TestisSpermatogonial stem cellsMeioticSperm cellsTestesProteinGametogenesisTesticularSpermatogoniaHaploidSpermatogenicGermStem cellsHormonalMiceRegulationDifferentiationLeydigTestosterone productionMaturationSpermiogenesisPubertyChromosomeSpermatidsAdultDefectsEstablishmentOccursGrowthGametesDrosophilaOccurSeminiferousDevelopmentFertilizationHumansMetabolicInflammatoryMaleRoleEntire processComplexLarge
Testis7
- Spermatogenesis is the process by which haploid spermatozoa develop from germ cells in the seminiferous tubules of the testis. (wikipedia.org)
- Hemicastration is a unilateral orchiectomy to remove an injured testis, which can induce hormonal changes and compensatory hypertrophy of the remaining testis, and may influence spermatogenesis. (animbiosci.org)
- The genome-wide DNA methylation pattern of remaining testis suggested that substantial genes harbored differentially methylated regions (1,139) in gene bodies, which were enriched in process of protein binding and cell adhesion. (animbiosci.org)
- Nevertheless, the mechanism of compensatory response and the consequent influence on spermatogenesis in the remaining testis is still poorly understood. (animbiosci.org)
- The testis is responsible for the production of sperm through a process known as spermatogenesis. (proprofs.com)
- Chimento A, Sirianni R, Casaburi I, Pezzi V. Role of Estrogen Receptors and G Protein-Coupled Estrogen Receptor in Regulation of Hypothalamus-Pituitary-Testis Axis and Spermatogenesis. (scielo.br)
- Spermatogenesis in testis and ovotestis is rare given the high circulating estrogen levels. (medscape.com)
Spermatogonial stem cells2
- The seminiferous tubules of the testes are the starting point for the process, where spermatogonial stem cells adjacent to the inner tubule wall divide in a centripetal direction-beginning at the walls and proceeding into the innermost part, or lumen-to produce immature sperm. (wikipedia.org)
- This involves spermatogonial stem cells (SSCs) dividing to form undifferentiated spermatogonia (uSPGs), which then progress through the meiotic and haploid phases of spermatogenesis to form mature sperm ( de Rooij, 1998 ). (elifesciences.org)
Meiotic4
- Moreover, RNA-seq results indicated that 46 differentially expressed genes (DEGs) involved in meiotic cell cycle, synaptonemal complex assembly and spermatogenesis were upregulated in the hemicastration group, while 197 DEGs were downregulated, which were related to arachidonic acid metabolism. (animbiosci.org)
- Histology evaluation: Arrest of spermatogenesis predominantly at pachytene stage of meiotic prophase or meiotic division stage (see 1), some germ cells appear apoptotic (see 2). (jax.org)
- Histology evaluation: Arrest of spermatogenesis during late pachytene stage of meiotic prophase (see 1), some seminiferous tubules have only spermatogonia and Sertoli cells present (see 1), some germ cells appear apoptotic (see 2). (jax.org)
- Histology evaluation: Arrest of spermatogenesis during pachytene stage of meiotic prophase, some tubules are greatly depleted of germ cells (see 1). (jax.org)
Sperm cells4
- Independent research from Bruce Hay's lab at California Institute of Technology 3 and Hermann Steller's lab at Rockefeller University in New York 4 show caspases to be directly involved in Drosophila sperm individualization, the process during which spermatids differentiate and become single sperm cells. (the-scientist.com)
- During spermatogenesis, 64 individual sperm cells form within a cyst that was once a single cell. (the-scientist.com)
- Male sperm cells are constantly produced in large quantities in the testicles during so-called spermatogenesis. (innovations-report.com)
- In this process, the typical elongated sperm cells are formed from round germ cells. (innovations-report.com)
Testes4
- The location [Testes/Scrotum] is specifically important as the process of spermatogenesis requires a lower temperature to produce viable sperm, specifically 1°-8 °C lower than normal body temperature of 37 °C (98.6 °F). Clinically, small fluctuations in temperature such as from an athletic support strap, causes no impairment in sperm viability or count. (wikipedia.org)
- Morphological analysis of testes based on H&E staining showed that the spermatogenesis was observed normally in the breeding season of wild mice in the heavily contaminated area. (intechopen.com)
- In conclusion, even if the testes and the process of spermatogenesis are hypersensitive to radiation, we could not detect radiation effects on the spermatogenesis and Cs in the examined large Japanese field mice testes following chronic radiation exposure associated with the FDNPP accident. (intechopen.com)
