Progenitor cells cell line teratocarcinoma. Medical search. Frequent questions

He has also gained salient experience in various experimental setups using hematopoietic stem cells, bone marrow, cord blood-derived and adipose tissue-derived MSCs, very small embryonic-like stem cells, leukemic cells, and germline-derived cells. (livedna.net)
He has also much experience in context of homing, mobilization, and engraftment of hematopoietic stem cells and cancer research. (livedna.net)
Until recently it was considered a fact that, for example, hematopoietic stem cells did not have the potential to differentiate into cells of other types than the cells constituting the blood system. (biomedcentral.com)

We report that perturbing the lipidome of tumor microenvironment by the expression of sulfotransferase 2B1b crucial in cholesterol and oxysterol sulfate synthesis, favored intratumoral representation of monocyte-derived antigen-presenting cells, including monocyte-DCs. (bvsalud.org)

The established dogma has however been challenged by recent findings suggesting that multipotent stem cells have a broader differentiation potential than previously thought. (biomedcentral.com)
Role of Otx2 in Embryonic Stem Cells (ESCs): Otx2 is an intrinsic determinant required to maintain the ESC metastable state by antagonizing ground state pluripotency and promoting commitment to differentiation. (cnr.it)
The production of terminally differentiated cells from such cells, therefore, requires successive changes of cell fates, meaning that genes relevant for the next stage of differentiation must be switched on and genes not relevant anymore must be switched off. (amegroups.org)
The development of the hematopoietic system has long served as model to understand how changes in gene regulatory networks drive the differentiation of the various blood cell types. (amegroups.org)
These cells are the original precursors of various cells in a tumor, whereas other intratumoral cells are limited in terms of their potential for proliferation and pluripotent differentiation. (biomedcentral.com)
In addition, normal adult stem cells (ASCs) self-renew, proliferate infinitely, have a multidirectional differentiation potential, similar to that of tumor cells, and can transform more easily into tumor stem cells than non-stem cells [ 20 , 21 ]. (biomedcentral.com)
CFC1 inhibited Activin A-induced NB cell differentiation and Smad2 phosphorylation in NB cell lines, indicating its involvement in tumorigenesis related to EGF-CFC co-receptor family molecule pathways. (oncotarget.com)
Accumulating evidence has shown that cancer stem cells (CSCs) are a small subpopulation of tumor cells that exhibit the properties of self-renewal, differentiation into various tumor cell types, tumorigenicity, and chemo/irradiation resistance [ 1 ]. (oncotarget.com)
In this review, we describe the cardiac differentiation from ES cells, iPS cells, and the current progress of using iPS cell-derived cardiomyocytes for heart disease modeling and for the development of therapeutic strategies. (biomedcentral.com)
The present invention relates to methods of inducing differentiation of stem cells. (justia.com)
In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. (justia.com)
The process of differentiation in stem cells involves selective development of immature cells to committed and fully mature cells of various lineages. (justia.com)
Differentiation of stem cells is known be triggered by various growth factors and regulatory molecules. (justia.com)
During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
Whilst differentiation of some lineage specific stem cells can be induced with a degree of certainty, a differentiation outcome of a population of pluripotent stem cells is less predictable. (justia.com)
Placing the cells under conditions which induce specific cell types has been one form of an attempt to regulate the differentiation outcome. (justia.com)
These conditions include growing the cells to high or low density, changing media, introducing or removing cytokines, hormones and growth factors, creating an environment which suits differentiation toward a specific cell type, such as providing a suitable substrate. (justia.com)
Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
The induction of cardiomyocyte differentiation in stem cells is especially useful in developing therapeutic methods and products for heart disease and abnormal heart conditions. (justia.com)
However, the molecular pathways that lead to specification and terminal differentiation of specific cell types, such as myocytes, from embryonic stem cells during development are not entirely clear. (justia.com)
Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)
culturing a stem cell in the presence of an embryonic cell and/or extracellular medium of an embryonic cell, under conditions that induce differentiation of the stem cell. (justia.com)
We also found that treating mice with a newly developed antagonist of the oxysterol receptors Liver X Receptors (LXRs), promoted intratumoral monocyte-DC differentiation, delayed tumor growth and synergized with anti-PD-1 immunotherapy and adoptive T cell therapy. (bvsalud.org)

