• An aspiration, using a 20 mL syringe, yields approximately 300 μL of bone marrow. (wikipedia.org)
  • Bone marrow aspiration may also be performed on the tibial (shinbone) site in children up to 2 years of age while spinous process aspiration is frequently done in a lumbar puncture position and on the L3-L4 vertebrae. (wikipedia.org)
  • For the bone marrow aspiration, an EZIO-10 drill with 28mm bone marrow needle was used. (caringmedical.com)
  • Diagnosis is usually based on complete blood count and peripheral smear and, in selected cases, bone marrow aspiration. (who.int)
  • Bone marrow aspiration for leishmania DNA is also not practical in was taken as the gold standard. (who.int)
  • With acute lymphocytic leukemia, the bone marrow makes too many of these lymphocytes and they do not mature correctly. (texaschildrens.org)
  • Starting in lymphocytes- Multiple myeloma cells originate from lymphocytes, a normal type of white blood cell that resides in the bone marrow. (pethealthnetwork.com)
  • They can skin and can extend to the bone marrow, simulate benign skin disorders, making them blood lymphocytes, lymph nodes, and a diagnostic challenge for dermatologists1,2. (bvsalud.org)
  • Leukopenia (a white count decreased to less than 4,000/μL) is seen in some viral infections or severe bacterial infections, and conditions that affect the bone marrow such as dietary deficiencies, chemotherapy, radiation therapy , and autoimmune diseases. (answerbag.com)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • If you have a blood disorder (which is not cancer all the time) and requires specialized treatment such as a bone marrow transplant, you are referred to a hematologist. (sarvodayahospital.com)
  • The aspirate yields semi-liquid bone marrow, which can be examined by a pathologist under a light microscope and analyzed by flow cytometry, chromosome analysis, or polymerase chain reaction (PCR). (wikipedia.org)
  • Once the needle is in the marrow cavity, a syringe is attached and used to aspirate ("suck out") liquid bone marrow. (wikipedia.org)
  • New blood cells (called "stem cells") begin in the bone marrow - the red spongy material found inside the bones - and are released to the bloodstream when mature. (nemours.org)
  • Bone marrow is the soft, spongy, gelatinous tissue found in the hollow spaces in the interior of bones. (medscape.com)
  • There are different types of AML, but this is usually a cancer of the blood in which too many granulocytes, a type of white blood cell, are produced in the marrow. (texaschildrens.org)
  • A stem cell in the bone marrow becomes cancerous, and produces a large number of abnormal white cells, called granulocytes. (rxmed.com)
  • Rituximab-containing chemotherapy produced a marked increase in the patient's platelet count, and her lymphoma went into complete remission. (elsevierpure.com)
  • Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
  • Bone Marrow Examination Red blood cells, most white blood cells, and platelets are produced in the bone marrow, the soft fatty tissue inside bone cavities. (msdmanuals.com)
  • It involves the abnormal development and function of bone marrow cells that produce blood cells and leads to the formation of scar tissue in the bone marrow. (radiationoncologyassociates.co)
  • The tissue is then brought again over the tendon and secured to itself and the ulna, utilizing bone anchors. (dnahelix.com)
  • Mini�bone anchors are used to safe the tissue to the ulnar border of the groove and imbricate the subsheath. (dnahelix.com)
  • Lymph tissue is found throughout the body in lymph nodes, the spleen, the thymus gland, adenoids and tonsils, the digestive tract, and bone marrow. (snmjournals.org)
  • Over time, the furiously hard-working bone marrow may stop working altogether and the stem cells are replaced by non-functioning scar tissue. (vic.gov.au)
  • The project, funded by the European Research Council , adapted magnetic resonance imaging (MRI) to non-invasively assess, in a single examination, the microstructure of both bone marrow and adipose tissue , comprised mainly of fat cells. (europa.eu)
  • We are the first to use radiation-free CT-like MR imaging techniques in patient studies to simultaneously measure bone marrow and cortical bone tissue changes," says Karampinos. (europa.eu)
  • Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
  • There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
