• Therefore, benzathine penicillin, 2.4 million units IM once per week for 1-3 weeks, can be considered after completion of these neurosyphilis treatment regimens to provide a comparable total duration of therapy. (cdc.gov)
  • Provided information on the availability of benzathine penicillin and procaine penicillin. (hiv.gov)
  • Benzathine penicillin reaches its peak level more slowly and is generally longer-acting than procaine penicillin. (msdmanuals.com)
  • Response of HIV-infected patients with asymptomatic syphilis to intensive intramuscular therapy with ceftriaxone or procaine penicillin. (druglib.com)
  • two penicillin-treated and one ceftriaxone-treated patient relapsed. (druglib.com)
  • Three penicillin-treated, and two ceftriaxone-treated patients were serofast. (druglib.com)
  • If concern exists regarding ceftriaxone safety for a patient with neurosyphilis, skin testing should be performed to confirm penicillin allergy and, if necessary, penicillin desensitization in consultation with a specialist is recommended. (cdc.gov)
  • Probenecid inhibits the tubular secretion of penicillin and usually increases penicillin plasma levels by any route the antibiotic is given. (nih.gov)
  • Because of its mechanism of action, probenecid is not recommended in conjunction with a penicillin in the presence of known renal impairment. (nih.gov)
  • Eleventh WHO's Model List of Essential Drugs 2002: benzathine benzylpenicillin, benzylpenicillin, phenoxymethylpenicillin and procaine benzylpenicillin are compatible with breastfeeding. (e-lactancia.org)
  • Penicillin G (benzylpenicillin) is the most commonly used antimicrobial substance used in equine medicine today. (slu.se)
  • Penicillin G sodium or potassium is recommended for streptococcal infections with bacteremia. (pfizermedicalinformation.com)
  • NOTE: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, peritonitis, and arthritis of pneumococcal etiology are better treated with penicillin G sodium or potassium during the acute stage. (pfizermedicalinformation.com)
  • When high, sustained serum levels are required, penicillin G sodium or potassium, either IM or IV, should be used. (pfizermedicalinformation.com)
  • one form is the poorly soluble penicillin G procaine and the other is the very soluble sodium salt. (slu.se)
  • In order to avoid the risk of toxic reactions against procaine, penicillin G sodium can be used. (slu.se)
  • In the literature contradictory information on the possibility of the usage of penicillin G sodium intramuscularly have been found. (slu.se)
  • The aim of the present study was to examine the pharmacokinetics of penicillin G following intramuscular administration of penicillin G sodium and penicillin G procaine, respectively. (slu.se)
  • The investigation was a pilot study in two clinically healthy Standard bred trotters with a cross-over design and therefore each horse was given both penicillin G sodium and penicillin G procaine intramuscularly. (slu.se)
  • The half-life (hours) for penicillin G sodium in the two horses was 2.55 and 2.38 respectively and for the penicillin G procain the half-life was 9.29 and 10.76. (slu.se)
  • The time over MEC (minimal effective concentration in vivo) for Streptococcus equi and Streptococcus zooepidemicus lasted for both the horses in the study for at least 8 hours after penicillin G sodium were injected. (slu.se)
  • The results from this study then imply that it would be possible to administer penicillin G sodium intramuscularly to horses twice a day. (slu.se)
  • As an adjuvant to therapy with penicillin or with ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin, for elevation and prolongation of plasma levels by whatever route the antibiotic is given. (nih.gov)
  • Penicillin G is an effective antibiotic for treating a variety of bacterial infections. (vetdepot.com)
  • Penicillin is a broad spectrum antibiotic that is commonly used in Pediatrics and Neonatology with very good tolerance even in premature newborns. (e-lactancia.org)
  • Based on API type, the antibiotics API market is segmented into penicillin antibiotics, cephalosporins, and carbapenem antibiotics. (pharmiweb.com)
  • Penicillin G Benzathine with Procaine and Penicillin G Procaine are two injectable antibiotics that are used to treat a variety of different diseases caused by gram-positive organisms in livestock and horses. (vetdepot.com)
  • Penicillin (sometimes abbreviated PCN ) refers to a group of beta-lactam antibiotics used in the treatment of bacterial infections caused by susceptible, usually Gram-positive , organisms. (wikidoc.org)
  • In 1939, Australian scientist Howard Walter Florey and a team of researchers ( Ernst Boris Chain , A. D. Gardner , Norman Heatley, M. Jennings, J. Orr-Ewing and G. Sanders) at the Sir William Dunn School of Pathology, University of Oxford made significant progress in showing the in vivo bactericidal action of penicillin. (wikidoc.org)