- Transplantation experiments have revealed that most cells which can perform the hallmark feature of SSCs (that is, re-establishing full spermatogenesis in testes lacking germ cells) are found within the single uSPG population, but may also be present among paired and aligned progenitors ( Kubota and Brinster, 2018 ). (elifesciences.org)
Protein1
- Now, researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Unit "Life & Health" at the University of Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice. (innovations-report.com)
Gametogenesis2
- Thus, spermatogenesis is the male version of gametogenesis, of which the female equivalent is oogenesis. (wikipedia.org)
- The creation of oogonia traditionally doesn't belong to oogenesis proper, but, instead, to the common process of gametogenesis , which, in the female human, begins with the processes of folliculogenesis , oocytogenesis, and ootidogenesis . (wikipedia.org)
Testicular4
- Undifferentiated spermatogonia divide mitotically to both repopulate the testicular stem cell population and provide progenitor cells that undergo spermatogenesis. (jci.org)
- Testicular biopsies are necessary to examine cellular alterations in spermatogenesis changes in men, which is a limitation in this type of research. (nature.com)
- In cases of nonobstructive (secretory) azoospermia, on the other hand, testicular sperm production is blocked at different stages of the process of sperm formation (spermatogenesis). (wikipedia.org)
- These effects on testicular function have also been demonstrated: unilateral orchiectomy restored spermatogenesis in nonrelapsing testicular cancer cases after 1 year, even in patients exhibiting oligospermia or azoospermia [ 3 ]. (animbiosci.org)
Spermatogonia1
- Contrary to expectations, a fragment containing the entire region between the TBPH gene and the bgcn translational start drove strong HEG expression only during late spermatogenesis rather than in the germline stem cells and spermatogonia as expected. (plos.org)
Haploid1
- The process of germ cell development in plants, from the primordial PLANT GERM CELLS to the mature haploid PLANT GAMETES. (bvsalud.org)
Spermatogenic2
- In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave. (jci.org)
- The stages VII + VII indicate crucial processes in spermatogenic development like initiation of meiosis, initiation of spermatid elongation, and release of fully matured spermatids. (nature.com)
Germ1
- On the one hand, reactive oxygen species (ROS) are mandatory mediators for essential cellular functions including the function of germ cells (oocytes and spermatozoa) and thereby the fertilization process. (hindawi.com)
Stem cells1
- This process starts with the mitotic division of the stem cells located close to the basement membrane of the tubules. (wikipedia.org)
Hormonal2
- Obesity can affect spermatogenesis via several mechanisms and processes, among others via hormonal changes. (nature.com)
- 17 Explain the process of hormonal regulation of spermatogenesis. (jagranjosh.com)
Mice1
- From this point forward, the steps and cell types of spermatogenesis are conserved between mice and humans. (jci.org)
Regulation1
- DNA methylation and histone modification have been implicated in the regulation of this process. (wikipedia.org)
Differentiation2
- Previous work has identified three types of uSPGs - single, paired and aligned - which emerge during the first phase of the differentiation process. (elifesciences.org)
- All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)
Leydig2
- Piperine stimulates pubertal Leydig cell development by increasing Leydig cell number and promoting its maturation while it inhibits spermatogenesis in the rat. (frontiersin.org)
- In order to examine whether PIP affected spermatogenesis by interfering with Leydig cell testosterone production, in the current study we evaluated the effects of PIP on pubertal Leydig cell development. (frontiersin.org)
Testosterone production1
- Your regular i started using both drugs mildly stimulate gonadotropin and testosterone production and do not suppress spermatogenesis. (mamapundit.com)
Maturation1
- Diagram showing the reduction in number of the chromosomes in the process of maturation of the ovum . (wikipedia.org)
Spermiogenesis1
- The spermatids are transformed into spermatozoa (sperm) by the process of spermiogenesis. (wikipedia.org)
Puberty1
- In humans, each of these processes initiates at puberty and continues throughout life. (jci.org)
Chromosome1
- This phenomenon occurs during spermatogenesis, resulting in three copies of the chromosome 21. (bvsalud.org)
Spermatids1
- In those men in whom spermatogenesis is blocked at the stage of round spermatids, in which meiosis has already been completed, these round cells can successfully fertilize oocytes after being injected into their cytoplasm. (wikipedia.org)
Adult2
- Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm production. (jci.org)
- In our study, we aim to elucidate at which cellular level of adult spermatogenesis the detrimental effects of obesity manifest. (nature.com)
Defects2
- In humans, chromosomal abnormalities arising from incorrect spermatogenesis results in congenital defects and abnormal birth defects (Down syndrome, Klinefelter syndrome) and in most cases, spontaneous abortion of the developing foetus. (wikipedia.org)
- The round-headed spermatozoa result from defects in the spermatogenesis process which leads to a malformation of the acrosome. (sharedjourney.com)
Establishment1
- The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis. (bvsalud.org)
Occurs1
- Oogenesis starts with the process of developing primary oocytes, which occurs via the transformation of oogonia into primary oocytes , a process called oocytogenesis . (wikipedia.org)
Growth3
- Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. (nih.gov)
- They influence sex-specific and sexually dimorphic processes such as spermatogenesis, muscle growth and neural development. (thermofisher.com)
- Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. (thermofisher.com)
Gametes2
- Spermatogenesis produces mature male gametes, commonly called sperm but more specifically known as spermatozoa, which are able to fertilize the counterpart female gamete, the oocyte, during conception to produce a single-celled individual known as a zygote. (wikipedia.org)
- These cells have the potential to become gametes but have not yet committed to the process. (jci.org)
Drosophila2
- Drosophila has long been an attractive, genetically tractable model system in which to study fundamental processes such as apoptosis which are common to higher eukaryotes. (caltech.edu)
- After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) this study found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. (sdbonline.org)
Occur1
- Spermatogenesis is highly dependent upon optimal conditions for the process to occur correctly, and is essential for sexual reproduction. (wikipedia.org)
Seminiferous1
- Spermatogenesis starts in the bottom part of seminiferous tubes and, progressively, cells go deeper into tubes and moving along it until mature spermatozoa reaches the lumen, where mature spermatozoa are deposited. (wikipedia.org)
Development1
- Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. (mdpi.com)
Fertilization2
- The acrosome therefore serves an integral function during the fertilization process at the point where sperm must bind to the zona pellucida, the external membrane of the egg. (sharedjourney.com)
- Concomitantly, the seminal vesicles, prostate gland, and bulbourethral gland produce seminal fluid that accompany and nourish the sperm as it is emitted from the penis during ejaculation and throughout the fertilization process (see image below). (medscape.com)
Humans2
- For humans, the entire process of spermatogenesis is variously estimated as taking 74 days (according to tritium-labelled biopsies) and approximately 120 days (according to DNA clock measurements). (wikipedia.org)
- The entire process of spermatogenesis can be broken up into several distinct stages, each corresponding to a particular type of cell in humans. (wikipedia.org)
Metabolic1
- [16] The differential evolution of metabolic processes in urban P. leucopus populations is thought to contribute to their success and survival in NYC urban forests. (wikipedia.org)
Inflammatory1
- Periodontal disease (PD) is characterized as an inflammatory process that compromises the support and protection of the periodontium. (bvsalud.org)
Male3
- Spermatogenesis takes place within several structures of the male reproductive system. (wikipedia.org)
- Obesity can disturb spermatogenesis and subsequently affect male fertility and reproduction. (nature.com)
- Male fertility relies on the continuous production of sperm via a process known as spermatogenesis. (elifesciences.org)
Role2
- We are the only laboratory in the world to date that has succeeded in generation and breeding of both PRM1 and PRM2 deficient mouse lines which are now used to study the role of these proteins in spermatogenesis. (idw-online.de)
- Strikingly, we also observe an even more severe loss of non-CG methylation , suggesting an unexpected role for the ADD in this process. (bvsalud.org)
Entire process1
- The detection limit (LOD) of HPV-16 DNA was as low as 1 pM, and the entire process could be completed within 70 min without the need for expensive equipment. (bvsalud.org)
Complex1
- Over the past three before you decide anything read: Anabolics 10th Edition Softcover by William complex multistep process, but. (mamapundit.com)
Large1
- At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH). (nih.gov)