• Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
  • In addition to the restoration of the liver parenchymal tissue by hepatocytes or/and LSPCs, or in some cases bone marrow (BM) derived cells, such as hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), the wound healing after injury in terms of angiopoiesis by liver sinusoidal endothelial cells (LSECs) or/and sinusoidal endothelial progenitor cells (SEPCs) is another important aspect taking place during regeneration. (ijbs.com)
  • These endogenous progenitors may represent the best candidates for cardiovascular cell therapy, as they are tissue-specific, often pre-committed to a cardiac fate, and display a greater propensity to differentiate towards cardiovascular lineages. (ox.ac.uk)
  • Tissue regeneration is a fascinating phenomenon, but the cellular and molecular mechanisms underlying regeneration remain incompletely understood. (biologists.com)
  • The first Special Issue "Mesenchymal Stem/Progenitor Cells and Their Derivates in Tissue Regeneration" has been recognized by many scientific groups and was a successful endeavor. (mdpi.com)
  • Mesenchymal stem/progenitor cells (MSCs) reside in many human tissues and organs and play important roles in tissue regeneration and tissue homeostasis. (mdpi.com)
  • Cells bearing MSC characteristics differ in the facets of proliferation and differentiation, which results in their diverse biological potential and applications in tissue regeneration. (mdpi.com)
  • Development of new blood vessels is necessary for the effective tissue regeneration. (hindawi.com)
  • The esophageal epithelium experiences a high rate of cellular renewal that supports rapid tissue regeneration in response to injury. (jci.org)
  • This week in the JCI , a study led by Anil Rustgi at the University of Pennsylvania identifies keratin 15 as a marker for a subpopulation of proliferative stem cells in the esophagus that are indispensible for maintaining homeostasis as well as regenerating tissue following injury. (jci.org)
  • Although wild-type mice displayed normal morphology 15 days after injury, tissue regeneration remained incomplete in mice lacking keratin 15 + cells. (jci.org)
  • However, persistent inflammation prevents proper tissue regeneration and instead results in fibrosis, the accumulation of connective tissue. (forbes.com)
  • This failed tissue regeneration is key to osteoarthritis. (forbes.com)
  • Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
  • Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • The success of this journey is critical when the number of progenitors in a tissue or organ is limited. (elifesciences.org)
  • It is well-established that early embryonic signaling pathways are critical for growth and patterning of new tissue during regeneration. (frontiersin.org)
  • The regeneration of a tissue intuitively recapitulates aspects of its embryonic development. (frontiersin.org)
  • In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)
  • Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
  • In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)
  • Inspired by creatures in nature that exhibit tissue regeneration, the team looked to the highly regenerative mammalian intestine, which turns over every four to five days. (technologyreview.com)
  • Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
  • In the adult, stem cells exist in many tissues throughout life and may play critical roles in physiological functions and tissue regeneration. (wisc.edu)
  • sped-up tissue regeneration by promoting progenitor and stem cell growth-via the WNT signaling pathway. (nfcr.org)
  • If harmful stimuli cannot be removed in time, increasing numbers of immune cells are recruited to the pulp tissue[5] and the immune-inflammatory balance is disrupted. (researchsquare.com)
  • In addition, there is considerable interest in delineating the mechanisms by which stem cells survive radiation exposure and promote tissue regeneration. (cdc.gov)
  • The important functions of skin stem cell populations in tissue development, homeostasis, and repair are described, as are the roles of resident and recruited cells in inflammatory responses. (cshlpress.com)
  • Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)
  • Embryonic stem cells retain the greatest differentiation potential, but concerns persist with regard to their immunogenic and teratogenic effects. (ox.ac.uk)
  • Although adult somatic stem cells are not tumourigenic and easier to use in an autologous setting, they exist in small numbers and possess reduced differentiation potential. (ox.ac.uk)
