Production putative gene. Medical search. Frequent questions

No virulence factors were detected for any strain and only the non-transferable erm(49) gene, which confers resistance to erythromycin and clindamycin, was identified in the genome of B. longum KABP042. (frontiersin.org)
Pathogens' inhibition was mostly mediated by the production of organic acids, but neutralization experiments strongly suggested the presence of additional antimicrobial compounds in probiotic culture supernatants such as the bacteriocin Lantibiotic B, whose gene was detected in the genome of B. longum KABP042. (frontiersin.org)
These rapid adaptations in fungi provide excellent models for studying general processes of eukaryotic genome evolution, including the functional and ecological impact of horizontal gene transfer 1 and changes in metabolism 2 . (nature.com)
The genes of human chromosome 21 identified by the genome efforts were investigated, and the success rates for de novo cloning, protein production, and antibody generation were 85, 76, and 56%, respectively. (nih.gov)
Until recently, however, functional analysis of the DED fungi was hampered by the lack of protocols for efficient gene knockout and by the unavailability of a full genome sequence. (sisef.it)
In the second session of the project, a gene encoding for an esterase was amplified by PCR from a bacterial sequenced genome belonging to Thalassospira sp. (unina.it)
Findings: We report the chromosome-scale genome assembly of Callicarpa americana L. (American beautyberry), a species within the early diverging Callicarpoideae clade of the Lamiaceae, known for its metallic purple fruits and use as an insect repellent due to its production of terpenoids. (datadryad.org)
Whole genome duplication analyses revealed three putative events, which together with local tandem duplication events, contributed to gene family expa, American beautyberransion of terpene synthases. (datadryad.org)
Conclusions: Access to the C. americana genome provides a roadmap for rapid discovery of genes encoding plant-derived agrichemicals and a key resource to understand the evolution of chemical diversity in Lamiaceae. (datadryad.org)
TSLP and IL1RL1 are two of the most consistently associated genes in genome-wide association studies of asthma. (ubc.ca)
The effect of Buchnera genome evolution on gene expression levels has also been analysed in order to assess the constraints imposed by the obligate symbiosis with aphids, underlining the importance of some gene sets for the survival of the two partners. (biomedcentral.com)
Utilising the published H. lupulus genome, 87 putative full-length and partial terpene synthase genes were identified. (biomedcentral.com)
Identification of putative novel class-I lanthipeptides in firmicutes: A combinatorial in silico analysis approach performed on genome sequenced bacteria and a close inspection of Z-geobacillin lanthipeptide biosynthesis gene cluster of the Thermophilic geobacillus sp. (lu.se)

Here we show that TaHRC , a gene that encodes a putative histidine-rich calcium-binding protein, is the key determinant of Fhb1 -mediated resistance to FHB. (nature.com)
We demonstrate that TaHRC encodes a nuclear protein conferring FHB susceptibility and that a deletion spanning the start codon of this gene results in FHB resistance. (nature.com)
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. (cancerindex.org)
The NMB0736 gene of Neisseria meningitidis serogroup B strain MC58 encodes the putative nitrogen regulatory protein, IIANtr (abbreviated to NM-IIANtr). (rcsb.org)
The phylogenetically ancient SLC26 gene family encodes multifunctional anion exchangers and anion channels transporting a wide selection of substrates, including Cl? (exposed-skin-care.net)

