Production siderophores. Medical search. Frequent questions

Analysis of siderophore production by this organism revealed that the biosynthesis of all salicylate-derived siderophores was interrupted. (nih.gov)
Biosynthesis of aminovinyl-cysteine-containing peptides and its application in the production of potential drug candidates. (stjohns.edu)
Additionally, among the virulence factor coding genes, secretory and membrane protein-coding genes in multi-copy gene families, 212 genes underwent positive selection and also suggest increased adaptation, such as fungal immune evasion mechanisms (aspf2), siderophore biosynthesis (sidD), fumarylalanine production (sidE), stress tolerance (atfA) and thermotolerance (sodA). (uni-wuerzburg.de)
Pretomanid kills actively replicating Mycobacterium tuberculosis by inhibiting mycolic acid biosynthesis, thereby blocking cell-wall production. (medscape.com)

This is followed by excretion of the siderophore into the extracellular environment, where the siderophore acts to sequester and solubilize the iron. (wikipedia.org)
99.9% of bacteria died within 5 days of incubation at 37°C. In addition, the annotated genome included evidence of versatile iron-acquisition capacities, including 2 siderophore systems and extracellular heme scavenging ( Table 5 ). (medscape.com)
In this chapter, we have outlined the roles of various extracellular molecules secreted by P. aeruginosa and specifically focused on the role of pyocyanin in inducing eDNA production, binding to eDNA via intercalation and facilitating biofilm promoting factors, whilst inducing oxidative stress to host cells via production of reactive oxygen species. (intechopen.com)
9,10 The pathogenesis of K. pneumoniae is because of the production of different virulence factors such as capsular polysaccharide, siderophore production, biofilm formation, hypermucoviscosity, haemagglutination, haemolysis and production of extracellular enzymes. (microbiologyjournal.org)
Cefiderocol functions as a siderophore and binds to extracellular free ferric iron. (medscape.com)

The mutant was found to be impaired for growth in macrophage-like THP-1 cells, suggesting that siderophore production is required for virulence of M. tuberculosis. (nih.gov)
Aerobactin mediates virulence and accounts for increased siderophore production under iron-limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae. (sigmaaldrich.com)
Mutations of the mexEF efflux pump system increased swarming, rhamnolipid production, and lethality in a mouse infection model, while mutations in mexR that increased expression of the mexAB-oprM efflux system increased virulence during an acute murine lung infection without affecting swarming or rhamnolipid gene expression. (stanford.edu)
13 Antimicrobial resistance is mainly because of the production of enzyme, virulence factors, efflux pumps and mutation. (microbiologyjournal.org)

In response to iron limitation in their environment, genes involved in microbe siderophore production and uptake are derepressed, leading to manufacture of siderophores and the appropriate uptake proteins. (wikipedia.org)
Rhizospheric microbes influence the plant physiology by imparting several beneficial effects, namely, Nitrogen fixation, increased nutrient uptake, and secondary metabolites production on their host plants. (hindawi.com)
Rhizospheric microbes play significant role/s in improving the growth and yield of host plant [ 9 ] by imparting several beneficial effects, namely, N 2 fixation, increased nutrient uptake, siderophores, and secondary metabolite/s production [ 8 , 10 ]. (hindawi.com)
In addition to passive diffusion via porin channels, cefiderocol is actively transported across the outer cell membrane of bacteria into the periplasmic space using a siderophore iron uptake mechanism. (medscape.com)

Siderophores (Greek: "iron carrier") are small, high-affinity iron-chelating compounds that are secreted by microorganisms such as bacteria and fungi. (wikipedia.org)
Examples of siderophores produced by various bacteria and fungi: Hydroxamate siderophores Catecholate siderophores Mixed ligands Amino carboxylate ligands A comprehensive list of siderophore structures (over 250) is presented in Appendix 1 in reference. (wikipedia.org)
Researchers have discovered that natural compounds released from bacteria and fungi in soil, known as siderophores, can decrease the toxicity of asbestos fibers. (nih.gov)
Plants, This research was part of an SRP Center project led by Willenbring bacteria, and fungi release siderophores to bind to iron in soil, while at Penn. (nih.gov)

