Pro inflammatory dramatically cell cycle. Medical search. Frequent questions

The ability of two cytokines, tumor necrosis factor alpha and interferon gamma, are evaluated as paracrine mediators of endothelial cell function during angioregression. (biomedcentral.com)
Polymorphonucleocytes (PMNs) are the first to begin bactericidal activities using inflammatory mediators and oxygen free radical metabolites. (medscape.com)
Upregulation of adhesion molecules on the conjunctival epithelium results in infiltration of eosinophils, neutrophils and lymphocytes into the conjunctiva, leading to subsequent cascades of inflammatory mediators that characterize the persistent clinical inflammation of chronic allergic conjunctivitis. (reviewofophthalmology.com)
Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)

The end products of its enzymatic activity possess anti-oxidative, anti-apoptotic and anti-inflammatory properties. (springer.com)
Polymorphonuclear neutrophils (PMN) have distinct phenotypes that drive inflammation but also regulate lymphocytes and are the rate-limiting cell for generating anti-inflammatory lipoxin A 4 (LXA 4 ). (aai.org)

KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. (wikipedia.org)
Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
The current understanding of aGVHD pathogenesis can be summarized as (1) initial tissue damage induced by the conditioning regimen followed by the denudation of auto- and alloantigens accompanied by massive inflammatory cytokine secretion ("cytokine storm") activating APCs, (2) auto- and alloantigen presentation mediated by APCs together with the costimulatory signaling prime donor's cytotoxic T lymphocytes and their proliferation, and (3) the migration of activated cellular effectors toward GVHD target tissues. (hindawi.com)
Collectively, these studies demonstrate that the rate of endothelial cell proliferation is highest during corpus luteum formation, then decreases and remains low during the mid-luteal phase and structural regression of the corpus luteum. (biomedcentral.com)
The regulation of endothelial cell proliferation in the corpus luteum of pregnancy is less clear. (biomedcentral.com)
IL-2 promotes further T cell proliferation to augment the immunogenic response to injury. (medscape.com)
IL-1 stimulates the proliferation of inflammatory cells and promotes angiogenesis through endothelial cell replication. (medscape.com)

Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
sulfate B (CSB) inhibits A beta beta(1-42)-induced apoptosis and reduces the peptide neurotoxicity on neuroblastoma cells, a cytoprotective effect that is partially reverted by AGE inhibitors such as pyridoxamine and L-carnosine. (sirtsignaling.com)
On the other end of the spectrum, the microvascular endothelial cells are the first cells to undergo apoptosis at the onset of corpus luteum regression. (biomedcentral.com)
Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
Cetuximab-bound EGF receptor inhibits activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased production of matrix metalloproteinase and vascular endothelial growth factor. (medscape.com)