A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
Wholegenome sequencing of deficient isolates revealed putative, underlying genetic changes. (nabsys.com)
Genetic and molecular analyses have led to the identification, cloning and characterization of a few genes that contribute to parasitic fitness in the pathogens. (sisef.it)
The identification of genes that were differentially expressed in the shell-forming mantle tissue and the comparison of the genotypes with the phenotypes under consideration of the inheritance of the characters is an appropriate approach to identify candidate genes that may be involved in the genetic mechanism resulting in the observed phenotypes. (peerj.com)
Genetic modification of the pathways through which the fungi recognizes extracellular signals could bring advancements to industrial enzyme production. (helsinki.fi)
Because of T. reesei s potential and use as a production strain, the species is an interesting platform for genetic modifications that would enhance the production capacities. (helsinki.fi)
Polymerase-chain-reaction- (PCR-) based assay did not detect the presence of rhamnosyltransferase C gene (rhlC) in P. chlororaphis, confirming the genetic basis for monorhamnose-lipid (R1L) synthesis in this organism. (usda.gov)
The present findings suggest that local IFN production may interact with a genetic factor ( PTPN2 ) to induce aberrant proapoptotic activity of the BH3-only protein Bim, resulting in increased β-cell apoptosis via JNK activation and the intrinsic apoptotic pathway. (diabetesjournals.org)
Susceptibility to T1D is linked to genetic factors, but T1D-predisposing genes have low penetrance and only a small proportion of individuals genetically at risk will develop the disease. (diabetesjournals.org)
In E . coli , the biosynthetic pathway for the production of glycine betaine from choline has been well characterized at the genetic level ( Landfald and Strom, 1986 ). (scialert.net)
At this moment we know little about both probability and consequences in relation to putative health and environmental effects of many genetic engineering applications. (biosafety-info.net)
Horizontal gene transfer: Horizontal gene transfer signifies a non-sexual transmission of genetic information within or between species. (biosafety-info.net)
With the advent of new global methods for genetic analysis such as large-scale sequencing, gene expression profiling, combined with classical linkage analysis, congenic and physical and in silico fine mapping, progress is considerably accelerating. (biomedcentral.com)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
Genetically inherited forms arise from defects of parathyroid gland development, defects in the parathyroid hormone (PTH) gene, defects in the calcium-sensing receptor gene, defects in PTH action, defects in the autoimmune regulator gene, and genetic syndromes. (medscape.com)
Recognition of a single-gene disorder as causal for a patient's 'multiple sclerosis-like' phenotype is critically important for accurate direction of patient management, and evokes broader genetic counselling implications for affected families. (medscape.com)

A putative operon contains crdS (Q9X2V0, family GT2, Pfam PF13632), encoding β-(1,3)-glucan synthase catalytic subunit, flanked by two additional genes. (wikipedia.org)
To identify genes in EPS production beyond the EPS biosynthetic gene operon, we selected the EPS-defective mutants of R. pseudosolanacearum strain SL341 from Tn5-inserted mutant pool. (ppjonline.org)
In S. lividans the GlxA gene is part of the cslA/glxA operon that contains genes encoding putative enzymes involved in glycan processing. (bl.uk)
Chapter 4 addresses another surprising finding in that a putative haem peroxidase (DtpA), part of the sco operon, plays a role in GlxA maturation and in the Cu-dependent morphological development. (bl.uk)
Our analysis showed that mRNA abundances, gene organization (operon) and gene essentiality are correlated in Buchnera (i.e., the most expressed genes are essential genes organized in operons) whereas no link between mRNA abundances and gene strand bias was found. (biomedcentral.com)
It has also been shown that neighbouring genes in a bacterial chromosome tend to be co-expressed, even if they are not in the same operon [ 10 ], suggesting the existence of a "supra-operonic" organization [ 11 ]. (biomedcentral.com)
Certainly, STAS domain-encoding SulP genes have already been found as the different parts of antibiotic operons, like the BLM bleomycin biosynthesis operon of (Du et al. (exposed-skin-care.net)

A separate locus contains a putative regulatory gene, crdR. (wikipedia.org)
[ 8 ] The hGR gene is one locus on the long arm of chromosome 5 (q31.3) and consists of 9 exons. (medscape.com)
We have now cloned, sequenced, and analyzed in silico the gene locus of NRRL B-30761 containing the putative coding sequences of rhamnosyltransferase chain A (rhlAPch, 894 bps), rhamnosyltransferase chain B (rhlBPch, 1272 bps) and N-acyl-homoserine lactone-dependent transcriptional regulatory protein (rhlRPch, 726 bps). (usda.gov)
However, progress in identifying the new susceptibility genes outside the MHC locus has been slow. (biomedcentral.com)
So far we have confirmed C5 as a putative susceptibility gene for the Cia2 locus on chromosome 2. (biomedcentral.com)