  • β-catenin of the canonical Wnt signalling pathway plays a role in cell fate determination, as it is critical for osteoblastogenesis, and the differentiation of chondrocytes into osteoblasts. (wikipedia.org)
  • TGF-β is important for cell proliferation and differentiation during skeletogenesis. (wikipedia.org)
  • Conditional inactivation of TGF-βr2 of osteochondroprogenitor cells in the cranial neural crest resulted in faster osteoprogenitor differentiation and disorganised chondrogenesis. (wikipedia.org)
  • It is thought that through a combination of biochemical and biophysical stimuli, the uncommitted stem cells of the embryo will undergo differentiation into certain cell lineages. (wikipedia.org)
  • performed in vivo lineage tracing studies to determine that expression of the keratin 15 promoter distinguishes a distinct basal stem cell population that is capable of self-renewal, proliferation, and differentiation into squamous-lineage cells. (jci.org)
  • Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
  • The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. (elifesciences.org)
  • The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. (elifesciences.org)
  • These early progenitor cells often travel long distances from their induction site to the site of terminal differentiation, making them vulnerable to environmental cues and movement of neighbouring tissues. (elifesciences.org)
  • When faced with these environmental hazards, progenitors may deviate from their correct pathway or change their potential, leading to a reduction in the pool of progenitors available for later stages of differentiation. (elifesciences.org)
  • Despite the importance of the developmental pathways followed by these small groups of progenitor cells and their impact on the physiology of the organism, we still know little about the set of developmental strategies that progenitor cells deploy in vivo to overcome the challenges imposed by the environment as they travel to the site of terminal differentiation. (elifesciences.org)
  • Utilizing the cell-reprogramming technology we induce neuronal differentiation of OPCs with proneural transcription factors. (rosalindfranklin.edu)
  • Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)
  • At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
  • This encouraged us to continue this Special Issue with a second part devoted to research concerning mesenchymal stem cell application in regenerative medicine. (mdpi.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Hart, D.A. (2014) Why Mesenchymal Stem Cell/Progenitor Cell Heterogeneity in Specific Environments? (scirp.org)
  • Wu, Y. and Zhao, R.C. (2012) The Role of Chemokines in Mesenchymal Stem Cell Homing to the Myocardium. (scirp.org)
  • Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
  • Fehrer, C. and Lepperdinger, G. (2005) Mesenchymal Stem Cell Aging. (scirp.org)
  • However, when the liver is severely damaged or hepatocyte proliferation is greatly inhibited, liver stem/progenitor cells (LSPCs) will contribute to the liver regeneration process. (ijbs.com)
  • This calls for dietary interventions and other strategies to improve muscle progenitor cell proliferation and lower oxidative stress that could aid muscle regeneration during aging. (ibtimes.com)
  • OPC architecture, proliferation and oligodendro-/myelino-genesis are finely regulated by the interplay of cell-intrinsic and extrinsic factors. (nature.com)
  • Our results unveil a novel player in the complex regulation of OPC biology, on the one hand showing that JNK1 ablation cell-autonomously determines alterations of OPC proliferation and branching architecture and, on the other hand, suggesting that JNK1 signaling in OLs participates in myelination in vivo. (nature.com)
  • Both a cell-intrinsic program and environmental factors participate in the regulation of OPC architecture, proliferation and oligodendro-/myelino-genesis. (nature.com)
  • Depletion of Krt15 -derived cells resulted in decreased proliferation, thereby leading to atrophy of the esophageal epithelium. (jci.org)
  • Transplanted murine bone marrow (BM) progenitor cells stimulate endogenous beta cell proliferation and insulin production. (uwo.ca)
  • Transplantation of ALDHhl cells improved systemic hyperglycemia via increased islet vascularization and proliferation resulting in increased islet size, but not islet number. (uwo.ca)
  • We found that NSPCs treated with VEGF-A showed lower rates of cell death and increased cell proliferation,' says senior author Tetsuya Taga. (news-medical.net)
  • Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
  • The upregulation of miR‑145 and miR‑221 was associated with the enhanced proliferation of periosteal cells and chondrogenic potential, respectively. (spandidos-publications.com)
  • Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)
  • BNP also stimulated the proliferation of WT1 + epicardium-derived cells but only in the hypoxic area of infarcted hearts. (elifesciences.org)
  • The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)
  • In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
  • H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)
  • We have shown that in the stomach, stem cell homeostasis is regulated by Wnt and Rspo secreted by stromal myofibroblasts 11 . (nature.com)
  • We demonstrate that while Rspo3 from myofibroblasts maintains colonic Lgr5 + cells during homeostasis, during injury its main function is not to maintain Lgr5 + cells but to interact with more differentiated cells that express Lgr4 but not Lgr5 and are able to regain expression of Wnt target genes and generate new crypts. (nature.com)
  • While some favor the concept of facultative progenitors involved in homeostasis and repair, neither a location nor markers for such cells have been defined. (bepress.com)
  • This review will discuss the basic biology of neural progenitor cells, the mechanisms regulating the generation of neurons and glia from these cells, and the techniques that are available for preparing such cells for transplantation into the nervous system. (northwestern.edu)
  • Within the Collaborative Research Centre (CRC) 1149 "Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma", we offer an exciting interdisciplinary project to understand the cellular and molecular mechanisms of glucocorticoid action in skeletal stem/progenitor cells during bone regeneration. (hotdailytrends.com)
  • Unraveling mechanisms of GC signaling in skeletal stem/progenitor cells will provide rationales for therapeutic approaches in the field of bone regeneration. (hotdailytrends.com)
  • ABDULKADIR, RR, ALWJWAJ, M, RAKKAR, K and OTHMAN, OA, Outgrowth Endothelial Cell Conditioned Medium Negates TNF-alpha-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms Stem Cell Reviews and Reports. (nottingham.ac.uk)
  • more specifically, we attempt to identify mechanisms that promote the regeneration of injured nerve fibers. (ccf.org)
  • Transplantation of ALDHhl mixed progenitor cells or culture- expanded multipotent stromal cells (MSC) into streptozotocin-treated NOD/SCID mice revealed endogenous islet regeneration occurred via distinct mechanisms. (uwo.ca)
  • The research in our laboratory focuses on understanding the molecular mechanisms that regulate neural stem cells and neurodevelopment with the goal of applying this knowledge in the treatment of neurological disorders and injuries. (wisc.edu)
  • My laboratory is investigating the mechanisms governing the behaviors and functions of neural stem cells in both healthy conditions and in neurological diseases. (wisc.edu)
  • Using neural stem cells as model systems, we are investigating the molecular mechanisms that regulate neuronal development during postnatal period and their implications in human neurodevelopmental disorders such as Rett Syndrome, Autism, and Fragile X syndrome. (wisc.edu)
  • Keep up with the Node 'Lab meeting' posts as the platform regularly highlights development and stem cell biology labs from across the globe and showcases research and researchers from the community. (biologists.com)
  • You have a background or ambitions in transgenic animal research, metabolic physiology, cell biology, molecular biology, and fluorescence/ confocal microscopy. (hotdailytrends.com)
  • These results establish the presence of a long-lived and indispensable Krt15 + progenitor cell population that provides additional perspective on esophageal epithelial biology and the widely prevalent diseases that afflict this epithelium. (jci.org)
  • The consortium's goal, the NIH said, is to translate recent advances in progenitor cell biology, including those made by the NHLBI's Progenitor Cell Biology Consortium and the Lung Repair and Regeneration Consortium , to develop new treatments for cardiovascular, pulmonary, and hematologic diseases. (genomeweb.com)
  • Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
  • However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)