Production of siderophores by 9 different soil fungi and wood-decay fungi was studied following CAS - assay and CAS - agar plate assay. (akjournals.com)
All the test fungi could produce siderophores, though the degree of production recorded to be very low both in Botryodiplodia theobromae and in Fusarium spp. (akjournals.com)

The researchers measured the release of iron from asbestos fibers in the presence of natural soil concentration levels of a fungal and a bacterial siderophore and specific organic acids, which are also released by organisms to bind to iron. (nih.gov)
They found that both fungal and bacterial siderophores removed iron from asbestos fibers. (nih.gov)
They also discovered that the fungal siderophores were more effective than the bacterial siderophores in reducing ROS. (nih.gov)
Through the determination of 429 bacterial strains, it was found that 97 isolates had phosphate solubilizing ability, 63 isolates could release potassium from potash feldspar, 123 isolates could produce IAA, 58 isolates could synthesize ACC deaminase, and 21 isolates could secret siderophore. (biomedcentral.com)
Background Bacterial siderophores are chelating compounds with the potential of application in agriculture, due to their plant growth-promoting (PGP) properties, however, high production and purification costs are limiting factors for their wider application. (researchgate.net)

and the strain has been deposited at two culture collection centers (=MCCC 1K00252 T = DSM 42140 T ). Thus, the strain MUSC 149 T was selected for genome sequencing as an attempt to identify biosynthetic gene clusters associated with secondary metabolite production. (scielo.br)

In this study, we observed the auxin production, siderophore synthesis, and phosphate solubilization abilities of B. seminalis strain 869T2. (escholarship.org)

Siderophores are usually classified by the ligands used to chelate the ferric iron. (wikipedia.org)

Ahmad C, Natascha P, Wei C, Hao Z (2008) Antimicrobial proteinaceous compounds obtained from bifidobacteria: from production to their application. (springer.com)
Collado MC, Hernández M, Sanz Y (2005) Production of bacteriocin-like compounds by human fecal Bifidobacterium strains. (springer.com)
The presence of these biosynthetic gene clusters in MUSC 149 T suggests the potential exploitation of the strain for production of medically important compounds. (scielo.br)
Biosynthetic gene clusters in charge of the production of these molecules will be reverse engineered to expand the chemical diversity and improve the industrial sustainable exploitation of such biobased compounds. (europa.eu)
SECRETed will develop novel hybrid molecules with tailor-made properties obtained from the combination of biosynthetic genes of amphiphilic compounds (biosurfactants and siderophores) produced by marine and extremophilic microorganisms. (europa.eu)
To expand the chemical diversity and enhance the industrial sustainable exploitation of such bio-based compounds, Biosynthetic gene clusters (BGCs) in charge of the production of these molecules will be reverse engineered by standardizing and modularizing the genetic elements comprising such clusters. (europa.eu)

Production of siderophores by Serratia marcescens and the role of MacAB efflux pump in siderophores secretion" Khilyas I.V. , Shirshikova T.V. , Matrosova L.E., Sorokina A.V., Sharipova M.R. , Bogomolnaya L.M. (2016) BioNano Science. (kpfu.ru)

For example, the anthrax pathogen Bacillus anthracis releases two siderophores, bacillibactin and petrobactin, to scavenge ferric ion from iron containing proteins. (wikipedia.org)
Siderophores of Marinobacter aquaeolei: petrobactin and its sulfonated derivatives. (ucsb.edu)
Petrobactin sulfonate, a new siderophore produced by the marine bacterium Marinobacter hydrocarbonoclasticus. (ucsb.edu)

The most effective siderophores are those that have three bidentate ligands per molecule, forming a hexadentate complex and causing a smaller entropic change than that caused by chelating a single ferric ion with separate ligands. (wikipedia.org)
Microbes usually release the iron from the siderophore by reduction to Fe2+ which has little affinity to these ligands. (wikipedia.org)
The impact of isotope exchange on MeHg production in the presence of organic ligands was evaluated with an iron-reducing bacterium, Geobacter sulfurreducens PCA. (ornl.gov)

