• IMs are found in the space between the tissue stroma cells and contain, among other components, fibrillar collagens and fibronectin. (nature.com)
  • Extracellular matrix is a fibrillar network composed of structural (collagens) and adhesion (fibronectin) proteins crucial for tissue architecture and biological pathway Histol Histopathol 27:1515-1528, 2012 . (springer.com)
  • This fibrillar network is composed of many structural proteins, such as collagens, and adhesion proteins, including fibronectin and proteoglycans (perlecan, decorin) [ 13 , 14 ]. (springer.com)
  • Collagens are crucial for the ECM architecture and particularly collagen I, III and VI are key components in animal tissues. (springer.com)
  • ECM components (i.e., fibronectin or collagens) directly interact with membrane receptors (i.e., integrins), particularly, by influencing cell behavior. (springer.com)
  • Matrix Metalloproteases (MMPs) are zinc-dependent endopeptidases, which degrade mainly components of the extracellular matrix (ECM) such as collagens, fibronectins and laminins, but also proteins responsible for adhesion such as integrins or even other MMPs and are thus a crucial factor for the capability of primary macrophages to detach and migrate through various tissues. (uni-hamburg.de)
  • MECs synthesize key extracellular matrix (ECM) proteins of the meninges such as various collagens, as well as fibronectin, laminin and tenascin, important for pia basal lamina integrity and thus for neuronal support and function [ 7 ]. (biomedcentral.com)
  • Collagenases degrade triple-helical fibrillar collagens, which are the main components of bone and cartilage. (periobasics.com)
  • Stromelysins [MMP-3, MMP-10, MMP-11, and MMP-7 (also known as matrilysins)] are small proteases that degrade components of the ECM, although not the triple-helical fibrillar collagens. (periobasics.com)
  • Extracellular Matrix (ECM) is a complex 3D-network of proteins and polypeptides and an essential component of the islet cell basement membrane (BM). (brighton.ac.uk)
  • Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)
  • however, in the corneal stroma, excessive infiltration of monocytes/macrophages is considered to be unfavorable because they secrete matrix metalloproteinases (MMPs) and other proteins undesirable for tissue healing. (medscape.com)
  • It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)
  • Our findings included a significant class of proteoglycans not previously associated with lymphomas as well as significant modulation of genes that code for extracellular matrix-associated proteins. (fortunepublish.com)
  • To acquire a comprehensive understanding of the biological functions of the matrisome and its components, including proteoglycans and glycosaminoglycans (GAGs), in GBM tumorigenesis, and to identify potential biomarker candidates, we studied the alterations of GAGs, including heparan sulfate (HS) and chondroitin sulfate (CS), the core proteins of proteoglycans, and other glycosylated matrisomal proteins in GBM subtypes vs. control human brain tissue samples. (bu.edu)
  • To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)
  • The research themes rank around molecular mechanisms matrix proteins and fibers exert in disorders affecting blood vessels, bone, skin and adipose tissue. (mcgill.ca)
  • We are interested how extracellular matrix proteins instruct cells to differentiate, migrate, and proliferate, and how cells sense normal and pathologically altered extracellular matrix. (mcgill.ca)
  • Engineered constructs were compared to human SAS and assessed for specific cell-cell interaction markers as well as for extracellular matrix proteins found in human meninges. (biomedcentral.com)
  • They stained positively for specific cell-cell interaction markers indicative of a functional meningeal tissue, as well as extracellular matrix proteins found in human meninges. (biomedcentral.com)
  • We designed a medium throughput approach to systematically test for interactions between these pneumococcal surface proteins and host proteins (extracellular matrix proteins, circulating proteins or immunity related proteins). (biomedcentral.com)
  • It now appears clearly that cell-surface proteins participate in many stages of the colonization process and/or the disease transition. (biomedcentral.com)