  • To enrich for analogous human progenitor cells, we purified human umbilical cord blood (UCB) and BM based on high aldehyde dehydrogenase activity (ALDHhl), a conserved function in multiple progenitor lineages. (uwo.ca)
  • Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. (hindawi.com)
  • Endothelial progenitors should be devoid of hematopoietic markers and able to form vessels both in vitro and in vivo . (hindawi.com)
  • In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
  • Therefore, the cells we used should be considered as hematopoietic precursors of myeloid angiogenic cells and are referred as PACs. (hindawi.com)
  • Sources of exogenous stem/progenitor cells that are currently under evaluation in the context of acute lung injury repair include embryonic stem cells, bone marrow- or fat-derived mesenchymal stem cells, circulating endothelial progenitors, and, recently, amniotic fluid stem/progenitor cells. (nih.gov)
  • Studies have shown that embryonic stem cells are more mechanosensitive than their differentiated counterparts. (wikipedia.org)
  • During embryonic development mesenchymal cells will form cellular structures known as 'condensations. (wikipedia.org)
  • In embryonic cells, Nfix has been shown to regulate intermediate progenitor cell (IPC) generation by promoting the transcription of the protein inscuteable (INSC). (wikipedia.org)
  • Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. (elifesciences.org)
  • Several embryonic tissues and organs originate from small sets of progenitor cells. (elifesciences.org)
  • The TMDU-led research team set out to investigate the effects of low oxygen conditions within the neural stem cell niche using a cell culture model of NSPCs isolated from the forebrains of embryonic mice. (news-medical.net)
  • Our study is aimed at investigating whether precursors of myeloid angiogenic cells (PACs) treated with known pharmaceuticals would produce media with better proangiogenic activity in vitro and if such media can be used to stimulate blood vessel growth in vivo . (hindawi.com)
  • Then, we used atorvastatin-stimulated cells or conditioned media from them in the Matrigel plug in vivo angiogenic assay. (hindawi.com)
  • Genetic in vivo lineage tracing revealed that the Krt15 promoter marks a long-lived basal cell population able to self-renew, proliferate, and generate differentiated cells, consistent with a progenitor/stem cell population. (jci.org)
  • and reprogramming progenitor cells in vivo to treat disease. (genomeweb.com)
  • In vivo, Dclk1+ cells are necessary for pancreatic regeneration following injury and chronic inflammation. (bepress.com)
  • Most clinical trials which utilize ADSCs for OA treatment have been based on the autologous cells from the stromal vascular fraction, as have most of the in vivo studies ( 6 , 7 ). (spandidos-publications.com)
  • The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
  • Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
  • In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
  • Contrary to mixed-progenitor cells, transplantation of cultured MSC stably reduced hyperglycemia via an increase in islet number directly associated with the ductal epithelium without evidence of NGN3+ endocrine precursor activation. (uwo.ca)
  • Nfix may suppress oligodendrocyte expression so cells remain committed to neuron development within the dentate gyrus. (wikipedia.org)
  • During Central Nervous System ontogenesis, myelinating oligodendrocytes (OLs) arise from highly ramified and proliferative precursors called oligodendrocyte progenitor cells (OPCs). (nature.com)
  • Myelinating OLs originate from parenchymal precursors expressing the neuron-glia antigen 2 (NG2) chondroitin sulphate proteoglycan and the platelet derived growth factor receptor alpha (PDGFRα), commonly referred to as oligodendrocyte progenitor cells (OPCs) 4 . (nature.com)
  • Our approach is focused on targeting endogenous oligodendrocyte progenitor cells (OPCs) to drive regeneration and repair. (rosalindfranklin.edu)
  • TGF-β determines and regulates cell lineages during endochondral ossification through Sox9 and Runx2 signalling pathways. (wikipedia.org)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • During embryo development, naïve cell lineages undergo concurrent processes of fate specification and morphogenesis as critical steps towards the generation of differentiated tissues and organs. (elifesciences.org)
  • Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and adipogenic) after suitable stimulation. (scirp.org)
  • Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ (2004) Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. (springer.com)
