Processes underlying neuronal. Medical search. Frequent questions

2) Glutamate receptor trafficking is a critical process for synaptic plasticity, learning and memory. (uhnresearch.ca)
She is known for her work on the neurobiological foundations of pain perception, processing and encoding, as well as underlying neuronal plasticity in connection with the emergence of chronic pain. (uni-heidelberg.de)
There is strong evidence that the epigenetic regulation of gene transcription, by way of covalent modifications of DNA and DNA-associated proteins, and through microRNAs, is an essential process underlying neuronal plasticity and memory. (benthamscience.com)
Thus, our study of the neuronal mechanisms of how pain is encoded in the brain - together with future studies of the underlying plasticity mechanisms - might be relevant for the development of treatments for psychiatric diseases such as anxiety and post-traumatic stress disorders. (neurosciencenews.com)

During development, they therefore grow out cellular processes, termed neurites, to establish synaptic connections with other neurons. (sciencedaily.com)
Motor neuron diseases (MNDs) are progressive degenerative diseases in which death of the cell bodies of motor neurons is the primary process. (medscape.com)
Some neurons process reward information that is dependent on the relative motivational value of the reward. (nature.com)
Neurons in the striatum and different areas of frontal and parietal cortex incorporate information about expected rewards into neuronal activity involved in the production of behaviour leading to reward acquisition. (nature.com)
These studies show that different aspects of reward functions are processed by different neurons in different brain structures. (nature.com)
To reconcile robust computations with variable neuronal activity, we here propose a conceptual change of perspective by employing variability of activity as the basis for stimulus-related information to be learned by neurons, rather than merely being the noise that corrupts the mean signal. (plos.org)
To estimate neuronal connectivity between each pair of neurons, we obtain the cross-correlation (CC) by collecting spike times of a neuron measured relative to every spike of a reference neuron (Fig. 1a ). (nature.com)
While it is clear, that RNA distribution patterns in neurons are created by active transport processes of mRNPs along microtubules, the essential enzymatic activities required are not known. (europa.eu)
Using hippocampal neurons in culture as a model system for neuronal polarization I first addressed the dynamics of microtubules in early developmental stages of neurons. (uni-muenchen.de)
The model organism Drosophila melanogaster , with its great variety of genetically traceable tools for labeling and manipulating single neurons, allows mapping of neuronal networks and identification of molecular signaling cascades involved in the regulation of food intake. (jove.com)
The selective neuronal dysfunction and subsequent loss of neurons in the striatum, cerebral cortex, and other parts of the brain can explain the clinical picture seen in cases of HD. (medscape.com)
By selectively activating or inhibiting specific neurons using optogenetics, researchers have been able to elucidate the underlying mechanisms and identify key players involved in epileptic activity. (lu.se)
To this end, detailed and high-quality data on the information processing in multiple neurons identified with respect to their phenotypes and connections in the brain is needed. (lu.se)
Implantable electrodes for long term monitoring and interaction with multiple neurons have the potential to provide such information but will only be useful if truly biocompatible, i.e. if they themselves do not cause significant tissue reactions such as inflammation, neuronal loss and glial encapsulation. (lu.se)

For example, the need for averaging neuronal activity over long periods or large groups of cells to assess a robust mean and to diminish the effect of noise correlations. (plos.org)

Our goal is to further our understanding of the physiological underpinnings of these processes, which could unlock avenues for better understanding depression. (charite.de)
I therefore deduce that microtubules are actively involved in the process of axon formation and that local microtubule stabilization in one neuronal process is a physiological signal specifying neuronal polarization. (uni-muenchen.de)
The antagonistic genetic correlation between milk yield and fertility is now well-documented, however, the underlying physiological mechanisms are still uncertain. (otago.ac.nz)
By enabling both recordings of neuronal signaling and interactions with neuronal networks in physiological conditions, ground breaking research can be expected in the near future. (lu.se)
This breakthrough has significantly advanced our knowledge of various physiological and pathophysiological processes in the brain. (lu.se)

The most striking neuropathology in HD occurs within the neostriatum, in which gross atrophy of the caudate nucleus and putamen is accompanied by selective neuronal loss and astrogliosis. (medscape.com)

