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  • therapeutic
  • In the future, these new methods could be used to develop manufacturing procedures for producing large quantities of stem cells for diagnostic and therapeutic applications. (kurzweilai.net)
  • Then, the iPSCs have to be differentiated into specific cell lineages prior to therapeutic application. (healthcanal.com)
  • Zevalin(R) (Ibritumomab Tiuxetan) is a form of cancer therapy called radioimmunotherapy and is indicated as part of the Zevalin therapeutic regimen for treatment of relapsed or refractory, low-grade or follicular B-cell non- Hodgkin's lymphoma, including patients with rituximab refractory follicular NHL. (bio-medicine.org)
  • tissues
  • Our finding offers new ways of generating stem cells for patients with dysfunctional or damaged tissues and organs. (medicalnewstoday.com)
  • Such stem cells can regenerate and replace those damaged cells and tissues and alleviate diseases that affect millions of people. (medicalnewstoday.com)
  • Decellularized organ scaffolds are being optimized to guide and spatially organize stem cell differentiation in efforts to rebuild functional tissues. (hindawi.com)
  • But this also means that transplanted organs, tissues or cells are seen as a potentially dangerous foreign incursion, which invariably provokes a vigorous immune response leading to transplant rejection. (nextbigfuture.com)
  • However, their generation and subsequent differentiation into specific cells or tissues entail cell line-specific manufacturing challenges and form a lengthy process that precludes acute treatment modalities. (nextbigfuture.com)
  • iPSCs
  • Endothelial cells, smooth muscle cells, and cardiomyocytes derived from hypoimmunogenic mouse or human iPSCs reliably evade immune rejection in fully MHC-mismatched allogeneic recipients and survive long-term without the use of immunosuppression. (nextbigfuture.com)
  • First, somatic cells must be reprogrammed to iPSCs, which takes considerable time and effort. (healthcanal.com)
  • This novel method skips the generally accepted process of mixing iPSCs with either mouse or human stromal cells during the differentiation process and, in essence, ensures no outside and potentially harmful DNA is introduced into the reprogrammed cells. (technologynetworks.com)
  • We used Sendai viral vectors to generate iPSCs efficiently from adult mobilized CD34+ and peripheral blood mononuclear cells (MNCs)," Dr. Kan explained. (technologynetworks.com)
  • These interesting findings reveal a protocol for the generation iPSCs using a readily available cell type," Dr. Ye added. (technologynetworks.com)
  • We also found that MNCs can be efficiently reprogrammed into iPSCs as readily as CD34+ cells. (technologynetworks.com)
  • Furthermore, these MNCs derived iPSCs can be terminally differentiated into mature blood cells. (technologynetworks.com)
  • organs
  • The technique worked for cells taken from various organs of newborn mice, but the efficiency was highest using white blood cells. (twincities.com)
  • The Cells' Development Depends on their Sense of Direction The research group, which in addition to Henrik Semb consists of Ph.D. Zarah L f- hlin and assistant professor Pia Nyeng, among others, originally set out to study how the body creates the complex piping systems that transport fluids and gasses in our organs. (medindia.net)
  • Endodermal cells, they form organs such as lung, liver and pancreas. (healthcanal.com)
  • In this way, he said, physicians might avoid the usual pitfall involved in transplanting cells or organs from other people - organ rejection, which requires organ recipients to take immune-suppressing drugs for the rest of their lives. (technologynetworks.com)
  • Huge numbers of stem cells are thought to be required to create new organs. (technologynetworks.com)
  • pancreas
  • And Jose Oberholtzer, M.D., Associate Professor of Surgery, Endocrinology and Diabetes, and Bioengineering at the University of Illinois at Chicago, and its Director of the Islet and Pancreas Transplant Program and the Chief of the Division of Transplantation, said work described in today's Cell "will leave a dent in the history of diabetes. (isscr.org)
  • The concentrations of the transcription factors determine here whether these cells develop into lung, liver or pancreas cells. (healthcanal.com)
  • diseases
  • This may contribute to the development of stem cell therapy targeted at other diseases. (medindia.net)
  • We know that in diseases like leukemia, the first scenario-no differentiated cells, two HCSs developing-must occur because more and more stem cells are made," explains Emerson. (innovations-report.com)
  • While earlier clinical trials raised safety concerns for genetically modified cells, especially in the context of inherited blood diseases such as X-linked severe combined immunodeficiency (X-SCID), the risk-to-benefit ratio for these patients favors gene therapy. (medgadget.com)
  • There are numerous clinical trials applying these adjustments in genetically modified cells for various diseases including X-SCID which have not raised safety concerns in hundreds of treated patients to date. (medgadget.com)
  • The fact that these cells were differentiated into mature blood cells suggests their use in blood diseases. (technologynetworks.com)
  • diabetes
  • This new advancement in stem cell technology can help manage diabetes more effectively in patients. (medindia.net)
  • Such cells may eventually be suitable for treating diabetes. (scientificamerican.com)
  • In people with diabetes these cells have stopped working properly. (scientificamerican.com)
  • Michael West, president and chief executive of Advanced Cell Technology Inc., said he would be 'disappointed' if his company didn't come up with cells that could be used to treat diabetes, Parkinson's disease and to repair heart muscle. (wsj.com)
  • biologist
  • Haruko Obokata, a biologist at Riken and the lead author of the two papers in Nature, said the technique worked using cells from older mice, but not as efficiently. (twincities.com)
  • And more work is needed to tell exactly what these cells are, cautioned reproductive biologist Kyle Orwig of the University of Pittsburgh Medical Center, who has watched Tilly's work with great interest. (lubbockonline.com)
  • treatments
  • If Sunday's report is confirmed, harnessing those stem cells might one day lead to better treatments for women left infertile because of disease - or simply because they're getting older. (lubbockonline.com)
  • endoderm
  • Professor Heiko Lickert, director of the IDR, in collaboration with Professor Gunnar Schotta of LMU München, showed that the Wnt/β-catenin signaling pathway regulates Sox17, which in turn regulates molecular programs that assign pluripotent cells to the endoderm, thus inducing an initial differentiation of the stem cells. (healthcanal.com)
  • Mice
  • The technique, performed only with cells from mice, might turn out to be a quicker and easier source of multipurpose stem cells than methods now in use. (twincities.com)
  • Recently, Tilly noted, a lab in China and another in the U.S. also have reported finding those rare cells in mice. (lubbockonline.com)
  • Melton said that the device Anderson and his colleagues at MIT are currently testing has thus far protected beta cells implanted in mice from immune attack for many months. (isscr.org)
  • nuclei
  • Together these proteins have an extraordinary ability to repair damaged nuclei so it may not be strictly necessary for the cells to be viable. (theconversation.com)