Procedural sedation with propofol. Medical search. Frequent questions

Procedural sedation and analgesia (PSA) is a technique in which a sedating/dissociative medication is given, usually along with an analgesic medication, in order to perform non-surgical procedures on a patient. (wikipedia.org)
Propofol has both sedative and amnestic effects, but provides no analgesia. (wikipedia.org)
Suitable for procedural sedation analgesia. (medscape.com)
Safety and Efficacy of Procedural Sedation and Analgesia in Pediatric Oncology Patients. (iasp-pain.org)
Objective Procedural sedation and analgesia are the standard of care for painful procedures in children that require immobility. (iasp-pain.org)
The aim is to assess the safety and efficacy of procedural sedation and analgesia in pediatric oncological patients in a large tertiary care hospital. (iasp-pain.org)
Method An observational study performed to review medical records of children who received procedural sedation and analgesia (PSA) for pediatric oncological procedures from July 2018 to September 2018. (iasp-pain.org)
Procedural sedation and analgesia (PSA) has become a widespread practice given the increasing demand to relieve anxiety, discomfort and pain during invasive diagnostic and therapeutic procedures. (uni-koeln.de)
Rural hospitals in New Zealand provide broad generalist clinical services, including procedural sedation and analgesia (PSA). (rrh.org.au)
Providing procedural sedation and analgesia is an essential rural hospital service which is patient and whānau (Māori-language word for extended family) centred, saves patient transfers, and should be supported by a safe, pragmatic and realistic framework of tools, recommendations and training for rural practitioners. (rrh.org.au)
Author Affiliation Sanjay Arora, MD Department of Emergency Medicine, Keck/USC School of Medicine, Los Angeles, CA INTRODUCTION Emergency physicians must be comfortable and confident in providing safe and effective procedural sedation and analgesia (PSA). (westjem.com)
Does end tidal CO2 monitoring during emergency department procedural sedation and analgesia with propofol decrease the incidence of hypoxic events? (bvsalud.org)
What are the analgesic and side effects of ketamine-propofol combination (ketofol) in comparison with propofol in procedural sedation and analgesia? (beem.ca)
They noted that the addition of ketamine to propofol in sub-dissociative doses is associated with less respiratory and haemodynamic complications during PSA, while achieving adequate analgesia and deeper sedation, possibly more amnesia and consequently high satisfaction in both patients and health-care professionals. (e-journal.gr)
Procedural sedation and analgesia (PSA) is often necessary in order to deal with anxiety, pain and stress that may accompany patients at the hospital during invasive, unpleasant and/or painful procedures. (e-journal.gr)
Myoclonus associated with etomidate for ED procedural sedation and analgesia. (wikem.org)
Propofol for emergency department procedural sedation and analgesia: a tale of three centers. (wikem.org)
A remifentanil infusion of 0.02-0.15 μg·kg −1 ·min −1 plus either ciprofol or propofol were used for analgesia and sedation. (theanesthesiaconsultant.com)
In addition, the literature is insufficient to determine the benefits of keeping an individual present to establish intravenous access during procedures with moderate sedation/analgesia. (tentgallery.in)
The American College of Emergency Physicians (ACEP) just published a new clinical policy on procedural sedation and analgesia in the emergency department, which revised the previous policy from 2005. (hospitalprocedures.org)
The policy states that, "Preprocedural fasting for any duration has not demonstrated a reduction in the risk of emesis or aspiration when administering procedural sedation and analgesia. (hospitalprocedures.org)
3. The minimum number of personnel necessary to manage procedural sedation and analgesia is two. (hospitalprocedures.org)
4. The policy states that ketamine, propofol, etomidate, and alfentanil can all be safely administered in the ED for procedural sedation and analgesia. (hospitalprocedures.org)
Procedural sedation and analgesia (PSA) is the administration of a short-acting sedative-hypnotic or dissociative agent, with or without an analgesic, for patients undergoing anxiety-provoking and/or painful procedures. (msdmanuals.com)
If PSA provides inadequate sedation or analgesia, injectable anesthetic (peripheral nerve block or local infiltration) may be added. (msdmanuals.com)

Deep sedation is a depression of consciousness in which the patient cannot be aroused but responds purposefully to repeated or painful stimuli. (medscape.com)
They found it took less time to begin the procedure (sedation start to scope-in time) when deep sedation with propofol (MAC) was provided by the Anesthesia Care Team than when nurses administered sedation with fentanyl, midazolam and diphenhydramine. (news-medical.net)
Capnography should be considered because it may decrease the risks during deep sedation. (guidelinecentral.com)
Supplemental oxygen administration should be considered for moderate sedation and should be administered during deep sedation. (guidelinecentral.com)
We suggest that capnography monitoring be considered for patients undergoing endoscopy targeting deep sedation. (guidelinecentral.com)
Deep sedation is nearly the same as general anesthesia, meaning that the patient is deeply asleep though able to breathe without assistance. (kyanesthesiagroup.com)
Deep sedation with a medication called propofol is often used for procedures such as upper endoscopy or colonoscopy. (kyanesthesiagroup.com)
Endoscopist-administered propofol sedation for colonoscopy has not been compared to anaesthetist-administered deep sedation in clinical trials. (endoscopie-digestive.com)
90 adult patients undergoing colonoscopy were randomized into Group A, Endoscopist-administered propofol sedation and Group B, anaesthetist-administered deep sedation. (endoscopie-digestive.com)
Endoscopist-administered propofol sedation for colonoscopy offered a better level of satisfaction and fewer side-effects than anaesthetist-administered deep sedation. (endoscopie-digestive.com)