  • However, the features initially ascribed to endothelial progenitor cells, i.e ., phenotype, expression of endothelial markers, and ability to form tube-like structures on Matrigel, can be mimicked by blood monocytes [ 3 ]. (hindawi.com)
  • Deconvolution of RNA-seq data of alveolar organoids indicated that the fibrosis cocktail rapidly increased the proportion of transitional cell types including the KRT5-/KRT17+ aberrant basaloid phenotype recently identified in the lungs of. (lu.se)
  • Currently our research expanded to investigate the mechanism of EPCs in bone and blood vessel formation and to analyze the phenotype and genotype of these cells. (rambam.org.il)
  • Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
  • Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
  • Specifically, we study the ability of endothelial progenitor cells (EPCs) to enhance bone regeneration. (rambam.org.il)
  • Strategies to enhance endogenous alveolar epithelial repair could include protection of epithelial progenitors from injury and/or stimulation of endogenous progenitor cell function. (nih.gov)
  • Liver regeneration is usually attributed to mature hepatocytes, which possess a remarkable potential to proliferate under mild to moderate injury. (ijbs.com)
  • To conclude, liver regeneration can be mainly divided into three distinct restoring levels according to the cause and severity of injury: hepatocyte dominant regeneration, LSPCs mediated regeneration, extrahepatic stem cells participative regeneration. (ijbs.com)
  • Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. (nature.com)
  • Chemical injury induced by DSS leads to a loss of both Lgr5 + cells and Axin2 + cells and epithelial regeneration is driven by Axin2 − cells, including differentiated Krt20 + surface enterocytes. (nature.com)
  • Regeneration requires stromal Rspo3, which is present at increased levels upon injury and reprograms Lgr5 − but Lgr4 + differentiated cells. (nature.com)
  • In contrast, depletion of stromal Rspo3 impairs crypt regeneration, even upon mild injury. (nature.com)
  • This has been studied mainly in the small intestine, where different cell types such as enterocyte progenitors 4 , more differentiated secretory Bmi1 + cells 3 , or even fully differentiated Paneth cells can repopulate crypts upon injury. (nature.com)
  • Here, we explore the dynamics of crypt regeneration and Wnt/Rspo signaling in the colon in the context of crypt injury. (nature.com)
  • This Rspo3-driven regeneration program is supported by injury-induced stromal remodeling, and is essential for epithelial recovery. (nature.com)
  • These cells can be isolated from different tissues in the adult human body, expanded in vitro and applied for the regeneration of tissues and organs damaged by age, disease or extensive injury. (mdpi.com)
  • These findings indicate that keratin 15 + progenitors give rise to a population of squamous epithelial cells that are critical to recovery from injury and disease. (jci.org)
  • Further, Krt15 + cells were radioresistant and contributed to esophageal epithelial regeneration following radiation-induced injury. (jci.org)
  • Our main focus is to enhance nerve regeneration following spinal cord injury via two strategies: (1) cell therapies within the injured spinal cord and (2) gene therapies within the motor cortex in the brain. (ccf.org)
  • Regeneration of Corticospinal Axons into Neural Progenitor Cell Grafts After Spinal Cord Injury. (ccf.org)
  • Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis" Cell Stem Cell Vol. 18 Iss. (bepress.com)
  • In neurologic diseases the shared common characteristics involve neuronal cell injury. (rosalindfranklin.edu)
  • Here, we investigated bleomycin-induced lung injury responses in young and aged mice at single-cell resolution to gain insights into the cellular and molecular contributions of aging to fibrosis. (researchgate.net)
  • It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
  • hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
  • Alexander Friedenstein and his colleagues first identified osteoprogenitor cells in multiple mammalian tissues, before any genetic or morphological criteria were put in place for bone marrow or connective tissues. (wikipedia.org)
  • The use of patient-specific induced pluripotent stem cells (iPSCs) in combination with bioengineering advances and genome editing offers unique opportunities for developing personalized disease models and tissues for regenerative medicine," the NIH said. (genomeweb.com)