Only four isolates harbored mutations to known genes involved in Fha production, highlighting the complexity of its regulation. (nabsys.com)
Gene organization in the bacterial chromosome has very well known effects on transcription and a standard example is the organization of genes into operons, which allows for a sophisticated regulation of gene expression [ 9 ]. (biomedcentral.com)
highly transcribed non-coding RNAs associated with transcriptional regulation, showing potential evidence of putative metabolic flexibility in response to substrate availability. (biomedcentral.com)
In their study, northern blotting analysis showed that two 22-nucleotide miRNAs - tae-miR021b and tae-miR2003a - preferentially accumulated in the embryo rather than the endosperm, suggesting important roles for miRNA-mediated gene regulation in wheat grain. (genomeweb.com)
Mitochondria are involved in a wide variety of cellular activities, including energy production, chemical signaling, and regulation of cell growth and division. (medlineplus.gov)

NCOR2, also known as SMRT, is a transcriptional corepressor that maintains the transcriptional silencing of certain target genes. (senescence.info)
The DNA-binding domain (DBD) of the hGRα corresponds to amino acids 420-480 and contains 2 zinc finger motifs through which the hGRα binds to specific DNA sequences, the glucocorticoid-response elements (GREs) in the promoter region(s) of target genes. (medscape.com)
RIViT-seq technology could speed up associating transcription factors with their target genes. (doe.gov)
For highly conserved miRNAs, 122 target genes were identified, including 92 targets that are conserved among other species and 30 non-homologous target genes. (genomeweb.com)

These results indicate that the NDP-sugar epimerase gene is required for EPS production and bacterial virulence in R. pseudosolanacearum . (ppjonline.org)
In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
Transfers of a single gene, a complete metabolic pathway 10 , whole chromosomes 11 or even cases of the integration of almost complete genomes from bacterial endosymbionts into their eukaryotic hosts 12 have been described. (nature.com)
Microarray and qPCR gene expression analysis implicated rs1078761 G as being associated with reduced BPIFA1 and BPIFB1 gene expression, suggesting that decreased levels of these genes are detrimental in CF.Functional assays to characterize the role of BPIFA1 and BPIFB1 in CF indicated that these molecules do not have an anti-bacterial role against P. aeruginosa, but do have an immunomodulatory function in CF airway epithelial cells. (ubc.ca)
To further investigate the mechanism of action of BPIFA1 and BPIFB1 during bacterial infection, gene expression was profiled using RNA-Seq in airway epithelial cells stimulated with P. aeruginosa and treated with recombinant BPIFA1 and BPIFB1.Viral infections are now recognized to play an important role in the short and long term health of CF patients. (ubc.ca)
Past genomic studies have comprehensively described the organization of the bacterial chromosome, for example in terms of gene localization, order and orientation. (biomedcentral.com)
Indeed, bacterial genomes carry, on average, from 78% (for genomes containing the polymerase PolC) to 58% (for the other genomes) of their genes on the leading strand [ 3 ]. (biomedcentral.com)
b) Bacterial iron consumption in the upper 120m of the ocean and (c) Changes (anomalies) in export carbon production when bacteria have a high requirement for iron. (us-ocb.org)

The impact is enhanced if coupled with the presence of functional genes for antibiotic resistance. (frontiersin.org)
A fosmid containing an ORF encoding a gene with potential esterase/lipase activity was detected by functional screening on tributyrin agar plates. (unina.it)
Treatment of RAW 264.7 with delta 9-THC inhibited forskolin-stimulated cAMP production in a dose-related manner, verifying the expression of functional cannabinoid receptors by this cell line. (aspetjournals.org)
More knowledge is required on the functional and allelic diversity of terpene synthase (TPS) genes responsible for the biosynthesis of volatile terpenes to assist in flavour-directed hop breeding. (biomedcentral.com)
Functional analysis of candidate genes for those loci is underway. (biomedcentral.com)

Streptomyces bacteria produce numerous specialized metabolites with industrial and medicinal applications, and they contain many associated biosynthetic gene clusters (BGCs). (mdpi.com)

The identification of genes involved in replication, segregation, toxin-antitoxin systems and conjugation, would aid the design of drugs to prevent the survival or transmission of plasmids carrying pathogenic properties. (frontiersin.org)