In these fragile patients, anesthetic drugs such as propofol and midazolam can facilitate cardio-respiratory complications even within standard doses, affecting respiratory drive and airway shape. (biomedcentral.com)
Because of its rapid onset and rapid offset profile, propofol is currently the most used IV anesthetic drug in the world. (theanesthesiaconsultant.com)
Propofol is an intravenous (IV) anesthetic medication widely used in for procedural sedation, in operating rooms, and intensive care units (ICUs). (biomedcentral.com)
Propofol is a critically important anesthetic for surgical patients and it's also widely used as a procedural sedation agent for patients undergoing colonoscopy and other procedures where doctors use an endoscope to look inside the body. (inquirer.com)
Anesthetists were left out at that time (with the exception of a very few institutions in Germany - e.g., the University of Mannheim - there was no "tradition" for them to be involved in gastroenterological endoscopy), and they only raised a warning finger to point out that propofol was an anesthetic agent and was therefore reserved for anesthetists alone (as specified in the specialist information for the drug at the time). (endoscopy-campus.com)
Propofol Injection, also known by the brand name "Diprivan," is an intravenous anesthetic agent used to induce and maintain anesthesia during surgeries and medical procedures. (damsonpharma.com)
I have found that using Gas in the beginning and bridging your anesthetic at the end with bolus propofol or propofol infusion is just as good as running a full tiva from the start in ponv patients. (studentdoctor.net)
Try seeing how people feel after a long propofol infusion vs a sevoflurane anesthetic. (studentdoctor.net)
3 hours) use of general anesthetic and sedation drugs during surgeries or procedures in children younger than 3 years or in pregnant women in the third trimester may affect the child's developing brain, the US Food and Drug Administration (FDA) warned today in a Safety Communication. (medscape.com)
As a result, the FDA is requiring warnings to be added to the labels of general anesthetic and sedation drugs. (medscape.com)
No specific anesthetic or sedation drug has been shown to be safer than any other, the FDA notes. (medscape.com)
In published studies of juvenile animals, use of anesthetic and sedation drugs that block N -methyl-D-aspartate receptors and/or potentiate γ-aminobutyric acid activity for longer than 3 hours increased neuronal apoptosis in the brain, resulting in long-term cognitive deficits, the FDA said. (medscape.com)
Adverse effects on brain development following use of general anesthetic and sedation drugs have been demonstrated in multiple animal species ranging from flatworm to nonhuman primates," they said. (medscape.com)
Consistent with animal studies, recent human data suggest that a single, relatively short exposure to general anesthetic and sedation drugs in infants or toddlers is unlikely to have negative effects on behavior or learning, the FDA said. (medscape.com)
They encourage health providers to discuss with parents, caregivers, and pregnant women the benefits, risks, and appropriate timing and duration of surgery or procedures requiring anesthetic and sedation drugs, as well as the health risks of not treating certain conditions. (medscape.com)

Intranasal dexmedetomidine and intravenous ketamine for procedural sedation in a child with alpha-mannosidosis: a magic bullet? (biomedcentral.com)
intranasal dexmedetomidine and intravenous ketamine could be a feasible option for MRI and lumbar puncture in children with alpha-mannosidosis needing sedation. (biomedcentral.com)
It is possible during conscious sedation, intravenous sedatives and narcotics administered to allay apprehension can result in the loss of consciousness and respiratory obstruction. (capnography.com)
Intravenous sedation prior to peribulbar anaesthesia for cataract surgery in elderly patients. (tentgallery.in)
It works quickly and the level of sedation is easily controllable, with patients waking up almost soon after the drug stops infusing via an intravenous line. (inquirer.com)
Propofol Injection is administered directly into a vein through an intravenous (IV) line. (damsonpharma.com)
Kentucky Anesthesia Group anesthesiologists often combine regional anesthesia with intravenous sedation, which can allow you to sleep during surgery. (kyanesthesiagroup.com)
An intravenous loading dose of ketofol or fentafol was given slowly, with doses ranging from 1ml to 2ml/10kg, to reach level 5 or 6 of the Ramsay Scale of Sedation (RSS), followed by small incremental doses which were given when RSS dropped to 4. (bvsalud.org)

