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  • therapeutic
  • The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. (mdanderson.org)
  • The process by which the leukemic cells prove resistant to TKIs and the restoration of BCR-ABL1 signal transduction from previous inhibition has initiated the pursuit for the causal mechanisms of resistance and strategies by which to surmount resistance to therapeutic intervention. (aacrjournals.org)
  • pluripotent
  • The G6PD data indicate that chronic myelogenous leukemia, polycythemia vera and essential thrombocythemia involve stem cells pluripotent for granulocytes, erythrocytes, megakaryocytes and lymphocytes. (semanticscholar.org)
  • Pubmed ID: 26455413 Tools for rapid and efficient transgenesis in "safe harbor" loci in an isogenic context remain important to exploit the possibilities of human pluripotent stem cells (hPSCs). (jove.com)
  • plasticity
  • This view has been challenged by recent observations that suggest a high degree of plasticity or transdifferentiation for stem cells ( 3 - 5 ). (pnas.org)
  • proteins
  • Serine/arginine (SR) protein-specific kinase (SRPK), a family of cell cycle-regulated protein kinases, phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing. (aacrjournals.org)
  • SR protein-specific kinase 1 (SRPK1) and SRPK2 are regulated by the cell cycle and are specific for SR proteins ( 3 ). (aacrjournals.org)
  • protein
  • The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. (genecards.org)
  • The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. (springer.com)
  • Studies have shown that the memory response to adenovirus is directed primarily to the hexon protein and is dominated by CD4 + T cells, probably due to the ability of the virus to block its presentation on HLA class I antigens. (microbiologyresearch.org)
  • HS associated to core protein, constitute the superfamily of heparan sulfate proteoglycans (HSPGs) present on the cell surface and in the extracellular matrix of all tissues. (springer.com)
  • molecules
  • We hypothesize that there are yet to be discovered regulators, and that the stem cell supportive ability of AFT024 comes from many interacting molecules. (pnas.org)
  • We determined if the altered expression of adhesion molecules during stem cell expansion could be a reason for the discrepancy. (scielo.br)
  • regulator
  • In support of these hypotheses, we have shown that one molecule, delta-like (dlk) ( 12 )/preadipocyte factor-1 (pref-1) ( 13 ) is preferentially expressed in AFT024, and functions as a positive stem cell regulator ( 14 ). (pnas.org)
  • intrinsic
  • These results suggest that CSPs are intrinsic cardiac stem cells and involved in the regeneration of diseased hearts. (rupress.org)
  • Recent work has shown that the process of blood cell formation is regulated by a variety of intrinsic transcription factors. (biologists.org)
  • erythrocytes
  • The complexity of this system is enormous, since as many as 10 10 erythrocytes and 10 8 -10 10 white blood cells are produced each hour each day during the lifetime of the individual. (scielo.br)
  • peripheral blood
  • When cART is interrupted, latently infected cells produce infectious virus that can be rapidly followed by a loss of peripheral blood CD4+ T cells and progression towards immunodeficiency. (mdpi.com)
  • subset
  • Additionally, it is possible that the subset of protected T cells will also be able to facilitate the immune-based elimination of latently infected cells if they can be activated to express viral antigens. (mdpi.com)
  • genes
  • Antisense morpholino-mediated knockdown of the Integrator subunit 5 (Ints5) in zebrafish embryos affects U1 and U2 snRNA processing, leading to aberrant splicing of smad1 and smad5 RNA, and reduced expression of the hematopoietic genes stem cell leukemia ( scl , also known as tal1 ) and gata1 . (biologists.org)
  • Adhesion
  • 1 ⇓ ⇓ ⇓ - 5 JAM-B has been previously shown to interact with JAM-C and contributes to leukoendothelial and interendothelial cell-cell adhesion. (bloodjournal.org)
  • The expression of CD62L, HLA-DR and CD117 was modulated after culture, particularly with TPO + FL + KL, explaining differences between the adhesion and engraftment of primary and cultured candidate stem cells. (scielo.br)
  • blood
  • Following the onset of circulation at about 21 days of development, yolk sac cells are found in embryonic blood. (bloodjournal.org)
  • See " A Molecular Model of Blood Cell Renewal " , e349. (pubmedcentralcanada.ca)
  • The North America market is expected to exhibit strong growth in the next few years due to the increasing demand for stem cell research and public awareness about cord blood banking. (transparencymarketresearch.com)
  • 50 infectious units/mm 3 of blood) are known to harbor a latent viral reservoir in resting CD4+ T cells [ 2 , 3 , 4 , 5 ]. (mdpi.com)
  • Stem cell origin of human myeloid blood cell neoplasms. (semanticscholar.org)
  • Through a collaboration with the Institute for Applied Cancer Science and Center for Co-Clinical Trials Moon Shot platforms, we're capitalizing on this new target in a Phase I clinical trial examining whether a drug designed to starve blood cancer cells improves clinical outcomes for AML patients. (mdanderson.org)
  • These rare cells are lifesaving, and are often the last resort, when transplanted into patients with blood malignancies. (parentsguidecordblood.org)
  • When parents donate UCB to a public cord blood bank (CBB) , the decision of whether or not to store the UCB unit is based primarily on the number of cells collected before and after processing. (parentsguidecordblood.org)
  • The processing usually removes most of the red blood cells and plasma. (parentsguidecordblood.org)
  • Unfortunately, the problems with our conventional cord blood transplant practices are even worse than described so far: not only are we not using the best tests available to measure UCB stem cells released for transplant, we also are not running those tests on the best samples to represent the UCB unit. (parentsguidecordblood.org)
  • Cytokines
  • UCB-CD34+ cells were cultured in the presence or absence of BM-MSC and/or cytokines for 3 and 7 days. (biomedcentral.com)
  • An RNA expression survey for known stem cell regulatory cytokines, both positive and negative, did not reveal significant differences among supportive and nonsupportive cell lines ( 8 ). (pnas.org)
  • Identification
  • Using RMCE, we successfully incorporated several transgenes useful for lineage identification, cell toxicity studies, and gene overexpression to study the hepatocyte lineage. (jove.com)
  • gene
  • Bioinformatic strategies were used to group time-ordered gene expression profiles generated from microarrays into signatures of quiescent and dividing stem cells. (pubmedcentralcanada.ca)