  • 2) Allergy nke penicillin na ọgwụ nje cephalosporin adịghị ekpughere ngwaahịa a.(3) Gbaa nke ọma tupu eji ya. (xinanranpharmacy.com)
  • This drug is indicated in the treatment of moderately severe infections due to penicillin-G-susceptible microorganisms that are susceptible to serum levels common to this particular dosage form. (pfizermedicalinformation.com)
  • The etiology behind penicillin shock in horses is not completely understood, but the most common reason is believed to be procaine toxicity. (slu.se)
  • The discovery of penicillin is usually attributed to Scottish scientist Sir Alexander Fleming in 1928, though others had earlier noted the antibacterial effects of Penicillium . (wikidoc.org)
  • The penicillin G dose was 11 mg/kg. (slu.se)
  • Penicillins are actively secreted and about 80% of a penicillin dose is cleared within three to four hours of administration. (wikidoc.org)
  • The focus of FDA guidance 263 will primarily address the injectable and oral versions of these products such as penicillin, tetracycline and sulfa products. (unl.edu)
  • The Jarisch-Herxheimer reaction occurred more often after treatment with penicillin than with erythromycin or tetracycline (p less than 0.005). (bmj.com)
  • This was not a satisfactory solution, however, so researchers looked for a way to slow penicillin secretion. (wikidoc.org)
  • They hoped to find a molecule that could compete with penicillin for the organic acid transporter responsible for secretion such that the transporter would preferentially secrete the competitive inhibitor. (wikidoc.org)
  • Antihistamine or adrenaline treatment may be a suitable antidote.Persons who are allergic to penicillins should avoid direct contact with the product. (theanimalpharmacy.com.au)
  • Food does not interfere with absorption of amoxicillin , but penicillin G should be given 1 hour before or 2 hours after a meal. (msdmanuals.com)
  • Availability was severely limited, however, by the difficulty of manufacturing large quantities of penicillin and by the rapid renal clearance of the drug necessitating frequent dosing. (wikidoc.org)
  • however, the risk for penicillin cross-reactivity between third-generation cephalosporins is negligible ( 618 - 621 ) (see Management of Persons Who Have a History of Penicillin Allergy). (cdc.gov)
  • During those times it became common procedure to collect the urine from patients being treated so that the penicillin could be isolated and reused. (wikidoc.org)
  • All penicillins are at least partially excreted in urine, and most reach high levels in urine. (msdmanuals.com)
  • Procaine penicillin was the treatment used most, and erythromycin the commonest alternative. (bmj.com)
  • [1] After further experiments, Fleming was convinced that penicillin could not last long enough in the human body to kill pathogenic bacteria and stopped studying penicillin after 1931, but restarted some clinical trials in 1934 and continued to try to get someone to purify it until 1940. (wikidoc.org)
  • Do-N-Joy Holsteins at Arlington, MN was charged in a May 11 warning letter from the U.S. Food and Drug Administration with misuse of the animal drug penicillin G procaine. (foodsafetynews.com)
  • The warning letter stems from an inspection of the Arlington dairy operation last Dec. 14, in which the Minnesota Department of Agriculture said it found the dairy did not use penicillin G procaine as directed by the approved labeling, a violation of the Federal Food, Drug, and Cosmetic Act. (foodsafetynews.com)
  • Reprinted with permission from Li M, Gehring R, Riviere JE, Lin Z. Probabilistic physiologically based pharmacokinetic model for penicillin G in milk from dairy cows following intramammary or intramuscular administrations. (avma.org)
  • Penicillins are excreted in breast milk in clinically insignificant amounts. (e-lactancia.org)
  • The name "penicillin" can also be used in reference to a specific member of the penicillin group Penam Skeleton, which has the molecular formula R-C 9 H 11 N 2 O 4 S, where R is a variable side chain . (wikidoc.org)
  • Their attempts to treat humans failed due to insufficient volumes of penicillin (the first patient treated was Reserve Constable Albert Alexander ), but they proved its harmlessness and effect on mice. (wikidoc.org)
  • On March 3, 1942 John Bumstead and Orvan Hess became the first in the world to successfully treat a patient using penicillin. (wikidoc.org)
  • A mouldy cantaloupe in a Peoria market in 1941 was found to contain the best and highest quality penicillin after a world-wide search. (wikidoc.org)
  • The development of penicillin for use as a medicine is attributed to the Australian Nobel Laureate Howard Walter Florey . (wikidoc.org)