He explores the emotional and cognitive processes that enable social behavior and their alterations in psychopathology. (tu-dresden.de)
To establish a possible causal relation between microtubule dynamics and axon formation I assessed the effects of specific pharmacological alterations of microtubule dynamics on neuronal polarization. (uni-muenchen.de)
Epileptogenesis refers to the multiphase process in which a normal brain undergoes alterations to support the generation of spontaneous seizures. (jle.com)
Once seizures occur, the epileptic disease state probably continues to progress, with each seizure having the potential to induce additional neuronal alterations that may further lower seizure thresholds [19]. (jle.com)
Appropriate screens for antiepileptogenic drug action would be tests for the ability of drugs to reduce alterations in molecular, cellular, and network properties that occur during the epileptogenic process. (jle.com)
These behavioral alterations are accompanied by diminished neuronal maturation and survival, reduced dendritic branching and spine maturation, and marked microglia activation. (bvsalud.org)
It will also be possible to monitor alterations in neuronal signaling during degenerative processes, thereby providing clues to the understanding of the underlying disease mechanisms. (lu.se)
However, the genetic alterations driving this evolutionary process are poorly understood. (lu.se)

The term neuroinflammation generally refers to more chronic, sustained injury when the responses of microglial cells contribute to and expand the neurodestructive effects, worsening the disease process. (wikipedia.org)
Direct injection of the cytokines IL-1α, IL-1β and TNF-α into the CNS result in local inflammatory responses and neuronal degradation. (wikipedia.org)
One may ask whether such drugs modify existing neuronal responses to natural rewards or constitute rewards in their own right, and as such engage existing neuronal reward mechanisms, directing subjects towards artificially rewarding goals. (nature.com)
Implementations have been inspired by stereotypical neuronal responses like tuning curves in the visual system, where, for example, ON/OFF cells fire or not depending on the contrast in their receptive fields. (plos.org)
The experimental approach measures high-density magnetoencephalography (MEG) signals from human participants to investigate the modulation of human auditory evoked responses (AER) induced by the overt processing of auditory STM during task performance. (umd.edu)
Here, using two different transgenic mouse models (SERT over-expression and SERT knock-out) combined with intra-amygdalar recordings in behaving animals, I show that SERT expression has an unequivocal influence on fear learning, amygdala hemodynamic responses and theta frequency (5-10Hz) neuronal oscillations. (ox.ac.uk)

Context and state of the art mRNA transport in general: Cytoplasmic mRNA transport and local translation are essential for many processes requiring symmetry breaking such as embryonic development, cell migration and neuronal differentiation (1). (europa.eu)
A third cluster with archetypal variant near ZNF613 and including variants associated with ROBO1, EFNA5, PALLD, GPC6, and PTPRT affected fertility but not milk yield, and were characterized by their effects on GnRH neuronal migration, embryonic development, and/or ovarian function. (otago.ac.nz)

Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. (jci.org)
However, the detailed molecular mechanisms underlying this process remain poorly understood. (cancerindex.org)
The emphasis of Prof. Kuner's research lies on the molecular mechanisms underlying the chronification of pain and the development of new strategies for pharmacological treatments. (uni-heidelberg.de)
It is likely that such screens would identify drugs with mechanisms of action different from traditional AEDs, since the molecular mechanisms underlying epileptogenesis and ictogenesis are different. (jle.com)

Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
Our previous study has shown that CCAAT-enhancer binding protein β (C/EBPβ) is an important regulator in METH-induced neuronal autophagy and apoptosis. (cancerindex.org)
We hypothesized that C/EBPβ is involved in METH-induced DDIT4-mediated neuronal autophagy and Trib3-mediated neuronal apoptosis. (cancerindex.org)
2016 ). RAD21 has been implicated in additional processes including mediation of epigenetic silencing and induction of apoptosis (Fisher et al. (springer.com)
Several mechanisms of neuronal cell death have been proposed for HD, including excitotoxicity, oxidative stress, impaired energy metabolism, and apoptosis. (medscape.com)

Based on in vitro studies and computational modeling, neuroscientists have now made an important contribution to the understanding of brain networks and their development: in their current study, they show how neuronal outgrowth and migration interact in shaping network architecture and the degree of modularity in mature networks. (sciencedaily.com)
Based on in vitro studies and computational modeling, neuroscientists Dr. Samora Okujeni and Prof. Dr. Ulrich Egert from the Bernstein Center Freiburg now made an important contribution to the understanding of brain networks and their development: in their current study, they show how neuronal outgrowth and migration interact in shaping network architecture and the degree of modularity in mature networks. (sciencedaily.com)
TRPM7 overexpressing astrocytes impaired neuronal outgrowth in vitro by increasing the production of chondroitin sulfate proteoglycans, a key component of the gliotic scar. (nih.gov)
These findings indicate that astrocytic TRPM7 is a critical regulator of the formation of a gliotic scar and provide a novel mechanism by which reactive astrocytes affect neuronal outgrowth. (nih.gov)

