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  • intervention
  • Follow-up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent-child dyadic social communication over this period. (nih.gov)
  • illness
  • Due to their obscurity, the prodromal symptoms of the first episode were also lacking or listed incompletely in the international classification systems and at first reconstructed on the basis of symptoms occurring in the further illness course . (barnardhealth.us)
  • Complaints
  • Initial complaints to professionals often focus on somatic (or physical) symptoms, particularly sleep disturbance and difficulties with memory and concentration. (nasmhpd.org)
  • often
  • While today it is often underrecognised and under-treated, historically such symptoms were the focus of much attention. (scribd.com)
  • changes
  • It is unknown whether the administration of human mutant alpha-synuclein (hm-α-syn, a human mutation which occurs in familial PD) into the OB of rats would trigger similar α-syn propagation and subsequently cause pathological changes in broader brain fields associated to PD and establish an animal model of prodromal PD. (biomedcentral.com)
  • sign
  • Symptom/sign can be presented with palpable lump on the breast, bloody nipple discharge , skin eruption around the nipple that does not go away and itch, skin thickness over the breast area. (healthtap.com)