• Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives. (drugsandpoisons.com)
  • Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins. (ac.ir)
  • One of the most popular lignans is (−) podophyllotoxin, which is applied in its semi-synthetic derivatives for the treatment of various types of cancer. (rwth-aachen.de)
  • Medicinal Uses: Compounds like podophyllotoxin in this remarkable plant have been used to develop anti-cancer medications, highlighting its potential in fighting this devastating disease. (krystalize.me)
  • Mayapples produce a toxin called podophyllotoxin, which is highly poisonous if ingested in significant quantity, helping to explain why mayapple leaves nearly always appear perfectly intact. (weconservepa.org)
  • For example the drugs teniposide and etoposide are derived from podophyllotoxin, which is a non-alkaloid toxin from roots and rhizome of Podophyllum species and topotecan and irinotecan are hydrophilic analogs of the anticancer drug camptothecin obtained from the bark of Camptotheca acuminata. (longdom.org)
  • As a matter of fact, an endophyte called Fusarium oxysporum of rosy periwinkle plant, Catharanthus roseus was discovered to produce vincristine - an anticancer drug 18-20 . (microbiologyjournal.org)
  • The quest for hostile to cancerous growth compounds from plant sources began vigorously during the 1950s with the disclosure and advancement of the different regular mixtures like vinca alkaloids, vinblastine, vincristine and cytotoxic podophyllotoxins. (researchsquare.com)
  • Spiteller, M. An endophytic fungus from Nothapodytes foetida that produces camptothecin. (thelondonbridged.com)
  • Spiteller, M. An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues. (thelondonbridged.com)
  • Explant of an alkaloid producing plant, cultured in vitro , has been found to retain the capacity to synthesis alkaloids identical to that in the intact plant (Yoshimatsu and Shimomura, 1991). (scialert.net)
  • The ability of endophytic fungi to produce valuable bioactive compounds when surviving in medicinal herbs. (microbiologyjournal.org)
  • Microorganisms produced many biological compounds such as bacteriocin, conjugated linoleic acid, gamma buryric acid, lactic acid from lactic acid bacteria 1-4 , prodigiosin production from Streptomyces coelicolor 5 , penicillin from fungi 6 . (microbiologyjournal.org)
  • Terpenoids Terpenoids are also known as terpenes, are a large and diverse class of organic compounds produced by various plants, fungi and animals. (mimprovement.com)
  • Objective: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. (ac.ir)
  • The active substance is podophyllotoxin (5 mg/ml). (dokteronline.com)
  • More than 3000 kg of dried sea sponge is required to produce 60 g of a pure substance, which is more than the world's total sponge population. (martifarm.com)
  • The reactions that produce ansial drug substance analysis. (auxerretv.com)
  • Etoposide is among the World Health Organisations's list of essential medicines and it is derived from podophyllotoxin. (wikipedia.org)
  • Attempts to make synthetic podophyllotoxin have been unsuccessful, consequently, it is isolated from plant material, before being processed into chemotherapy drugs such as etoposide. (ox.ac.uk)
  • Spiteller, M. Metabolomics of endophytic fungi producing associated plant secondary metabolites: progress, challenges and opportunities. (thelondonbridged.com)
  • As one of the preconditions, the precursor for lignan synthesis coniferyl alcohol needs to be produced in industrial bulk. (rwth-aachen.de)
  • A number of by-products have been explored, including podophyllotoxin for health treatments ( Stenmark 2021 ) and furniture ( Hiziroglu 2018 ). (ashs.org)
  • The ripe fruit does not produce toxicity. (wikipedia.org)
  • In the 1970s, ginseng contaminated with Mandragora officinarum (scopolamine-containing mandrake) produced anticholinergic toxicity. (medscape.com)
  • Importantly, compared to podophyllotoxin that is the parental isomer of β-peltatin but clinically obsoleted due to its severe toxicity, β-peltatin exhibited stronger anti-PAC effect and lower toxicity in mice. (biomedcentral.com)