Here we develop a method for reconstructing neuronal circuitry by applying a generalized linear model (GLM) to spike cross-correlations. (nature.com)
The second approach, which we take here, is to use all of the data to carry out mesoscopic neuroanatomy, that is, to reveal the fine neuronal circuitry in which neural circuit computation is carried out. (nature.com)

It is not possible to pin down those age differences in volume on specific neuronal processes, but those differences may reflect synaptic or neuronal pruning. (databasefootball.com)

In this dissertation I present a novel approach for integrating 'bottom-up' (neural network modeling) and 'top-down' (experiment) methods to study the dynamics of cortical circuits correlated to shortterm memory (STM) processing that underlie the task-specific modulation of human auditory perception during performance of the delayed-match-to-sample (DMS) task. (umd.edu)
To accomplish this goal, a new signal processing method based on independent component analysis (ICA) was developed for removing artifact contamination in the MEG recordings and investigating the functional neural circuits underlying the task-specific modulation of human AER. (umd.edu)
Modulation of neuronal dopamine levels in diseases such as tardive dyskinesia, Tourette syndrome , Huntington's chorea , schizophrenia , and tardive dystonia , which are characterized, in part, by a hyperdopaminergic state, should provide symptomatic benefits for patients with these diseases," they say. (medscape.com)

The underlying self-organization process is regulated by neuronal activity but the detailed mechanisms are still poorly understood. (sciencedaily.com)
The mechanisms underlying impaired neuronal function are not fully understood, but evidence is accumulating that the presence of the gliotic scar produced by reactive astrocytes play a critical role in these detrimental processes. (nih.gov)
However, the underlying neuronal mechanisms are not well understood yet. (umd.edu)
The underlying cause for most neurodegenerative disorders is poorly understood and current treatments are largely ineffective. (lu.se)
The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. (lu.se)

Engagement of posterior parietal cortex (PPC) in visuospatial attention and arithmetic processing has been extensively documented using neuroimaging methods. (mit.edu)
The current recordings of the increased activity of the vMGB show that the processing of the auditory information begins before the auditory pathways reach the cerebral cortex. (sciencedaily.com)
This study shows that this is indeed the case: The part of the vMGB that transports information from the ear to the cerebral cortex processes auditory information differently when speech is to be recognized than when other components of communication signals are to be recognized, such as the speaker's voice for example. (sciencedaily.com)
One aspect underlying such complex representations in IT cortex is that receptive fields (RFs) span much of the central visual field. (jneurosci.org)
Water diffusion in brain cortex closely tracks underlying neuronal activity. (cea.fr)
Takeda et al have shown that ALS pathology initiated by cytoplasmic inclusions and neuronal loss in layer II-III of the transentorhinal cortex (TEC)-molecular dentate gyrus (DG) projection and subiculum is specific to ALS. (medscape.com)
Marked neuronal loss also is seen in deep layers of the cerebral cortex. (medscape.com)

It is widely assumed among researchers that neuronal growth is hereby controlled to stabilize neuronal activity at a specific target level. (sciencedaily.com)
Hence, it has remained unclear if the overlap of two functions in the PPC is the product of averaging, or they truly stem from a common profile of activity within the same neuronal populations in the human PPC. (mit.edu)
Classical models of neuronal networks therefore map a set of input signals to a set of activity levels in the output of the network. (plos.org)
We're especially interested in the connections between patterns of activity, memory traces, and neuronal filters such as those underlying our vital needs. (charite.de)
Recent rapid global advances in genetic techniques make it possible to zero in and observe the activity of individual nerve cells or that of larger neuronal assemblies and measure various forms of control - from molecules to entire network ensembles. (charite.de)
Together, our data support a model in which the V409I/A mutations disrupt microtubule regulation typically conferred by XMAP215 proteins during neuronal morphogenesis and migration, and this impact on tubulin activity at the molecular level scales with the impact at the cellular and tissue levels. (elifesciences.org)
He pioneered the development of optogenetics, a powerful method that enables neuronal activity to be controlled with light. (mit.edu)
This has identified a number of classes of AEDs that primarily suppress neuronal excitability by blocking Na + channels or enhancing inhibitory GABAergic activity [4, 5]. (jle.com)

