Eleventh WHO's Model List of Essential Drugs 2002: benzathine benzylpenicillin, benzylpenicillin, phenoxymethylpenicillin and procaine benzylpenicillin are compatible with breastfeeding. (e-lactancia.org)
Benzathine penicillin reaches its peak level more slowly and is generally longer-acting than procaine penicillin. (msdmanuals.com)
Injectable1
The focus of FDA guidance 263 will primarily address the injectable and oral versions of these products such as penicillin, tetracycline and sulfa products. (unl.edu)
Injection13
Penicillin G procaine injection is used to treat certain infections caused by bacteria. (medlineplus.gov)
Penicillin G procaine injection should not be used to treat gonorrhea (a sexually transmitted disease) or early in the treatment of certain serious infections. (medlineplus.gov)
Penicillin G procaine injection comes as a suspension (liquid) in a prefilled syringe to inject into the muscles of the buttocks or thigh by a doctor or nurse in a medical facility. (medlineplus.gov)
If you stop receiving penicillin G procaine injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
You may experience a sudden severe reaction immediately after receiving a dose of penicillin G procaine injection that may last for approximately 15 to 30 minutes. (medlineplus.gov)
In 1939, Australian scientist Howard Walter Florey and a team of researchers ( Ernst Boris Chain , A. D. Gardner , Norman Heatley, M. Jennings, J. Orr-Ewing and G. Sanders) at the Sir William Dunn School of Pathology, University of Oxford made significant progress in showing the in vivo bactericidal action of penicillin. (wikidoc.org)
NOTE: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, peritonitis, and arthritis of pneumococcal etiology are better treated with penicillin G sodium or potassium during the acute stage. (pfizermedicalinformation.com)
Penicillin (sometimes abbreviated PCN ) refers to a group of beta-lactam antibiotics used in the treatment of bacterial infections caused by susceptible, usually Gram-positive , organisms. (wikidoc.org)
Antibacterial1
The discovery of penicillin is usually attributed to Scottish scientist Sir Alexander Fleming in 1928, though others had earlier noted the antibacterial effects of Penicillium . (wikidoc.org)
Nafcillin1
As an adjuvant to therapy with penicillin or with ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin, for elevation and prolongation of plasma levels by whatever route the antibiotic is given. (nih.gov)
Secretion3
Probenecid inhibits the tubular secretion of penicillin and usually increases penicillin plasma levels by any route the antibiotic is given. (nih.gov)
This was not a satisfactory solution, however, so researchers looked for a way to slow penicillin secretion. (wikidoc.org)
They hoped to find a molecule that could compete with penicillin for the organic acid transporter responsible for secretion such that the transporter would preferentially secrete the competitive inhibitor. (wikidoc.org)
Infections1
This drug is indicated in the treatment of moderately severe infections due to penicillin-G-susceptible microorganisms that are susceptible to serum levels common to this particular dosage form. (pfizermedicalinformation.com)
Allergic1
Antihistamine or adrenaline treatment may be a suitable antidote.Persons who are allergic to penicillins should avoid direct contact with the product. (theanimalpharmacy.com.au)
Renal2
Because of its mechanism of action, probenecid is not recommended in conjunction with a penicillin in the presence of known renal impairment. (nih.gov)
Availability was severely limited, however, by the difficulty of manufacturing large quantities of penicillin and by the rapid renal clearance of the drug necessitating frequent dosing. (wikidoc.org)
Antibiotic1
Penicillin is a broad spectrum antibiotic that is commonly used in Pediatrics and Neonatology with very good tolerance even in premature newborns. (e-lactancia.org)
Dose1
Penicillins are actively secreted and about 80% of a penicillin dose is cleared within three to four hours of administration. (wikidoc.org)
Urine2
During those times it became common procedure to collect the urine from patients being treated so that the penicillin could be isolated and reused. (wikidoc.org)
All penicillins are at least partially excreted in urine, and most reach high levels in urine. (msdmanuals.com)
Organisms1
Even in these early stages, penicillin was found to be most effective against Gram-positive bacteria, and ineffective against Gram-negative organisms and fungi. (wikidoc.org)
Penicillins are excreted in breast milk in clinically insignificant amounts. (e-lactancia.org)
Variable1
The name "penicillin" can also be used in reference to a specific member of the penicillin group Penam Skeleton, which has the molecular formula R-C 9 H 11 N 2 O 4 S, where R is a variable side chain . (wikidoc.org)
Food does not interfere with absorption of amoxicillin , but penicillin G should be given 1 hour before or 2 hours after a meal. (msdmanuals.com)
Search1
A mouldy cantaloupe in a Peoria market in 1941 was found to contain the best and highest quality penicillin after a world-wide search. (wikidoc.org)
Medicine1
The development of penicillin for use as a medicine is attributed to the Australian Nobel Laureate Howard Walter Florey . (wikidoc.org)
Place1
Some of the pioneering trials of penicillin took place at the Radcliffe Infirmary in Oxford. (wikidoc.org)
Treat2
Their attempts to treat humans failed due to insufficient volumes of penicillin (the first patient treated was Reserve Constable Albert Alexander ), but they proved its harmlessness and effect on mice. (wikidoc.org)
On March 3, 1942 John Bumstead and Orvan Hess became the first in the world to successfully treat a patient using penicillin. (wikidoc.org)