Processes iqgap1. Medical search. Frequent questions

Ras GTPase-activating-like protein IQGAP1. (embl.de)

The G protein-coupled LPA] receptor has been implicated in breast cancer metastasis although the molecular mechanisms underlying this process are largely unknown. (uwo.ca)
In the current study, investigators examined a protein called IQGAP1, well-known for its role in regulating a wide range of cellular processes. (northwestern.edu)
If scientists could modify LBRC via the IQGAP1 protein, Muller said, it may represent a way to fine-tune inflammation without disturbing other processes in the body. (northwestern.edu)
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
For confirmation of gene expression, protein levels of both IQGAP1 and P53 were measured by western blot analysis, which showed that diethylnitrosamine enhanced protein expression of IQGAP1 and diminished that of p53. (waocp.org)

Many cellular processes including cell division and cell migration require coordination between the actin and microtubule (MT) cytoskeletons. (umn.edu)
Unbiased proteomic/transcriptomic analyses of mouse keratinocytes expressing MmuPV1 E6 substantiated its effect on these cellular processes and divulged that some of these effects may be mediated in part through it upregulating E2F activity. (bvsalud.org)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (microarraystation.com)

Additionally, P-arrestin2 and IQGAP1 associate in response to LPA and IQGAP1 knockdown blocks breast cancer invasion. (uwo.ca)

This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)

The finding that activation of G12 proteins promotes cancer cell migration and invasion has highlighted the need to understand the biologic processes underlying this phenomenon. (biomedcentral.com)

Original methods of prioritization took into account the overrepresented Gene Ontology biological processes, the centrality of vertices in the associative gene network, describing the interactions of endothelial apoptosis genes with genes associated with lymphedema, and the association of the analyzed genes with diseases that are comorbid to lymphedema. (biomedcentral.com)
Analysis of interactions of these genes in the associative gene network of lymphedema can improve understanding of mechanisms of interaction between endothelial apoptosis and lymphangiogenesis, and shed light on the role of disturbance of these processes in the development of edema, chronic inflammation and connective tissue transformation during the progression of the disease. (biomedcentral.com)
Results: Our results show that the expression of mRNA of IQGAP1, TRAIL decoy receptors, NF-κB, and IL-8 genes was elevated in hepatocellular carcinoma, as compared to normal liver tissue, while their expression was further up-regulated by increasing the dose of diethylnitrosamine. (waocp.org)

We found that Rapl interacts with the multi-functional scaffolding proteins P-arrestin2 and IQGAP1 that are critical regulators breast cancer cell invasiveness. (uwo.ca)
Thus, our data suggests a novel mechanism by which LPA regulates breast cancer cell invasiveness via Rapl, P-arrestin2, and IQGAP1. (uwo.ca)
Electron microscopy typically shows fusion of epithelial cell foot processes, or so-called foot process effacement. (biomedcentral.com)
Upregulation of Tβ 4 by cDNA-mediated transfection was found to cause actin depolymerization in fibroblast cells ( 1 ), which demonstrated that the modulation of Tβ 4 affected the polymerization state of actin cytoskeleton, as well as other cell processes associated with the organization of actin cytoskeleton, such as cell migration. (spandidos-publications.com)

This process is crucial for the body's inflammatory response, and the ability to modify that response could help treat a variety of conditions, according to William Muller, MD, PhD , professor of Pathology and senior author of the study. (northwestern.edu)

You wouldn't want to target IQGAP1 or calcium signaling all throughout the body because that would probably be incompatible with life," Muller said. (northwestern.edu)

These data suggest that PKC may regulate interactions of EWS and other RNA-binding proteins with their RNA targets and that IQ domains may provide a regulatory link between Ca2+ signal transduction pathways and RNA processing. (embl.de)

These studies confirm and extend findings that secreted factors contribute to the oncogenic potential of G12 signaling, and suggest potential therapeutic targets to control this process. (biomedcentral.com)

