Loading...
  • neuronal progenitors
  • We have generated a reporter mouse line, which allows identification and classification of early neuronal progenitors. (blogspot.com)
  • We further demonstrate that these cells are the sole class of neuronal progenitors targeted by fluoxetine in the adult brain and suggest that the fluoxetine-induced increase in new neurons arises as a result of the expansion of this cell class. (blogspot.com)
  • M. Metzger, S. Conrad, T. Skutella, and L. Just, "RGMa inhibits neurite outgrowth of neuronal progenitors from murine enteric nervous system via the neogenin receptor in vitro ," Journal of Neurochemistry , vol. 103, no. 6, pp. 2665-2678, 2007. (hindawi.com)
  • oligodendrocyte
  • and at the University of Bath in the United Kingdom created the transgenic zebra fish to express fluorescent proteins in oligodendrocyte progenitor cells. (photonics.com)
  • Oligodendrocyte progenitor cells develop in certain parts of the nervous system and migrate to their target axons. (photonics.com)
  • According to Appel, adult humans have many oligodendrocyte progenitor cells and, following demyelination, those near the lesion divide, migrate into the lesion, and partially wrap and myelinate axons. (photonics.com)
  • Using time-lapse photography and transgenic zebra fish labeled with enhanced GFP, researchers have determined that oligodendrocyte progenitor cells appear to explore their surroundings by extending filopodialike processes as they migrate and begin to enwrap axons. (photonics.com)
  • The images highlighted the movement of the highly branched filopodialike processes that are extensions of the oligodendrocyte progenitor cell walls. (photonics.com)
  • Interestingly, when oligodendrocyte progenitor cells met, they changed migratory paths. (photonics.com)
  • To further investigate, the scientists marked different oligodendrocyte progenitor cells with various colors of fluorescent protein and watched as the cells encountered each other in the developing embryo. (photonics.com)
  • Because myelination is important for a functioning nervous system, and its destruction plays a key role in multiple sclerosis and other diseases, the researchers examined how the oligodendrocyte progenitor cells responded to injury. (photonics.com)
  • They hypothesized that, if the cells use the extension and retraction of the filopodia to recognize other nearby oligodendrocyte progenitor cells, then other cells would fill the void if oligodendrocyte progenitor cells were destroyed. (photonics.com)
  • Oligodendrocyte progenitor cells (OPCs), also known as oligodendrocyte precursor cells, NG2-glia or polydendrocytes, are a subtype of glial cells in the central nervous system. (wikipedia.org)
  • Oligodendrocyte progenitor cells are a subtype of glial cells in the central nervous system, characterized by expression of the proteoglycans PDGFRA, and CSPG4. (wikipedia.org)
  • tissue
  • Two hypotheses explain the role of adult progenitor cells in tissue regeneration. (escardio.org)
  • Hyperglycemia is associated with endothelial cell (EC) dysfunction and reduced neovascularization in response to tissue ischemia, processes that are essential for wound healing and prevention of cardiovascular ischemia ( 1 - 3 ). (diabetesjournals.org)
  • Importantly, there must exist an easily accessible, abundant cell source with the capacity to express the phenotype of the desired tissue, and a biocompatible scaffold to deliver the cells to the damaged region. (springer.com)
  • peer-reviewed publications were screened for relevance in order to identify key advances in stem and progenitor cell contribution to the field of bone tissue engineering. (springer.com)
  • In this review, we briefly introduce various adult stem cells implemented in bone tissue engineering such as mesenchymal stem cells (including bone marrow- and adipose-derived stem cells), endothelial progenitor cells, and induced pluripotent stem cells. (springer.com)
  • Stem and progenitor cell implementation in bone tissue engineering strategies have the ability to make a major impact on regenerative medicine and reduce patient morbidity. (springer.com)
  • Cellular and molecular factors play an important role in activating stem cells to divide and transform into skin tissue-making cells. (hindawi.com)
  • If you get normal tissue developing from marker cells then it is a progenitor cell line. (protocol-online.org)
  • For the repair of large bone defects, a bone tissue engineering strategy has to employ osteogenic cells, osteoinductive growth factors, and osteoconductive scaffolds. (hindawi.com)
  • Various stem cells have been explored as the cell source for tissue engineering applications as they can be expanded and differentiated in culture to meet the demand [ 1 - 3 ]. (hindawi.com)
  • Currently, bone marrow derived mesenchymal stem cells (BMSCs), adipose tissue stem cells (ASCs), amniotic stem cells (ASCs), and multipotent adult stem cells (MAPCs) have been shown to possess osteogenic potential, and their potential use in bone regeneration has been explored [ 6 - 9 ]. (hindawi.com)
  • Among those adult stem cells, BMSCs have been the most commonly used in bone tissue engineering. (hindawi.com)