Sener S, Eken C, Schultz CH, Serinken M, Ozsarac M. Ketamine with and without midazolam for emergency department sedation in adults: a randomized controlled trial. (wikem.org)
The policy cites studies performed in both children and adults using agents as varied as midazolam, fentanyl, ketamine, and propofol as monotherapy and combined. (hospitalprocedures.org)

The University of Colorado Hospital previously used a model where GI procedural nurses provided sedation under supervision from gastroenterologists for cases that did not require general anesthesia (called the GI luminal unit). (news-medical.net)
The line of demarcation between conscious sedation and general anesthesia is sometimes very thin. (capnography.com)
General Anesthesia: Propofol is widely used for the induction and maintenance of general anesthesia during surgical procedures. (damsonpharma.com)

While procedural sedation is often used to avoid airway intervention, sedation is a continuum and a patient can easily slip into a deeper state. (wikipedia.org)
In addition to airway protection and rescue, procedural sedation goals must include pain relief, muscle relaxation, and procedure amnesia. (medscape.com)
Unlike GI procedural nurses, the Anesthesia Care Team has the training and expertise to perform advanced airway and cardiovascular interventions if an emergency arises. (news-medical.net)
For this reason, the association of dexmedetomidine and ketamine, maintaining active upper respiratory reflexes and minimally impacting on airway shape, could allow safer sedation. (biomedcentral.com)
Because of the difficult airway management and a history of snoring sleep, notwithstanding a previous adeno-tonsillectomy procedure, we decided to associate ketamine and dexmedetomidine for the procedural sedation. (biomedcentral.com)
We recommend anesthesia provider-administered sedation be considered for complex endoscopic procedures or patients with multiple medical comorbidities or at risk for airway compromise. (guidelinecentral.com)
Moreover sedation procedures are performed by non anesthesiologists at remote from 'OR locations' (operating room), who may not be as well experienced and adept as anesthesiologists, in recognizing airway obstruction, apnea and hypoventilation. (capnography.com)
Concurrent URI, airway procedure, and use of combined ketamine + propofol were associated with increased risk. (journalfeed.org)
A trained observer (who may also be the person giving the PSA drugs) is required to monitor the patient (sedation level, airway, ventilation, vital signs, pulse oximetry and/or capnography) throughout the sedation and recovery periods. (msdmanuals.com)

Using a physician anesthesiologist-led Anesthesia Care Team model increases patient access to care, compared to nurse-administered sedation for gastrointestinal (GI) endoscopy procedures, according to research being presented at the American Society of Anesthesiologists' ADVANCE 2022, the Anesthesiology Business Event. (news-medical.net)
The researchers analyzed the sedation-to-scope-in time of 5,640 endoscopy patients, comparing 4,606 who received nurse-administered sedation for GI procedures between Jan. 1 and June 30, 2021, to 1,034 who had MAC between July 1 and Oct. 31, 2021. (news-medical.net)
Following endoscopy patients and gastroenterologists have to fill in questionnaires (PSSI, CSSI) (see abbreviations) about their sedation experiences. (biomedcentral.com)
We recommend that the combination of an opioid and benzodiazepine is a safe and effective regimen for achieving minimal to moderate sedation for upper endoscopy and colonoscopy in patients without risk factors for sedation-related adverse events. (guidelinecentral.com)
3) Wiskin AE, Smith J, Wan SKY, Nally MWJ, Shah N. "Propofol anaesthesia is safe in children with food allergy and undergoing endoscopy. (sinaiem.org)
Effects of sedation and supplemental oxygen during upper alimentary tract endoscopy. (tentgallery.in)
Sedation in endoscopy: better administered by the anesthetist than the gastroenterologist? (endoscopy-campus.com)
Patient safety during sedation with anesthesia professionals during routine upper endoscopy and colonoscopy: an analysis of 1,38 million procedures. (endoscopy-campus.com)
Sedation for GI endoscopy directed by anesthesia professionals (ADS) is used with the intention of improving throughput and patient satisfaction. (endoscopy-campus.com)
During the 1970s, sedation with benzodiazepines (plus opiates as well if appropriate) became the standard, at least for therapeutic endoscopy. (endoscopy-campus.com)
As I had an inner drive to do more and more ERCPs myself - including successful procedures (instead of having to call the senior physician because the endoscopy nurse thought the patient had now had enough …) - the introduction of propofol sedation at a few institutions in Germany came just in time for me. (endoscopy-campus.com)
This study aimed to determine the current status of facilities, equipment, and personnel for endoscopic sedation from endoscopy units of representative hospitals in South Korea. (koreamed.org)
All included endoscopy units had regulations and educational programs regarding sedation training for endoscopists and nursing personnel. (koreamed.org)
This study presents data regarding endoscopic sedation clinical practice in 50 endoscopy units in South Korea. (koreamed.org)
This study presents the current status of endoscopic sedation clinical practice in 50 qualified endoscopy units accredited by the KSGE, which provide excellent quality management. (koreamed.org)
First, a pilot survey was conducted using a questionnaire developed by the Quality management and Endoscopic sedation committee of KSGE among senior endoscopists and head nurses in charge of each of the 13 endoscopy units of board members of the committee via a website ( https://ko.surveymonkey.com ) between August 1st and 30th, 2018. (koreamed.org)
It rapidly induces unconsciousness and loss of sensation, allowing surgeons to perform the necessary interventions while the patient remains asleep and free from pain.Sedation for Medical Procedures: Propofol is used for procedural sedation, especially during medical imaging studies (e.g., endoscopy, colonoscopy) or minor interventions that require patient relaxation and cooperation. (damsonpharma.com)

