GTPaseProteinARFsCholera toxinAntibodyARF5ArabidopsisFunctionallyGolgiEncodesExpressionCellularProteinsCatalogVirulenceTumorInteractionTypeGeneralStorageRoleGrowthRequiresPutativeElongationRegulatesPathwaysReversibleLocusGuanine nucleotideReceptorsPolyCytosolicHumanTransferaseBioinformaticsMolecularRegulationAntibodiesVivoMechanismFamilyCloselyTumor necrosMechanisticActivationTranscriptionalTranscription FactorResultsMonoAssaysSignal TransductionCytokinesIdentityShow
GTPase7
- Canis lupus familiaris ADP ribosylation factor like GTPase 3 (ARL3), mRNA. (genscript.com)
- GIT1 is a GTPase-activating protein for the ADP ribosylation factor family. (antibodiesinc.com)
- ADP-ribosylation factor family members (Arfs) in mice possess GTPase activities, and some members have been found to function in meiosis. (appliedbioinfo.com)
- Probable ADP-ribosylation factor GTPase-activating protein AGD5 OS=Arabidopsis thaliana GN=AGD5 PE=1. (yeastrc.org)
- Probable ADP-ribosylation factor GTPase-activating protein AGD6 OS=Arabidopsis thaliana GN=AGD6 PE=1. (yeastrc.org)
- The ADP-ribosylation factor (Arf)-like small GTPase Arl13b is a small GTPase mainly found in primary cilia of neuroeptithelial cells, radial glial cells and fibroblast. (angioproteomie.com)
- Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
Protein9
- ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene. (wikipedia.org)
- ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1 (ARL2L1), is a protein that in humans is encoded by the ARL13B gene. (nsjbio.com)
- Protein expression is influenced by many factors that may vary between experiments or laboratories. (genscript.com)
- ADP-Ribosylation Factor 6 (ARF6) is a GTP-binding protein that functions as a regulator of cytoskeleton remodeling and endocytic recycling. (antibodyguide.com)
- The product of this gene is an epsilon subunit of coatomer protein complex. (nih.gov)
- SYS1 forms a complex with ADP-ribosylation factor-related protein ARFRP1 (MIM 604699) and targets ARFRP1 to the Golgi apparatus (Behnia et al. (antibodypedia.com)
- MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al. (nih.gov)
- Disappearance of aHIF induction under hypoxia was only confirmed in the cell lines expressing high levels of HIF2a protein selleck products and low amounts of HIF1a protein. (thrombin-inhibitor.com)
- They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
ARFs1
- However, unlike ARFs, ARL4 does not activate the cholera toxin ADP-ribosyltranferase. (prospecbio.com)
Cholera toxin4
- These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. (wikipedia.org)
- ARF6 is an allosteric activator of cholera toxin catalytic subunit, an ADP-ribosyltransferase. (antibodyguide.com)
- This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. (creative-biolabs.com)
- ARF has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. (nsjbio.com)
Antibody3
- The following product was used in this experiment: ARF4 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-37841, RRID AB_2554449. (thermofisher.com)
- Lysates were probed with an ARF4 polyclonal antibody (Product # PA5-37841) at a dilution of 0.5 µg/mL and incubated for 1 hour, followed by chemiluminescent detection. (thermofisher.com)
- If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)
ARF51
- ADP-ribosylation factor 5 (ARF5) is a member of the human ARF gene family. (wikipedia.org)
Arabidopsis1
- Strong similarity to gbM95166 ADP-ribosylation factor from Arabidopsis thaliana. (cornell.edu)
Functionally1
- The ADP-ribosylation factor (ARF) family comprises a group of structurally and functionally conserved proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. (nsjbio.com)
Golgi1
- Brefeldin A blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. (adooq.com)
Encodes1
- This gene encodes a member of the ADP-ribosylation factor-like family. (nsjbio.com)
Expression1
- Some species of Mucor are sources of biotechnological products, such as biodiesel from Mucor circinelloides and expression of heterologous proteins from Mucor lusitanicus. (bvsalud.org)
Cellular1
- Cellular aging or cellular senescence is the critical factor for the process of aging. (hindawi.com)
Proteins1
- Arf family members, represented by Arf (ADP- Ribosylation Factor), Arl (Arf-like), and Sar (Secretion-associated and Ras-related) proteins, are involved in the vesicle creation process. (bvsalud.org)
Catalog1
- We are continuously updating our catalog with advanced verified products. (doronscientific.com)
Virulence3
- However, only a few virulence factors have been described in these organisms. (bvsalud.org)
- In F. oxysporum many of the virulence factors are secreted, and the secretion process requires the formation of vesicles. (bvsalud.org)