The ongoing annotation of these genomes should spark a new wave of interest in the DED pathosystem, as it should lead to the formal identification of genes modulating parasitic fitness. (sisef.it)
Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)
The isolates initially characterized as staphylococci were tested for coagulase production (in tubes) and with Slidex Staph Plus test (bioMérieux, Marcy l'Etoile, France) to confirm their identification as S. aureus . (cdc.gov)

Shifting its repressive activity towards PPARs, by selectively disabling one of its two major receptor-interacting domains, resulted in premature ageing in mice and related metabolic diseases accompanied by reduced mitochondrial function and antioxidant gene expression. (senescence.info)
We also identified the mitochondrial ATP8 as a novel susceptibility gene. (biomedcentral.com)
Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A). Hum Mol Genet. (medlineplus.gov)

The approach is based on affinity reagents raised toward bioinformatics-designed protein epitope signature tags corresponding to unique regions of individual gene loci. (nih.gov)

Quantitative PCR and high-throughput methods, such as expressed sequence tag analysis, have been used for measuring gene expression and identifying subsets of elm genes that are differentially expressed in the presence of O. novo-ulmi . (sisef.it)
These analyses have also helped identify genes that were differentially expressed in DED fungi grown under defined experimental conditions. (sisef.it)
In addition, reviewer#3 concern on confidence for genes reported as differentially expressed should be addressed as suggested. (peerj.com)

A membrane-bound phosphatidylserine synthase, encoded by pssAG, is also necessary for maximal production of curdlan of high molecular mass. (wikipedia.org)
A set of 34 genes clustered around the rifK gene encoding AHBA synthase were defined by sequencing all but 5 kilobases (kb) of a 95 kb contiguous region of DNA from A. mediterranei. (nih.gov)
In higher plants, the isomeric C5 isopentenyl pyrophosphate (IPP) is synthesized in 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, and is used as the precursor of geranylgeranyl diphosphate (GGPP) by GGPP synthase gene, GGPPS. (researchsquare.com)
Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation. (aspetjournals.org)
In the current study, we show that delta 9-THC produces a marked inhibition of inducible nitric oxide synthase (iNOS) transcription and nitric oxide production by the macrophage line RAW 264.7 in response to lipopolysaccharide (LPS). (aspetjournals.org)
HlRLS alleles produced ( R )-(-)-linalool, whilst alleles of two sesquiterpene synthase genes, HlAFS1 and HlAFS2 produced α-farnesene. (biomedcentral.com)

Output from the circadian clock is transduced through regulating transcription of downstream genes directly by the oscillator components. (go.jp)
The expression of HIF-1 downstream genes, cancer colony formation, and Matrigel invasion of glioblastoma cells were stimulated by conditioned medium from astrocytes pre-exposed to hypoxia. (cancerindex.org)
This is the first indication of a direct interaction between a candidate gene for T1D and the activation of a specific downstream proapoptotic pathway in β-cells. (diabetesjournals.org)

Well-known susceptibility genes include HLA-DR , CTLA-4 , IFIH1 ( MDA5 ), and PTPN22 ( 2 ). (diabetesjournals.org)
This paper proposes the outline of a comprehensive prospective approach to understand the susceptibility of an ecosystem to unintended and irreversible harm from gene drives. (biosafety-info.net)
Here we present preliminary data using an integrative genomics strategy to identify new putative susceptibility genes contributing to the pathogenesis of CIA. (biomedcentral.com)
The strains were tested for antimicrobial drug susceptibility, production of β-lactamases, and presence of mec A by PCR ( 5 ). (cdc.gov)

These may have impacts on the extent of horizontal gene transfer, and on how modified genes are expressed and affect the recipient organisms. (biosafety-info.net)

Both these gene clusters are highly conserved in streptomycetes. (bl.uk)

Moreover, transcriptomic analyses have demonstrated that, in free-living bacteria, gene transcription levels and chromosomal organization are mutually influenced. (biomedcentral.com)
We define putative regulators of commitment and probabilistic rules of transition through machine learning methods, and employ clustering and correlation analyses to interrogate gene regulatory interactions in multipotent cells. (lu.se)
Differential expression analyses of the algivorous flagellate Orciraptor agilis (Viridiraptoridae, Cercozoa, Rhizaria) suggested the involvement of a highly expressed putative glycoside hydrolase of family GH5_5. (megazyme.com)