The presence of neuronal intranuclear inclusions (NIIs) initially led to the view that they are toxic and, hence, pathogenic. (medscape.com)

Understanding of the neuro-architecture of key areas in the insect brain and its attached sensory systems will be used to create III-V nanowire and molecular dye-based network systems that mimic neural computations underlying specific behaviours (in particular, navigation). (lu.se)

The computational approach uses a large-scale neural network model based on the electrophysiological knowledge of the involved brain regions to simulate system-level neural dynamics related to auditory object processing and performance of the corresponding tasks. (umd.edu)
Our objective is to unravel fundamental dynamic neural and glial mechanisms underlying learning-related altered neural network structures and information processing in conscious individuals using implantable and biocompatible nanostructured neural interfaces. (lu.se)
CRISPR interference silencing of LINC01876 results in reduced size of cerebral organoids and premature differentiation of neural progenitors, implicating L1s in human-specific developmental processes. (lu.se)

To modulate cell migration in these networks they manipulated an enzyme that is centrally involved in the regulation of the neuronal cytoskeleton. (sciencedaily.com)
We find that ectopic expression of TUBA1A -V409I/A mutants disrupt neuronal migration in mice and promote excessive neurite branching and a decrease in the number of neurite retraction events in primary rat neuronal cultures. (elifesciences.org)
However, we have uncovered several novel mechanisms potentially affecting milk production and fertility such as GnRH neuronal migration. (otago.ac.nz)

We end the chapter with a discussion on the potential relevance of epigenetic processes in sustaining memory traces in the brain over very long periods of time. (benthamscience.com)

These neuronal phenotypes are accompanied by increased microtubule acetylation and polymerization rates. (elifesciences.org)

This is correlated with increased hippocampal neurogenesis, neuronal survival, spine maturation, and inhibition of microglia activation. (bvsalud.org)

However, the extant evidence in humans stems from neuroimaging methods that have relied on group analyses without much knowledge about the profile of neurophysiological engagement within localized neuronal populations at the individual brain level. (mit.edu)
Within the realm of epilepsy research, optogenetic tools have played a crucial role in investigating the contributions of different neuronal populations to the generation of seizures and hyperexcitability. (lu.se)

This study provides insight into how nuclear Hangover/RNA signaling is linked to the cytoplasmic regulation of cAMP levels and results in neuronal adaptation and behavioral changes (Ruppert, 2017). (sdbonline.org)

beta-amyloid is the main component of neuritic (senile) plaques, which consist of degenerated axonal or dendritic processes, astrocytes, and glial cells around an amyloid core. (msdmanuals.com)

It assesses current understanding of the neuronal mechanisms that underlie syntactic structure and processing. (mpi.nl)

In my studies, I addressed the role of microtubule dynamics in initial neuronal polarization. (uni-muenchen.de)
To this end I aimed to investigate the following issues: 1) How do microtubule dynamics and stability change during initial neuronal development? (uni-muenchen.de)
These results suggested that SAD kinases and GSK-3beta regulate neuronal polarization -at least in part- by modulating microtubule dynamics. (uni-muenchen.de)
In line with my previous observations I found that microtubules are stabilized along the shaft of the growing axons while dynamic microtubules enrich at the tip of the growing process, suggesting that a well- balanced shift of microtubule dynamics towards more stable microtubules is necessary to induce axon formation. (uni-muenchen.de)

This includes fundamental neuronal mechanisms related to information processing in underlying different brain states such as awake and asleep, mechanisms underlying learning and memory and mechanisms underlying sensory perceptions. (lu.se)

While these traditional AEDs have had a profound effect by reducing the expression of epileptic seizures, their function invariably elicits some impairment of the normal neuronal excitability underlying cognitive function [6-8]. (jle.com)
While anticonvulsants reduce the duration or frequency of seizures by suppressing neuronal excitation or excitability, real antiepileptogenic agents would act by blocking the initial epileptogenic process or by altering the epileptic disease state after the seizure onset [11]. (jle.com)

