Progenitor allogeneic cord blood. Medical search. Frequent questions

Each dose is patient-specific, containing healthy stem cells from an allogeneic pre-screened donor, meaning it comes from a different individual rather than using the patient's own cells. (wikipedia.org)
Omidubicel is made from umbilical cord donor stem cells that are processed with nicotinamide, a form of vitamin B3, to enhance and expand the number of progenitor cells, the product's maker, Israel-based Gamida Cell, explained in a press announcement . (medscape.com)
There is also a small risk of infections and malignancies from donor blood. (medscape.com)
Ex Vivo expanded unrelated donor umbilical cord blood transplant protocol for patients with severe sickle cell or transfusion dependent thalassemia. (ucsf.edu)
who are medically suitable for transplant who do not have an identified matched sibling or fully matched unrelated donor with an identified suitably matched unrelated donor cord blood unit. (ucsf.edu)
The Allogeneic bone-marrow transplantation represents the only curative treatment and requires a compatible donor HLA. (longdom.org)
The donor must be between 18 and 50 years at the time of the registration which takes place after a medical interview and a blood sample to determine its typing HLA. (longdom.org)
Umbilical cord blood (UCB) transplantation (CBT) has been an important alternative donor option for patients lacking matched related donor (MRD) or unrelated donor (URD) grafts. (bvsalud.org)
Worldwide, 50,000 hematopoietic stem cell transplant (HSCT) procedures are undertaken annually to replace a person's blood-forming cells - hematopoietic stem cells (HSCs) - to treat blood disorders and cancers, yet two-thirds of patients who need HSCT lack matched donor tissue. (utoronto.ca)
Cord blood (CB) biobanking is being developed worldwide to increase the probability of finding matched donor HSC. (utoronto.ca)
Despite advances in using umbilical cord blood, donor material remains restricted by limited stem cells and the lack of ethnic diversity to provide sufficiently matched material. (utoronto.ca)
A new cell therapy, donor lymphocyte infusion, emerged in the 1990s to ensure that the donor stem cells remain engrafted whereby lymphocytes from the blood of a donor are given to a patient who has already received a hematopoietic stem cells from the same donor. (mastercellbank.com)
Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis. (anthonynolan.org)
Effect of donor type and conditioning regimen intensity on allogeneic transplantation outcomes in patients with sickle cell disease: a retrospective multicentre, cohort study. (gitmo.it)
HSCT may be autologous (the patient's stem cells are used) or allogeneic (the stem cells come from a donor). (smart-immune.com)
Allogeneic hematopoietic stem cell donation: standardised assessment of donor outcome data. (focusonthedonor.nl)
Therefore, we sought to translate these results to a clinically relevant canine-to-canine allogeneic transplant model for Duchenne muscular dystrophy (DMD) and determine if CXCR4 is important for donor cell engraftment. (biomedcentral.com)
We used a clinically acceptable regimen of hematopoietic stem cell transplantation to establish mixed donor/host blood cell chimerism and immune tolerance in a canine model of Duchenne muscular dystrophy ( cxmd ) [ 9 ]. (biomedcentral.com)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)

The patient was treated with chemotherapeutic drugs (cyclophosphamide, vincristine, therarubicin, and cisplatin), irradiation of the abdominal cavity, and surgical resection of the adrenal gland, followed by autologous peripheral blood stem cell transplantation (PBSCT). (biomedcentral.com)
These primitive cells undergo division and differentiation to form the various peripheral blood cells. (nationalacademies.org)
FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
Peripheral blood stem cell transplantations (PBSCT) are now the most common cell therapy procedure. (mastercellbank.com)
Bone marrow was the original and most common source of MSCs and they are also found in Wharton's Jelly, Cord Blood, Adipose Tissue, Molar Teeth, Amniotic Fluid and Peripheral Blood. (mastercellbank.com)
The role of CD34 + dose of peripheral blood progenitor cells (PBPC) has not been previously analyzed in a large population undergoing reduced-intensity conditioning/nonmyeloablative HCT. (elsevierpure.com)
peripheral blood, or placental/umbilical cord blood). (cdc.gov)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
2 , 3 Normally, the bone marrow serves as the source for replenishing the cellular components of peripheral blood including red and white blood cells and platelets. (sajbl.org.za)
HSCT is the transplantation of stem cells, usually derived from the bone marrow, peripheral blood, or umbilical cord blood, to produce additional normal healthy blood cells, including T-cells. (smart-immune.com)
Clinical outcomes after Peripheral Blood Stem Cell Donation by related donors: a Dutch single center cohort study. (focusonthedonor.nl)
Managing a dual role - experiences and coping strategies of parents donating haplo-identical G-CSF mobilised peripheral blood stem cells to their children. (focusonthedonor.nl)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)