When a transplant occurs which includes lymphocytes, monocytes or progenitors thereof, particularly bone marrow, a graft may attack the host as foreign, resulting in graft-versus-host disease. (justia.com)

Rossant, J. & Vijh, K. M. Ability of outside cells from preimplantation mouse embryos to form inner cell mass derivatives. (nature.com)
Stem cells may be derived from adult tissues but the most potent are extracted from developing human embryos. (edu.au)
1981 and 1988 were important years in the history of organoids because in these years pluripotent stem cells from mouse embryos and embryonic stem cells derived from human blastocysts were isolated and cultured for the very first time (3). (facellitate.com)
3. Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. (facellitate.com)
CFC1, which functions in the development of embryos and decides the left-right axis, was strongly expressed in sphere-forming cells only and was related to the unfavorable prognosis of NB patients. (oncotarget.com)
Embryonic stem (ES) cells are naturally derived from early stage embryos and induced pluripotent stem (iPS) cells are reprogrammed from somatic cells with overexpression of four reprogramming factors, Oct4, Sox2, Klf4 and c-Myc. (biomedcentral.com)

The pluripotent stem cells differentiate further into cells commonly called multipotent stem cells. (biomedcentral.com)
Examples of multipotent stem cells are those producing blood, nerve and muscle cells. (biomedcentral.com)
Multipotent stem cells are present in the adult individual as well as the fetus and umbilical cord. (biomedcentral.com)
Although several reports indicate an ability of multipotent stem cells to produce cells even outside their normal limits, most of these findings remain highly controversial. (biomedcentral.com)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

Dr. Abdelbaset-Ismail has developed remarkable technical skills in cell transplantation for various animal models, molecular characterization, propagating cells in vitro and in vivo. (livedna.net)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
Mouse ES cells have been widely utilized as an in vitro model to study cardiogenesis, as cardiomyocytes were found to spontaneously differentiate from ES cells after withdrawal of LIF (leukemia inhibitory factor), which functions to maintain the pluripotency of undifferentiated mouse ES cells [ 2 - 4 ]. (biomedcentral.com)
The induction of a specific differentiated cell type can be useful for transplantation or drug screening and drug discovery in vitro. (justia.com)

The mechanisms underlying the appearance of asymmetry between cells in the early embryo and consequently the specification of distinct cell lineages during mammalian development remain elusive. (nature.com)
Johnson, M. H. & Ziomek, C. A. The foundation of two distinct cell lineages within the mouse morula. (nature.com)
These stem cells are considered committed to certain cell lineages. (biomedcentral.com)
A wide variety of hematopoietic cells exist, with the major protective lineages being lymphoid and myeloid. (justia.com)
The immune system which results from cells of the lymphoid and myeloid lineages is developed in vivo, so as to recognize self from non-self. (justia.com)
Specifically, human iPS cells could be utilized to generate patient-specific lineages for a variety of translational research. (biomedcentral.com)

ES cells were aggregated into three-dimensional structures, termed embryoid bodies (EBs), and suspended in media containing fetal calf serum. (biomedcentral.com)

The identification of CSCs was achieved by isolating highly tumorigenic tumor cells from primary tumors and tumor cell lines. (oncotarget.com)
PHD2 is certainly the major prolyl hydroxylase that adjusts HIF-1 proteins balance in nonhypoxic cells, whereas knockdown of PHD1 or PHD3 will not really affect HIF-1 proteins amounts in many tumor cell lines (Berra range 350C1700 at a quality of 30,000. (forgetmenotinitiative.org)

Role of Otx2 in dopaminergic neurogenesis: dose-dependent, anterior -posterior and dorsal-ventral integrated control by Otx2 regulates proliferation, number and neurotransmitter phenotype of dopaminergic progenitors. (cnr.it)
Sphere formation, cell proliferation, colony formation in soft agar, and xenograft tumor formation were analyzed. (oncotarget.com)

fication and isolation via fluorescence-activated cell sort- ing (FACS). (lu.se)
Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)