  • While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
  • The blood microvascular endothelium consists of a heterogeneous population of cells with regionally distinct morphologies and transcriptional signatures in different tissues and organs. (researchgate.net)
  • We uncovered a small--molecule approach to control this process and found it worked for many tissues, including the inner ear, to produce large populations of functional sensory hair cells," says Karp. (technologyreview.com)
  • Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
  • During development, stem cells and resulting progenitor cells are responsible for generating all the tissues and cells of an organism. (wisc.edu)
  • Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
  • Now, researchers in Japan have shed new insight into the dynamics of the neural stem cell niche, the home of stem cells in the brain. (news-medical.net)
  • In a new study published in Inflammation and Regeneration , researchers from Tokyo Medical and Dental University (TMDU) investigated the effects of hypoxic (low oxygen) conditions on the neural stem cell niche during development. (news-medical.net)
  • Neural stem and progenitor cells (NPSCs) give rise to the cells of the brain and nervous system. (news-medical.net)
  • While other factors may also contribute to NSPC maintenance, these results shed new light on the composition of the neural stem cell niche during development, and may serve as a foundation for further studies of self-organization of the hypoxic niche. (news-medical.net)
  • 2023) Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia. (news-medical.net)
  • Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
  • Neural stem cells in the postnatal brain have significant roles in both normal brain functions, such as learning and memory and the brain's response to injuries. (wisc.edu)
  • Neurons are terminally differentiated cells with limited neurogenesis. (rosalindfranklin.edu)
  • In addition to the olfactory neurons, the epithelium is composed of supporting cells, Bowman glands and ducts unique to the olfactory epithelium, and basal cells that allow for the regeneration of the epithelium, including the olfactory sensory neurons. (medscape.com)
  • Further understanding of these endogenous angiogenic or putative neogenic programs activated by distinct human progenitor subsets may provide new approaches for combinatorial cellular therapies to treat diabetes. (uwo.ca)
  • NYSE American: AGE), a biotechnology company developing therapeutics for human aging and cell regeneration, and LyGenesis, Inc. ("LyGenesis"), a privately held biotechnology company developing cell therapies that enable organ regeneration, announced today that they will proceed to negotiate an agreement for a merger of the two companies. (businesswire.com)
  • A new study reports Sirt1 can help glial cells to regenerate from progenitor cells in preterm babies with hypoxia related injuries. (neurosciencenews.com)
  • However, in spite of their resistance to hypoxia only a small portion of cells survive when transplanted into an infarct scar (6). (escardio.org)
  • Prognostic, Diagnostic and Therapeutic Potential of Endothelial Progenitor Cells for Patients with Ischaemic Stroke: hype or hope BIOCELL. (nottingham.ac.uk)
  • As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
  • In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)
  • Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
  • Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
  • They then investigated how the serum would affect muscle progenitor cell function by calculating the cell number, capacity to manage oxidative stress, etc. (ibtimes.com)
  • In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
  • However, major advances in the study of neural progenitor cells have altered these perceptions, and rational approaches to the repair of the damaged nervous system using transplanted progenitor cells now seem feasible. (northwestern.edu)
  • Their technique led to 2,000 times more hair cell progenitors than previous approaches. (technologyreview.com)
  • The establishment of large-scale genomic collaborative efforts along with the development of new single-cell transcriptomic techniques and multi-omics approaches have enabled characterization of the mutational and transcriptional profiles of many cancer types and helped to identify clinically actionable alterations as well as predictive and prognostic biomarkers. (cdc.gov)