We are committed to providing you with products and processes that make it easy for you to focus on results. (vwr.com)

Mitochondria dynamically change their morphology via fusion and fission, a process called mitochondrial dynamics. (biomed.news)

Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). (novusbio.com)

These effects of Cdk5 inhibition or suppression were accompanied by decreased Rac activity, increased Rho activity, and enhanced binding of E-cadherin to the Rac effector Ras GTPase-activating-like protein (IQGAP1). (molvis.org)
Phospho-PKC-α also signals the GTPase activating-like protein IQGAP1 to dissociate β-catenin from adherens junctions to promote F-actin polymerization beneath the bound bacteria and promotes invasion through active actin remodeling [7-11]. (research-in-field.com)

We analized the expression of the scaffold proteins IQGAP1, FKBP51 and AmotL2 and the Na,K-ATPase α and β subunits in colorectal cancer and liver metastases after the administration of oxaliplatin-based chemotherapy. (ull.es)

Therefore, we propose that IQGAP1 acts as a small GTPase scaffolding platform within the small GTPase network, and recruits and/or regulates small GTPases, small GTPase regulators and effectors to orchestrate cell behavior. (abo.fi)
By interacting with these binding partners, IQGAP1 regulates multiple cellular processes, such as signaling by MAPK, cAMP and Ca2+, phagocytosis, cardiac remodelling and exocytosis. (nih.gov)

Ca2+ is a versatile intracellular signaling molecule that modulates diverse cellular processes. (nih.gov)
Additionally, lysosomal calcium plays a role in membrane fusion and fission events involved in cellular processes such as endocytic maturation, autophagosome-lysosome fusion, lysosomal exocytosis, and lysosomal reformation upon autophagy completion. (biomed.news)
Identifications of the dys-regulated or perturbed miRNAs and their key target genes are important for understanding the regulatory networks associated with the studied cellular processes. (biomedcentral.com)

Role of IQGAP1 in Microbial Pathogenesis. (nih.gov)
Studies elucidating the molecular mechanisms by which Salmonella usurps IQGAP1 function and exploring the possible participation of IQGAP1 in the pathogenesis of other microbes are in progress. (nih.gov)

1. Regulation of extracellular matrix degradation and metastatic spread by IQGAP1 through endothelin-1 receptor signalling in ovarian cancer. (nih.gov)
2. hMENA is a key regulator in endothelin-1/β-arrestin1-induced invadopodial function and metastatic process. (nih.gov)
The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. (springermedicine.com)

Autophagy is a dynamic process in which the eukaryotic cells break down intracellular components by lysosomal degradation. (biomed.news)
Autophagy is a general term for the process of the lysosomal degradation of intracellular components, a process occurring exclusively in eukaryotic cells. (biomed.news)

ATG9A interacts with IQGAP1 and the ESCRT machinery in membrane remodeling. (wikipedia.org)
This study proved that LGR5, which is highly expressed in breast cancer cells, interacts with IQGAP1 through its C-terminal end, reducing the phosphorylation ratio of IQGAP1, thereby improving the viability, migration and invasion ability of breast cancer cells, and ultimately increasing the malignant transformation rate of breast cancer. (researcherslinks.com)
OmpA interacts with its receptor PIK-75 endothelial cell glycoprotein 96 (Ecgp96) to invade the human brain microvascular endothelial cells (HBMEC) an model of the BBB [3 4 The molecular events and signaling mechanisms underlying this conversation that aid in the invasion process are well-characterized. (research-in-field.com)

Here, using several approaches including binding analysis with fusion proteins, siRNA-mediated gene silencing, RT-PCR, and knockout mice, we investigated whether IQGAP1 modulates AMPK signaling. (nih.gov)

In addition, we demonstrate that IQGAP1 promotes Arf6 activation downstream of β1 integrin engagement. (abo.fi)
We documented that IQGAP1 promotes cell motility and enhances tumorigenesis of human breast epithelial cells. (nih.gov)