The TME consists of various cellular components, including immune cells, stromal cells, and extracellular matrix, along with soluble factors and signaling molecules. (biomedcentral.com)
These checkpoints act as molecular brakes on immune cells, preventing excessive activation and potential damage to healthy tissues. (biomedcentral.com)
However, cancer cells exploit these checkpoints to evade immune surveillance and suppress antitumor immune responses. (biomedcentral.com)
This innovative approach enhances the patient's immune system to target and eliminate tumor cells. (biomedcentral.com)
As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
Neutrophils are the first immune cells that infiltrate the damaged tissue as early as 24 h after injury. (springer.com)
From this viewpoint, we summarize the changes in innate immune cells seen in moderate and severe COVID-19 and highlight the roles of pro-inflammatory cytokines and type I interferons (IFNs) in the clinical outcomes. (molcells.org)
The innate immune cells serve as the first line of host defense and are essential for a rigorous immunity to viruses. (molcells.org)
Most host cells express cytoplasmic RLRs, whereas TLRs (TLR3, 7, and 8) are generally expressed in the endosomes of innate immune cells. (molcells.org)
Endothelial cells communicate with cells comprising the functional unit of the corpus luteum, i.e ., other vascular cells, steroidogenic cells, and immune cells. (biomedcentral.com)
Previous studies have focused intensively on the interactions between HCC cells and a wide variety of immune cells such as Kupffer cells, NK cells, T cells, and several antigen-presenting cells. (biomedcentral.com)
These tissue PMNs, unlike inflammatory PMNs, expressed a highly amplified LXA 4 circuit and were sex-specifically regulated during immune-driven dry eye disease. (aai.org)
These results identify female-specific regulation of LXA 4 -producing tissue PMN as a potential key factor in aberrant effector T cell activation and initiation of immune-driven dry eye disease. (aai.org)
This entire inflammatory response is orchestrated by the immune system. (arizonafamilyhealthcentre.com)
This involves every white blood cell such as: neutrophils, eosinphils (involved with allergies and parasites), basohils, monocyctes, mast cells, macrophages, natural killer cells, dendritric cells, B& T lymphocytes and other immune cells such as microglia (found in the brain), osteoclasts (found in the bone) and more. (arizonafamilyhealthcentre.com)
An autoimmune process, whereby the body's immune system attacks the insulin-producing cells of the pancreas, is the defect behind type 1 diabetes. (fitnessology.net)
Beta-glucans are a type of sugar that protects our cells and promotes a healthy immune response. (honeycolony.com)
1 Thus, unlike the periodic spikes in seasonal allergens where avoidance can mitigate the level of exposure, the constant presence of perennial allergens results in continual priming of the allergic response, altering the immune reaction to future exposures and leading to a chronic inflammatory state. (reviewofophthalmology.com)
2 In contrast, a chronic AC elicited by continuous exposure to lower levels of allergen involves recruitment of secondary immune cells and a more extensive inflammatory response. (reviewofophthalmology.com)
All of these components amplify initial responses and alter future immune responses by priming the antigen recognition sites on dendritic cells. (reviewofophthalmology.com)
There were also significant differences in microbial composition in dust samples and in innate immune cells between the two groups of children. (medscape.com)

Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
Then, 3-4 days later inflammatory monocytes are recruited into ischemic area of the heart. (springer.com)
This type of inflammation contains the following events: dilation of blood vessels, increased permeability of the small blood vessels called capillaries, clotting of fluid and blood "leaked "into the damaged tissue, migration of white blood cells such as monocytes, macrophages, granulocytes and swelling. (arizonafamilyhealthcentre.com)
These growth factors act on surrounding cells and stimulate chemotaxis of neutrophils, monocytes, and fibroblasts to the area of injury. (medscape.com)

acute neutrophil-driven inflammatory diseases. (sirtsignaling.com)
The concept of polymorphonuclear neutrophils' (PMNs') single-track fate as terminally differentiated and short-lived primary effector cells of host defense and acute inflammation is rapidly evolving. (aai.org)
Using single-cell RNA-seq, we identify a myeloid-biased subset within the LT-HSC population (mLT-HSCs) that is much more common amongst aged LT-HSCs and is uniquely primed to respond to acute inflammatory challenge. (biorxiv.org)
LT-HSCs from young and aged mice have differential responses to acute inflammatory challenge. (biorxiv.org)

Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)
Finally, chemokines are discussed as a vital endothelial cell secretory products that contribute to the recruitment of eosinophils and macrophages. (biomedcentral.com)
ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. (jci.org)

HSPCs directly sense inflammatory stimuli in vitro and have a robust transcriptional response. (biorxiv.org)

Histomorphometric and immunohistochemistry analysis revealed that MSU-induced inflammatory cell infiltration, as well as the elevated expression of c-Fos and pro-inflammatory proteins (inducible nitric oxide synthase and cyclooxygenase-2) observed in synovial tissue, were significantly inhibited by treatment with lemnalol. (sirtsignaling.com)
Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification , tissue stiffening , loss of stem cell function , genetic alterations, and impaired energy production . (fightaging.org)
These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
Ab depletion of tissue PMN abrogated LXA 4 formation in lymph nodes, as well as caused a marked increase in Th1 and Th17 cells and a decrease in Tregs. (aai.org)
Platelets elaborate a number of proinflammatory substances, such as adenosine diphosphate, tissue growth factor beta (TGF-ß), and platelet-derived growth factors (PDGF). (medscape.com)
In essence, tissue cells become less responsive to insulin. (fitnessology.net)