  • Here we review recent insights into the biophysical, biochemical, and epigenetic processes that underlie regenerative healing in amphibians, focusing particularly on tail and limb regeneration in Xenopus . (frontiersin.org)
  • Since human salivary gland stem cells with c-Kit expression are believed to have enhanced regenerative potencies, our model system provides a stable platform to investigate molecular features associated with c-Kit expression that may contribute to protection or stabilization of the stem cell niche. (cdc.gov)
  • At least two populations of epithelial stem/progenitor cells give rise to the lung anlage, comprising the laryngo-tracheal complex versus the distal lung below the first bronchial bifurcation. (nih.gov)
  • Various stem cell populations have been tested and their potential for cardiac repair has been analyzed. (ox.ac.uk)
  • We identify two populations of cells with active Wnt signaling: highly proliferative Lgr5 + /Axin2 + cells, as well as secretory Lgr5 − /Axin2 + cells. (nature.com)
  • Lgr5 is a well-established marker of these basal stem cells in the gastrointestinal tract 1 and lineage tracing experiments have demonstrated that Lgr5 + cells give rise to clonal cell populations establishing entire colonic crypts 2 . (nature.com)
  • Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)
  • In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)
  • Transcriptional profiling demonstrated that Krt15 + basal cells are molecularly distinct from Krt15 - basal cells. (jci.org)
  • The researchers exposed progenitor cells from a mouse cochlea, grown in a lab dish, to molecules that stimulate a cell signaling pathway known as Wnt, which makes the cells multiply rapidly. (technologyreview.com)
  • The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
  • Nfix interacts with myostatin and regulates temporal progression of muscle regeneration through modulation of myostatin expression. (wikipedia.org)
  • Concluding, high concentrations of atorvastatin stabilize tubes and enhance the paracrine angiogenic activity of human PAC cells in vitro . (hindawi.com)
  • In vitro, Dclk1+ cells proliferate readily and sustain pancreatic organoid growth. (bepress.com)
  • In vitro neurosphere assays revealed striking increases in the number of neurosphere forming cells from p107 −/− brains that exhibited enhanced capacity for self-renewal. (rupress.org)
  • This constant replacement of the epithelium is driven by cells located in the base of colonic crypts, which constantly divide and give rise to the various differentiated cell types. (nature.com)
  • The stratified organization of the epithelium restricts proliferative cells to the basal layer, and these cells must migrate toward the lumen as they differentiate. (jci.org)
  • The esophageal lumen is lined by a stratified squamous epithelium comprised of proliferative basal cells that differentiate while migrating toward the luminal surface and eventually desquamate. (jci.org)
  • Herein, we have described a long-lived progenitor cell population in the mouse esophageal epithelium that is characterized by expression of keratin 15 ( Krt15 ). (jci.org)
  • Originally thought to behave as supporting cells for the lung epithelium and endothelium with a singular f. (researchgate.net)
  • Escopete S, Lopez L, Camberos V, Hasaniya N, Bailey L and Kearns-Jonker M . Evaluating the Exosome Content in Neonatal & Adult Cardiovascular Progenitor Cells, Basic Research Symposium Loma Linda/ Inland Empire Stem Cell Symposium Joint Meeting, October 2020. (llu.edu)
  • Hughes L, Camberos V, Bray J, Hasaniya N, Bailey L, and Kearns-Jonker MK Prostaglandin E2 Induces YAP1 and Agrin through EP4 in Neonatal Islet-1+ Cardiac Progenitor Cells. (llu.edu)
  • Runx2 (which may also be known as Cbfa1), and Osx (a zinc finger containing transcription factor) are necessary for osteochondroprogenitor cells to differentiate into the osteoblast cell lineage. (wikipedia.org)
  • Sox9 blocked osteochondroprogenitor cells were found to express osteoblast marker genes, reprogramming the cells into the osteoblastic lineage. (wikipedia.org)
  • citation needed] The positioning of the osteoprogenitor cell condensations determines the cell lineage before the signalling molecules can. (wikipedia.org)
  • Their distance in relation to the nearest epithelial surface will determine the cell lineage. (wikipedia.org)
  • Using genetic lineage tracing, we show that Doublecortin-like kinase-1 (Dclk1) labels a rare population of long-lived, quiescent pancreatic cells. (bepress.com)
  • Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