We showed that IQGAP1 is overexpressed in HER2-positive breast cancer and knockdown of IQGAP1 decreases HER2 expression, signaling, HER2-stimulated cell proliferation and ameliorates resistance to tratuzumab. (nih.gov)
Interestingly, Salmonella entry into host cells was significantly increased and decreased by IQGAP1 knockdown and overexpression, respectively. (nih.gov)

My laboratory is presently investigating the IQGAP1-mediated mechanisms by which Salmonella subverts the actin cytoskeleton to establish infection. (nih.gov)
Recent work implicates the participation of IQGAP1 in metabolic function, but the molecular mechanisms underlying these effects are poorly understood. (nih.gov)
Identifications of the perturbed miRNAs regulatory networks are important for understanding the molecular mechanisms of the studied biological processes. (biomedcentral.com)

We observed that IQGAP1 is a component of the cytoskeletal rearrangements by which Salmonella enters cells. (nih.gov)

Expression of LGR5 and phosphorylation ratio of IQGAP1 showed opposite trends in breast cancer and normal body. (researcherslinks.com)
Viability, migration and invasion ability of breast cancer cells were all affected by LGR5 expression and IQGAP1 phosphorylation ratio. (researcherslinks.com)
LGR5 affected IQGAP1 phosphorylation process by linking to IQGAP1 through its own C-terminus. (researcherslinks.com)
Because phosphorylation is a dynamic process difficult to quantify, we must at first acquire an inventory of phosphoproteins and characterize their phosphorylation sites. (biomedcentral.com)

In addition, nucleic acid constructs can be designed with tunable levels of flexibility, PF-06250112 biocompatibility, bioactivity and biodegradability, and fabricated to respond to numerous PF-06250112 environmental cues such as temp, pH, ionic strength, cell signaling, and degradation processes [1, 2]. (bso14.org)

Calmodulin alters the binding of all IQGAP1 target proteins that have been evaluated, thereby modulating cell function. (nih.gov)
Currently, we are identifying other IQGAP1-binding proteins that are expressed at altered levels in carcinoma and are studying their roles in tumorigenesis. (nih.gov)
These data suggest that PKC may regulate interactions of EWS and other RNA-binding proteins with their RNA targets and that IQ domains may provide a regulatory link between Ca2+ signal transduction pathways and RNA processing. (embl-heidelberg.de)

In vitro analysis reveals that IQGAP1 binds directly to the α1 subunit of AMPK. (nih.gov)
In vitro , knock-down of IQGAP1 favoured the acquisition of a mesenchymal phenotype and CSC-like properties induced by H. pylori infection. (oncotarget.com)

GPCRs mediate a vast variety of critical biological processes ranging from proliferation and motility to cellular reception and excitability. (ufl.edu)

RESULTS: Differentially expressed genes were mainly concentrated in the biological process of cell-cell adhesion. (bvsalud.org)

Lysosomal calcium is not only acting as a positive regulator of autophagy, but it is also responsible for turning-off this process through the reactivation of the mTOR kinase during prolonged starvation. (biomed.news)

GPCR signaling pathways are of particular importance for the nervous system function where they control many fundamental processes including excitability, differentiation, sensory perception, and synaptic transmission. (ufl.edu)

IQGAP1: insights into the function of a molecular puppeteer. (nancynausullivan.com)

In addition, we observed a direct interaction between IQGAP1 and CaMKK2, which is mediated by the IQ domain of IQGAP1. (nih.gov)
19. The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. (nih.gov)

Six days after tumor injection, when the xenograft grew to approximately 100 AZD-3965 mm3, the mice were divided randomly into IQGAP1 four groups: a negative control group, which was to be treated with PBS (n? (nonamimaho.com)
In mice, IQGAP1 deficiency leads to gastric hyperplasia. (oncotarget.com)
Transgenic mice deleted for iqgap1 and WT littermates were infected with Helicobacter sp. (oncotarget.com)
After one year of infection, iqgap1 +/- mice developed more preneoplastic lesions and up to 8 times more gastro-intestinal neoplasia (GIN) than WT littermates. (oncotarget.com)