Similar finding in esophageal epithelium was observed, where overexpression of KLF4 resulted in increased inflammation that eventually lead to the development of esophageal squamous cell cancer in mice. (wikipedia.org)
Thus, development of strategies targeting particular subsets of inflammatory cells and providing well-timed resolution of inflammation may be crucial for proper healing and recovery. (springer.com)
What cells or tissues are involved with inflammation? (arizonafamilyhealthcentre.com)
Inflammation is a body wide phenomena and effects all cells in the body. (arizonafamilyhealthcentre.com)
Continuous activation and degranulation of mast cells activate cellular-mediated inflammation, structural cells of the corneal and conjunctival epithelium, vascular endothelial cells and fibroblasts. (reviewofophthalmology.com)

Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
Other particles may be engulfed by epithelial cells, primarily in the vicinity of the bronchial-alveolar duct junctions, and retained for much longer periods, with gradual removal to lymph nodes. (cdc.gov)

the kidneys where it is involved in the differentiation of embryonic stem cells and induced pluripotent stem (iPS) cells to renal lineage in vitro and its dysregulation has been linked to some renal pathologies. (wikipedia.org)

Important insights on the morphology and function of luteal endothelial cells have been gained from a combination of in vitro and in vivo studies on endothelial cells. (biomedcentral.com)
In vitro, conditioned medium from exo-adipocytes promoted HepG2 cell migration and increased tube formation of human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)

The cyclic nature of the capillary bed in the corpus luteum offers a unique experimental model to examine the life cycle of endothelial cells, involving discrete physiologically regulated steps of angiogenesis, blood vessel maturation and blood vessel regression. (biomedcentral.com)
Available evidence indicates that microvascular endothelial cells of the corpus luteum are not alike, and may differ during the process of angiogenesis and angioregression. (biomedcentral.com)

Several inflammatory cytokines and adipokines were dramatically dysregulated in the metabolic tissues of aged MTMR14 KO mice compared to control mice. (biomedcentral.com)

Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
Thus, we need fat for optimum cellular cycle as well as function. (dietscan.net)
Here, we explore the role of HCC-derived exosomes in the cellular and molecular conversion of adipocytes into tumor-promoting cells. (biomedcentral.com)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)

and platelet/endothelial cell adhesion molecule-1, PECAM-1). (biomedcentral.com)

Insulin is the hormone that helps the cells and tissues of the body use glucose. (fitnessology.net)

They also damage bacterial cell membranes , increase oxidative stress, disrupt iron regulation, and can increase the efficacy of antibiotics by up to 100 times. (honeycolony.com)

KLF4 is an anti-tumorigenic factor and its expression is often lost in various human cancer types, such as Colorectal cancer, gastric cancer, esophageal squamous cell carcinoma, intestinal cancer, prostate cancer, bladder cancer and lung cancer. (wikipedia.org)
However, in some cancer types KLF4 may act as a tumor promoter where increased KLF4 expression has been reported, such as in oral squamous cell carcinoma and in primary breast ductal carcinoma. (wikipedia.org)
Also, overexpression of KLF4 in skin resulted in hyperplasia and dysplasia, which lead to the development of squamous cell carcinoma. (wikipedia.org)
However, whether PKM2 can promote head and neck squamous cell carcinoma (HNSCC) progression and immunosuppression remains unknown. (researchsquare.com)

KLF4 is expressed in the cells that are non-dividing and are terminally differentiated in the intestinal epithelium, where KLF4 is important in the regulation of intestinal epithelium homeostasis (terminal cell differentiation and proper localization of the different intestinal epithelium cell types). (wikipedia.org)

To intelligently employ bio-signaling molecules in one's medical practice (or one's home skincare regimen), there should be familiarity with the significant differences among the bio-signals patterns produced by adipose (fat) stem cells and bone marrow mesenchymal stem cells, and for completeness, fibroblasts. (barefacedtruth.com)
bFGF is a chemotactic and mitogenic factor for fibroblasts and endothelial cells. (medscape.com)

