex mechanisms involved in cell fate specification and maintenance. (duke.edu)
  • The GFP transgene was highly expressed in the majority of c- kit + cells in embryonic sites of haematopoiesis, such as the aorta gonad mesonephros region, fetal liver, and bone marrow. (pnas.org)
  • In many cases these maneuvers lead to improvement in conscious state should trigger further bleeding physicians need to be identii ed to determine if you are shown in fig patients with bmikg m a vasopressin v receptors aqp channels in the first visible sign of diabetes during surgery the a abcsa see chapter specific infections e g bupivacaine lignocaine lidocaine each of these embryonic lung mesenchymal cells around the proximal end. (nationalnewstoday.com)
  • The embryonic chick can regenerate its retina by transdifferentiation of the retinal pigmented epithelium (RPE) and by activation of stem/progenitor cells present in the ciliary margin. (biomedcentral.com)
  • skeletal muscle
  • Skeletal muscle is an important contributor to blastema formation ( Brockes, 1997 ). (rupress.org)
  • Although in lethally irradiated mice, bone marrow-derived SCs replenish the depleted satellite cell pool and subsequently incorporate effectively into exercised skeletal muscle ( 9 ), less is known about the ability of bone-marrow-derived SCs to ameliorate muscle damage under more clinically relevant conditions. (pnas.org)
  • A skeletal muscle cell is susceptible to injury by direct trauma or indirect causes such as neurological dysfunction or innate genetic defects. (biomedcentral.com)
  • fate
  • 2011). Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas. (nechiporuklab.org)
  • Concomitantly with RPE transdifferentiation, the transcriptional factor Mitf, an RPE-specific marker, is down-regulated, suggesting a change in cell fate of the injured RPE. (biomedcentral.com)
  • axolotl
  • These viruses, when modified by changing their coat protein, can infect axolotl cells only when they have been experimentally manipulated to express the receptor for that coat protein, thus allowing for the possibility of targeting specific cell types. (biologists.org)
  • When these retroviruses are pseudotyped with ASLV-A envelope glycoprotein that mediates infection specifically through the avian TVA receptor, they are capable of infecting only axolotl cells that have been made to express the receptor. (biologists.org)
  • undergo
  • Mitotic cells might undergo senescence by failing to replicate. (hindawi.com)
  • The cells of the budding yeast Saccharomyces cerevisiae undergo a robust morphological cycle, involving reorganization of the actin cytoskeleton, septin ring formation, and polarized growth. (duke.edu)
  • show that when a neoblast becomes a mature epidermal cell, it has to undergo multiple transition steps. (elifesciences.org)
  • Curiously, axolotls can be induced to undergo a final metamorphosis and rendered terrestrial by administration of the hormone thyroxine. (capeia.com)
  • formation
  • Our findings also identify satellite cells as potential targets in promoting mammalian blastema formation. (rupress.org)
  • Callus formation occurs from pericycle-like cells through a la. (bioportfolio.com)
  • Pattern formation in the morphogenesis of an animal is regulated by genetic induction factors that put cells to work after damage has occurred. (wikipedia.org)
  • Despommier [ 3 ] has already elegantly reviewed the process of capsule formation with emphasis on nurse cell formation. (biomedcentral.com)
  • The present review article deals with the whole process of capsule formation but puts more emphasis on the analogy between nurse cell formation and muscle cell repair. (biomedcentral.com)
  • molecular
  • The molecular mechanisms that maintain the undifferentiated state of the metanephric mesenchymal precursor cells have not yet been identified. (nih.gov)
  • Organelle transport in eukaryotic cells is regulated by a precisely coordinated activity of phosphoinositide lipids, small GTPases, and molecular motors. (duke.edu)
  • This month was notable for a preponderance of plant development preprints, many molecular maps (supported by single cell sequencing), a hearty helping of human development and a multiplicity of (Drosophila) melanogaster mechanics. (biologists.com)
  • Recent advances in generating green fluorescent protein (GFP)-expressing transgenic frogs, salamanders, and fish, combined with molecular marker analyses, have enabled in vivo tracking of cells with high precision. (biomedcentral.com)
  • Six2
  • Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. (nih.gov)
  • We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud. (nih.gov)
  • gene expression
  • Viral gene transfer is an attractive alternative, as it can provide stable gene expression and can, in principle, be targeted to specific cell types based on the availability of a receptor. (biologists.org)
  • hybridization showed a complementary pattern of and gene expression in the blastema of the regenerating OS. (researchhunt.com)
  • RNA interference (RNAi) is a highly conserved post-transcriptional gene regulatory mechanism triggered by small, non-coding double-stranded RNA molecules that can specifically silence gene expression by either repressing translation and/or inducing mRNA degradation , . (cylch.org)
  • migration
  • Most migration of blastema cells occur on days 15 and 20 of culture. (zjrms.com)
  • Macrophages are an important source of both inflammatory and anti-inflammatory signals, arriving in mammalian wounds 48-96 h after injury, where they clear dead cells, release proinflammatory cytokines, and subsequently produce factors that dampen inflammation and stimulate angiogenesis, fibroblast migration, and replication ( 17 ). (pnas.org)
  • lineage
  • I am interested in developing methods for recording lineage and transcriptional event histories within the genome of the cells. (jccfund.org)
  • The process by which differentiated cell types arise from more primitive stem and progenitor cells generally proceeds down a strict lineal hierarchy defined by progressive functional specialization concomitant with restriction of lineage potential. (embopress.org)
  • regenerative medicine
  • This review will focus on the cardiovascular pathologies correlated to senescence, the effect of aging on the cardiac endogenous resources of stem cells, and the potential strategies of regenerative medicine to be applied to maintain the heart younger and healthier. (hindawi.com)
  • De novo generation of human hematopoietic stem cells (HSCs) from renewable cell types has been a long sought‐after but elusive goal in regenerative medicine. (embopress.org)
  • developmental
  • The report in BMC Developmental Biology by Juan Carlos Izpisúa Belmonte and colleagues adds a new twist to a rapidly evolving view of the origin of blastemal cells. (biomedcentral.com)
  • epidermal
  • The egr-5 gene is highly expressed when cells start to develop into epidermal cells. (elifesciences.org)
  • Reducing this gene's activity blocks the cells from differentiating properly, meaning that they do not form mature epidermal cells. (elifesciences.org)
  • The loss of new epidermal cells causes a disruption in the overall integrity of the worm's outer surface and this triggers a wound response throughout the whole animal. (elifesciences.org)
  • However, without egr-5 , the flatworms still cannot make new epidermal cells and they ultimately die. (elifesciences.org)
  • occurs
  • The ankyrin family of proteins form specialized membrane domains in various cell types, including neurons and cardiomyocytes but little is known about how this process occurs. (duke.edu)
  • cardiovascular
  • Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis. (hindawi.com)