The aim of this study was to elucidate the consequences of IQGAP1 deletion on H. pylori -induced gastric carcinogenesis. (oncotarget.com)
IQGAP1 and E-cadherin expression was evaluated in gastric tissues and in gastric epithelial cell lines in response to H. pylori infection. (oncotarget.com)
The consequences of IQGAP1 deletion on gastric epithelial cell behaviour and on the acquisition of cancer stem cell (CSC)-like properties were evaluated. (oncotarget.com)
Our results indicate that alterations in IQGAP1 signalling promote the emergence of CSCs and gastric adenocarcinoma development in the context of an H. pylori infection. (oncotarget.com)

[ 95 ] Effectors can be involved in several, sometimes unrelated, processes at different time-points of infection. (medscape.com)
H. pylori infection induced IQGAP1 and E-cadherin delocalization from cell-cell junctions. (oncotarget.com)

It is a useful approach to infer the perturbed miRNAs and their key target genes associated with the studied biological processes using gene expression data. (biomedcentral.com)
To date, many miRNAs and their target genes have been found to play important roles in various biological processes. (biomedcentral.com)

Coordination of the activity of multiple small GTPases is required for the regulation of many physiological processes, including cell migration. (abo.fi)
To date, at least more than 200 different types of post translational modifications (PTM) have been identified of which only a few are reversible and important for the regulation of biological processes. (biomedcentral.com)

He studies IQGAP1 - Cancer, cell signaling, and normal function of cell homeostasis. (wisc.edu)

Shigella is able to move within and spread between cells by assembling actin at the pole of the bacterium, a process that generates force. (massgeneral.org)

Western blot was used to analyze the expression of LGR5 and (phosphorylated IQGAP1)/(IQGAP1). (researcherslinks.com)
These DEGs were uploaded to the DAVID online analysis platform to analyze biological processes for which they were enriched. (bvsalud.org)

Both CaMKK2 and AMPK associate with IQGAP1 in cells. (nih.gov)
Enteropathogenic Escherichia coli (EPEC) also usurps IQGAP1 to infect host cells. (nih.gov)
Cancer cells undergo a renewal process to escape immune surveillance and then attack the immune system. (bvsalud.org)

and other non-autophagy membrane remodeling processes such as plasma membrane repair. (wikipedia.org)

GPCRs regulate different biological and pathophysiological processes. (usherbrooke.ca)

The majority of mechanistic studies have been conducted in IQGAP1 the cellular level and show DNA-built carriers primarily interact with scavenger receptors [5, 6]. (bso14.org)

The relative expression levels of LGR5 and phosphorylated IQGAP1 were detected by Western blot. (researcherslinks.com)

IQGAP1 is a key node within the small GTPase network. (abo.fi)

Anatomy23

Organisms5

Diseases6

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes30

Disciplines and Occupations2

Information Science2

GTPase1

Protein5

Cellular3

Additionally1

Differentiation2

Invasion1

Genes3

Cell4

Author1

Target1

Data1

Control1

Products1

Fusion1

Family1

Gtpase-activating-like Pro2

Scaffold1

Regulates2

Cellular processes3

Pathogenesis2

Metastatic3

Intracellular2

Interacts3

Modulates1

Promotes2

Knockdown2

Mechanisms3

Salmonella1

Phosphorylation4

Degradation1

Proteins3

Vitro2

Proliferation1

Expressed genes1

Regulator1

Pathways1

Molecular1

Interaction2

Mice4

Gastric4

Infection2

MiRNAs2

Regulation2

Function1

Actin1

Analyze2

Cells3

Membrane1

GPCRs1

Studies1

Expression levels1

Network1