Additionally, we found a shared region amongst some of the plasmids that consists of conjugation genes. (frontiersin.org)
Additionally, genes conferring virulence and antibiotic resistance were identified amongst the plasmids. (frontiersin.org)
Additionally, gene expression profiling in target tissues and immune cells in parental strains and their F2 progeny is performed. (biomedcentral.com)

Although its basic precursors (3-amino-5-hydroxy benzoic acid AHBA, and acetic and propionic acids) had been established, and several biosynthetic intermediates had been identified, very little was known about the origin of AHBA nor had the PKS and the various genes and enzymes that modify the initial intermediate been characterized. (nih.gov)
Disruption of the PKS genes at the end of rifA abolished rifamycin B production and resulted in the formation of P8/1-OG, a known shunt product of rifamycin biosynthesis, whereas disruption of the orf6 and orf9 genes, which may encode deoxysugar biosynthesis enzymes, had no apparent effect. (nih.gov)
Although the genes that encode carotenogenesis and flavonoids enzymes are well characterized, the transcriptional regulatory mechanisms that are related to the pathway genes remain to be investigated. (researchsquare.com)
As part of the cslA-glxA gene cluster are two genes encoding for putative polysaccharide degrading enzymes. (bl.uk)
The available carbon sources, most commonly different types of sugars, have a significant effect on the production and secretion of enzymes by T. reesei. (helsinki.fi)

The deletion of this transporter caused a decrease in cellulase production and/or secretion. (helsinki.fi)
2010). NMR answer structures have already been resolved for the STAS BIIE 0246 supplier domain name of putative sulfate transporter Rv1739c from (Sharma et al. (exposed-skin-care.net)
The ABCB7 gene provides instructions for making a protein known as an ATP-binding cassette (ABC) transporter. (medlineplus.gov)
Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. (medlineplus.gov)

Among several EPS-defective mutants, we identified a mutant, SL341P4, with a Tn5-insertion in a gene encoding a putative NDP-sugar epimerase, a putative membrane protein with sugar-modifying moiety, in a reverse orientation to EPS biosynthesis gene cluster. (ppjonline.org)
Therefore, we overexpressed the ribosome-recycling factor, ribosomal protein S12, and three S12 variants in Streptomyces clavuligerus to enhance the production of such metabolites. (mdpi.com)
At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
Using human tissue arrays, a systematic profiling of protein expression and subcellular localization was undertaken for the putative gene products. (nih.gov)
Plasmid stabilization/stability protein-encoding genes were observed in some plasmids but were not established for participating in plasmid segregation. (frontiersin.org)
After cloning and gene heterologous expression in E. coli, the recombinant protein was obtained as high level in soluble form and then purified to homogeneity. (unina.it)
Gene cloning and expression were followed by a production of the recombinant protein in a soluble form. (unina.it)
T. reesei is used for both endogenous and heterogenous protein production. (helsinki.fi)
Alternatively spliced transcript variants that encode the same protein have been described for this gene. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
In the mitochondria of developing red blood cells (erythroblasts), the ABCB7 protein plays a critical role in the production of heme. (medlineplus.gov)
Production and secretion of PTH are regulated by a G protein-coupled calcium-sensing receptor. (medscape.com)
Unlike other protein hormones, its production and secretion are stimulated by decreased intracellular calcium concentrations, which reflect serum calcium concentrations. (medscape.com)

A total of 32,164 genes was annotated including 53 candidate terpene synthases and 47 putative clusters of specialized metabolite biosynthetic pathways. (datadryad.org)

At least five genes were shown to be essential for the synthesis of AHBA, five genes were determined to encode the modular type I PKS that uses AHBA as the starter unit, and 20 or more genes appear to govern modification of the polyketide-derived framework, and rifamycin resistance and export. (nih.gov)