[ 7 ] More recent data from striatal neuronal cultures transfected with mutant huntingtin and transgenic mice carrying the spinocerebellar ataxia-1 (SCA-1) gene (another CAG repeat disorder) suggest that NIIs may not be necessary or sufficient to cause neuronal cell death, but translocation into the nucleus is sufficient to cause neuronal cell death. (medscape.com)

During neuronal development, the formation of the axon is the initial step in breaking cellular symmetry and the establishment of neuronal polarity. (uni-muenchen.de)

The fundamental biological importance of rewards has created an increasing interest in the neuronal processing of reward information. (nature.com)
He uses a range of approaches, including synthetic biology, nanotechnology, chemistry, electrical engineering, and optics to develop tools capable of revealing fundamental mechanisms underlying complex brain processes. (mit.edu)

The extent of gross striatal pathology, neuronal loss, and gliosis provides a basis for grading the severity of HD pathology (grades 0-4). (medscape.com)

This polarized distribution of microtubule stability was confirmed by testing the resistance of neuronal microtubules to pharmacologically induced depolymerization. (uni-muenchen.de)

Mutations affecting zipcodes, RBPs or motor-proteins required for neuronal mRNA localization were shown to lead to severe neurodegenerative diseases as ALS, FXTAS and FXS (7), underlining the need to understand the mechanisms that drive neuronal mRNA transport. (europa.eu)
Apo E proteins influence beta-amyloid deposition, cytoskeletal integrity, and efficiency of neuronal repair. (msdmanuals.com)

However, the cellular signaling process upon which hang acts remains unclear, and how the broadly expressed hang protein mediates specific behavioral changes in response to global increases of cellular stressors such as ethanol remains an open question (Ruppert, 2017). (sdbonline.org)

Since ictogenesis and cognition are both mediated by neuronal excitability, it may not be possible to discover optimal non-impairing AEDs using traditional screens. (jle.com)

Identify the different processes and stages that occur during animal development. (uaeu.ac.ae)
Understanding the underlying neuronal processes will not only be important for the further development of computer-based speech recognition. (sciencedaily.com)
The aim of this study was to identify the genes and pathways underlying the growth of the mouse sclera during postnatal development. (molvis.org)
Genes identified as involved in the main biologic processes during postnatal scleral development were further confirmed using qPCR. (molvis.org)
My research is focused on understanding the processes underlying midbrain dopaminergic (mDA) neuronal development using human embryonic stem cells (hESCs). (sloankettering.edu)
Abstract: The development of the brain is a highly complex process, involving various mechanisms on different spatial and temporal scales. (surrey.ac.uk)
Exploring the molecular processes regulating the development of cortical connectivity is thrilling, especially when they end up being so specific. (kcl.ac.uk)
Regardless of the specific neuronal processes underlying observed differences in volume, it is likely that this volumetric reduction from 5-25 years reflects the typical process that unfolds during development. (databasefootball.com)
Since the development of epilepsy is a multistep progressive process [12], there may be several mechanisms in addition to the neuronal excitability and hypersynchronization associated with the paroxysmal event that are susceptible to pharmacologic intervention. (jle.com)

This new method should also give scientists greater insight into the cell processes underlying neuronal activation and how water is involved in them. (cea.fr)
In neuronal cell lines, ethanol exposure reduces cyclic AMP (cAMP) levels, which results in cellular tolerance. (sdbonline.org)
Main emphasis of Epilepsy Center is to explore mechanisms underlying epileptogenesis, and develop gene- and cell-therapy based treatment strategies for epilepsy. (lu.se)
For gene therapy, a combinatorial approach with multiple target genes, as well as more complex optogenetic approaches are studied, while for cell-therapy human induced pluripotent stem cells and human induced neuronal cells are investigated. (lu.se)

The underlying network models are extremely robust to noise and cross-talk, making implementation feasible with weak signals and non-ideal components/connections. (lu.se)

To understand how cellular stress changes neuronal function, Hangover function was analyzed on a cellular and neuronal level. (sdbonline.org)
A Hang-related protein, ZNF699, is associated with alcoholism in humans (Riley, 2006), supporting the idea that a cellular stress mechanism underlying ethanol tolerance is evolutionarily conserved between humans and D. melanogaster. (sdbonline.org)