  • However, during injury, the equilibrium between production and degradation of fibrous tissue is disrupted leading to excessive deposition of extracellular matrix proteins resulting in fibrosis. (pancreapedia.org)
  • The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)
  • Flow-induced NF-κB activation is downstream of conformational activation of integrins, resulting in new integrin binding to the subendothelial extracellular matrix and signaling. (rupress.org)
  • The alterations observed in the expression of ECM components (Fibronectin, Laminin, Collagen IV), integrin receptors (VLA-4, VLA-6), chemokines (CXCL12, CCL25, CCL21) and their receptors (CXCR4, CCR7, CCR9) and in vitro transwell assays on the capacity of migration of WT and mutant thymocytes suggest that the lack of EphA4 alters T-cell differentiation by presumably affecting cell adhesion between TECs and T-TEC interactions rather than by thymocyte migration. (bvsalud.org)
  • Matrix metalloproteinases (MMPs) are involved in the degradation of protein components of the extracellular matrix and thus play an important role in tumor invasion and metastasis. (biomedcentral.com)
  • Degradation of the extracellular matrix allows tumor cells to detach from the primary tumor mass, invade local tissue, intravasate, extravasate and build new metastatic formations [ 1 ]. (biomedcentral.com)
  • MMPs are proteolytic enzymes highly specialized in the degradation of ECM component [ 15 , 16 ] and each member of the MMP family is specifically involved in degradation of one or several ECM components. (springer.com)
  • A persistent epithelial defect allows the corneal stroma to be exposed to the external environment and permits the process of stromal degradation. (medscape.com)
  • Degradation of matrix is a key event in progression, invasion and metastasis of potentially malignant and malignant lesions of the head and neck. (biomedcentral.com)
  • Snail a zinc-finger transcription factor has been found to regulate epithelial mesenchymal transition in part by increasing extracellular matrix degradation via upregulation of matrix metalloproteinase (2). (crispr-reagents.com)
  • Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)
  • pathophysiology mesangial expansion is not limited to the matrix but includes mesangial cell proliferation and accumulation of bonemarrow-derived macrophages.3 Proliferation of mesangial cells, accumulation of extracellular matrix, and infiltration by macrophages are interrelated. (docksci.com)
  • Acidosis of the bone microenvironment results in increased osteoclast resorption pit formation via the release of proteolytic enzymes such as Cathepsins B D and L which degrade the extracellular matrix and facilitate metastasis (5). (crispr-reagents.com)
  • Procathepsin L and processed mature CatL can degrade laminin and fibronectin extracellular matrices (19) while CatL can also degrade collagen (20). (crispr-reagents.com)
  • MMPs are able to degrade practically all ECM components and can be classified according to their substrate specificity as collagenases, gelatinases, stromelysins, and matrilysins 6 (Figure 10.2). (periobasics.com)
  • We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
  • Expression of isoforms 1-3 of TGFβ cytokine is influenced by tagging polymorphisms in the TGFβ1, TGFβ2 and TGFβ3 gene, and these SNPs may be associated with the risk of asthma development and severity as well as with other diseases. (researchsquare.com)
  • 2022). Fibronectin isoforms in skeletal development and associated disorders. (mcgill.ca)
  • Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
  • Thus, PIs-ECM expression, localization and remodelling was analysed pre-and post-enzymatic digestion using qRT-PCR (for gene expression), western blotting (for protein expression) and immunocytochemistry (for cellular localization) techniques. (brighton.ac.uk)
  • Also, qRT-PCR gene analysis and immunoblotting of protein content of PIs detected alterations in ECM expression levels. (brighton.ac.uk)
  • Group A Streptococcus (GAS), a β-haemolytic human pathogen, expresses a NEAT protein, Shr, which binds several haemoproteins and extracellular matrix (ECM) components. (tcdb.org)
  • Die Abhängigkeit der Protein Expression von „soluble MMPs" von der pro- oder antiinflammatorischen Polarisation ist ein wichtiger Aspekt in Krankheiten, in dem sich diese von MT1-MMP - einem konstitutiv exprimierten MMP in Makrophagen - unterscheiden. (uni-hamburg.de)