Eight (0.7%) patients developed transient oxygen desaturation only as an adverse effect of ketamine-propofol drug combination with 50% procedures utilizing propofol 1 mg/kg for sedation. (iasp-pain.org)

Procedural sedation policies should be established to define who can administer medication, who must monitor the patient, which classes and doses of procedural sedation medications should be used, and what resources should be kept on hand for resuscitation. (medscape.com)
Elderly patients are at greater risk of developing constipation, sedation, and confusion when treated with opioids, and it is reasonable to adjust doses to account for age-related changes in pharmacokinetics. (saem.org)
Small doses of esketamine combined with propofol can be safely and effectively used for hysteroscopic surgery. (biomedcentral.com)
The data recorded included age, sex, weight, type of procedure, drugs and doses used, procedural success, complications and if the patient was observed to grimace or groan. (bmj.com)
may administer incremental doses of 0.5-2 mg/kg IV q5-15min PRN if initial sedation inadequate (Mace et al. (medscape.com)

They found limited evidence to support superiority of ketofol compared to other agents, specifically to propofol. (e-journal.gr)
Objectives: The aim of this study was to compare the efficacy and safety of ketofol (a mixture of propofol and ketamine) versus fentafol (a mixture of propofol and fentanyl) during the ERPC. (bvsalud.org)
The K group was given ketofol (1ml containing 5mg of propofol and 5mg of ketamine) and F group was given fentafol (1ml containing 5mg propofol and 5mcg fentanyl). (bvsalud.org)
Ketofol showed less propofol consumption and a short recovery time. (bvsalud.org)

Thiopental induces a state of sedation, amnesia, and unconsciousness, which is important for ensuring that patients do not experience pain or awareness during surgery. (neurosurgery.directory)
One of the goals of emergency department (ED) procedural sedation (PS) is to induce amnesia for brief painful procedures, in addition to analgaesia. (bmj.com)

Therefore, other pharmacological agents that induce an adequate level of sedation without respiratory depression are of increasing interest to clinicians. (biomedcentral.com)
The goal of PSA is to provide needed sedation and pain relief while minimizing respiratory depression, hypoxia, and hypotension. (msdmanuals.com)
Monitor closely for signs of respiratory depression and sedation. (medscape.com)

Objective The aim of the study was to compare haemodynamic responses, recovery and discharge times, and physician satisfaction of etomidate-remifentanil and propofol-remifentanil combinations in patients undergoing elective colonoscopy. (deu.edu.tr)

and (d) the propofol infusion syndrome (PIS) which can lead to hyperkalemia and cardiac arrest in ICU patients after prolonged exposure to propofol infusions. (theanesthesiaconsultant.com)
The propofol loading was at 0.5-1.0 mg/kg, with a maintenance infusion rate of 1.5 mg/kg/h. (theanesthesiaconsultant.com)
The propofol infusion syndrome (PIS) is a potentially lethal syndrome that occurs due to prolonged infusion described in adults and pediatric ICU patients who are on mechanical ventilation. (theanesthesiaconsultant.com)
INTERVENTIONS: Patients were randomly assigned to target-controlled infusion propofol or dexmedetomidine loading followed by maintenance dose for procedural sedation. (afpm.org.my)
Patient perception of pain was scored with the verbal rating scale (VRS) every 5 s after the start of the propofol infusion, and the evaluation was stopped once the patient became unresponsive. (biomedcentral.com)
The burning pain from propofol infusion travels along the blood vessels, causing discomfort and anxiety in patients, and may even result in a traumatic anesthesia experience, making propofol infusion-related pain the major problem encountered in clinical anesthesia practice [ 3 ]. (biomedcentral.com)
Background: Patient-maintained propofol TCI sedation (PMPS) allows patients to titrate their own target-controlled infusion (TCI) delivery of propofol sedation using a handheld button. (aber.ac.uk)
To facilitate further investigation of this procedural sedation technique, PMPS-capable TCI infusion devices should be submitted for regulatory approval for clinical use. (aber.ac.uk)