Genomic studies on bacteria have clearly shown the existence of chromosomal organization as regards, for example, to gene localization, order and orientation. (biomedcentral.com)
This is a perfect illustration of the mutual influence between gene expression levels and chromosomal organization in bacteria. (biomedcentral.com)

At least three mutations in the ABCB7 gene have been identified in people with X-linked sideroblastic anemia with ataxia. (medlineplus.gov)

In four contrasting cultivars (Wakatu™, Wai-iti™, Nelson Sauvin™, and 'Nugget'), terpene production during cone development was investigated in detail, with concentrations of some of the major terpenes increasing up to 1000-fold during development and reaching maximal levels from 50-60 days after flowering. (biomedcentral.com)

NCOR2 expression and its occupancy on peroxisome proliferator-activated receptor (PPAR) target gene promoters are increased with age in major metabolic tissues. (senescence.info)

The betA gene sequence reported in this study contains several base substitutions with that of reported sequences in GenBank, resulting in the altered amino acid sequences of the translated proteins. (scialert.net)

Rifamycin production in A. mediterranei is governed by a single gene cluster consisting of structural, resistance and export, and regulatory genes. (nih.gov)

Researchers claim a common SNP in the putative promoter of the MUC5B gene appears to be strongly associated with the development of both familial interstitial pneumonia (FIP) and idiopathic pulmonary fibrosis (IPF). (genengnews.com)
The studies, combined with mucin gene resequencing, homed in on a SNP in the putative promoter of MUC5B , 3 kb upstream of the transcription start site. (genengnews.com)
We genetically constructed a dirhamnose-lipid (R2L) synthesizing P. chlororaphis by cloning and expressing a rhamnosyltransferase C (rhlC) gene of P. aeruginosa using an expression vector (pBS29-P2-gfp) containing a P. syringae promoter. (usda.gov)
Against this background, we develop a Monte Carlo time-series stochastic model of transcription where the parameters governing promoter status, mRNA production and mRNA decay in multipotent cells are fitted to experimental static gene expression distributions. (lu.se)
The model suggests distinct dependencies of different commitment-associated genes on mRNA dynamics and promoter activity, which globally influence the probability of lineage commitment. (lu.se)

Indeed, manifestation of SulP genes Rv1739c and Rv1707 was upregulated in triggered macrophages 24 hrs post-infection, therefore may are likely involved in mycobacterial success, latency, or pathogenesis in hypoxic BIIE 0246 supplier or additional stress circumstances. (exposed-skin-care.net)

Alternative splicing of the hGR gene in exon 9 generates 2 highly homologous receptor isoforms, termed α and β. (medscape.com)

Projects focused on gene expression profiling of ageing and of dietary manipulations of ageing, such as caloric restriction. (senescence.info)
While the selective inactivation of Ophiostoma genes by insertional mutagenesis remains a challenge, an alternative approach based on RNA interference is now available for down-regulating the expression of targeted genes. (sisef.it)
Moreover, expression of the gene among unaffected subjects carrying at least one copy of the variant allele was 37.4 times as high as it was among unaffected subjects who were homozygous for the wild-type allele. (genengnews.com)
To investigate whether CF patients have a dysregulated response to rhinovirus infection, primary airway epithelial cells from CF and healthy control children were infected with rhinovirus and gene expression profiles were assessed by RNA-Seq. (ubc.ca)
Although rhinovirus stimulation resulted significantly altered gene expression, the response to infection was not different in CF patients compared to healthy controls. (ubc.ca)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
We demonstrate that upon hitting a host cell, motile Pseudomonas aeruginosa induce a specific gene expression program. (elifesciences.org)
Collectively, this series of experiments indicates that NF-kappa B/Rel is positively regulated by the cAMP cascade to help initiate iNOS gene expression in response to LPS stimulation of macrophages. (aspetjournals.org)
Of considerable interest is also whether commitment involves a limited set of genes or the entire transcriptional program, and to what extent gene expression configures multiple trajectories into commitment. (lu.se)
We use a combined modeling approach guided by gene expression classifier methods that infers a time-series of stochastic commitment events from experimental growth characteristics and gene expression profiling of individual hematopoietic cells captured immediately before and after commitment. (lu.se)
Probability of commitment in time is a function of gene expression as defined by a logistic regression model obtained from experimental single-cell expression data. (lu.se)
Alleles corresponding to seven TPS genes were amplified from ripe cone cDNA from multiple cultivars and subsequently functionally characterised by transient expression in planta . (biomedcentral.com)
The roles of immunomodulatory elements such as microRNAs, which alter gene expression, and regulatory T cells (Tregs), which suppress T cell-mediated responses, in TDI sensitization are unknown. (cdc.gov)
Alterations in expression of putative miR-210 transcription factor targets were observed in the dLN during TDI sensitization. (cdc.gov)