- The virulence factor involved in the pathogenesis of Mucorales is high affinity iron permease (FTR1), allowing Mucorales survival in iron-poor environments. (medscape.com)
Tumor2
- Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
- Other high-risk groups include patients with cancer, especially those who are neutropenic and those receiving broad-spectrum antibiotics, and individuals receiving immunosuppressive agents, including oral or intravenous steroids and tumor necrosis factor (TNF)-alpha blockers (patients with rheumatoid disorders). (medscape.com)
Interaction1
- Previous reports indicate that the mechanisms of DN involve a multifactorial interaction of metabolic and hemodynamic factors such as high blood glucose, advanced glycation end-products (AGEs), and the renin-angiotensin system (RAS). (hindawi.com)
Type1
- Moreover, arl3 mRNA levels increased significantly when plant tissue was added as a sole carbon source, suggesting that the product of these genes could play pivotal roles during plant infection, the corresponding mutant ∆arl3 was less virulent compared to the wild-type strain. (bvsalud.org)
General1
- Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use. (thermofisher.com)
Storage1
- For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap. (antibodiesinc.com)
Role2
- While many factors contribute, recent evidence indicates that the spectrin based membrane skeleton plays a pivotal role in these processes. (yale.edu)
- ADP-ribosylation factor plays a significant role in the growth of Mucorales. (medscape.com)
Growth1
- We followed up this analysis by showing that loss of cln5 alters the intracellular and extracellular amounts of proliferation repressors during growth and increases the extracellular amount of conditioned medium factor, which regulates cAMP signalling during the early stages of development. (frontiersin.org)
Requires1
- Successful mucormycosis treatment requires correction of the underlying risk factor(s), antifungal therapy (traditionally with a polyene), and aggressive surgery. (medscape.com)
Putative1
- The in vivo effects of nicotinamide on developing M. xanthus cells correlate with its in vitro effects on ADP-ribosylation and the developmental profile of putative ADP-ribosylation substrates. (microbiologyresearch.org)
Elongation1
- The mechanism of ADP- ribosylation of elongation factor 2 catalyzed by fragment A from diphtheria toxin. (microbiologyresearch.org)
Regulates2
- BRAG2/GEP100/IQSec1 interacts with clathrin and regulates ?5?1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5). (genscript.com)
- Using M. tuberculosis as an exemplar, we show that DarT-DarG regulates growth by ADP-ribosylation of DNA at the origin of chromosome replication. (nature.com)
Pathways1
Reversible2
- Genes coding for the reversible ADP- ribosylation system of dinitrogenase reductase from Rhodospirillum rubrum. (microbiologyresearch.org)
- Reversible ADP- ribosylation is demonstrated to be a regulatory mechanism in prokaryotes by heterologous expression. (microbiologyresearch.org)
Locus1
- Nucleotide sequence and transcriptional products of the csg locus of Myxococcus xanthus. (microbiologyresearch.org)
Guanine nucleotide1
- Like other regulatory GTPases, Rho requires GDP/GTP exchange dependent on guanine nucleotide exchange factors (GEFs) for its activation [ 5 ]. (biomedcentral.com)
Receptors1
- One important mechanism of endocrine disruption is altered gene expression, mediated by inappropriate activation or deactivation of receptors that act as transcription factors. (nih.gov)
Poly5
- Gibson, B. A. & Kraus, W. L. New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. (nature.com)
- Dr. Michael Witcher from the Lady Davis Institute for his research on the regulation of CTCF poly(ADP)ribosylation in breast cancer. (mcgill.ca)
- 1. Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair. (nih.gov)
- 2. Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair. (nih.gov)
- 14. Poly(ADP-ribose) Polymerase 1 Modulates Interaction of the Nucleotide Excision Repair Factor XPC-RAD23B with DNA via Poly(ADP-ribosyl)ation. (nih.gov)
Cytosolic1
- Activation of a cytosolic ADP- ribosvl transferase by nitric oxide generating agents. (microbiologyresearch.org)
Human4
- Association between epidermal growth factor receptor amplification and ADP-ribosylation factor 1 methylation in human glioblastoma. (cancerindex.org)
- Stimulation of mono(ADP-ribosyl)ation by reduced extracellular calcium levels in human fibroblasts. (microbiologyresearch.org)
- Products are chemical reagents for research use only and are not intended for human use. (dcchemicals.com)
