Thus, the assembly of the molecular framework will depend in part on the structure and functionality of available starting materials, the selectivity (regio and stereo) of the various reactions that may be used to stitch them together, and the loss or relocation of functional groups in the intermediate compounds formed on the way to the final product. (msu.edu)
Indeed, new synthetic routes to known compounds continue to be reported, particularly as new reactions are developed and applied to difficult transformations. (msu.edu)
Moreover, the palladium catalyst was also used extensively in cross-coupling reactions, such as Buchwald-Hartwig, Suzuki-Miyaura, Heck, Sonogashira, Negishi, and Stille to synthesize a variety of useful compounds [ 17 ] [ 18 ] . (encyclopedia.pub)
Https1
Intramolecular Cyclization" Encyclopedia , https://encyclopedia.pub/entry/46176 (accessed December 05, 2023). (encyclopedia.pub)
Synthesis4
Furthermore, a long multi-step synthesis requires many hours of effort by the chemists conducting the reactions. (msu.edu)
8. For a given target molecule, several different reaction sequences may serve to accomplish its synthesis. (msu.edu)
For all but the simplest of these, a majority of the reactions in the synthesis involve functional group modification, preceding or following a smaller number of carbon-carbon bond forming reactions. (msu.edu)
Accordingly, a number of strategies have been established for the synthesis of these skeletons, including intramolecular Fischer indole synthesis, Witkop photocyclizations, Diels-Alder reactions, Friedel-Crafts reactions, Pictet-Spengler reactions, 6π-electrocyclizations, and transition-metal-catalyzed domino reactions. (encyclopedia.pub)
Functional2
6. If numerous functional groups are present at intermediate stages, some of these may require protection from unwanted reaction. (msu.edu)
The ability of gold to activate unsaturated groups in different modes, together with its tolerance to a wide range of functional groups and reaction conditions, turns gold-based complexes into efficient and highly sought after catalysts. (frontiersin.org)
Conditions2
This tandem aza-Cope/Mannich reaction is characterized by its mild reaction conditions, diastereoselectivity, and wide synthetic applicability. (wikipedia.org)
Due to the mild heating conditions of the reaction carried out, unlike the more stringent ones for a purely hydrocarbon Cope rearrangement, this heteroatomic Cope rearrangement introduced the hypothesis that having a positive charge on a nitrogen in the cope rearrangement significantly reduces the activation barrier for the rearrangement. (wikipedia.org)
Presence1
Notably, compared to the previous Heck reaction, the relative rate of alkene insertion in this reaction is higher, likely due to the presence of the strong electron-withdrawing nitro group. (encyclopedia.pub)