Optimization for the production of siderophores was done by varying the levels of pH and Fe (III) concentrations in the low nutrient medium. (akjournals.com)
PGPRs increase the availability of nutrients through the solubilization of unavailable forms of nutrients and by the production of siderophores which aids in the facilitating of nutrient transport. (wikipedia.org)
Rice production in Ghana has become unsustainable due to the extremely nutrient-poor soils. (mdpi.com)

Besides siderophores, some pathogenic bacteria produce hemophores (heme binding scavenging proteins) or have receptors that bind directly to iron/heme proteins. (wikipedia.org)

All these strains were positive for biochemical tests such as ammonia production, catalase test, oxidase test, nitrate reduction test, and urease test. (journalcra.com)
Indole acetic acid and EPS production was common for all the strains with IAA production in range from 8.5-70µg/ml, and EPS production from 379-892 mg/ml. (journalcra.com)

Many siderophores are nonribosomal peptides, although several are biosynthesised independently. (wikipedia.org)

These studies are mostly focused on understanding a complex, yet finite set of geochemical and biomolecular processes controlling behavior, transformations, and net MeHg production in the environment. (ornl.gov)

Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates. (stjohns.edu)

The wide variety of siderophores may be due to evolutionary pressures placed on microbes to produce structurally different siderophores which cannot be transported by other microbes' specific active transport systems, or in the case of pathogens deactivated by the host organism. (wikipedia.org)

Mycobacterium tuberculosis is an important pathogen of mammals that relies on 2-hydroxyphenyloxazoline-containing siderophore molecules called mycobactins for the acquisition of iron in the restrictive environment of the mammalian macrophage. (nih.gov)

On the ambiguity of NRPS structure predictions: Four bidentate chelating groups in the siderophore pacifibactin. (ucsb.edu)

Microbes release siderophores to scavenge iron from these mineral phases by formation of soluble Fe3+ complexes that can be taken up by active transport mechanisms. (wikipedia.org)
Siderophores are also important for some pathogenic bacteria for their acquisition of iron. (wikipedia.org)
Because of this property, they have attracted interest from medical science in metal chelation therapy, with the siderophore desferrioxamine B gaining widespread use in treatments for iron poisoning and thalassemia. (wikipedia.org)
In bacteria, Fe2+-dependent repressors bind to DNA upstream to genes involved in siderophore production at high intracellular iron concentrations. (wikipedia.org)
However, the stress condition of iron might be a decisive factor for siderophore production. (akjournals.com)
Previous studies have shown that the presence of iron, which is often on the outer layer of asbestos, can increase this ROS production. (nih.gov)
Based on this connection between iron and asbestos toxicity, researchers explored whether natural soil concentrations of siderophores, which have an affinity to bind to iron, can remove iron from asbestos and thus lower its toxicity. (nih.gov)
They treated solutions containing asbestos with siderophores or organic acids, extracted samples from those solutions at regular intervals for up to 16 days, and measured the total dissolved iron. (nih.gov)
Removal of iron by siderophores could potentially form the basis of a low-cost bioremediation strategy, which should be explored as a viable approach for managing asbestos-contaminated sites. (nih.gov)
But they also found that the honey interfered with the bacteria's ability to capture iron - which use siderophores in their process of infection and growth. (healthimpactnews.com)
The role of reduced iron powder in the fermentative production of tetanus toxin. (sigmaaldrich.com)
Iron(III) coordination chemistry of alterobactin A: a siderophore from the marine bacterium Alteromonas luteoviolacea. (ucsb.edu)

Although a widening range of siderophore functions is now being appreciated, siderophores are among the strongest (highest affinity) Fe3+ binding agents known. (wikipedia.org)

Plant-growth-promoting (PGP) activities include the production of phytohormones, siderophores and 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase as well as the solubilization of inorganic phosphate. (eurekaselect.com)

Albinism (also called achromia, achromasia, or achromatosis) is a congenital disorder characterized by the complete or partial absence of pigment in the skin, hair and eyes due to absence or defect in any one of a number of proteins involved in the production of melanin. (nih.gov)

The genome B. kashiwanohense PV20-2 harbors a unique region encoding genes putatively involved in siderophore production. (biomedcentral.com)
Through bioinformatics analysis, 21 gene clusters identified in the genome were associated with the production of bioactive secondary metabolites. (scielo.br)