  • TGF-β2 treatment upregulated the expression of Col1α1, Col4α2, FN, CTGF, TGM2, and TSP-1 mRNA and protein in cultured astrocytes. (arvojournals.org)
  • TGF-β2 is capable of inducing the expression of ECM and basement membrane components in cultured ONH astrocytes via CTGF and upregulated TSP-1, a protein naturally involved in the activation of latent TGF-β. (arvojournals.org)
  • The mRNA expression of MMP-2 and MMP-9 was determined by reverse transcription-polymerase chain reaction, and the protein expression of MMP-2 and MMP-9 by gelatin zymography analysis and qualified by the gel electrophoresis image analysis in different HA concentrations. (molvis.org)
  • We investigated the effects of different level of HA concentrations on mRNA and protein expressions of MMP-2 and MMP-9 in cultured trabecular meshwork cells using reverse transcription-polymerase chain reaction (RT-PCR) method and gelatin zymography analysis. (molvis.org)
  • Little attention, however, has been paid to glycosylation of the ECM components that constitute the majority of glycosylated protein mass and presumed biological properties. (bu.edu)
  • The expression of recombinant human COL4A1 protein includes the construction of the expression vector containing the recombinant DNA and the transformation of the expression vector into the E.coli, which provides a variety of macromolecules and components required for transcription and translation. (cusabio.com)
  • In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
  • The effect of CTGF silencing on the TGF-β2-modulated expression of these genes was investigated by transfection of CTGF small interfering (si)RNA before TGF-β2 treatment. (arvojournals.org)
  • Analysis by RNA sequencing revealed altered expression of genes associated with extracellular matrix remodeling, endo-lysosomal processing, and mitochondrial energy metabolism under pathophysiological flow conditions. (biomedcentral.com)
  • We aimed to identify differentially expressed genes (DEGs), the most critical hub genes, transcription factors, signaling pathways, and biological processes (BPs) associated with the pathogenesis of primary SGC. (genominfo.org)
  • NF-κB activation by fluid flow, leading to expression of target genes such as E-selectin, ICAM-1, and VCAM-1, may regulate early monocyte recruitment and fatty streak formation. (rupress.org)
  • TGFβ is a pleiotropic cytokine that regulates cell proliferation, contributes to epithelial-to-mesenchymal transition (EMT), suppresses the function of immune cells compromising immune response, contributes to the conversion of fibroblasts to myofibroblasts and causes overproduction of extracellular matrix (ECM) in tissues undergoing fibrosis. (researchsquare.com)
  • An understanding of the pathophysiology of sterile corneal ulceration requires a review of the processes involved in epithelial and stromal wound healing, as well as an examination of the role of precorneal tear film, corneal nerves, proteolytic enzymes, and cytokines. (medscape.com)
  • These processes are facilitated by a phenotypic change among quiescent keratocytes to become active myofibroblasts, a task mediated by transforming growth factor-beta (of presumptive epithelial origin). (medscape.com)
  • Introduction The primary cause of prostate and breast cancer death is usually metastasis which is regulated by signaling pathways such as epithelial mesenchymal transition a dynamic process that promotes cell motility with decreased adhesive ability (1). (crispr-reagents.com)
  • In the present study, we reevaluate the lymphoid, epithelial, and extracellular matrix (ECM) phenotype of EphA4-/- mice grouped into three categories with respect to their proportions of DP thymocytes. (bvsalud.org)
  • In this study we investigated the expression pattern of the 23 MMPs, currently known in humans, in different gynecological cancer cell lines. (biomedcentral.com)
  • The expression of MMPs was analyzed by RT-PCR, Western blot and gelatin zymography. (biomedcentral.com)
  • While the three cervical cancer cell lines expressed 10-14 different MMPs, the median expression in endometrial and choriocarcinoma cells was 7 different enzymes. (biomedcentral.com)
  • MMPs are zinc dependent proteases which are capable of degrading one or more components of the extracellular matrix. (biomedcentral.com)