PURPOSE: Allogeneic hematopoietic cell transplantation (HCT) in patients with myelodysplastic syndrome (MDS) improves overall survival (OS). (bvsalud.org)
Despite improvements, mortality after allogeneic hematopoietic cell transplantation (HCT) for nonmalignant diseases remains a significant problem. (duke.edu)
Pulmonary Complications in Pediatric and Adolescent Patients Following Allogeneic Hematopoietic Cell Transplantation. (duke.edu)
Reduced-intensity conditioning/nonmyeloablative conditioning regimens are increasingly used in allogeneic hematopoietic cell transplantation (HCT). (elsevierpure.com)

Omidubicel is composed of human allogeneic stem cells from umbilical cord blood that are processed and cultured with nicotinamide (a form of vitamin B3). (wikipedia.org)
A single intravenous infusion of Omisirge contains human allogeneic stem cells taken from umbilical cord blood, according to the FDA's announcement . (pharmalive.com)
The cells are processed using Gamida's proprietary nicotinamide technology, which enriches the hematopoietic progenitor cells, preserves their stemness and promotes their migration to the bone marrow. (pharmalive.com)
Omisirge also facilitates the recovery of white blood cells, leading to an overall safer transplantation procedure. (pharmalive.com)
Hastening the return of the body's white blood cells can reduce the possibility of serious or overwhelming infection associated with stem cell transplantation," Peter Marks, director of the FDA's Center for Biologics Evaluation and Research, said in a statement. (pharmalive.com)
CordIn is a cryopreserved stem/progenitor cell-based product of purified CD133+ cells composed of ex vivo expanded allogeneic UCB cells. (ucsf.edu)
Bone marrow is the place for the production of the hematopoietic cells which differentiate in to three groups: red blood cells, white blood cells and platelets. (longdom.org)
however, allogeneic cells require additional precautions to prevent graft vs. host disease. (sai-med.com)
HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
Colonies derived from different types of progenitor cells are classified and counted based on morphological and phenotypic criteria. (stemcell.com)
CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
The National Health System has designated the Vall d'Hebron University Hospital as a reference centre ( CSUR ) in Neuroblastoma, Childhood sarcomas , and Paediatric allogeneic stem cells . (vallhebron.com)
According to data from the Spanish Register of Tumours in Infants (RETI), ours it the Department that treats the most children in Spain, and is the leading centre for the transplant of haematopoietic progenitors or stem cells (better known as "bone marrow transplants"), having performed more than 1200 such operations. (vallhebron.com)
B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
As the cells reproduce, they commit to a particular task or cell line and become known as committed progenitor cells . (nationalacademies.org)
These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
The ambitious Xcellerate proposal plans to raise USD 20 million over five years to cover cerebral palsy research using three types of cells: umbilical cord blood stem cells, mesenchymal stem cells, and induced neural progenitor stem cells. (parentsguidecordblood.org)
A meta-analysis 6 led by CP Alliance Research Foundation compared these five previous studies and concluded that stem cell interventions for people with cerebral palsy had a small but statistically significant impact on gross motor skills, over the follow-up period of six months, with the most efficacy seen from umbilical cord blood stem cells. (parentsguidecordblood.org)
In theory, children with cerebral palsy would benefit the most from neural stem cells to repair neurologic damage in the brain, but these cells do not migrate like cord blood cells and therefore must be implanted directly into the brain, which raises additional safety concerns for their administration. (parentsguidecordblood.org)
To determine safety and efficacy of 100 million intravenously administered CTEcells™ allogeneic umbilical cord mesenchymal stem cells. (therapeuticsolutionsint.com)
In one embodiment stem cells are administered in order to protect the endothelium from apoptosis and to preserve the blood brain barrier. (therapeuticsolutionsint.com)
In another embodiment stem cells are administered together with endothelial progenitor cells in order to regenerate neural endothelium. (therapeuticsolutionsint.com)
To determine safety and efficacy of intravenously administered allogeneic JadiCell umbilical cord blood mesenchymal stem cells in patients with moderate-to-severe COPD. (therapeuticsolutionsint.com)
Increasing the number of hematopoietic stem and progenitor cells within an umbilical cord blood (UCB) graft shortens the time to hematopoietic recovery after UCB transplantation. (duke.edu)
