• Colchicine lowers levels of uric acid in the bloodstream, thus preventing the formation of uric acid crystals. (usiale.org)
  • Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. (david-cook.org)
  • Because agents that lower uric acid can precipitate attacks of gout, low-dose colchicine is typically used as prophylaxis (usually for 6 months) when such therapy is initiated. (medscape.com)
  • Recommended drugs for acute attacks were oral non-steroidal anti-inflammatory drugs (NSAIDs), oral colchicine (ES = 0.87 (95% confidence interval, 0.25 to 1.50)), or joint aspiration and injection of corticosteroid. (bmj.com)
  • Use of any colchicine product in conjunction with P-gp inhibitors is contraindicated in patients with renal or hepatic impairment. (medscape.com)
  • aspirin decreases effects of probenecid by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
  • probenecid increases levels of imipenem/cilastatin by decreasing renal clearance. (medscape.com)
  • probenecid increases levels of methotrexate by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
  • aceclofenac will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
  • Long-term (prophylactic) regimens of oral colchicine are absolutely contraindicated in patients with advanced renal failure (including those on dialysis). (homecuresforgout.org)
  • These agents increase the risk of renal stones, with about a 9-10% risk for probenecid. (medscape.com)
  • Colchicine toxicity can be potentiated by the concomitant use of cholesterol-lowering drugs (statins, fibrates). (homecuresforgout.org)
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  • Colchicine/probenecid is used in the treatment of Gouty Arthritis and belongs to the drug class antigout agents . (drugs.com)
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  • nirmatrelvir will increase the level or effect of colchicine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • Apart from inhibiting mitosis (a process heavily dependent on cytoskeletal changes), colchicine also inhibits anti-inflammatory effect. (homecuresforgout.org)
  • Since one of the defining characteristics of cancer cells is a significantly increased rate of mitosis, this means that cancer cells are significantly more vulnerable to colchicine poisoning than are normal cells. (homecuresforgout.org)
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  • However, the therapeutic value of colchicine against cancer is (as is typical with chemotherapy agents) limited by its toxicity against normal cells. (homecuresforgout.org)
  • Probenecid is sometimes used with certain kinds of antibiotics to make them more effective in the treatment of infections. (david-cook.org)
  • The British drug development company Angiogene is developing a prodrug of a colchicine congener, ZD6126 [15] (also known as ANG453) as a treatment for cancer . (homecuresforgout.org)
  • colchicine is also used for the constipation predominant irritable syndrome in women and also for the treatment of persistent or severe aphthous stomatis. (catalystphotogroup.com)
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  • Brand names include ColBenemid, Col-Probenecid, and Proben-C. "ColBenemid - Proben-C". About Health. (wikipedia.org)
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  • Probenecid is available only with your doctor's prescription. (david-cook.org)
  • adagrasib will increase the level or effect of colchicine by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • amiodarone will increase the level or effect of colchicine by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • probenecid will increase the level or effect of baricitinib by decreasing elimination. (medscape.com)
  • probenecid increases levels of meropenem/vaborbactam by decreasing elimination. (medscape.com)