In general, these medications are usually given intravenously when used for procedures in the emergency department (ED), with some exceptions for children (for more information, see Pediatrics, Sedation). (medscape.com)
Therefore, we conclude that ketamine and propofol are safe and effective as both sedative and an analgesic in procedures on pediatric oncology patients. (iasp-pain.org)
The Anesthesia Care Team model allows us to optimize patient flow and utilize faster-acting medications, resulting in shorter total case lengths and reduced post-anesthesia care unit (PACU) length of stay for upper and lower GI endoscopic procedures, compared to a model where nurses provided sedation. (news-medical.net)
The time savings for Anesthesia Care Team-administered MAC sedation likely would apply to non-GI procedures as well, the authors note. (news-medical.net)
Procedural sedation is an emerging cornerstone in pediatrics aiming to control pain, decrease fear and emotional response when immobility is required or during painful procedures. (biomedcentral.com)
Finally, venous access may be troublesome, scaring and painful for these children, who often require repeated hospital admissions and procedures, so that a sedation sequence based on an intranasal premedication, facilitating cannulation without putting the patient at risk, may offer further advantages. (biomedcentral.com)
Conscious sedation is a strategy for improving patient safety and comfort during these procedures. (biomedcentral.com)
We recommend that all patients undergoing endoscopic procedures be evaluated to assess their risk of sedation related to pre-existing medical conditions. (guidelinecentral.com)
We recommend the routine monitoring of blood pressure, oxygen saturation, and heart rate in addition to clinical observation for changes in cardiopulmonary status during all endoscopic procedures using sedation. (guidelinecentral.com)
Hence it is obvious that some type of ventilation monitoring is required to safeguard against hypoxia during sedation procedures outside of the operating room. (capnography.com)
It is only a matter of time that capnography will find its way to becoming incorporated as a standard of practice for monitoring ventilation during sedation procedures. (capnography.com)
Examples include the use of capnography in the EMT / ambulance services for monitoring ventilation, and emergency medical rooms for procedures and sedation. (capnography.com)
Presently, several procedures are being performed under sedation outside of the operating room. (capnography.com)
1) One retrospective analysis of propofol being used in 76 procedures in 55 patients with egg, soy or nut allergy revealed 13 adverse events, but none due to propofol. (sinaiem.org)
The purpose of our study is to determine the half effective dose (ED 50 ), 95% effective dose (ED 95 ), and 99% effective dose (ED 99 ) of esketamine for attenuating propofol injection pain using Dixon's up-and-down method to provide a reference for optimal dose selection for surgeries and procedures. (biomedcentral.com)
3. Duration of antagonistic effects of nalmefene and naloxone in opiate-induced sedation for emergency department procedures. (tentgallery.in)
These ranged from delayed procedures to unintended intraoperative awareness when a patient was given too little propofol in an attempt to conserve supplies. (inquirer.com)
In the German-speaking countries (and also in Scandinavia), the majority of endoscopic procedures (usually diagnostic) that were carried out in the 1960s and 1970s were conducted without sedation. (endoscopy-campus.com)
1 Procedural sedation (conscious sedation) is extremely common in the ED and can be performed safely and improve the patient and provider experience during difficult procedures. (hospitalprocedures.org)
The emergency care of children sometimes requires diagnostic and current barriers and help inform the development of pediatric proce- therapeutic procedures that are anxiety-inducing, prolonged, and/or dural sedation programs, guidelines, and training initiatives specific painful. (bvsalud.org)
It provides a calming effect, reducing anxiety and discomfort during these procedures.Intensive Care Unit (ICU) Sedation: In the ICU, Propofol is used for sedation of critically ill patients who require mechanical ventilation or other medical interventions. (damsonpharma.com)
Surgical Anesthesia: Propofol is frequently used to induce and maintain anesthesia during various surgical procedures. (damsonpharma.com)

Propofol is not considered an analgesic, so opioids such as fentanyl may be combined with propofol to alleviate pain. (neurosurgery.directory)

Conclusion According to the results of our study, the majority of the pediatric patients responded and reported no adverse events during the procedure with ketamine and propofol. (iasp-pain.org)
This trial may show that the synergy of esketamine and propofol anaesthesia reduces PONV as well as other short-term adverse events, thereby providing a better safety and satisfaction profile of ERAS for laparoscopic appendectomy and cholecystectomy. (biomedcentral.com)
We recommend that providers undergo specific training in the administration of endoscopic sedation and possess the skills necessary for the diagnosis and management of sedation-related adverse events, including rescue from a level of sedation deeper than that intended. (guidelinecentral.com)
The tolerability, sedation characteristics, and adverse events such as hypotension were comparable between both groups. (theanesthesiaconsultant.com)
Secondary outcomes measures included depth of sedation, occurrence of sedation-related adverse events and time to medical readiness for discharge from the postanaesthsia care unit (PACU). (aber.ac.uk)
Conclusions: Patient-maintained propofol sedation during lower-limb arthroplasty under spinal anaesthesia results in reduced drug exposure and fewer episodes of sedation-related adverse events compared with anaesthetist-controlled propofol TCI sedation. (aber.ac.uk)
This study describes the clinical experiences of African medical providers who use pediatric proceduralsedation, including clinical indications, medications, adverse events, training, clinical guideline use, and comfort level. (bvsalud.org)