Cord blood is now being enriched with functional stem and progenitor cells and also immune modulatory cells. (mastercellbank.com)
allogenic natural killer cells (NK-cells) generated ex vivo from umbilical cord blood progenitor cells in cancer immunotherapy. (mastercellbank.com)
Cultivated Autologous Limbal Epithelial Cells (CALEC) use of lung derived mesenchymal progenitor cells for the treatment of advanced emphysema. (childrenshospital.org)
There are exciting new developments in the field of autologous transplant of genetically modified hematopoietic stem/progenitor CD34+ cells. (childrenshospital.org)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
In humans, at least two subsets of DC are known in the blood, myeloid DC (also known as interstitial or dermal DC), and plasmacytoid DC (pDC) and Langerhans cells (LC) in the tissues [ 3 ]. (biomedcentral.com)
BACKGROUND:Umbilical cord blood has become an important source of hematopoietic stem and progenitor cells for therapeutic applications. (duke.edu)
Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)
In vascular medicine, various stem cells and adult progenitors have been highlighted as having a vasoreparative role in ischaemic tissues. (biomedcentral.com)
This review will examine the clinical potential of several stem and progenitor cells that may be utilised to regenerate defunct or damaged vasculature and restore blood flow to the ischaemic tissue. (biomedcentral.com)
In particular, we focus on the therapeutic potential of endothelial progenitor cells as an exciting new option for the treatment of ischaemic diseases. (biomedcentral.com)
EDIT-301 is an investigational cell therapy consisting of autologous CD34+ hematopoietic stem and progenitor cells edited by CRISPR/CAS12a at the gamma globin gene (HBG1 and HBG2). (drugbank.com)
Recent medical advances in the field of regenerative medicine and tissue transplantation have highlighted the importance of umbilical cord blood (UCB) as a valuable alternative source of haematopoietic stem cells, which are potentially life-saving in a vast array of clinical applications. (sajbl.org.za)
In view of the fact that UCB has become a valuable, non-invasive source of stem cells for regenerative therapy, establishment of a public cord blood bank (CBB) in South Africa would vastly improve the availability of haematopoietic stem cells for research and therapeutic uses, and increase the tissue genetic diversity that currently impedes the South African bone marrow registry. (sajbl.org.za)
Derived from the fetal allantois, it provides a rich source of multipotent stem cells, including CD34+ and CD38- haematopoietic progenitor cells. (sajbl.org.za)
These progenitor cells have greater clonal expansion and proliferative capacity than normal bone marrow cells. (sajbl.org.za)
Deficiency or malfunction of these blood cells occurs in disease conditions prevalent in Africa, including cancers like leukaemia and haemoglobinopathies like thalassaemia or sickle-cell disease. (sajbl.org.za)
While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
Its role is to educate T-cell progenitors to become mature, specialized T-cells. (smart-immune.com)
Stem cell sources have been expanded from bone marrow to the use of mobilised hemopoietic progenitor cells and stem cells harvested from umbilical cord blood. (focusonthedonor.nl)
[ 18 ] Arylsulfatase A deficiency leads to defective glial and neuronal differentiation from neural progenitor cells. (medscape.com)
Bone marrow is a heterogeneous cell population which includes hematopoietic and mesenchymal progenitor cells. (embrapa.br)
Multipotent mesenchymal stromal cells (MSCs) were first isolated from bone marrow and then from various adult tissues including placenta, cord blood, deciduous teeth, and amniotic fluid. (embrapa.br)
This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
To participate in this study, you must have a disorder that compromises your body's ability to make blood cells. (nih.gov)
Embryonic myogenic progenitor cells express CXCR4, G-protein coupled cell surface receptor, and migrate towards regions of SDF-1 expression during limb muscle development, suggesting that CXCR4/SDF-1 plays a role in muscle cell homing. (biomedcentral.com)
Many of the clinical complications of PV relate directly to the increase in blood viscosity associated with red cell mass elevation and indirectly to the increased turnover of red cells, leukocytes, and platelets with the attendant increase in uric acid and cytokine production. (basicmedicalkey.com)
Most CAR-T cell-based gene therapy products that are under clinical evaluation consist of autologous enriched T cells, whereas CAR-NK cell-based approaches can be generated from allogeneic donors. (nature.com)
First, T or NK cells are isolated from patient's or donor's blood. (nature.com)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)
Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)