Role of Otx2 in Epiblast Stem Cells (EpiSCs): Otx2 stabilizes the primed EpiSC state by suppressing mesendoderm into neural fate switch in cooperation with BMP4 and Fgf2. (cnr.it)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)

Mesenchymal stem cells with IGF-1 and TGF-β1 in laminin gel for osteochondral defects in rabbits. (livedna.net)
Specifically, about the paracrine activities of amniotic fluid stem cells, renal stem cells, embryonic stem cells, mesenchymal stem cell, induced pluripotent stem cells as well as other stem cells. (biomedcentral.com)

No immunoreactivity is seen with murine EC, EG or ES cells. (sigmaaldrich.com)

A recent study indicates that even adult humans might harbor cells resembling pluripotent embryonic stem cells. (biomedcentral.com)
An important breakthrough happened when it was reported that the adult intestinal stem cells expressing the single leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) can form 3D intestinal organoids in Matrigel-containing media and can self-organize and differentiate into crypt-villus structures (4). (facellitate.com)

Nat Rev Mol Cell Biol 21, 571-584 (2020). (facellitate.com)

The cells giving rise to the foetus, are called pluripotent embryonic stem cells, since they can form every cell type in the body. (biomedcentral.com)

Mechanistically, IFNα promoted the development of a vascular antimetastatic niche characterized by liver sinusoidal endothelial cells (LSECs) defenestration extracellular matrix and glycocalyx deposition, thus strengthening the liver vascular barrier impairing CRC trans-sinusoidal migration, without requiring a direct action on tumor cells, hepatic stellate cells, hepatocytes, or liver dendritic cells (DCs), Kupffer cells (KCs) and liver capsular macrophages (LCMs). (bvsalud.org)
phagocytic and ROS making capacity, and Compact disc11b+ Kupffer cells with cytokine-producing capability. (enmd-2076.com)
In today's study, we looked into the immunological function of Kupffer cells/macrophages in CCl4-induced hepatitis in mice. (enmd-2076.com)
The populace of Compact disc11b+ Kupffer cells/macrophages significantly elevated 24 hour (h) after CCl4 administration, in c-lipo-pretreated mice especially. (enmd-2076.com)
The Compact disc11b+ Kupffer cells portrayed intracellular TNF and surface area Fas-ligand (FasL). (enmd-2076.com)
Furthermore, anti-TNF Ab pretreatment (which reduced the FasL appearance of Compact disc11b+ Kupffer cells), anti-FasL Ab mice or pretreatment attenuated the liver organ injury induced by CCl4. (enmd-2076.com)
The adoptive transfer and cytotoxic assay against principal cultured hepatocytes verified the function of Compact disc11b+ Kupffer cells in CCl4-induced hepatitis. (enmd-2076.com)
Oddly enough, the serum MCP-1 Metoclopramide HCl level elevated and peaked at six h after c-lipo pretreatment quickly, suggesting which the MCP-1 made by c-lipo-phagocytized Compact disc68+ Kupffer cells Metoclopramide HCl may recruit Compact disc11b+ macrophages in the periphery and bone tissue marrow. (enmd-2076.com)
The CD11b+ Kupffer cells producing TNF and FasL play a pivotal role in CCl4-induced acute hepatic injury thus. (enmd-2076.com)

These cells are commonly termed embryonic germ (EG) cells because they are derived from primordial germ cells found at the genital ridges in developing fetuses. (biomedcentral.com)
Human embryonal carcinoma (EC) cells are the stem cells of teratocarcinomas, and they are key components of germ cell tumors (GCTs). (sigmaaldrich.com)
This antibody reacts with TRA-1-60 antigen that is expressed upon the surface of human tetracarcinoma stem cells (EC), human embryonic germ cells (EG) and human embryonic stem cells (ES). (sigmaaldrich.com)

When the host lacks the ability to raise a defense against a particular disease, there may also be an interest in administering specific T-cells or B-cells or precursors thereof which may supplement the host's compromised immune system. (justia.com)