The literature has not presented firm conclusions regarding ideal sedative agents in terms of efficacy and safety in PSA or even present firm data regarding superiority of specific drugs over others which are considered the "gold-standard" in sedation (i.e. propofol). (e-journal.gr)
The authors concluded that "ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting. (theanesthesiaconsultant.com)
STUDY OBJECTIVE: To determine the efficacy of sedation with dexmedetomidine compared to propofol for claustrophobic adults undergoing magnetic resonance imaging (MRI) in our institution. (afpm.org.my)

The aim of this trial is to determine the safety and effectiveness of dexmedetomidine sedation compared to the standard used propofol TCI sedation during endoscopic oesophageal interventions. (biomedcentral.com)
The first 64 consenting patients will be randomized to either the propofol or the dexmedetomidine group. (biomedcentral.com)
Dexmedetomidine is a relatively new representative for procedural sedation. (biomedcentral.com)
The aim of this trial is to determine the safety and effectiveness of dexmedetomidine compared to the in our hospital standard used propofol sedation, both administered by anesthesia nurses. (biomedcentral.com)

We suggest that endoscopists use propofol-based sedation (endoscopist-directed or anesthesia-provider administered) when it is expected to improve patient safety, comfort, procedural efficiency, and/or successful procedure completion. (guidelinecentral.com)
However, data on its safe-ty are sparse because of the lack of adequately powered, randomized controlled trials comparing it with endoscopist-directed sedation (EDS). (endoscopy-campus.com)

Propofol for migraine in the emergency department: A pilot randomised controlled trial. (emergencymedjc.com)
Profiling adverse respiratory events and vomiting when using propofol for emergency department procedural sedation. (tentgallery.in)
Procedural sedation (PS) is common in the emergency department (ED) and ideally patients should have no recall of the procedure. (bmj.com)

These agents should be used for procedural sedation with rapid onset and short duration. (medscape.com)

Methods: The study was approved by the local ethics committee, including data from 60 patients scheduled for ambulatory surgery undergoing general anaesthesia with propofol and remifentanil, using TCI. (researchgate.net)
There were no significant differences in remifentanil or propofol effect-site concentrations for movers vs. non-movers. (researchgate.net)
Conclusion: The qCON was able to reliably detect LOC during general anaesthesia with propofol and remifentanil. (researchgate.net)

citation needed] Although there is no age limit for PSA, the elderly have a greater chance of complications such as longer than intended sedation time, increased sensitivity to medications, adverse effects of medications, and higher than expected drug levels due to difficulty clearing the drugs. (wikipedia.org)
Dissociation, which could be considered a type of moderate sedation, is seen when using medications in the phencyclidine group (eg, ketamine). (medscape.com)
Prior to the administration of medications, clinicians must know the level of sedation required for a given procedure and the appropriate dose of the pharmacologic agent or agents chosen. (medscape.com)
The medications used during sedation typically have additional beneficial effects, as important as sedation. (medscape.com)
This study was designed to explore patterns of procedural sedation use including indications, equipment, medications, logistical and medical staff support available by rural hospitals, and whether current professional guidelines support rural sedation practice. (rrh.org.au)
Of the 15 patients who got propofol, six patients required additional medications. (emergencymedjc.com)

Has this new form of conscious sedation the potential to be safer and more effective for patients and endoscopists than propofol during endoscopic oesophageal interventions? (biomedcentral.com)

It is helpful to know when the patient had their last meal but there is not a lot of research that supports mandatory fasting to prevent complications of aspiration in procedural sedation. (emergencymedicinecases.com)
Studies that have attempted to define the incidence of aspiration or pulmonary complications during sedation/anesthesia of children with respect to nil per os (NPO) status or other factors are difficult because of the relatively infrequent rate of these complications. (silverchair.com)

In the study, researchers compared GI cases performed under the former nurse-provided sedation model to those performed under the Anesthesia Care Team model. (news-medical.net)
Jeffrey B. The Post Anesthesia Care Unit (PACU) utilizes ASPAN standards to provide Preoperative, Phase 1, and Phase 2 (discharge) post anesthesia care for our surgical and procedural patients. (tentgallery.in)

Secondary outcomes included recovery status, pain, sedation level and overall recovery, delirium and cognition, anxiety and depression and total consumption of analgesic agents. (biomedcentral.com)
Ketamine can attenuate pain associated with IV propofol injection through local and central analgesic effects. (biomedcentral.com)
Thirty gynecological patients undergoing hysteroscopic surgery were enrolled in a sequential method to determine the effective dose of esticketamine for analgesic propofol injection in order of operation. (biomedcentral.com)

The aim of this RCT was to compare PMPS with anaesthetist-controlled propofol TCI sedation (ACPS) in patients undergoing elective primary lower-limb arthroplasty surgery under spinal anaesthesia. (aber.ac.uk)