Since then, allogeneic hematopoietic stem cell transplantation (HSCT) has evolved to become a frequently used and effective therapy for many hematologic malignancies. (longdom.org)
In recent years, especially after the advent of reduced intensity conditioning in the late 1990s, allogeneic HSCT is increasingly used in older patients and as an effective salvage strategy for patients with lymphoma or myeloma not responding to chemotherapy or autologous HSCT. (longdom.org)
If more donors where available and the efficacy and safety of HSCT improved, HSCT could benefit more patients with blood diseases. (utoronto.ca)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
Allogeneic HSCT carries significant risks such as rejection of the graft, infection, graft versus host disease (GVHD), and potential long-term side effects, translating into a 50% morbidity and mortality rate at 3 years post HSCT. (smart-immune.com)
Smart Immune's ProTcell platform is designed to reconstitute a T-cell compartment in around three months , compared with 12-18 months through the standard HSCT approach, significantly reducing the time to full immune recovery and possibly opening access to allogeneic medicine to more patients. (smart-immune.com)

The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
The FDA approval was based on phase 3 testing that pitted the use of omidubicel in 62 patients against standard unmanipulated cord blood transplants in 63 patients following myeloablative conditioning. (medscape.com)
With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
Source material for hematopoietic (bone marrow) transplantation is in great demand as at least 20,000 allogeneic transplants are performed each year. (utoronto.ca)
Cord blood stem cell transplants have now been successfully given to treat patients with more than 70 diseases. (mastercellbank.com)
Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
This study will assess the safety and effectiveness of certain cord blood transplants. (nih.gov)
The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. (nih.gov)

Omidubicel is indicated for use in people twelve years of age and older with blood cancers (hematologic malignancies) planned for umbilical cord blood transplantation following myeloablative conditioning to reduce the time to neutrophil recovery and the incidence of infection. (wikipedia.org)
Omisirge is indicated for patients scheduled to undergo umbilical cord blood transplantation after myeloablative conditioning treatments such as chemotherapy or radiotherapy. (pharmalive.com)
Engraftment failure and delays, likely due to diminished cord blood unit (CBU) potency, remain major barriers to the overall success of unrelated umbilical cord blood transplantation (UCBT). (duke.edu)

Transplant of haematopoietic progenitors (autologous, allogeneic relatives and unrelated donors). (vallhebron.com)

Allogeneic bone marrow transplantation, as we understood it, allows saving lives, but cannot take place without donors. (longdom.org)
2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
The present study reports the molecular and epidemiological characterization of 31 HIV-1 isolates from blood donors from the State of Amazonas who donated blood between April 2006 and March 2007. (embrapa.br)
Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)

Based on our findings, we suggest that 131 I-MIBG treatment with myeloablative allogeneic SCT should be considered as first-line therapy for high-risk neuroblastoma patients when possible. (biomedcentral.com)
We decided to perform cord blood stem cell transplantation (CBSCT) for hematopoietic rescue after the myeloablative therapies. (biomedcentral.com)

Smart Immune announced in October 2022 that SMART102, a human T-cell progenitor cell injection derived from cord blood using the ProTcell platform, has entered clinical testing with the first adult patient treated. (smart-immune.com)

HSCs are characterized by their unique ability to self-renew and give rise to the entirety of the blood and immune system throughout the lifetime of an individual. (longdom.org)
Omidubicel is an ex vivo expanded single cord blood product that has demonstrated rapid engraftment, improved immune reconstitution, and reduced infectious complications in clinical trials. (bvsalud.org)
The failure of the immune system to function as it should, can result from immune deficiencies present at birth, acquired diseases such as blood cancers, medications that suppress or damage the immune system, unnecessary or over-the-top immune responses such as allergies, or immune responses to one's self, called autoimmunity. (smart-immune.com)
Smart Immune is the first company to develop thymus-empowered allogeneic T-cell therapies and advance them into clinical testing through its T-cell progenitor platform, ProTcell. (smart-immune.com)
Smart Immune is working to improve the prognosis of immune-compromised patients with life-threatening diseases such as high-risk blood cancers and primary immunodeficiencies. (smart-immune.com)
ProTcell is Smart Immune's thymus-empowered T-cell therapy platform to fully and rapidly re-arm the immune system, aimed at enabling next-generation allogeneic T-cell therapies for all. (smart-immune.com)

Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling. (gitmo.it)

For pediatric patients with acute lymphoblastic leukemia (ALL), relapse is an important cause of treatment failure after unrelated cord blood transplant (UCBT). (duke.edu)
Dr. Kurtzberg is an internationally renowned expert in pediatric hematology/oncology, pediatric blood and marrow transplantation, umbilical cord blood banking and transplantation, and novel applications of cord blood and birthing tissues in the emerging fields of cellular therapies and regenerative medicine. (duke.edu)

Omidubicel, sold under the brand name Omisirge, is a blood-based cell therapy used for the treatment of blood cancers. (wikipedia.org)
Omidubicel is a nicotinamide-modified allogeneic hematopoietic progenitor cell therapy derived from cord blood. (wikipedia.org)
The efficacy of omidubicel was based on the amount of time needed for recovery of the participant's neutrophils (a type of white blood cell that helps protect the body from infections) and the incidence of infections following transplantation. (wikipedia.org)
The FDA has approved Gamida Cell 's omidubicel-onlv, now to be marketed as Omisirge , in patients over 12 years of age with blood cancers, the company announced Monday. (pharmalive.com)
Gamida supported Omisirge's regulatory bid with data from a global, randomized Phase III study, which showed that the cell therapy significantly speeds up neutrophil recovery after stem cell transplantation compared to standard cord blood. (pharmalive.com)
The FDA's "approval is an important advance in cell therapy treatment in patients with blood cancers. (medscape.com)
Adverse events are consistent with allogeneic hematopoietic stem cell transplantation . (medscape.com)
Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)
A phase 3 trial (ClincialTrials.gov identifier NCT02730299) of omidubicel-onlv, a nicotinamide-modified allogeneic hematopoietic progenitor cell therapy manufactured from a single umbilical cord blood (UCB) unit, showed faster hematopoietic recovery, reduced rate of infections, and shorter hospital stay compared with patients randomized to standard UCB. (bvsalud.org)
Iodine-131-metaiodiobenzylguanidine ( 131 I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. (biomedcentral.com)
Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
Parent's Guide to Cord Blood Foundation reported in their March 2016 newsletter that CP Alliance is partnering with Cell Care , the largest family cord blood bank in Australia, on a clinical trial that offers sibling cord blood therapy at the Murdoch Childrens Research Institute to cerebral palsy patients in Australia. (parentsguidecordblood.org)
In order to enable children with cerebral palsy to receive multiple stem cell therapies, cord blood clinical trials are exploring therapy with sibling units and eventually unrelated allogeneic cord blood. (parentsguidecordblood.org)
In one aspect, for example, an isolated cell that is capable of self-renewal and culture expansion and is obtained from a subepithelial layer of a mammalian umbili-cal cord tissue. (therapeuticsolutionsint.com)
The Hematopoietic Cell Transplant Comorbidity Index predicts survival after allogeneic transplant for nonmalignant diseases. (duke.edu)
Phase I/II Study of Stem-Cell Transplantation Using a Single Cord Blood Unit Expanded Ex Vivo With Nicotinamide. (duke.edu)
Its clinical introduction in 1986 replaced bone marrow (BM) as a stem cell source to almost 100% in the and to autologous approximately 75% in the allogeneic transplant setting. (mastercellbank.com)
The first successful cord blood stem cell transplant was performed 30 years ago in October 1988 with a boy with Fanconi anemia. (mastercellbank.com)
We analyzed here, the transduction efficiency of a pDC cell line, GEN2.2, and of pDC derived from CD34+ progenitors, using lentiviral vectors (LV) pseudotyped with different envelope glycoproteins such as the vesicular stomatitis virus envelope (VSVG), the gibbon ape leukaemia virus envelope (GaLV) or the feline endogenous virus envelope (RD114). (biomedcentral.com)
Noninvasive white blood cell quantification in umbilical cord blood collection bags with quantitative oblique back-illumination microscopy. (duke.edu)
CD34 + cell content of 126 341 cord blood units in the US inventory: implications for transplantation and banking. (duke.edu)
CD34+ cell dose is critical for cord blood (CB) engraftment. (duke.edu)
Hematopoietic Stem- and Progenitor-Cell Gene Therapy for Hurler Syndrome. (gitmo.it)
Are you considering a blood stem cell transplant? (nih.gov)
Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
In this study, we used a canine-to-murine xenotransplantation model to quantitatively compare canine muscle cell engraftment, and test the most effective cell population and modulating factor in a canine model of DMD using allogeneic transplantation experiments. (biomedcentral.com)
The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)