  • Under physiological conditions, expression of MMPs is tightly regulated on an mRNA level (transcription), e.g. activation of MMPs and inhibition of active MMPs by TIMPs (tissue inhibitors of MMPs). (biomedcentral.com)
  • Matrix-Metalloproteasen (MMPs) sind zinkabhängige Endopeptidasen, die vor allem Bestandteile der extrazellulären Matrix (EZM) wie Kollagene, Fibronektine und Laminine, aber auch für die Adhäsion verantwortliche Proteine wie Integrine oder auch andere MMPs proteolytisch spalten und damit ein entscheidender Faktor für die Fähigkeit primärer Makrophagen sind, sich abzulösen und durch verschiedene Gewebe zu wandern. (uni-hamburg.de)
  • Tissue inhibitors of matrix metallo-proteinases (TIMPs) are known to have the ability to inhibit the catalytic activity of MMPs. (biomedcentral.com)
  • Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)
  • The structural organization of all MMPs presents a prepeptide sequence that directs their secretion in the extracellular environment and a propeptide domain that maintains them in their zymogenic form. (periobasics.com)
  • In addition to connective tissue and ECM components, proteinase inhibitors such as α1-proteinase inhibitor, antithrombin-III and α2-macroglobulin are selectively cleaved by MMPs. (periobasics.com)
  • While some islet BM components are produced by endothelial cells (ECs), the source of others remains unknown. (nature.com)
  • Whereas endothelial cells plated on fibronectin or fibrinogen activate NF-κB in response to flow, cells on collagen or laminin do not. (rupress.org)
  • Ongoing inflammation, airway injury, and healing are part of the remodeling process in asthma and perhaps lead to disordered repair and fibrosis as a consequence. (atsjournals.org)
  • In addition to providing biomechanical support to the islets, ECM components are required for β-cell development, proliferation, survival, and proper insulin secretion. (nature.com)
  • Thus any modification of ECM components can be transmitted via integrins and impact on cell movement during development and proliferation, differentiation, apoptosis. (springer.com)
  • Sufficient dietary supply of calcium (Ca) and phosphorus (P) is essential for all vertebrates to ensure various biological processes including bone formation, blood clotting, cell proliferation and energy metabolism. (biomedcentral.com)
  • This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
  • In vivo, fibronectin and fibrinogen are deposited at atherosclerosis-prone sites before other signs of atherosclerosis. (rupress.org)
  • Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. (tamu.edu)
  • The interactions with the various BM components differentially affect β-cells, although the underlying mechanism is largely unknown. (nature.com)
  • The enzymatic isolation process disrupts islet cell membranes, damages cell-to-cell interactions and inhibits vital functions. (brighton.ac.uk)
  • Mammalian epithelia are critically dependent on interactions with components in the underlying basal lamina for proper morphogenesis and function. (embl.de)
  • It is influenced by angiogenesis, cell-cell and cell-extra cellular matrix (ECM) interactions. (biomedcentral.com)
  • The dynamics of cell-extracellular matrix interactions in normal and pathological situations. (mcgill.ca)
  • The Reinhardt laboratory is interested in components and mechanisms involved in the biogenesis, function and pathological aspects of the extracellular matrix and its interactions with cells. (mcgill.ca)
  • Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)
  • Matrix metalloproteinase are a family of zinc dependent endopeptidases that are capable of degrading most components of the extra cellular matrix (ECM) [ 7 - 9 ]. (biomedcentral.com)
  • His expression promotes invasion and metastasis of murine and human melanoma cells and human breast cancer cells. (wikipedia.org)
  • Degeneration of matrix is a key event in invasion and metastasis of malignant lesions of the head and neck. (biomedcentral.com)
  • To develop new and effective chemopreventive agents against bone metastasis we assessed the effects of muscadine grape skin extract (MSKE) whose main bioactive component is anthocyanin on bone turnover using prostate and breast malignancy cell models overexpressing Snail transcription factor. (crispr-reagents.com)
  • LN metastases have the potential to seed additional tissues and can induce metastatic tolerance, a process by which tumor-specific immune tolerance in LNs promotes further disease progression. (stanford.edu)
