• As vitamin B12 is involved in so many functions in the body, from producing DNA, RNA, and red blood cells to producing energy, a vitamin B12 deficiency can manifest in a wide variety of symptoms. (curejoyinc.com)
  • In most cases, vitamin B12 deficiency happens because the stomach cannot produce enough of a substance called intrinsic factor (IF), which is needed for vitamin B12 to be absorbed. (mybodylanguage.co.uk)
  • Megaloblasts are large nucleated red blood cell (RBC) precursors with noncondensed chromatin due to impaired DNA synthesis. (msdmanuals.com)
  • Red blood cells (RBC) are produced in the bone marrow. (ivis.org)
  • a form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. (icdlist.com)
  • Impaired absorption occurs because of deficiency of intrinsic factor which is produced by the parietal cells of the stomach. (wikidoc.org)
  • With pernicious anaemia, antibodies damage the cells in the stomach that produce intrinsic factor. (mybodylanguage.co.uk)
  • IF is produced by the parietal cells of the stomach. (medscape.com)
  • The committed stem cells will produce colonies of its cell type and these committed cells are called Colony-Forming Unit (e.g. (wikilectures.eu)
  • The chemical processes of living cells in which energy is produced in order to replace and repair tissues and maintain a healthy body. (diagnose-me.com)
  • Megaloblasts can be detected through routine blood testing before a person develops the symptoms of anaemia. (orangehealth.dev)
  • The glycolytic pathway allows the cell to produce energy to maintain membrane stability with minimal utilization of oxygen. (ivis.org)
  • IF is produced by the parietal cells of the stomach. (medscape.com)
  • These are large, immature red blood cells produced when the cytoplasm develops normally, but the DNA synthesis is impaired and cell division is delayed. (osmosis.org)
  • They can divide elsewhere endomitotically, produce binucleated E s or take up the DNA synthesis and become polyploid. (karger.com)