  • Bone marrow can be 1 of 2 types, red or yellow, depending on whether it consists of mainly hematopoietic (and therefore, red-colored) tissue or fatty (and therefore a yellow-colored) tissue. (medscape.com)
  • This chronic inflammatory disease results from the response to bacteria in dental biofilm and may remain confined to the gingival tissues with minimal tissue alterations or this disease may progress to extreme periodontal destruction with the loss of attachment and alveolar bone. (bvsalud.org)
  • Multiple myeloma causes cancer cells to accumulate in the bone marrow, where they suffocate out the healthy blood cells. (reclaimingintimacy.org)
  • Laboratory analysis of your blood may reveal the M proteins produced by myeloma cells. (reclaimingintimacy.org)
  • Another abnormal protein produced by myeloma cells - called beta-2-microglobulin - may be detected in your blood and give your doctor clues about the aggressiveness of your myeloma. (reclaimingintimacy.org)
  • Imaging tests may be recommended to detect bone problems associated with multiple myeloma. (reclaimingintimacy.org)
  • In Multiple myeloma a serum or urine monoclonal component is produced by bone marrow plasma cells. (sebia.com)
  • Sometimes, there are too many plasma cells- In cases of multiple myeloma, plasma cells developing within the bone marrow undergo a "malignant" transformation, and way too many plasma cells are manufactured. (pethealthnetwork.com)
  • The major symptoms associated with multiple myeloma are caused by the spread of cancer cells, hyperviscosity syndrome (thick blood), and the underproduction of normal cells within the bone marrow (see explanations above). (pethealthnetwork.com)
  • The patient's urine contains Bence-Jones proteins, a characteristic type of immunoglobulin (protein) produced by many dogs and cats with multiple myeloma. (pethealthnetwork.com)
  • Lesions are caused by bone replacement by expanding plasmacytomas or by cytokines that are secreted by malignant plasma cells that activate osteoclasts and suppress osteoblasts, leading to bone loss. (merckmanuals.com)
  • The malignant cells spread- Once released from the bone marrow, the malignant plasma cells often spread to other sites. (pethealthnetwork.com)
  • Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (merckmanuals.com)
  • The common stem cell produces 2 other stem cells, the myeloid stem cell and the lymphoid stem cell. (medscape.com)
  • Also, radiologic examinations are used to properly stage lymphoma, such as CT, MRI, ultrasound, and 18 F-FDG PET, which may or may not be accompanied by low-dose CT (PET/CT). (snmjournals.org)
  • It is not curative in any of these disorders but may produce clinically useful palliation. (nih.gov)
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
  • Medical hematology focuses on the diagnosis & treatment of blood disorders and bone marrow disorders. (sarvodayahospital.com)
  • The diagnosis for hematological disorders generally starts from blood examination and may involve bone marrow examination too. (sarvodayahospital.com)
  • A hematologist diagnoses and treats blood and bone marrow disorders. (sarvodayahospital.com)
  • Their treatment modality may include cancerous and non-cancerous disorders that affect the components of blood or blood-producing organs. (sarvodayahospital.com)
  • Supported by one of the best Hematologists in Delhi NCR, India, we offer the best treatment for all blood & bone marrow disorders. (sarvodayahospital.com)
  • Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
  • Hence, primary hemostatic disorders are characterized by prolonged bleeding time, and the characteristic physical examination findings are petechiae and purpura. (medscape.com)
  • The bone marrow produces the cellular elements of the blood, including platelets, red blood cells and white blood cells. (wikipedia.org)
  • Macroglobulinemia is a malignant plasma cell disorder in which B cells produce excessive amounts of IgM M-proteins. (merckmanuals.com)
  • Examination of the bone marrow helps to determine why certain blood cells are decreased in the blood count, and provides information on whether the bone marrow is healthy enough to recover. (petplace.com)
  • Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (merckmanuals.com)
  • She had severe thrombocytopenia without any hematological or coagulatory abnormalities, and a bone marrow examination revealed an increased number of megakaryocytes without any abnormal cells or blasts. (elsevierpure.com)