Resource-limited in resource-limited settings in Africa and identify potential barriers to the provision of safe pediatric sedation. (bvsalud.org)
Quantitative data about provider background and sedation practices were collected concurrently with qualitative data about perceived barriers to pediatric procedural sedation and suggestions to improve the practice of pediatric sedation in their settings. (bvsalud.org)
The three major qualitative themes regarding barriers to safe pediatric sedation in their settings were: lack of resources, lack of education, and lack of standardization across sites and providers. (bvsalud.org)
The results of this study suggest that training specialized pediatric sedation teams, creating portable "pediatric sedation kits, " and producing locally relevant pediatric sedation guidelines may help reduce current barriers to the provision of safe pediatric sedation in resource-limited African settings. (bvsalud.org)

2021) also conducted a phase I trial in which subjects received continuous ciprofol or propofol infusions for up to 12 hours. (theanesthesiaconsultant.com)

Although several guidelines for endoscopic sedation have been proposed, the majority of the statements are based on experts' opinions due to the lack of relevant evidence [ 8 - 10 ]. (koreamed.org)

The American Society of Anesthesiologists defines the continuum of sedation as follows: There is another type of sedation known as dissociative sedation. (wikipedia.org)

Current data suggest that African providers believe pediatric pro- cedural sedation is an important clinical skill, but face barriers in · Procedural sedation is an incredibly valuable tool in pediatric emer- implementation due to scarcity of pediatric equipment and medica- gency medicine, as it decreases pain and anxiety in children, and tions, limited clinical guideline use, and lack of pediatric training. (bvsalud.org)
Epidurals and spinal blocks require neuraxial anesthesia, which is used in a variety of clinical situations, including surgical, obstetric, and procedural. (kyanesthesiagroup.com)

Although the aim of the conscious sedation nurse/personnel is to provide conscious sedation, the line between conscious sedation and sleep is very narrow and the patient drifts quite often into an unconscious state. (capnography.com)
Patients receiving conscious sedation can either be brought to the PACU or delivered to stage 2 recovery (see Phases of Postanesthetic Recovery in this chapter) at the discretion of the anesthesiologist. (tentgallery.in)

Propofol is particularly suitable for outpatient and same-day surgeries because of its strong sedative and hypnotic effects, fast onset, quick recovery, and low incidence of postoperative nausea and vomiting (PONV). (biomedcentral.com)

the autonomic nervous system is unable to respond to surgical or procedural stimuli. (medscape.com)
Propofol is used for surgical anesthesia, procedural sedation, and intensive care unit (ICU) sedation. (theanesthesiaconsultant.com)
0.05), whereas surgical duration, emergence time, visual analogue scale (VAS) score of postoperative uterine contraction pain, and Riker sedation/anxiety scale (SAS) score were not significantly different. (biomedcentral.com)

Chemically, propofol is not related to barbiturates and has largely replaced sodium thiopental (Pentothal) for induction of anesthesia because recovery from propofol is more rapid and "clear" when compared with thiopental. (neurosurgery.directory)
We recommended a dose of 0.2 mg/kg IV esketamine before induction of anesthesia to reduce the pain of propofol injection. (biomedcentral.com)

In order to do this, a practitioner must be able to recognize the level of sedation and understand the increasing cardiopulmonary risk that is associated with deeper sedation. (wikipedia.org)

Our range of products include propofol injection ip, mct rof 10ml propofol injection, propofol injection 1%, troypofol-mct 20mg propofol injection and troypofol 10mg propofol injection. (damsonpharma.com)
1. What is Propofol Injection?Ans. (damsonpharma.com)
2. How is Propofol Injection administered?Ans. (damsonpharma.com)
If you are seeking information about "MCT Rof 10mL Propofol Injection," I strongly recommend contacting a healthcare professional, such as a doctor or pharmacist. (damsonpharma.com)

Low-dose ketamine (0.5 mg/kg) and propofol (2 mg/kg) were administered. (iasp-pain.org)
There were no significant dose-dependent changes in blood pressure in either the ciprofol or propofol groups. (theanesthesiaconsultant.com)
During induction, the target dose of esketamine was first given via venous access in the left hand of the patient, and 30 s later, a fixed dose of 2 mg/kg (1 ml/s) of propofol was given. (biomedcentral.com)

The electronic survey consisted of 31 questions, regarding general information, staffing level and procedural sedation practice. (rrh.org.au)
Due to these ingredients, common practice is to avoid propofol in patients with pre-existing allergies to egg or soy products. (sinaiem.org)
Despite 92% of key informants stating that pediatric procedural sedation was critical to their practice, only half reported feeling adequately trained. (bvsalud.org)
Background: Little is known about the practice of pediatric procedural sedation in Africa, despite being incredibly useful to the emergency care of children. (bvsalud.org)

It is also used for procedural sedation, especially during medical imaging or minor interventions, and for sedation of critically ill patients in the intensive care unit (ICU). (damsonpharma.com)

Propofol is a fast-acting and effective medication with a higher-risk-profile, which physician anesthesiologists have the skills and training to deliver and monitor. (news-medical.net)
This resource provides evidence-based recommendations for a variety of applications of intranasal medication including pain control, sedation and seizure management. (emergencymedicinecases.com)