  • Moreover CatL expression was higher in prostate and breast tumor tissue compared to normal tissue. (crispr-reagents.com)
  • In this study we show that CatL expression increases with tumor grade in prostate and breast patient tissue. (crispr-reagents.com)
  • Their expression is related to the progression of gynecological cancers (e.g. endometrial, cervical or ovarian carcinoma). (biomedcentral.com)
  • The uncontrolled progression of these processes through a series of self-sustaining amplification loops can initiate unrestrained platelet activation and aggregation, and eventually lead to thromboembolic events ( 7 , 8 ). (spandidos-publications.com)
  • In addition, NT5E functions as an adhesion and signaling molecule and can regulate cellular signaling with extracellular matrix components such as fibronectin and laminin. (wikipedia.org)
  • Thus, we hypothesized that pericytes regulate β-cells through the production of BM components. (nature.com)
  • In health, PSCs are known to not only play a role in regulating normal extracellular matrix turnover but are also thought to have progenitor cell functions as well as a role in innate immunity. (pancreapedia.org)
  • In health, the process of fibrogenesis is a well-regulated dynamic process which is necessary for regular turnover of extracellular matrix (ECM) that allows remodeling and maintenance of normal pancreatic architecture. (pancreapedia.org)
  • The extracellular matrix is essential for the architecture of the tissue and a myriad of associated biological functions. (springer.com)
  • 1 2 In tissue culture experiments in trabecular meshwork (TM) cells, TGF-β2 augmented the synthesis of extracellular matrix (ECM) and its cross-linking by transglutaminases. (arvojournals.org)
  • The second morphological component of progressive renal destruction involves the extraglomerular interstitium.4 Careful morphometric studies of human kidney tissue have shown a striking correlation between the extent of renal dysfunction and the magnitude of tubulointerstitial disease.5,6 The main morphological expression of several disease processses, such as obstructive uropathy, analgesic abuse, and pyelonephritis, is in the tubulointerstitium. (docksci.com)
  • Within bone tissue, the use of nano-modified scaffolds is a promising alternative aiming to accelerate the repair process and to reestablish the height and volume of the bone lost. (bvsalud.org)
  • Hyaluronic acid (HA) is one of the major components of the ECM and may attribute to the filtration function of the trabecular meshwork. (molvis.org)
  • In some cases of lupus patients, adequate T cell expression of CD73 is missing, which shows an impaired regulatory function of T cells. (wikipedia.org)
  • Loss of the ECM during the islet isolation process is considered to be a significant factor in the poor engraftment rate of transplanted β-cells, thus limiting cell replacement therapy to diabetes 6 . (nature.com)
  • The initial aim was to study the biology of PIs within our controlled cell culture environment RCCS and then to investigate the effects of digestive enzymes on PIs-ECM contacts and to determine if the novel 3D- microgravity cell culture system could restore and enhance ECM expression. (brighton.ac.uk)
  • PIs digestion with collagenase-accutase enzyme was optimized such that cell viability was not affected but cellular stress and subsequent remodelling of ECM expression was achieved. (brighton.ac.uk)
  • This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
  • After the use of search strategies, 18 articles that describe processes of cell adhesion to bone grafts were selected. (bvsalud.org)
  • We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
  • Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
  • The SAS imposes a unique environment to its cellular component, the meningothelial cells (MECs) which are a key constituent of the dura mater and the leptomeninges (arachnoid and pia mater). (biomedcentral.com)
  • Alterations of these biological processes may not only interfere with critical MEC functions impacting CSF and hence optic nerve homeostasis, but may likely alter SAS structure, thereby further impeding cerebrospinal fluid flow. (biomedcentral.com)
  • Clearance of myelin debris by macrophages and microglia following demyelination is a crucial process to allow remyelination. (encyclopedia.pub)