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. (nature.com)
Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1. (livedna.net)
Pituitary sex hormones enhance the pro metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase 1. (livedna.net)
Expression analysis of the human Hox Complex in teratocarcinoma cells (N-tera2/D1) upon treatment with retinoic acid and the definition of temporal colinearity concept. (cnr.it)
Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
The stimulus for the change of cell fate originates from extrinsic signals which set a cascade of intracellular processes in motion that eventually terminate at the genome leading to changes in gene expression and the development of alternate gene regulatory networks. (amegroups.org)
In the developing embryo, TFs regulating the assembly/disassembly of transcriptional complexes and ultimately gene expression, are directed by complex extrinsic signalling processes which connect all cells within a multi-cellular organism to their environment. (amegroups.org)
Methods: The gene expression profiling of adherent (control) and sphere-forming primary NB cells was conducted using a gene expression microarray. (oncotarget.com)
Sleeping Elegance is far more susceptible to more than expression inhibition than piggyBac and Tol2, the cargo capacity of Sleeping Attractiveness is constrained, and contrary to Tol2 and piggyBac that Inhibitors,Modulators,Libraries are lively in all mamma lian cell kinds tested, Sleeping Elegance display cell form dependent exercise. (p450inhibitors.com)
Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
Morphogen gradients induce sharply defined domains of gene expression in a concentration-dependent manner, yet how cells interpret these signals in the face of spatial and temporal noise remains unclear. (elifesciences.org)

Beta-galactosidase of ROSA26 mice is a useful marker for detecting the definitive erythropoiesis after stem cell transplantation" (PDF). (wikipedia.org)
in 1956 and Till and McCulloch in 1961, demonstrating that lethally irradiated mice could be rescued with cells from freshly isolated bone marrow [ 10 ] and that BM cells formed spleen clonies (CFU-S) following transplantation to irradiated recipients [ 30 ], respectively. (biomedcentral.com)
The field of the subject invention is the use of major histocompatibility complex antigen lacking cells and organs which may serve as universal donors in cellular and organ therapies including transplantation and to produce chimeric non-human mammals. (justia.com)
The differentiated ES cell cultures are heterogeneous and contain undifferentiated ES cells, which could result in teratoma formation after transplantation into the host. (biomedcentral.com)
To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)

Two cells in the same position can have very different retinoic acid levels, and the levels in a particular cell can vary from one minute to the next. (elifesciences.org)
The experiments also show that proteins that interact with retinoic acid help to reduce noise within a cell. (elifesciences.org)

In other cases, where certain cells are lacking, such as islets of Langerhans in the case of diabetes, or cells which secrete dopamine in the case of Parkinson's disease, or bone marrow cells in various hematopoietic diseases, or muscle cells in muscle wasting disease, or retinal epithelial cells in visual disorders, it would be desirable to be able to provide cells which could fulfill the desired function. (justia.com)

Herein, we used mouse models of hepatic metastatization to demonstrate that the continuous infusion of therapeutic doses of interferon-alpha (IFNα) controls CRC invasion by acting on hepatic endothelial cells (HECs). (bvsalud.org)

According to the hypothesis, only a small group of stem cell-like tumor cells can form new tumors. (biomedcentral.com)
Poor health outcomes are usually linked to diseased cells spreading from the intestine to create new tumors in the liver or other parts of the body. (bvsalud.org)
Treatment involves surgically removing the initial tumors in the bowel, but patient survival could be improved if, in parallel, their immune system was 'boosted' to destroy cancer cells before they can form other tumors. (bvsalud.org)
As a result, these liver organ immune system cells, including B cells and their cytokines, mainly become innate immune effectors against tumors and infections simply by their T helper-1 immune response in the liver organ. (enmd-2076.com)

Bioactive phospholipids enhance migration and adhesion of human leukemic cells by inhibiting Heme oxygenase 1 (HO-1) and inducible nitric oxygenase synthase (iNOS) in a p38 MAPK-dependent manner. (livedna.net)
Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications. (livedna.net)
There are different types of stem cells that best can be described in the context of normal human development [ 23 ]. (biomedcentral.com)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
The unique properties of human stem cells have aroused considerable optimism about their potential as new pathways for alleviating human suffering caused by disease and injury. (edu.au)
This issue was considered by the House of Representatives Standing Committee on Legal and Constitutional Affairs in its report entitled Human Cloning: Scientific, Ethical and Regulatory Aspects of Human Cloning and Stem Cell Research (hereafter the Andrews Report , after the Chair of the Committee, Mr Kevin Andrews, MP) released in September 2001. (edu.au)
Both ES cells and iPS cells are pluripotent stem cells with capabilities of indefinite self-renewal and can be differentiated into almost all cell types of the body, which make them valuable for studying early developmental biology, for modeling and as therapy for human diseases. (biomedcentral.com)
It really is today generally accepted which the livers of mice and human beings contain types of innate immune system cells [11]C[13]. (enmd-2076.com)