Single-cell RNA-seq unmasked the existence of two subsets within the LT-HSC population that was apparent upon stimulation but not steady-state. (biorxiv.org)

Inherited genetic variants such as single-nucleotide polymorphisms (SNPs) of candidate genes, encoding various cytokines, chemokines, and inflammatory regulators, have become a subject of interest of genetic studies searching for independent predictors of GVHD development and HSCT outcome [ 4 - 7 ]. (hindawi.com)

Afterwards, however, the hearts of Hmox1-deficient mice undergo adverse late LV remodeling due to overactive and prolonged post-ischemic inflammatory response. (springer.com)
Circulating inflammatory cytokines were significantly elevated and plasma adipokine levels were abnormally regulated in aged MTMR14 KO mice. (biomedcentral.com)
We examined the consequences of CTCF depletion in immortalised human and mouse cells using shRNA knockdown and CRISPR/Cas9 genome editing and examined the growth and development of heterozygous Ctcf ( Ctcf +/- ) mice. (preprints.org)

This study also evaluated the usefulness of abdominal ultrasonography in assessing the visceral fat correlated with systemic inflammatory status, as an alternative method to identify patients at risk of endometrial cancer. (sirtsignaling.com)

It is suggested that the same is true in mesenchymal stem cells (MSCs). (wikipedia.org)

Extramedullary hematopoiesis (EMH) is likely the result of abnormal trafficking of hematopoietic stem cells (HSC) from the bone marrow to organs such as the spleen, liver, and lung, causing organomegaly and sometimes organ dysfunction. (cancernetwork.com)
Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. (biorxiv.org)
One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)

Background/Aim: In endometrial cancer, visceral obesity, as a risk factor, is associated with a chronic inflammatory process, confirmed by the elevation of serum inflammatory markers in obese patients. (sirtsignaling.com)
Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below). (medscape.com)

The potential clinical applications of research directed on corpus luteum endothelial cells are intriguing considering reproductive processes in which vascular dysfunctions may play a role such as ovarian failure, polycystic ovary syndrome (PCOS), and ovarian hyperstimulation syndrome (OHSS). (biomedcentral.com)

Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)

For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)

Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive tumor growth. (biomedcentral.com)
Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
Exosomes, released by malignant cells, represent a novel way of cell-cell interaction and have been shown to play an important role in cancer cell communication with their microenvironment. (biomedcentral.com)
Our results provide new insights into the concept that tumor cell-derived exosomes can educate surrounding adipocytes to create a favorable microenvironment for tumor progression. (biomedcentral.com)
Tumor behavior is determined by not only the malignant potential of tumor cell itself but also the signals from its microenvironment. (biomedcentral.com)
Thus, it is clear that the crosstalk between tumor cells and their surrounding microenvironment is crucial for HCC development. (biomedcentral.com)
Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. (aacrjournals.org)

Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)

However, running the proper blood chemistries can detect these inflammatory processes in the blood vessels. (arizonafamilyhealthcentre.com)

Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis. (stanfordchildrens.org)
Depressed lymph node PMN and LXA 4 in females correlated with an increase in effector T cells (Th1 and Th17), a decrease in regulatory T cells (Treg), and increased dry eye pathogenesis. (aai.org)
May involve decrease in reticuloendothelial cell function or increase in platelet production. (medscape.com)

This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment. (researchgate.net)

In this study, the anti-cancer effects of pentadecanoic acid were evaluated in human breast carcinoma MCF-7/stem-like cells (SC), a cell line with greater mobility, invasiveness, and cancer stem cell properties compared to the parental MCF-7 cells. (mdpi.com)
Myelofibrosis (MF) is a hematopoietic stem cell malignancy classified as a myeloproliferative neoplasm (MPN). (cancernetwork.com)
Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)
Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers the only curative modality for many hematological disorders. (hindawi.com)
It's no secret to readers here that DrJohn and DrGeorge have day jobs as stem cell researchers, both in the lab and the clinic, and have developed skincare products whose hero ingredients (human growth factors, cytokines, mRNAs,miRNAs, etc) derive from stem cells on permanent loan from bone marrow of young adult humans. (barefacedtruth.com)
Add to that more than a decade of nearly criminal misuse of the words "stem cell" in cosmetic advertising, and the mountain we have had to climb is both steep and high. (barefacedtruth.com)