Abnormal protein synthesis in synapses is a core mechanism underlying ASD. (kcl.ac.uk)
NBI-98854 is a novel, highly selective inhibitor of the vesicular monoamine transporter 2 (VMAT2) protein that modulates neuronal dopamine levels. (medscape.com)

Acute neuroinflammation is generally caused by some neuronal injury after which microglia migrate to the injured site engulfing dead cells and debris. (wikipedia.org)
There are a number of proteases that possess the potential to degrade both the extracellular matrix and neuronal cells that are in the neighborhood of the microglia releasing these compounds. (wikipedia.org)

An increased understanding of the relationship between transposons and pathological processes in the brain will result in novel diagnostic tools and therapeutic approaches for neurodegenerative disorders. (lu.se)

Moreover, reduced volume resulted from the typical process likely relates to observed gains in performance over age, perhaps reflecting a higher efficiency of cognitive processes. (databasefootball.com)

Learning in neuronal networks has developed in many directions, in particular to reproduce cognitive tasks like image recognition and speech processing. (plos.org)
Gilson M, Dahmen D, Moreno-Bote R, Insabato A, Helias M (2020) The covariance perceptron: A new paradigm for classification and processing of time series in recurrent neuronal networks. (plos.org)
This process goes hand in hand with advancements in the theory of neuronal networks and increasing availability of detailed anatomical data on brain connectivity. (frontiersin.org)
The implantable electrodes will be used to establish stable high-fidelity communication between neuronal networks in the central nervous system and computers for research and therapeutic purposes. (lu.se)
We also put a lot of effort in developing software to be able to analyze the enormous amount of data acquired from implanted electrodes and for computer assisted interaction with neuronal networks. (lu.se)

Next, we describe the close association that is observed between defective epigentic processes and impaired memory in several cognitive diseases. (benthamscience.com)

an open-source software framework for the configuration, execution, and analysis of benchmarks for neuronal network simulations. (frontiersin.org)
For spiking neuronal network simulators, such applications are simulations of network models which have proven to be of relevance for the field. (frontiersin.org)

Neurologists, neurosurgeons, neurophysiologists, brain imaging specialists, neuropathologists and basic researchers are all contributing to the process of achieving the common goal. (lu.se)

It also attempts to place the processing of drug rewards within a general framework of neuronal reward mechanisms. (nature.com)

The brain structures involved in the processing of natural rewards also seem to be the critical structures for the action of drugs of abuse. (nature.com)

Nevertheless, there is some evidence from functional [ 12 - 14 ] and biochemical studies [ 15 ] that the process of conversion from nondemented to clinically evident demented state is not so linear. (hindawi.com)

In a recent study, the neuroscientist from Dresden and her team discovered another building block in the mystery of human speech processing. (sciencedaily.com)
The original MNIST dataset underlying the results presented in the study are available from http://yann.lecun.com/exdb/mnist/ . (plos.org)
The goal of this study is to improve the yield of A9 mDA neuronal subtype that is highly susceptible to degeneration in Parkinson's (PD) patients. (sloankettering.edu)
6) We study membrane trafficking in myelin formation and how changes to this process lead to immune disorders. (uhnresearch.ca)
The Kinect 3 study involved 234 patients with moderate to severe tardive dyskinesia with underlying schizophrenia, schizoaffective disorder , bipolar disorder , or major depressive disorder. (medscape.com)

Anatomy62

Organisms16

Diseases19

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology8

Phenomena and Processes48

Disciplines and Occupations2

Information Science3

Health Care1

Plasticity4

Neurons14

Averaging neuronal activity1

Physiological5

Selective neuronal1

Alterations8

Responses6

Embryonic development2

Molecular mechanisms4

Apoptosis5

Outgrowth4

Circuitry2

Synaptic1

Modulation3

Understood5

Cortex7

Activity8

Inclusions1

Computations1

Neural3

Migration3

Memory traces1

Phenotypes1

Hippocampal1

Populations2

Cytoplasmic1

Glial1

Underlie1

Microtubule dynamics4

Mechanisms related1

Seizures2

Mice1

Symmetry1

Fundamental2

Pathology1

Microtubules1

Proteins2

Behavioral1

Cognition1

Development9

Cell4

Robust1

Cellular2

Protein2

Microglia2

Neurodegenerative1

Cognitive processes1

Networks5

Diseases1

Simulations2

Researchers1

Framework1

Brain structures1

Evidence1

Study5