  • However, abnormal cells were eventually found during the third bone marrow examination. (elsevierpure.com)
  • However, how these aberrant myeloid cells and fibroblasts are produced remains unclear. (bvsalud.org)
  • Engrafted human cells were analyzed with flow cytometry, and proliferation of fibroblastic cells and bone marrow fibrosis were assessed with the histo-pathological examination. (bvsalud.org)
  • Fibrotic bone marrow contained CD45-vimentin+ cells of both human and mouse origin, suggesting that circulating malignant CD34+ subsets contribute to myelofibrotic changes in PMF through direct and indirect mechanisms. (bvsalud.org)
  • CONCLUSION: A patient-derived xenotransplantation (PDX) model of PMF allows in vivo examination of disease onset and propagation originating from immature CD34+ cells and will support the investigation of pathogenesis and development of therapeutic modalities for the disorder. (bvsalud.org)
  • system to demonstrate donor bone-marrow-derived cell fusion with adult recipient hepatocytes, cardiomyocytes, and Purkinje cells [15]. (woofahs.com)
  • Ianus et al[17] used Y chromosome fluorescent in situ hybridization (FISH), in combination 87976-03-2 supplier with an insulin-promoter-driven Cre/Lox system, to display the production of BM-derived insulin-producing cells without Cre-mediated activation of enhanced green fluorescence protein through cell blend. (woofahs.com)
  • The most successful liver repopulation with bone-marrow-derived cells was observed in mice with fumarylacetoacetate hydrolase (FAH? (woofahs.com)
  • cells engraft in beige/nude/xid immune-deficient mice and their progeny can be recovered from the murine bone marrow for as long as 18?months posttransplantation [28, 29]. (woofahs.com)
  • When reisolated from the marrow of beige/nude/xid mice, the human cells were lacking of CD34 expression absolutely. (woofahs.com)
  • and immune-mediated diseases such as aplastic anemia, in which the bone marrow loses its ability to produce red-blood cells. (petmd.com)
  • Medications for the underlying cause may be necessary, in addition to various medications to stimulate the production of neutrophils (a type of white blood-cell that fights infection), and another medication to stimulate the production of red-blood cells by bone marrow. (petmd.com)
  • When a child has leukemia, the bone marrow, for an unknown reason, begins to make abnormal blood cells (usually white blood cells) that do not mature correctly, but continue to reproduce themselves. (texaschildrens.org)
  • When the immature white blood cells, called blasts, begin to crowd out other healthy cells in the bone marrow, the child experiences the symptoms of leukemia (such as fevers, infections, anemia, bone pain, or bleeding). (texaschildrens.org)
  • When the bone marrow becomes scarred it can't make enough blood cells and this can cause anemia, enlargement of the spleen and liver, fatigue, and other problems. (radiationoncologyassociates.co)
  • Increased production of JAK proteins causes the wrong number of blood cells and cytokines to be produced. (radiationoncologyassociates.co)
  • Bone marrow examination typically reveals an increase in abnormal megakaryocytes (platelet-forming cells) and other abnormalities that are characteristic of myelofibrosis. (radiationoncologyassociates.co)
  • [ 1 ] Most of the neutrophils are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
  • The trailblazers are bone marrow-derived cells (BMDCs) that were earlier implicated in building blood vessels in established tumors. (rupress.org)
  • For a long time we thought the tumor cells got there and then brought the bone marrow cells afterwards," she says. (rupress.org)
  • But careful examination showed that, both in mice and humans, the BMDCs showed up several days before the first tumor cells. (rupress.org)
  • These fibroblast actions in turn attract the fibronectin-binding BMDCs, which settle into their niche and start producing other factors that attract the tumor cells. (rupress.org)
  • These cancer cells then produce abnormal proteins that cause complications with normal cell development. (reclaimingintimacy.org)
  • The machine will produce a report that displays all abnormalities found during examination such as cancerous cells or benign growths. (datapipesoft.com)
  • Red blood cells (RBC) are produced in the bone marrow. (ivis.org)