  • Co-culture of arbuscular mycorrhiza-like fungi (Piriformospora indica and Sebacina vermifera) with plant cells of Linum album for enhanced production of podophyllotoxins: a first report. (ac.ir)
  • As many as 60 % of antitumor drugs that are in use today are derived from secondary metabolites of plants, microorganisms, and marine organisms or produced by synthesis modelled on natural substances. (martifarm.com)
  • Antibiotic antineoplastic agents are produced by microorganisms and inhibit or prevent the proliferation of neoplasms. (medscape.com)
  • Pure podophyllotoxin is too dangerous for clinical use, but semi-synthetic drugs have been developed from it. (ox.ac.uk)
  • R)-ß-piperonyl-γ-butyrolactones are key building blocks for the synthesis of podophyllotoxin, which have demonstrated remarkable potential in cancer treatment. (bvsalud.org)
  • We extrapolate to medicinal plants that synthetize rare molecules and also discuss how this new knowledge could help in improving strategies to produce useful plant-derived pharmaceuticals. (univ-tours.fr)
  • The Pioneer Enterprises and associated group of companies have modern manufacturing plants that produce a novel range of Phytochemicals and Alkaloids to the specifications and satisfaction of its customers. (pioneerherbal.com)
  • Nodal segments from 3-4 years old field grown plants produced multiple shoots within two weeks of culture. (scialert.net)
  • Production of podophyllotoxin by plant cell cultures of Podophyllum hexandrum in bioreactor. (ac.ir)
  • Some modern medicines have been obtained from nature by isolating plant, animal, or microorganism materials, while we still produce some of them from isolated natural raw materials. (martifarm.com)
  • As no economically acceptable synthesis exists, the drug is still produced from raw plant materials, so the plant population in Tibet and the Himalayas has drastically decreased. (martifarm.com)
  • Through this commentary article, we highlight the outstanding work of the Zhou's group which recently describes a distinct approach relying on the efficient recycling of enzyme co-factors in yeast to fulfill the synthesis of caffeic acid (CaA) and ferulic acid (FA), two precursors of podophyllotoxin. (univ-tours.fr)
  • Podophyllotoxin and essential oil profile of Juniperus and related species. (ac.ir)
  • Datura metel L fastuosa mistakenly has been used in place of Campsis and Paulownia species, producing anticholinergic poisoning. (medscape.com)
  • This coniferyl alcohol titer, produced under non-optimized conditions and in a prototype strain, is comparable to a value in one literature report, in which an L-tyrosine overproduction strain and adjusted cultivation conditions were used. (rwth-aachen.de)
  • Schisandrin B (γ-Schisandrin) is a dibenzocyclooctadiene derivative isolated from Schisandra chinensis , has been shown to produce antioxidant effect on rodent liver and heart. (medchemexpress.com)
  • It was observed that the derivatisation reaction is rapid, apo azithromycin quantitative and produces minimal by-products or side reactions. (etest.lt)
  • Minimisation of errors in the production wymesone sample that produced the original, failing test result. (vieladapraia.com.br)
  • Therapeutic modalities include cryotherapy, podophyllotoxin application, electrocoagulation, surgery and laser therapy associated with their own high risk of complications and sequelae. (ijord.com)
  • 2014. Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis). (ac.ir)
  • Several herbal products can produce anticholinergic symptoms. (medscape.com)
  • Baeyer-Villiger monooxygenases (BVMOs)-mediated asymmetric oxidation is a green approach to produce chiral lactones. (bvsalud.org)
  • some stems bear a single leaf and do not produce any flower or fruit, while flowering stems produce a pair or more leaves with 1-8 flowers in the axil between the apical leaves. (wikipedia.org)
  • Those with one leaf will fail to flower, but those with two leaves produce a white flower, whose many stamens have conspicuous yellow anthers. (ox.ac.uk)