If the executions are carried out with propofol, it would almost certainly be added to the list by the EU and I've been told that it's unlikely the sole US manufacturer of propofol, Hospira, would have the capacity to make up the difference. (inquirer.com)

L'objectif de cette revue était de rapporter les effets hallucinatoires survenus chez un sujet de 30 ans, au réveil d'une sédation au propofol pour endoscopie digestive. (bvsalud.org)

Total duration time and procedural difficulty did not differ between the groups. (endoscopie-digestive.com)

No apnea was observed in any patients in the ciprofol group, but 5 patients in the propofol 2.0 mg/kg group experienced apnea. (theanesthesiaconsultant.com)
A Preponderance of evidence suggests that procedural sedation is associated with undetected apnea or hypoventilation that can result in oxygen desaturation. (capnography.com)
To detect apnea or hypoventilation during procedural sedation, a specific monitor of ventilation is required. (capnography.com)

For this reason, a physician who is performing PSA should be prepared to care for a patient at least one level of sedation greater than that intended. (wikipedia.org)
Moderate sedation is a depression of consciousness in which the patient can respond to external stimuli (verbal or tactile). (medscape.com)
That change, along with a redesigned patient flow that required procedural consents to be signed before patients arrived in the GI suite, provided the opportunity to increase daily GI procedural volume by 25%, while using the same number of procedural suites, Dr. Faruki said. (news-medical.net)
A physician should be present throughout propofol sedation and must remain immediately available until the patient meets discharge criteria. (guidelinecentral.com)
This study was based on the sequential allocation up-and-down rule designed by Dixon, and each patient was induced by esticketamine combined with propofol. (biomedcentral.com)
The majority of exams are performed under sedation to satisfy both the patient and endoscopist. (koreamed.org)
A nurse should be present for continuous monitoring of the patient in addition to the procedural operator. (hospitalprocedures.org)
Median sedation satisfaction scores were physician 9.0, nurse 10, patient 10. (bmj.com)
With moderate sedation, the patient may doze off but awakens easily. (kyanesthesiagroup.com)

Propofol is an injectable emulsion containing water, egg lecithin, soybean oil and glycerin. (sinaiem.org)
Propofol Injectable Emulsion Safety Data Sheet. (sinaiem.org)

These endoscopic interventions are minimal invasive treatment options usually done with sedation on an outpatient basis. (biomedcentral.com)
The introduction of propofol sedation provided the basis without which the development of highly invasive methods such as transgastric pancreatic interventions at the end of the 1990s would never have become possible. (endoscopy-campus.com)

The time to discharge was about 5 hours in the propofol arm and 9 hours in the usual care arm. (emergencymedjc.com)
In addition, endoscopic physicians are preferring to use hypnotic agents such as propofol, for quick recovery and discharge to reduce heath care cost. (capnography.com)

A majority of the respondents felt that a minimum safe level for procedural sedation in their rural hospital required only a single doctor. (rrh.org.au)
The emla cream was removed 20 min before the cannulation attempt, in order to avoid stimulating the child by stripping the dressing from the skin just before venipuncture, targeting a good sedation level before the puncture. (biomedcentral.com)
The acceptance level among patients after propofol sedation is high. (biomedcentral.com)
Continuous monitoring will allow recognition of patients who have progressed to a deeper level of sedation. (guidelinecentral.com)

In this EM Cases episode on Pediatric Procedural Sedation with Dr. Amy Drendel , a world leader in pediatric pain management and procedural sedation research, we discuss how best to manage pain and anxiety in three situations in the ED: the child with a painful fracture, the child who requires imaging in the radiology department and the child who requires a lumbar puncture. (emergencymedicinecases.com)

Propofol is also painful when administered intravenously, therefore, lidocaine is commonly used as a pretreatment to help decrease the pain associated with administering propofol. (wikipedia.org)

Diseases3

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology3

Phenomena and Processes2

Disciplines and Occupations1

Health Care8

Analgesia25

Deep sedation10

Anesthetic15

Intravenous8

Midazolam2

General anesthesia3

Airway9

ENDOSCOPY17

Ketamine-propofol1

Doses5

Ketofol4

Amnesia2

Respiratory depression3

Etomidate1

Infusion8

Procedures22

Fentanyl1

Adverse events7

Efficacy3

Dexmedetomidine4

Endoscopist-directed2

EMERGENCY-DEPARTMENT3

Rapid onset1

Remifentanil3

Medications6

Endoscopists1

Complications2

Anesthesia care2

Analgesic3

Patients undergoi1

Pediatric sedation4

20211

Endoscopic sedation1

Dissociative sedation1

Clinical2

Conscious2

Onset1

Surgical3

Induction of anesthesia2

Deeper sedation1

Injection4

Dose3

Practice4

Intensive care1

Medication2

Hospira1

Endoscopie1

Duration1

Apnea3

Patient9

Injectable2

Interventions2

Discharge2

Level4

Pain and anxiety1

Painful1