  • MMP-2 and MMP-9 (also known as gelatinases based on their substrate preference) contain fibronectin-like domain repeats which aid in substrate binding. (periobasics.com)
  • This recovery of insulin secretory function was directly associated with increased ECM expression as demonstrated by enhanced cytoplasmic staining in the remodelled RCCS-cultured PIs. (brighton.ac.uk)
  • Immune suppressive functions of T regulatory cells are also dependent on CD73 expression. (wikipedia.org)
  • Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)
  • We believe that ECM interaction is an accurate biomarker for functional islets integrity and by maintaining high levels of its expression we hope to be able to improve islet cells graft function for current clinical islet transplantation programmes. (brighton.ac.uk)
  • We also used a machine learning approach to identify robust BCNHL biomarkers that include YES1, FERMT2, and FAM98B, which have not previously been associated with BCNHL in the literature, but together provide ~99.9% combined specificity and sensitivity for differentiating lymphoma cells from healthy B-cells based on measurement of transcript expression levels in B-cells. (fortunepublish.com)
  • This might be due to the fact that remyelination is a sophistically orchestrated process that calls for the interplay between oligodendrocyte lineage cells, neurons, central nervous system (CNS) resident innate immune cells, and peripheral immune infiltrates and that this process may somewhat differ in humans and rodent models used in research. (encyclopedia.pub)
  • Furthermore, altering the extracellular matrix to promote p38 activation in cells on fibronectin suppresses NF-κB activation, suggesting a novel therapeutic strategy for treating atherosclerosis. (rupress.org)
  • The development of isolation and culture methods for PSCs in 1998 helped to unravel the mechanisms involved in the process of pancreatic fibrogenesis (5, 11) and also helped researchers to investigate the functions of these cells both in health and disease. (pancreapedia.org)
  • The COL4A1-VEGFD fusion leads to production of mature VEGFD after proteolytic processing, which may act as an autocrine growth factor for tumour cells. (cusabio.com)
  • Defining the cells and proteinases responsible for destruction of lung extracellular matrix associated with cigarette smoking will be required for development of appropriate proteinase inhibitors for application in COPD. (atsjournals.org)
  • At the age of defect onset, GPR56 expression is restricted specifically to developing granule cells in the rostral cerebellum, suggesting that GPR56 regulates properties of these cells. (jneurosci.org)
  • These enzymes are expressed as zymogens, which are subsequently processed by other proteolytic enzymes (such as serine proteases, furin, plasmin, and others) to generate the active forms. (periobasics.com)
  • The role of macrophage proteinases in the development of emphysema, a major component of COPD, will be discussed. (atsjournals.org)
  • Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)
  • Extracellular matrix and vascular dynamics in the kidney of a murine model for Marfan syndrome. (mcgill.ca)
  • Here, we show that pericytes produce multiple components of the mouse pancreatic and islet interstitial and BM matrices. (nature.com)
  • Calcium (Ca) and phosphorus (P) are essential nutrients that are linked to a large array of biological processes. (biomedcentral.com)
  • No specific or efficient treatment exists for Alport syndrome, an X-linked hereditary disease caused by mutations in collagen type IV, a crucial component of the glomerular basement membrane. (hindawi.com)
  • Although these gross morphological changes have been characterized, the specific histopathologies underlying BFPP and the developmental processes affected by GPR56 mutations have remained unknown. (jneurosci.org)
  • The specific expression and distribution of the different BM components in the islets were yet to be fully characterized. (nature.com)
  • MSKE paederosidic acid decreased Snail and pSTAT3 expression and abrogated Snail-mediated CatL activity migration and invasion. (crispr-reagents.com)
  • Specific granule components are readily released in response to a variety of stimuli, and Liou and Campbell have shown that neutrophil migration in culture is associated with quantum release of primary granules ( 3 ). (atsjournals.org)