  • Further methods of the present invention are directed to utilizing the neural progenitor cells cultured in this fashion in the treatment of various neuropathological conditions, and in targeting delivery of cells transfected with a particular gene to diseased or damaged tissue. (google.com)
  • It is the progenitor cells that proliferate into the various lymphocytes, neutrophils, macrophages, and other cells that comprise blood tissue of the body. (google.com)
  • After their marker was found, it was proven that these progenitor could move through the body and migrate towards the tissue where they are needed. (wikipedia.org)
  • The majority of progenitor cells lie dormant or possess little activity in the tissue in which they reside. (wikipedia.org)
  • In case of tissue injury, damaged or dead cells, progenitor cells can be activated. (wikipedia.org)
  • Growth factors or cytokines are two substances that trigger the progenitors to mobilize toward the damaged tissue. (wikipedia.org)
  • ECFCs are now known to be tissue-resident progenitor cells in adults that maintain some vasculogenic ability. (wikipedia.org)
  • This involves covering of the wound by a layer of epithelial cells known as the wound cap and subsequent innervation of this area with nerves that give off signals that revert local differentiated cells (such as muscle, cartilage and connective tissue) back to their undifferentiated cell lineage also known as mesenchymal cells. (wikipedia.org)
  • The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. (wikipedia.org)
  • Dendritic cells that circulate in blood do not have all the typical features of their counterparts in tissue, i.e. they are less mature and have no dendrites. (wikipedia.org)
  • The choroid plexuses are vascularized layers of tissue found in the third, fourth, and lateral ventricles of the brain, which through the function of their ependymal cells, are responsible for the synthesis of cerebrospinal fluid (CSF). (wikipedia.org)
  • In addition to its intracellular role as the major actin-sequestering molecule in cells of many multicellular animals, thymosin β4 shows a remarkably diverse range of effects when present in the fluid surrounding animal tissue cells. (wikipedia.org)
  • cytokines
  • Acute coronary syndromes are associated with increased levels of inflammatory and hematopoietic cytokines which can mobilise the progenitor cells from the bone marrow. (escardio.org)
  • When the cytokines, growth factors and other cell division enhancing stimulators take on the progenitors, a higher rate of cell division is introduced. (wikipedia.org)
  • Work with cell cultures and experiments with animals have shown that administration of thymosin β4 can promote migration of cells, formation of blood vessels, maturation of stem cells, survival of various cell types and lowering of the production of pro-inflammatory cytokines. (wikipedia.org)
  • retinal
  • Analysis of retinal cell development in chick embryo by immunohistochemistry and in ovo electroporation techniques," BMC Developmental Biology , vol. 10, article 8, 2010. (hindawi.com)
  • Expression and cell localization of brain-derived neurotrophic factor and TrkB during zebrafish retinal development," Journal of Anatomy , vol. 217, no. 3, pp. 214-222, 2010. (hindawi.com)
  • proteins
  • For example, the 3D shape changes to the intracellular domain may render it recognizable to catalytic proteins (enzymes) that are located inside the cell and have physical access to it. (wikipedia.org)
  • Such modifications may enable the intracellular domain to act as an enzyme itself, meaning that it may now catalyze the modification of other proteins in the cell. (wikipedia.org)
  • Immature dendritic cells phagocytose pathogens and degrade their proteins into small pieces and upon maturation present those fragments at their cell surface using MHC molecules. (wikipedia.org)
  • Successful beta-selection requires that TCRβ is produced, TCRβ is capable of pairing with pre-Tα to generate the pre-TCR, and that the pre-TCR can interact on the cell surface with the TCR signalling proteins. (wikipedia.org)
  • myogenic
  • This response relies on the muscle's ability to activate myogenic progenitor cells (MPCs) resulting in myogenesis. (pnas.org)
  • Muscle injury and subsequent activation of myogenic progenitor cells is associated with oxidative stress. (pnas.org)
  • In this study, we demonstrate that cytoglobin is up-regulated in activated myogenic progenitor cells, where it localizes to the nucleus and contributes to cell viability. (pnas.org)
  • Myogenic progenitor cells isolated from these mice were severely deficient in their ability to form myotubes as compared with myogenic progenitor cells from wild-type littermates. (pnas.org)
  • ischemia
  • Both mechanisms require the presence of the mobile pool of progenitor cells which are mobilised in the setting of endothelial injury or myocardial ischemia and subsequent homing and engraftment to the site of injury. (escardio.org)
  • 1 , 4 - 7 In experimental studies, increased neovascularization by these cells improves cardiac function after myocardial ischemia. (bloodjournal.org)
  • migratory
  • Evidence that migratory cells participate in the formation of virtually all cardiac structures in transplanted heart comes from work of Quaini documenting the systemic chimerism in cases in which a male patient received a heart from a female . (escardio.org)