- Also, the availability of recombinant human hematopoietic growth factors has improved supportive care during life-threatening infections in these patients. (medscape.com)
Transferase1
- This product consists of highly purified C3 Transferase (Cat. (cytoskeleton.com)
Bioinformatics1
- ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments. (nih.gov)
Molecular1
- The Golgi apparatus is a highly reactive organelle that exhibits functional and morphological perturbations in response to molecular-level and contextual factors. (molcells.org)
Regulation1
- Dr. Volker Blank from the Lady Davis Institute for his research on bZIP transcription factor mediated regulation of breast cancer cells. (mcgill.ca)
Antibodies1
- Absave is the leading savings website for Antibodies and Immunological Products. (absave.com)
Vivo1
- 19 The oligomerization domain of NPM also contains a highly conserved motif that appears critical for mediating ADP-ribosylation factor (ARF) binding in vivo . (haematologica.org)
Mechanism2
- We provide a set of high-resolution structures of this enzyme in ligand-free and pre- and post-reaction states, which reveals a specialized mechanism of catalysis that includes a key active-site arginine that extends the canonical ADP-ribosyltransferase toolkit. (nature.com)
- Fig. 3: Mechanism of DNA ADP-ribosylation. (nature.com)
Family1
- Together, our structural and mechanistic data provide details of this PARP family member and contribute to a fundamental understanding of the ADP-ribosylation of nucleic acids. (nature.com)
Closely1
- We work closely with the top suppliers in the world to bring you the best products at the most competitive prices. (absave.com)
Tumor necros3
- We also measured the expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β. (spandidos-publications.com)
- Activated mast cells can release histamine and other inflammatory mediators, such as eicosanoids, proteoglycans and a number of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-13 ( 5 , 9 ). (spandidos-publications.com)
- Although many molecules, including inflammatory cytokines such as IL-1, tumor necrosis factor (TNF), and IL-6 and growth factors, have been implicated as pathogenic factors in RA, the coagulation system is also involved in the inflammatory processes in RA synovitis. (biomedcentral.com)
Mechanistic1
- The mechanistic role of MGP in transforming growth factor-beta (TGF-ß) signaling was examined in the LX-2 stellate cell line by using a loss of function approach. (bvsalud.org)
Activation1
- After the activation of mast cells, degranulation is triggered, which results in the release of mediators, such as products of arachidonic acid metabolism, cytokines, proteases and histamine ( 4 , 5 ). (spandidos-publications.com)
Transcriptional2
- Previous study found that nuclear factor kappa B (NF-κB) is a major transcriptional factor in CCL5. (news-medical.net)
- Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. (arigobio.com)
Transcription Factor1
- Homologous to the maize transcription factor Viviparous-1. (or.jp)
Results1
- Roferon and Intron A differ from the natural product only in amino acid residue at position 23 and achieve similar results in hairy cell leukemia. (medscape.com)
Mono1
- Alkylation-induced mono(ADP-ribosyl)-histones H1 and H2B. (microbiologyresearch.org)
Assays1
- We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients. (epigenetics-modulation-frontier.com)
Signal Transduction1
- Cytoskeleton, Inc. offers a wide range of kits and products for drug screening, signal transduction and cytoskeletal research. (cytoskeleton.com)
Cytokines3
- In addition, Dex carry MHC and T-cell costimulatory molecules to present allergens to induce the production of Th2 cytokines in allergic donors, which are important immunostimulatory factors of anaphylactic immune responses ( 17 , 18 ). (spandidos-publications.com)
- AEDK decreased gene expression and the secretion of the pro-inflammatory cytokines, TNF-α and IL-1β by inhibiting nuclear factor-κB. (spandidos-publications.com)
- Synovial cells are markedly activated by cytokines, adhesion molecules, and coagulation factors, resulting in hyperplasia of the synovial tissue, and the activated synovial cells produce inflammatory cytokines and degradative enzymes. (biomedcentral.com)
Identity1
- Product identity, quality, purity and activity are assured by our robust quality control programs and procedures. (epigenetics-modulation-frontier.com)
Show1
- We also show that thymine-linked ADP-ribose DNA adducts reversed by DarG antitoxin (functioning as a noncanonical DNA repair factor) are used not only for targeted DNA damage to induce toxicity, but also as a signalling strategy for cellular processes. (nature.com)