  • Effete red cells are phagocytized and metabolized by the macrophages of spleen, bone marrow, and liver. (ivis.org)
  • A Reed-Sternberg cell is an abnormal B cell that is larger than normal white blood cells and is found only in HD through examination under a microscope ( 2 ). (snmjournals.org)
  • Leukemia is a type of cancer that starts in immature blood cells in the bone marrow. (medicalnewstoday.com)
  • Blood cells are created inside bone marrow, and the number of each type of blood cell is carefully regulated to maintain the correct balance. (vic.gov.au)
  • These cells are created from stem cells within the bone marrow. (vic.gov.au)
  • However, the stem cells of a person with polycythaemia vera are abnormal and produce more blood cells than is necessary. (vic.gov.au)
  • Most often, the bone marrow makes too many red blood cells. (vic.gov.au)
  • Secondary polycythaemia refers to elevated numbers of red blood cells not caused by bone marrow abnormalities. (vic.gov.au)
  • Too many plasma cells lead to thick blood- Plasma cells produce proteins called immunoglobulins that are the foot soldiers of the immune system. (pethealthnetwork.com)
  • The marrow fat was shown to differ depending on the age and sex of subjects, unlike the bone, suggesting complex pathophysiological influences on fat cells. (europa.eu)
  • MGH researcher Jonathan Tilly and his team found new evidence that female mammals can produce egg cells throughout life and have traced their production out of the ovary and into the bone marrow. (harvard.edu)
  • Harvard researchers have found new evidence that female mammals can produce egg cells throughout life and have traced their production out of the ovary and into the bone marrow in findings that could both reshape science's understanding of female reproduction and provide new avenues for treatment of infertility. (harvard.edu)
  • The researchers believe that egg stem cells in the donor bone marrow established themselves in the sterile mice and began producing egg cells, also called oocytes. (harvard.edu)
  • Sickle cell anemia may become life-threatening when damaged red blood cells break down (hemolytic crisis), when the spleen enlarges and traps the blood cells (splenic sequestration crisis), or when a certain type of infection causes the bone marrow to stop producing red blood cells (aplastic crisis). (health.am)
  • Supplementation with folic acid, an essential element in producing cells, is required because of the rapid red blood cell turnover. (health.am)
  • Bone marrow is vitally important for the production of blood cells, specifically red blood cells, white blood cells, and platelets. (kingdomah.com)
  • The pathologist's report typically provides information about the health of the marrow, what types of cells are present, whether abnormal cells are found, and other details that may help to explain the patient's illness. (kingdomah.com)
  • When extra white cells are needed, the bone marrow increases production. (answerbag.com)
  • When many neutrophils are needed, they are released from the bone marrow as immature cells, called bands or stab cells. (answerbag.com)
  • Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
  • One type of stem cell is involved in producing blood cells and the other is involved in producing stromal cells, which are responsible for the supporting stroma. (medscape.com)
  • However, the yellow marrow can revert to red if there is increased demand for red blood cells, such as in instances of blood loss. (medscape.com)
  • Normally, only mature cells are released from the marrow into the bloodstream. (medscape.com)
  • These stem cells divide to eventually give rise to red blood cells, platelets, and most white blood cells in the red marrow. (medscape.com)
  • Bone marrow thus contains blood cells at varying stages of development. (medscape.com)
  • Illustration of the pelvis to show the site of bone marrow and blood cells derived from bone marrow. (medscape.com)
  • When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)
  • Similarly, the bone marrow produces and releases more white blood cells in response to infections, and it produces and releases more platelets in response to bleeding. (medscape.com)
  • As age progresses, more of the red bone marrow turns into yellow bone marrow and the production of new blood cells becomes more difficult. (medscape.com)
  • The bone marrow stroma contains mesenchymal stem cells. (medscape.com)