Several single gene disorders share clinical and radiologic characteristics with multiple sclerosis and have the potential to be overlooked in the differential diagnostic evaluation of both adult and paediatric patients with multiple sclerosis. (medscape.com)
Here we review single gene disorders that have the potential to mimic multiple sclerosis, provide an overview of clinical and investigational characteristics of each disorder, and present guidelines for when clinicians should suspect an underlying heritable disorder that requires diagnostic confirmation in a patient with a definite or probable diagnosis of multiple sclerosis. (medscape.com)

Built YchM deletion exhibited artificial lethality with multiple fatty acidity biosynthesis genes, as well as the YchM polypeptide bodily interacted numerous proteins from the fatty acidity biosynthetic pathway. (exposed-skin-care.net)

The chromosomes of two Fhadeficient isolates included unexpected structural variation that did not appear to influence Fha production. (nabsys.com)
One of these isolates was resistant to methicillin by disk diffusion and E-test, and the presence of the mec A gene was confirmed by PCR. (cdc.gov)
All 28 MRSA strains (27 bovine and 1 human) produced PBP2a, according to latex agglutination test (Oxoid Ltd.). Eight of 27 randomly chosen bovine strains and the human strain containing the mec A gene, as well as 4 bovine and 2 human mec A-negative isolates, were phage typed with MRSA phages ( 6 ) at the Institute of National Public Health and Medical Officers Service in Hajdú-Bihar County. (cdc.gov)

Open up in another window Physique 2 Structural topology style of SLC26 polypeptides displaying the brief cytoplasmic N-terminal area accompanied by a transmembrane domain name with 12 putative membrane-spanning -helices, as well as the C-terminal cytoplasmic area, largely composed of the STAS domain name. (exposed-skin-care.net)

In this thesis, three putative and one already published genes believed to be involved in hexose sugar sensing will be deleted from a T. reesei production strain with the help of CRISPR/Cas9. (helsinki.fi)

This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)

This study also demonstrates a simultaneous deletion of two genes in T. reesei. (helsinki.fi)
No function offers however been reported for the IVS, and its own deletion was necessary for production from the 1st STAS domain name crystals diffracting to high res (Pasqualetto et al. (exposed-skin-care.net)

Depending on the genes it carries, it could act as a fitness factor to the host, or serve as a virulence factor by transforming the host into a pathogen. (frontiersin.org)

The sensitization response was intensified following Treg depletion, as evidenced by amplified total dLN cellularity, Th2 expansion, and IL-4 mRNA production. (cdc.gov)

We developed an electrochemiluminescent antibody capture assay to monitor the production of the acellular vaccine immunogen filamentous hemagglutinin (Fha). (nabsys.com)
We are also pursuing three additional QTLs on chromosomes 1, 5, 18 controlling leukocyte-endothelial cell adhesion, anticollagen antibody production and arthritis severity. (biomedcentral.com)

Plant cell cultures are widely used in the micro-propagation of clonal plants, especially virus-free plants, and in the production of useful metabolites such as paclitaxel. (go.jp)
Background: Plants exhibit wide chemical diversity due to production of specialized metabolites which function as pollinator attractants, defensive compounds, and signaling molecules. (datadryad.org)
In the case of Streptomyces a development switch occurs with the concomitant production of secondary metabolites, many of which have pharmaceutical properties. (bl.uk)

This extremely large set of miRNAs is likely associated with the polyploid nature of wheat, which is reasonably consistent with the higher gene numbers, ranging from 94,000 to 96,000, reported in bread wheat than its diploid progenitor and other species such as rice, maize, and Arabidopsis ," the scientists wrote in their paper. (genomeweb.com)

