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  • endothelial cell
  • Hyperglycemia is associated with endothelial cell (EC) dysfunction and reduced neovascularization in response to tissue ischemia, processes that are essential for wound healing and prevention of cardiovascular ischemia ( 1 - 3 ). (diabetesjournals.org)
  • Outgrowth endothelial cells are an EPC subtype committed to endothelial cell formation. (wikipedia.org)
  • Our hypothesis is that immobilization of the endothelial-cell specific lectin Ulex europa eus-I (UEL-I) into the nanofibrous graft matrix will provide anchor sites in order to enhance cell-specific attachment and stabilize these cells the nanofibrous surface that will be under shear forces, thereby promoting cellular growth across the materia l surface. (sbir.gov)
  • Populations
  • Molecular genetic analysis of early outgrowth putative EPC populations suggests they do indeed have monocyte-like expression patterns, and support the existence of a separate population of progenitors, the late outgrowth, or endothelial colony forming cell (ECFC). (wikipedia.org)
  • By method of isolation and cell function, three main populations of putative adult EPCs have been described. (wikipedia.org)
  • These cells have been shown to have 28 genes regulating the cell cycle to be upregulated, showing that they are proliferative cells having the ability to replace and give rise to multiple cell populations in the pancreas. (wikipedia.org)
  • Hippocampal and hypothalamic progenitor cultures converged to indistinguishable populations and produced neurons of all three categories, confirming that even short-term culture confers or selects for immature progenitors with enough plasticity to elaborate neuronal phenotypes usually inhibited in vivo by the local microenvironment. (nih.gov)
  • The identification and purification of keratinocyte stem cells (KSCs) that are capable of self-renewal and maintenance of differentiating cell populations could contribute both to our understanding of the biology of these cells, and to significant clinical applications, such as the culturing of keratinocytes for transplantation to severe burn wounds. (ingentaconnect.com)
  • multipotent
  • Stem cells are multipotent/pluripotent source of a wide range of cell lineages that are crucial for tissue development, repair, and regeneration. (springer.com)
  • This transcription factor has been shown to give rise to the multipotent stem cell lineages contributing to the endocrine, exocrine and ductal cells of the pancreas. (wikipedia.org)
  • It is important to note here that the developing dorsal and ventral buds are characterized as endoderm, and it isn't until the expression of Pdx1 (specification of endoderm to a stem cell multipotent state) that the endoderm to pancreatic progenitor transition occurs. (wikipedia.org)
  • Human adipose tissue is a source of multipotent stem cells. (springer.com)
  • isolation
  • Considerable data have accumulated in recent years on the characterization, isolation, and function of stem/progenitor cells in the lung. (springer.com)
  • While some other authors have contested these, and maintained that they are true EPCs, many investigators have begun to term these cells colony forming unit-Hill cells (CFU-Hill) or circulating angiogenic cells (CAC) instead (depending on the method of isolation), highlighting their role as hematopoietic myeloid cells involved in promoting new vessel growth. (wikipedia.org)
  • Facile isolation and the characterization of human retinal stem cells," Proceedings of the National Academy of Sciences of the United States of America , vol. 101, no. 44, pp. 15772-15777, 2004. (hindawi.com)
  • Oligodendrocyte
  • Oligodendrocyte progenitor cells (OPCs), also known as oligodendrocyte precursor cells, NG2-glia or polydendrocytes, are a subtype of glial cells in the central nervous system. (wikipedia.org)
  • Oligodendrocyte progenitor cells are a subtype of glial cells in the central nervous system, characterized by expression of the proteoglycans PDGFRA, and CSPG4. (wikipedia.org)
  • and at the University of Bath in the United Kingdom created the transgenic zebra fish to express fluorescent proteins in oligodendrocyte progenitor cells. (photonics.com)
  • Oligodendrocyte progenitor cells develop in certain parts of the nervous system and migrate to their target axons. (photonics.com)
  • According to Appel, adult humans have many oligodendrocyte progenitor cells and, following demyelination, those near the lesion divide, migrate into the lesion, and partially wrap and myelinate axons. (photonics.com)
  • Using time-lapse photography and transgenic zebra fish labeled with enhanced GFP, researchers have determined that oligodendrocyte progenitor cells appear to explore their surroundings by extending filopodialike processes as they migrate and begin to enwrap axons. (photonics.com)
  • The images highlighted the movement of the highly branched filopodialike processes that are extensions of the oligodendrocyte progenitor cell walls. (photonics.com)
  • Interestingly, when oligodendrocyte progenitor cells met, they changed migratory paths. (photonics.com)
  • To further investigate, the scientists marked different oligodendrocyte progenitor cells with various colors of fluorescent protein and watched as the cells encountered each other in the developing embryo. (photonics.com)
  • Because myelination is important for a functioning nervous system, and its destruction plays a key role in multiple sclerosis and other diseases, the researchers examined how the oligodendrocyte progenitor cells responded to injury. (photonics.com)
  • They hypothesized that, if the cells use the extension and retraction of the filopodia to recognize other nearby oligodendrocyte progenitor cells, then other cells would fill the void if oligodendrocyte progenitor cells were destroyed. (photonics.com)
  • proteins
  • When the inhibition of these is lifted, they result in the translocation of Bax and activation of mitochondrial dysfunction resulting in release of mitochondrial apoptogenic proteins cytochrome c, SMAC, and apoptosis-inducing factor (AIF) leading to caspase activation and cell death. (wikipedia.org)
  • For example, the 3D shape changes to the intracellular domain may render it recognizable to catalytic proteins (enzymes) that are located inside the cell and have physical access to it. (wikipedia.org)
  • Such modifications may enable the intracellular domain to act as an enzyme itself, meaning that it may now catalyze the modification of other proteins in the cell. (wikipedia.org)