  • With sensorineural hearing loss (SNHL), the damaged hair cells of the organ of Corti within the cochlea interfere with typical hearing and, as a result, cause impaired language development. (intechopen.com)
  • Approximately half of congenital SNHL is hereditary and is the result of genetic mutations causing improper development of cochlear hair cells. (intechopen.com)
  • We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
  • The thymus supports T-cell development via specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. (frontiersin.org)
  • However, experimental evidence suggests these cells are important for thymus function by either directly influencing T-cell development, or by indirectly regulating TEC development and/or function. (frontiersin.org)
  • Mesenchymal cells in the lung are crucial during development, but also contribute to the pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most common and deadly form of fibrotic interstitial lung diseases. (researchgate.net)
  • The cell(s) of origin are believed to be the hepatic stem cells, although this remains the subject of investigation. (medscape.com)
  • In this study, we isolated stable radioresistant acinar progenitor cells from the submaxillary gland of the Sprague Dawley rat. (cdc.gov)
  • However, the inner ear does contain progenitor cells that can be induced to multiply and turn into hair cells with a certain combination of drugs, according to researchers at MIT, Brigham and Women's Hospital (BWH), and Massachusetts Eye and Ear. (technologyreview.com)
  • At the same time, to prevent the cells from differentiating too soon, the researchers exposed the cells to molecules that activate another signaling pathway, known as Notch. (technologyreview.com)
  • Humans, unlike some other animals, don't regenerate the cells when that happens. (technologyreview.com)
  • Stem cells rely on extracellular signals produced by the niche, which dictate their ability to self-renew, expand and differentiate. (karger.com)
  • Stem cell niche. (bvsalud.org)
  • During this process, progenitors retain long-lasting apical contacts that enable the epithelial layer to pull a subset of progenitors on their way to the vegetal pole. (elifesciences.org)
  • In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)
  • The sense of smell is mediated through stimulation of the olfactory receptor cells by volatile chemicals. (medscape.com)
  • Resident cardiac progenitor cells: at the heart of regeneration. (ox.ac.uk)
  • Stem cell therapy has recently emerged as an innovative strategy over conventional cardiovascular treatments to restore cardiac function in patients affected by ischemic heart disease. (ox.ac.uk)
  • however, this dogma has recently been challenged with the identification of a reservoir of resident stem cells, defined as cardiac progenitor cells (CPCs). (ox.ac.uk)
  • Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
  • Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
  • Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
  • Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
  • Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. (elifesciences.org)
  • While Lgr5 + cells are long-lived and act as stem cells during homeostatic conditions, experimental models have demonstrated that Lgr5 + stem cells per se are not essential for maintaining epithelial integrity 3 . (nature.com)
  • However, experimental pancreatitis converts Kras mutant Dclk1+ cells into potent cancer-initiating cells. (bepress.com)
  • Alternatively, exogenous stem/progenitor cells can be delivered into the lung either intravenously, intratracheally, or by direct injection. (nih.gov)
  • Further work will be needed to translate stem/progenitor cell therapy for the lung. (nih.gov)
  • Victoria Ptasinski defended her Ph.D. thesis 'Alveolar Progenitor Cells in Lung Damage and Regeneration in Pulmonary Fibrosis' on Monday, November 27, 2023. (lu.se)
  • In doing so, I have turned my attention toward the cells that form the barrier of the lung facing the outer environment. (lu.se)
  • NEW YORK (GenomeWeb) - The National Institutes of Health announced that it will commit as much as $40 million over the next seven years to fund the creation of the National Heart, Lung, and Blood Institute Progenitor Cell Translational Consortium (PCTC), as well as put up $8.2 million for a coordinating center to manage consortium's activities and outreach. (genomeweb.com)
  • Lung regeneration deteriorates with aging leading to increased susceptibility to pathologic conditions, including fibrosis. (researchgate.net)