A third is that since the SNP occurs in the putative promotor for MUC5B, it could disrupt transcription binding sites and potentially cause ectopic production of MUC5B in cells or locations that cause injury to the bronchoalveolar unit. (genengnews.com)
Occupational exposure occurs during the production of propylene oxide and its derivatives and during production of hydroxypropyl starch ethers. (who.int)

The involvement of some of the genes in the biosynthesis of rifamycin B was examined. (nih.gov)
Replication genes were not identified in some plasmids, a situation that has led to the possibility of host interaction involvement. (frontiersin.org)

In this study, Cara cara navel orange fruit at four development stages were used to identify the key genes and TFs for carotenoids and flavonoids accumulation. (researchsquare.com)
Furthermore, 15/15 candidate TFs might regulate at least three key genes and contribute to carotenoids/flavonoids accumulation in CNO fruit. (researchsquare.com)
Collectively, our results suggest that DXS1 , DXR , GGPPS2 , PSY1 and LCYB genes were the most important genes for carotenoids accumulation, while PAL-1 , PAL-4 , 4CL-2 , 4CL-5 , CHS-1 and CHI for flavonoids biosynthesis. (researchsquare.com)

A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
Anonymous Reviewer ( 2017 ) Peer Review #2 of 'Candidate genes for shell colour polymorphism in Cepaea nemoralis (v0.2)' . (peerj.com)
However, the mechanisms by which most candidate genes predispose to T1D remain unclear. (diabetesjournals.org)
We presently evaluated the mechanisms by which PTPN2 , a candidate gene for T1D, modulates β-cell apoptosis after exposure to type I and II interferons (IFNs), cytokines that contribute to β-cell loss in early T1D. (diabetesjournals.org)
However, these genes only account for part of interindividual differences in disease predisposition or phenotypic diversity, and the pathophysiologic mechanisms by which most candidate genes predispose to T1D remain unclear. (diabetesjournals.org)

After incubation at 37°C for 24 h, the colonies were tentatively identified according to morphologic features, pigment production, Gram stain results, catalase test results, type of hemolysis, and characteristic growth on BP agar. (cdc.gov)

The putative mechanism for cannabinoid biological action involves binding to cannabinoid receptor types 1 and 2 (CB1 and CB2) to negatively regulate adenylate cyclase and inhibit intracellular signaling via the cAMP cascade. (aspetjournals.org)

It s possible that these genes are involved in the uptake and use of other carbon sources. (helsinki.fi)

TSLP and IL-33, the exclusive IL1RL1 ligand, are secreted by epithelial cells and other immune cells and play essential roles in Th2 polarization, activation and proliferation of immune cells and participate in many asthma cardinal features such as chronic inflammation, airway remodeling and mucus production. (ubc.ca)

Perhaps, the authors may state at the end of the manuscript which are the next steps to identify the genes involved in pattern formation that they would propose. (peerj.com)

In the study, a total of 524 potential targets were identified for 124 putative miRNA families through degradome sequencing. (genomeweb.com)

Anatomy1

Organisms6

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes42

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science7

Genome13

Encodes5

Genetic16

Operon7

Locus5

Regulation5

Target genes4

Bacterial8

Functional5

Biosynthetic gene1

Toxin-antitoxin systems1

Identification3

Mitochondrial3

Loci1

Differentially expressed3

Synthase6

Downstream3

Susceptibility4

Horizontal gene tra1

Highly conserved1

Analyses3

Additionally3

Enzymes5

Transporter4

Protein14

Clusters1

Encode1

Chromosomal2

Mutations1

Terpene1

Metabolic1

Sequences1

Cluster1

Promoter5

Pathogenesis1

Homologous1

Expression14

Single gene2

Proteins1

Isolates3

Transmembrane1

Strain1

Resistance1

Deletion2

Virulence1

MRNA production1

Antibody2

Metabolites3

MiRNAs1

Occurs2

Involvement2

Flavonoids3

Candidate5

Pigment production1

Mechanism1

Uptake1

Immune1

Identify1

Targets1