  • A bone marrow smear was performed, in which 'cerebriform' cells were identified, confirming the diagnosis of Sézary syndrome. (bvsalud.org)
  • An aspirate needle is inserted through the skin using manual pressure and force until it abuts the bone. (wikipedia.org)
  • A bone marrow aspirate may be recommended. (petplace.com)
  • We report here a patient from Bihar, presented to us with prolonged fever and pancytopenia, bone marrow aspirate showed microfilaria. (annexpublishers.co)
  • ABSTRACT This study estimated the sensitivity and specificity of the rK39 strip test compared with the immunofluorescent antibody test and microscopy of bone marrow aspirate smears (the gold standard) in 47 children with suspected visceral leishmaniasis. (who.int)
  • Samples for direct agglutination test (DAT) leishmaniasis by 3 different methods: light can be easily obtained, but must be sent microscopy of bone marrow aspirate to distant medical centres [ 9 ]. (who.int)
  • If further experiments bear out the study's results and the processes discovered in mice hold true for humans, the findings could have far-reaching ramifications for treatment of human infertility and solve the mystery surrounding reported cases of spontaneous restoration of fertility in sterile women who've undergone bone marrow transplants. (harvard.edu)
  • Primary sites of disease include peripheral blood, bone marrow. (merckmanuals.com)
  • However, 2 mink farmers with vascular disease DNA was extracted from lymph nodes (patient 1) and from and microangiopathy similar to that in mink with Aleutian peripheral blood and bone marrow (patient 2) before ampli- disease were found to have AMDV-specifi c antibodies and fi cation with AMDV-specifi c primers. (cdc.gov)
  • The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
  • Bone marrow is commonly collected and examined when abnormalities are found in the circulating blood. (kingdomah.com)
  • LEUKERAN (chlorambucil) can severely suppress bone marrow function. (nih.gov)
  • Drug therapy to suppress the activity of the bone marrow, such as frequent injections of interferon or tablets called hydroxyurea. (vic.gov.au)
  • On physical examination, an obvious limp was noted. (caringmedical.com)
  • MATERIAL AND METHODS: The study included 45 patients who were given a thorough physical examination. (bvsalud.org)
  • Daily physical examinations should be given after initial treatment, including frequent monitoring of body temperature and a periodic complete blood count (CBC). (petmd.com)
  • The person (usually with one of the preceding risk factors) can have diffuse midepigastric pain but also have a benign physical examination. (dummies.com)
  • The diagnostic process for histiocytosis typically begins with a physical examination, blood work and imaging studies. (tgh.org)
  • Preoperative Planning All preoperative information obtained from the history, the physical examination, and imaging studies should be thoroughly reviewed and synthesized into the operative plan. (dnahelix.com)
  • In order to diagnose leukemia, a doctor will first perform a physical examination . (medicalnewstoday.com)
  • Diagnosis requires bone marrow examination and demonstration of M-protein. (merckmanuals.com)
  • Once a diagnosis is suspected additional tests or procedures that may be used to diagnose primary myelofibrosis include blood tests and a bone marrow examination 2 . (radiationoncologyassociates.co)
  • The diagnosis is made by serum and urine biochemicals exams, by radiological examination and by marrow analysis. (sebia.com)
  • Diagnosis is made by examination of the blood film. (rxmed.com)
  • Bone marrow studies are necessary to confirm the diagnosis. (rxmed.com)
  • For decades, definite diagnosis of were patients with hepatosplenomegaly, visceral leishmaniasis has required in- fever, anaemia (with or without neutropae- vasive procedures to find the parasite in nia) or hypergammaglubolinaemia who had the organs, such as spleen, bone marrow, been referred from endemic regions. (who.int)
  • A bone tumor may produce a distinctive "punched-out" appearance on an X-ray. (tgh.org)
  • Both types of bone marrow are highly vascular, being enriched with numerous blood vessels and capillaries. (medscape.com)
  • While arthroscopy with or without core decompression is the standard of care for unresolved cases of avascular necrosis of the talus, we present a case of avascular necrosis of the talar dome where symptoms resolved satisfactorily with direct bone marrow injections into structures into and around the ankle. (caringmedical.com)