In the last decade, the number of transplantations of HPCs derived from cord blood has increased, particularly for children. (nationalacademies.org)

Factors Associated with Long-Term Risk of Relapse after Unrelated Cord Blood Transplantation in Children with Acute Lymphoblastic Leukemia in Remission. (duke.edu)

The use of gametes, embryonic and fetal tissue as well as blood and blood products raises additional questions that need to be separately addressed. (who.int)

Currently only private umbilical cord banking is practised in South Africa and the regulatory framework for human tissue use is still rudimentary with no clear guidelines. (sajbl.org.za)

1 , 2 UCB is the blood in the cut umbilical cord and placenta after delivery. (sajbl.org.za)

The rapid evolution of Blood and Marrow Transplant (BMT), coupled with diverse outcomes associated with heterogeneous groups of patients, led to the formation of two important organizations early in the development of the field: the Center for International Blood and Marrow Transplant Research (CIBMTR) and the Foundation for the Accreditation of Cellular Therapy (FACT). (factglobal.org)

We analyzed MSCs from 5 untreated patients and from 3 CML patients after sex-mismatched allogeneic BMT. (embrapa.br)

The ProTcell platform has the potential for enabling a broad range of future applications including CAR ProTcell for allogeneic, long-lasting, targeted immuno-oncology therapies. (smart-immune.com)

When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)

Treatment of thrombopathy requires, first of all symptomatic measures: haemostatic glues, desmopressin and the blood transfusion which must be only reserved for the difficult gestures or for the high hemorrhagic risk. (longdom.org)

All participants in the study had confirmed blood cancers. (wikipedia.org)
It is a therapeutic option for treating several serious blood cancers and some other conditions. (smart-immune.com)

In the novel and exciting field of regenerative medicine, umbilical cord blood (UCB), also known as placental blood, is no longer considered biological waste. (sajbl.org.za)

Stratagraft (allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen-dsat) is an allogeneic cellularized scaffold product used for the treatment of adults with thermal burns containing intact dermal elements for which surgical intervention is clinically indicated (also known as deep partial-thickness burns). (drugbank.com)
Until now, the recanalization of occluded blood vessels via thrombolysis and thrombectomy, although highly potent, remains the only treatment in humans that enhances stroke outcome. (explorationpub.com)

METHODS: We performed targeted sequencing in 309 patients age 50-75 years with International Prognostic Scoring System (IPSS) intermediate-2 or high-risk MDS, enrolled in the Blood and Marrow Transplant Clinical Trials Network 1102 study and assessed the association of gene mutations with OS. (bvsalud.org)
The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)

Moreover, xenotransplantation accurately predicted results in canine-to-canine allogeneic transplantation experiments, an important pre-clinical model for future human clinical trials. (biomedcentral.com)

Biology of Blood and Marrow Transplantation , 20 (9), 1418-1425. (elsevierpure.com)

Anatomy9

Organisms2

Diseases3

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes4

Named Groups1

Health Care1

Donor19

Peripheral15

Hematopoietic cell transplantation4

Cells69

HSCT6

Transplants8

Umbilical cord blood tran3

Haematopoietic1

Donors5

Myeloablative2

Adult1

Immune6

Bone marrow transpla1

Pediatric2

Cell33

Transplantations1

Acute Lymphobl1

Embryonic1

Tissue1

Placenta1

Outcomes1

MSCs1

Therapies1

Cancer1

Transfusion1

Cancers2

Placental1

Treatment2

Patients2

Clinical trials1

Biology of Blood and Marrow Transplantation1