Errors arising in stem and progenitor cells have a much greater influence on the tissue in which they are found than errors arising in postmitotic differentiated cells. (biomedcentral.com)
Organoids are self-organizing culture systems generated from stem cells or tissue-specific progenitor cells. (facellitate.com)
Stem cells divide indefinitely and produce different types of cells replicating the complexity of a tissue or an organ. (facellitate.com)
Embryonic stem (ES) cells are derived from the embryo and are pluripotent, thus possessing the capability of developing into any organ, cell type or tissue type. (justia.com)
To do so, cells release signaling molecules that can move around within a tissue and be detected by receptors on other cells. (elifesciences.org)
We tend to assume that the signaling molecules are evenly distributed across a tissue and affect all the receiving cells in the same way. (elifesciences.org)
Cells responding to the signal somehow can ignore this noise and establish sharp boundaries between different cell types so that neighboring cells have distinct roles in the tissue. (elifesciences.org)

Cell 24 , 71-80 (1981). (nature.com)

Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades. (livedna.net)

Rossant, J. & Lis, W. T. Potential of isolated mouse inner cell masses to form trophectoderm derivatives in vivo . (nature.com)

Role of Orthopedia in migration of diencephalic progenitors fated to populate the telencephalic amygdala. (cnr.it)

We demonstrate that RA forms a noisy gradient during critical stages of hindbrain patterning and that cells use distinct intracellular binding proteins to attenuate noise in RA levels. (elifesciences.org)

It is therefore of interest to find effective ways to produce cells which may function, proliferate, and differentiate as appropriate, while being safe from attack by a recipient's immune system. (justia.com)

In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs. (justia.com)
The protective mechanism which protects the host from disease, as a result of invasion of viruses, bacteria, or other pathogens, is also able to recognize cells which come from a different mammalian host, even an allogeneic host. (justia.com)

The self-renewal and proliferative nature of stem cells raised the hope to fight against various diseases. (biomedcentral.com)

Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
Interferon alpha is a small protein which helps to coordinate how the immune system recognizes and deactivates foreign agents and cancerous cells. (bvsalud.org)

Louvet-Vallee, S., Vinot, S. & Maro, B. Mitotic spindles and cleavage planes are oriented randomly in the two-cell mouse embryo. (nature.com)
A fertilized egg is totipotent, meaning that its potential is total, and as the fertilized egg divides all the cells in the embryo remain totipotent until the fertilized egg has reached the 8/16-cell stage. (biomedcentral.com)
In theory, and to some extent in practice, an 8-cell embryo can be divided into eight single cells, and each cell has the potential of generating an individual if implanted in a woman's uterus. (biomedcentral.com)

Continuous administration minimized the risk of the implanted cancer cells spreading to the liver while also creating fewer side effects. (bvsalud.org)
The immunohistochemical evaluation from the liver organ and the stream cytometry from the liver organ mononuclear cells demonstrated that clodronate liposome (c-lipo) treatment significantly reduced the spindle-shaped F4/80+ or Compact disc68+ cells, as the oval-shaped F4/80+ Compact disc11b+ cells elevated. (enmd-2076.com)
It really is popular that liver organ HGFB NK cells and NKT cells potently generate IFN- in response to IL-12 and/or LPS [11]C[13]. (enmd-2076.com)
Oddly enough, liver organ B cells (mainly B-2 cells) generate IL-12 and IFN- however, not IgM, in response to LPS (vice versa for spleen B cells) [14]. (enmd-2076.com)
Furthermore, these IL-12-making liver organ B cells, as opposed to spleen B cells, phagocytose bacterias and eliminate them [15], [16]. (enmd-2076.com)