  • Leukemia produces symptoms that also occur with other, unrelated conditions. (medicalnewstoday.com)
  • The MRI techniques were also used to assess bone marrow fat and the thin cortical bone in the spine, where fractures typically occur. (europa.eu)
  • At 24-, 48- and 72-hour intervals after treatment, 6 mice per sex and control group and 7 mice per sex of the test material group were sacrificed to prepare bone marrow smears. (europa.eu)
  • INTRODUCTION: Primary myelofibrosis (PMF) is a clonal stem cell disorder characterized by myeloid dominant hematopoiesis and dysregulated proliferation of fibroblasts in the bone marrow. (bvsalud.org)
  • Immune-deficient mouse kinds of liver damage allow examination of human being stem cell migration to sites of damage and subsequent contribution to repair and survival. (woofahs.com)
  • Infection may produce a symmetrical peripheral polyarthropathy. (cdc.gov)
  • These tests are included in general health examinations and help investigate a variety of illnesses, including infection, allergy, and leukemia. (answerbag.com)
  • Periodontal disease is a chronic bacterial infection that affects the gingiva and bone that supports the teeth. (bvsalud.org)
  • Then, with a twisting motion of clinician's hand and wrist, the needle is advanced through the bony cortex (the hard outer layer of the bone) and into the marrow cavity. (wikipedia.org)
  • The needle is then advanced with a twisting motion and rotated to obtain a solid piece of bone marrow. (wikipedia.org)
  • Of patients producing either IgG or IgA, 40% also have Bence Jones proteinuria, which is free monoclonal kappa ( κ ) or lambda ( λ ) light chains in the urine. (merckmanuals.com)
  • Basic examination of urine. (medlineplus.gov)
  • Abdomen examination showed mild hepatosplenomegaly which was firm and non tender, without any free fluid. (annexpublishers.co)
  • Rat liver homogenate incubated for two hours with 32 P labelled vamidothion produced 0,0-dimethyl phosphate, phosphoric acid and an unknown compound which was possibly dimethyl phosphothionate. (inchem.org)
  • Bone marrow supersedes the liver as the major hematopoietic organ at 32-36 weeks' gestation. (medscape.com)
  • The more dilute the serum when it stops producing a positive reaction, the higher the concentration of antibodies present in the blood. (kingdomah.com)
  • p>Our combined expertise allows us to diagnose and treat common, rare and complex bone tumors in children. (nemours.org)
  • The pediatric hematology/oncology experts at Tampa General Hospital specialize in diagnosing and treating all types of solid tumors and blood and bone marrow malignancies in infants, children and young adults. (tgh.org)
  • Recently, Interferon Alpha has been shown to normalize the bone marrow, and bring about remission. (rxmed.com)
  • Recent evidence suggests that higher marrow fat content correlates with fracture risk. (europa.eu)
  • Histological examination of gingivitis or periodontitis lesions reveals that the polymorphonuclear leukocyte (PMN) appears to play a key role in the maintenance of the periodontal health (3). (bvsalud.org)
  • Numbers of circulating RBCs are affected by changes in plasma volume, rate of RBC destruction or loss, splenic contraction, erythropoietin (EPO) secretion, and the rate of bone marrow production. (ivis.org)
  • In a series of experiments on sterile female mice, researchers from Massachusetts General Hospital (MGH), a Harvard teaching hospital, were able to restore egg production by transplanting bone marrow from fertile mice. (harvard.edu)
  • The facility's primary mission was to produce high-purity uranium metal necessary for nuclear weapons production and other defence missions. (cdc.gov)
  • A Ct of 12 to 70 mg-min/m 3 produces eye lesions. (cdc.gov)
  • The research team leader, Associate Professor of Obstetrics, Gynecology, and Reproductive Biology Jonathan Tilly, characterized criticism of the current paper as more severe than that directed at last year's work, a fact he attributed to the findings that the bone marrow, rather than the ovaries, are the ultimate site of egg cell generation. (harvard.edu)
  • Histological examination of two male and two female rats from each group showed no abnormality attributable to ingestion of the test compound (Rivett and Corbett, 1966). (inchem.org)