On the other hand, all the species of Trichoderma showed their excellency in siderophore production. (akjournals.com)
Rhizobial species vary in their enzymatic production and several enzymes are found to be necessary for the symbiotic effectiveness. (eurekaselect.com)
In conclusion, the plant endophytic bacterium Burkholderia seminalis 869T2 exerted positive effects on growth and production in several plant species. (escholarship.org)
Previous studies provide evidence for the production of reactive oxygen species by alveolar macrophages, after overloading with UF-TiO2 particles and cytotoxicity of UF-TiO2 in rat lung alveolar macrophages. (nih.gov)

Metabolic compensation constrains the temperature dependence of gross primary production. (exeter.ac.uk)

According to the authors, this study indicates that siderophores in the soil environment can decrease asbestos fiber toxicity and possibly lower health risks. (nih.gov)

They quantified ROS generated by macrophages from mice exposed to asbestos fibers with and without siderophore treatment and observed a decrease in the amount of ROS generated, and thus the toxicity of asbestos, when fibers were treated with siderophores. (nih.gov)

glucosidase production by the yeast Debaryomyces pseudopolymorphus UCLM-NS7A: Optimization using response surface methodology. (uel.br)

For several years, the main focus of research has been the production and characterization of enzymes. (kpfu.ru)

Using a macrophage infection model combined with genomic and transcriptomic analyses, we show that a compensatory mutation in the rne gene, encoding RNase E, increased pyoverdine and pyochelin siderophore gene expression, causing macrophage ferroptosis and lysis. (stanford.edu)
Tissue-resident immunity underlies essential host defenses against pathogens, but analysis in humans has lacked in vitro model systems where epithelial infection and accompanying resident immune cell responses can be observed en bloc. (bvsalud.org)

Together these data show how P. aeruginosa RNase E variants can cause host damage via increased siderophore production and host cell ferroptosis but may also be targets for gallium precision therapy. (stanford.edu)

Furthermore, inoculations of strain 869T2 into hot pepper caused increased flower and fruit production, and a higher percentage of fruits turned red. (escholarship.org)

Phytosiderophores are siderophores produced by plants. (wikipedia.org)

The optimum pH for production of siderophores remained at neutral pH level though the range varied from pH 6.0-8.0. (akjournals.com)
The optimum range of the concentration of Fe (III) required for siderophore production was recorded to be 1.5-21.0 µM. (akjournals.com)

Siderophores usually form a stable, hexadentate, octahedral complex preferentially with Fe3+ compared to other naturally occurring abundant metal ions, although if there are fewer than six donor atoms water can also coordinate. (wikipedia.org)

The major groups of siderophores include the catecholates (phenolates), hydroxamates and carboxylates (e.g. derivatives of citric acid). (wikipedia.org)

B9 produced 2.87 mg·L -1 less indoleacetic acid under 0.1 mg·L -1 Cd stress, whereas the siderophore production decreased by 17.34%, accordingly. (aes.org.cn)

Reaction of a model siderophore with Ni(II), Co(II) and Zn(II) in aqueous solution:kinetics and spectroscopy. (uel.br)

Siderophores are then recognized by cell specific receptors on the outer membrane of the cell. (wikipedia.org)

Functional analysis revealed BGCs related to ectoine production in all genomes analysed. (jgenomics.com)

Organisms9

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes7

Technology, Industry, Agriculture1

Information Science1

Biosynthesis4

Extracellular5

Virulence4

Uptake4

Bacteria and fungi4

Fungi2

Bacterial5

Secondary metabolite1

Auxin1

Ferric iron1

Compounds6

Efflux1

Petrobactin3

Ligands3

Nutrient3

Heme1

Strains2

Peptides1

Biomolecular1

Synthesis1

Organism1

Pathogen1

Bidentate1

Iron12

Affinity1

Solubilization1

Proteins1

Genome2

Species4

Metabolic1

Soil1

Mice1

Optimization1

Enzymes1

Infection2

Host1

Strain1

Plants1

Range2

Form1

Groups1

Stress1

Model1

Specific1

Analysis1