• Effective uricosuria reduces the miscible urate pool, retards urate deposition, and promotes resorption of urate deposits.Probenecid inhibits the tubular secretion of penicillin and usually increases penicillin plasma levels by any route the antibiotic is given. (drugcentral.org)
  • Thereafter, alkalization of the urine and the usual restriction of purine-producing foods may be somewhat relaxed.Probenecid should be continued at the dosage that will maintain normal serum urate levels. (drugcentral.org)
  • aspirin decreases effects of probenecid by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
  • Rarely, severe allergic reactions and anaphylaxis have been reported with the use of probenecid. (nih.gov)
  • Probenecid decreases both hepatic and renal excretion of sulfobromophthalein (BSP). (nih.gov)
  • Probenecid decreases both hepatic and renal excretion of sulfobromophtalein (BSP). (nih.gov)
  • pyrazinamide decreases levels of cyclosporine by unknown mechanism. (medscape.com)
  • pyrazinamide decreases effects of probenecid by unknown mechanism. (medscape.com)
  • Probenecid tablets are indicated for the treatment of the hyperuricemia associated with gout and gouty arthritis. (nih.gov)
  • Probenecid-AFT tablets 500mg are used to treat gout and gouty arthritis to relieve painful symptoms at all stages of the condition, also to prevent attacks of gout in people at risk of developing gout. (inhousepharmacy.vu)
  • Probenecid inhibits the tubular secretion of penicillin and usually increases penicillin plasma levels by any route the antibiotic is given. (nih.gov)
  • Probenecid competes withe meropenem for active tubular secretion. (medscape.com)
  • probenecid increases levels of methotrexate by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
  • aceclofenac will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
  • The tubular reabsorption of phosphorus is inhibited in hypoparathyroid but not in euparathyroid individuals.Probenecid does not influence plasma concentrations of salicylates, nor the excretion of streptomycin, chloramphenicol, chlortetracycline, oxytetracycline, or neomycin. (drugcentral.org)
  • Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. (jairadhesales.co.in)
  • Probenecid-AFT 500mg is also used to prevent hyperuricaemia which can be induced or aggravated by some diuretics that are used to treat oedema and hypertension. (inhousepharmacy.vu)
  • It has the following structural formula:C13H19NO4S M.W. 285.36Probenecid is white or nearly white, fine, crystalline powder. (drugcentral.org)
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially allopurinol (Zyloprim), colchicine and/or probenecid (Col-Probenecid, Benemid), ethionamide (Trecator-SC), and vitamins. (medlineplus.gov)
  • If you have diabetes, pyrazinamide may interfere with urine ketone tests. (medlineplus.gov)
  • Probenecid-AFT tablets 500mg also have another use in increasing the effectiveness of penicillin antibiotics by prolonging the length of time the antibiotic remains in the blood before it is excreted into the urine. (inhousepharmacy.vu)
  • Probenecid-AFT tablets 500mg also increase and prolong the blood concentration of beta-lactam antibiotics like penicillin, by inhibiting the secretion of penicillin by the kidneys into the urine, which means it stays in the blood for longer and is therefore more effective. (inhousepharmacy.vu)
  • Probenecid also acts on the kidney to prevent certain antibiotics, such as penicillin, from being passed in the urine. (medbroadcast.com)
  • By their mechanism of action, some uricosurics (such as probenecid) increase the blood plasma concentration of certain other drugs and their metabolic products. (wikipedia.org)
  • Probenecid belongs to the class of medications called uricosurics . (medbroadcast.com)
  • Probenecid increases plasma concentrations of methotrexate in both animals and humans. (nih.gov)
  • probenecid increases levels of imipenem/cilastatin by decreasing renal clearance. (medscape.com)
  • probenecid increases levels of meropenem/vaborbactam by decreasing elimination. (medscape.com)
  • Probenecid has been used in patients with some renal impairment but dosage requirements may be increased. (nih.gov)
  • Because of its mechanism of action, probenecid is not recommended in conjunction with a penicillin in the presence of known renal impairment. (nih.gov)
  • If probenecid is given with methotrexate, the dosage of methotrexate should be reduced and serum levels may need to be monitored. (nih.gov)
  • Therapy with probenecid should not be started until an acute gouty attack has subsided. (nih.gov)
  • In patients on probenecid who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (nih.gov)
  • A case reported demonstrated a decrease in cyclosporine plasma levels after pyrazinamide was added onto a renal transplant patient's therapy. (medscape.com)
  • Probenecid may not be effective in chronic renal insufficiency particularly when the glomerular filtration rate is 30 mL/minute or less. (nih.gov)
  • pyrazinamide and pexidartinib both increase inhibition of GI absorption. (medscape.com)
  • pyrazinamide and valoctocogene roxaparvovec both increase Other (see comment). (medscape.com)
  • probenecid will increase the level or effect of baricitinib by decreasing elimination. (medscape.com)
  • Probenecid crosses the placental barrier and appears in cord blood. (nih.gov)
  • Probenecid has also been reported to inhibit the renal transport of many other compounds including aminohippuric acid (PAH), aminosalicylic acid (PAS), indomethacin, sodium iodomethamate and related iodinated organic acids, 17-ketosteroids, pantothenic acid, phenolsulfonphthalein (PSP), sulfonamides, and sulfonylureas. (nih.gov)