Among these, we show that Klf5 , Ikzf1 and Stat3 play important roles in age-related inflammatory myeloid bias. (biorxiv.org)

KLF4 is also important in regulating centrosome number and chromosome number (genetic stability), and in promoting cell survival. (wikipedia.org)
Whether within the body or in a laboratory flask, growth factors and cytokines patterns are determined by the genetic material within the cells that produce them. (barefacedtruth.com)

While CTCF is essential for embryonic development, little is known of its absolute requirement in somatic cells and the consequences of CTCF haploinsufficiency. (preprints.org)

Do you know that fat stem cells and bone marrow stem cells are really, really different? (barefacedtruth.com)

Design We performed whole-genome transcriptional analysis of colonic biopsies from patients with histologically active and inactive UC, and non-inflammatory bowel disease (non-IBD) controls. (bmj.com)
We identify a new transcriptional signature associated with the involved mucosa of UC patients in remission that is significantly different from that of uninvolved or non-inflammatory bowel disease mucosa. (bmj.com)
Introduction Rheumatoid arthritis (RA) is an inflammatory disease of unknown cause. (exposed-skin-care.net)

This includes blood pressure, filtering and removal of various metabolic waste products, blood volume, red blood cell count, electrolytes, acid base balance… Guyton's Textbook of Medical Physiology has nearly 200 pages devoted to renal function, and that is a bare-bones overview with little time spent on pathophysiology. (robbwolf.com)

To begin with considering to be produced barely aside leukocytes, cytokines are again known to be secreted nigh a heterogeneity of other cells including those within the understanding and those forming the blood-brain barriers (BBBs). (wgc2010.sk)

Adipose stem cells are most proficient at creating more fat cells, and at producing pro-inflammatory cytokine patterns. (barefacedtruth.com)

Fat is what cell membranes are made of. (dietscan.net)

Significant improvement was noted in peripheral blood cytokine levels (IL-6, IL-8, IL-10, IL-17, IL-23, and sCD74/MIF ratio) from baseline to 8 weeks.Conclusions: MBSR significantly improved perceived stress and self-control scores while decreasing ALT levels, steroid requirements, and inflammatory cytokine levels in this pilot study in adult AIH. (stanfordchildrens.org)

Lactate production and the expression of galectin-9, a critical immunosuppression molecule, were detected after PKM2 knockdown and overexpression in HNSCC cells. (researchsquare.com)

Given the global prevalence of NAFLD, a better understanding of the interplay between HCC cells and adipocytes is urgently needed. (biomedcentral.com)
Exosomes were isolated from HCC cell line HepG2 and added to adipocytes. (biomedcentral.com)
Our results demonstrated that HCC cell HepG2-derived exosomes could be actively internalized by adipocytes and caused significant transcriptomic alterations and in particular induced an inflammatory phenotype in adipocytes. (biomedcentral.com)

SIRT1 is an enzyme located primarily in the cell nucleus. (sirtsignaling.com)

It was shown to stimulate EMT in some systems by promoting/maintaining stemness of cancer cells, as is the case in pancreatic cancer, head and neck cancer, endometrial cancer, nasopharyngeal cancer, prostate cancer and non-small lung cancer. (wikipedia.org)
Unfortunately, patients are already in the terminal stage at this time, and the cancer cells have already invaded the surrounding organs or metastasized far away, which leads to the loss of the curative chance for most patients ( 1 ). (frontiersin.org)

Anatomy24

Organisms13

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Chemicals and Drugs111

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Phenomena and Processes82

Disciplines and Occupations1

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Immune21

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Tissue6

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Induced plur1

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Epithelium1

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