It has been suggested that adults contain 20 different types of stem cells. (biomedcentral.com)
Differential dosage-dependent roles of OTX2 in specifying regional identities and neuronal cell types during brain development. (cnr.it)
In mammals, the immune systems serves as the primary defense with many different types of cells and mechanisms to protect the host. (justia.com)
However, all developmental processes originate from pluripotent precursor cell types. (amegroups.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
In any case, the respective cell types may then be selectively cultured to enrich their percentage population to eventually obtain a single cell type and culture. (justia.com)

However, random variations (noise) that affect how many of these molecules are produced, how they move through the space between cells and how they bind to receptors makes the reality much more complex. (elifesciences.org)

2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)
Stem cell technology in humans derives from earlier and complementary work in animal studies. (edu.au)
Since stem cells derived from humans are the source material of organoids, they bridge the gap between animal models and humans. (facellitate.com)

Stem cells can also be identified by functional assays. (wikipedia.org)
Co-IP assays Cells had been lysed in altered radioimmunoprecipitation assay stream, and WCLs had been incubated over night with anti-FLAG (Sigma-Aldrich, St. Louis, MO), anti-PHD2 (Novus Biologicals, Littleton, Company), anti-PHD3 (Novus Biologicals), or anti-hydroxyproline (Abcam) antibody in the existence of proteins ACagarose beans (Novus Biologicals). (forgetmenotinitiative.org)

Stem cells are undifferentiated cells which can give rise to a succession of mature functional cells. (justia.com)

The transfected cells had been subjected to a chromosomal transposition assay to deter mine their transposition action. (p450inhibitors.com)

Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? (biomedcentral.com)
We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and the cancer stem cell (CSC) theory, wherein pCSCs exist in precancerous lesions and have characteristics of both CSCs and normal stem cells. (biomedcentral.com)

The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
This strategy was tested on mice in which colorectal cancer cells had been implanted into the wall of the large intestine. (bvsalud.org)

mouse and cell depletion tests demonstrated that NKT cells and NK cells weren't mixed up in hepatic damage. (enmd-2076.com)

It includes the possible stem cell therapy mechanisms involved and outcomes recorded so far, the limitations of using these regenerative medicines, and the progressive improvement in stem cell therapy by adopting approaches like PiggyBac, Sleeping Beauty, and the Sendai virus. (biomedcentral.com)
STEM CELL THERAPY IN UKRAINE AND RUSSIA Recently, there have been changes in stem cells treatment laws in Ukraine and Russia. (nbscience.com)

However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)

In order to find more promising treatments to stimulate renal repair, stem cell-based technology has been proposed as a potentially therapeutic option. (biomedcentral.com)
So as a new therapeutic approach, stem cells are under research with a focus on reducing the burden of several kidney diseases. (biomedcentral.com)
The present invention also provides methods of using the differentiated cells of the present invention for therapeutic purposes. (justia.com)

Since the establishment of the first cell line by Gey et al. (intechopen.com)
Moreover, IFNα endowed LSECs with efficient cross-priming potential that, along with the early intravascular tumor burden reduction, supported the generation of antitumor CD8+ T cells and ultimately led to the establishment of a protective long-term memory T cell response. (bvsalud.org)

Anatomy53

Organisms15

Diseases12

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes60

Disciplines and Occupations1

Information Science3

Hematopoietic stem3

Monocyte derived1

Differentiation23

Lymphocytes1

Embryos6

Multipotent5

Vitro4

Lineages6

Fetal1

Tumor cell lines2

Proliferation2

Isolation2

Neural2

Mesenchymal2

Murine1

Adult2

Biol1

Pluripotent embryonic stem1

Kupffer9

Germ3

Precursors1

Expression12

Transplantation6

Retinoic acid2

Epithelial1

Endothelial cells1

Tumors4

Human8

Tissue7

19811

Pivotal role1

Vivo1

Migration1

Intracellular1

Differentiate1

Mammalian2

Nature of Stem Cells1

Protein3

Embryo3

Liver5

Types6

Complex1

Humans3

Assays2

Functional1

Assay1

Precancerous2

Mice2

Hepatic1

Stem cell th2

Organ1

Therapeutic3

Establishment2