  • There are many signal transduction pathways in a cell and each of these involves many different proteins. (wikipedia.org)
  • Immature dendritic cells phagocytose pathogens and degrade their proteins into small pieces and upon maturation present those fragments at their cell surface using MHC molecules. (wikipedia.org)
  • Successful beta-selection requires that TCRβ is produced, TCRβ is capable of pairing with pre-Tα to generate the pre-TCR, and that the pre-TCR can interact on the cell surface with the TCR signalling proteins. (wikipedia.org)
  • spleen
  • They also upregulate CCR7, a chemotactic receptor that induces the dendritic cell to travel through the blood stream to the spleen or through the lymphatic system to a lymph node. (wikipedia.org)
  • migrate
  • After their marker was found, it was proven that these progenitor could move through the body and migrate towards the tissue where they are needed. (wikipedia.org)
  • During embryo development, these cells divide and migrate throughout the central nervous system and give rise to oligodendrocytes, which then grow and enwrap the axons to create the myelin sheath. (photonics.com)
  • Once activated, they migrate to the lymph nodes where they interact with T cells and B cells to initiate and shape the adaptive immune response. (wikipedia.org)
  • Once they have come into contact with a presentable antigen, they become activated into mature dendritic cells and begin to migrate to the lymph node. (wikipedia.org)
  • mice
  • Myogenic progenitor cells isolated from these mice were severely deficient in their ability to form myotubes as compared with myogenic progenitor cells from wild-type littermates. (pnas.org)
  • By tagging bone marrow cells of mice with a genetic label, or barcode, researchers were able to track and describe the family tree of individual blood cells as they form in their natural environment. (medicalxpress.com)
  • In one type of assay, lethally irradiated recipient mice are coinjected with congeneic donor-derived "test" cells along with syngeneic (host-type) "competitor" cells to provide shortterm radioprotection, ensure survival, and provide a selective pressure to identify stem cells with high competitive repopulating potential. (stemcell.com)
  • After sublethal irradiation these animals can be transplanted with donor "test" cells from wild-type mice without the need for co-transplanted radioprotective cells to promote survival. (stemcell.com)
  • retinal
  • Analysis of retinal cell development in chick embryo by immunohistochemistry and in ovo electroporation techniques," BMC Developmental Biology , vol. 10, article 8, 2010. (hindawi.com)
  • Expression and cell localization of brain-derived neurotrophic factor and TrkB during zebrafish retinal development," Journal of Anatomy , vol. 217, no. 3, pp. 214-222, 2010. (hindawi.com)
  • activation
  • Muscle injury and subsequent activation of myogenic progenitor cells is associated with oxidative stress. (pnas.org)
  • Frequency Therapeutics successfully completed a first-in-human study evaluating its lead Progenitor Cell Activation (PCA™) candidate FX-322, which is in development to restore hearing in patients with hearing loss due to loss of inner ear hair cells. (genengnews.com)
  • These cells are characterized by high endocytic activity and low T-cell activation potential. (wikipedia.org)
  • Simultaneously, they upregulate cell-surface receptors that act as co-receptors in T-cell activation such as CD80 (B7.1), CD86 (B7.2), and CD40 greatly enhancing their ability to activate T-cells. (wikipedia.org)
  • Therapy
  • Cell Therapy Manufacturing Capacity Increased in Mountain View, California. (webwire.com)
  • HACKENSACK, New Jersey-(June 26, 2006)- Progenitor Cell Therapy, LLC (PCT), a leading full service provider for the contract development of cell therapies, announced today that it has completed construction of additional Class 10,000 clean room space at its manufacturing facility in Mountain View, California. (webwire.com)
  • In the past three months, we designed and constructed additional new Class 10,000 clean rooms to meet the growing demand for PCT s cell therapy contract manufacturing services , said Stewart Craig Ph.D., PCT s Chief Technology Officer and Vice President. (webwire.com)
  • Given the rapidly expanding sector of cellular therapy and global lack of manufacturing capacity for such products, it is expected the company s expansion strategy for both its West (California), and East (New Jersey) coast facilities will further enhance PCT s position as the leading contract development company for the cell therapy industry. (webwire.com)
  • We continue to strategically position our core business to meet the demands of the maturing cell therapy industry. (webwire.com)
  • Progenitor Cell Therapy is a client-based cell therapy services company that supports the development of cellular therapies by providing cGMP-compliant cell manufacturing and consulting services that address regulatory, financial, technical, process, and quality system strategies. (webwire.com)
  • Stem cell therapy emerges as a promising approach in cardiovascular medicine. (bloodjournal.org)
  • formation
  • Evidence that migratory cells participate in the formation of virtually all cardiac structures in transplanted heart comes from work of Quaini documenting the systemic chimerism in cases in which a male patient received a heart from a female . (escardio.org)
  • Apoptosis
  • Local pathology of neurotoxin exposure often includes neuron excitotoxicity or apoptosis but can also include glial cell damage. (wikipedia.org)
  • Neurotrophins activating LNGFR may signal a cell to die via apoptosis, but this effect is counteracted by anti-apoptotic signaling by TrkA, TrkB, or TrkC signaling in cells that also express those receptors. (wikipedia.org)
  • Many cancers do exhibit p53 gene mutations, making gene therapies that target this gene [clarification needed] impossible, but an alternate pathway may be to focus on therapeutic to target PUMA and induce apoptosis in cancer cells. (wikipedia.org)
  • Inhibiting PUMA induced apoptosis may be an interesting target for reducing the side effects of cancer treatments, such as chemotherapy, which induce apoptosis in rapidly dividing healthy cells in addition to rapidly dividing cancer cells. (wikipedia.org)
  • Cells that fail to produce a functional pre-TCR are eliminated by apoptosis. (wikipedia.org)