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  • regulates
  • Somatostatin , also known as growth hormone-inhibiting hormone ( GHIH ) or by several other names , is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. (wikidoc.org)
  • epithelial
  • Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer. (springer.com)
  • Gene expression from adeno-associated virus vectors in airway epithelial cells. (springer.com)
  • therapeutic
  • Finally, according to the relevance of HS moieties effects on this complex medullar niche, we describe recent data that identify HS mimetics or sulfated HS signatures as new glycanic tools and targets, respectively, for hematopoietic and mesenchymal stem cell based therapeutic applications. (springer.com)
  • There has been a rapid growth in the number of clinical trials that utilize gene transfer either for cell marking or therapeutic intent. (springer.com)
  • The discovery of adult stem cells has led to an ongoing revolution of therapeutic and regenerative medicine and the proposal of novel therapies for previously terminal. (ebscohost.com)
  • vitro
  • Primitive hematopoietic cells demonstrate specific adhesion to Opn in vitro via beta1 integrin. (edu.au)
  • In vitro experiments demonstrated that cells of the immune system are exceptionally sensitive to microgravity. (springer.com)
  • Buravkova LB, Rykova MP, Grigorieva V, Antropova EN (2004) Cell interactions in microgravity: cytotoxic effects of natural killer cells in vitro. (springer.com)
  • Cogoli A (1996) Gravitational physiology of human immune cells: a review of in vivo, ex vivo and in vitro studies. (springer.com)
  • We found that matrix metalloproteinase 2 (MMP-2) facilitated invasion of the mesangial cells into ECM and proliferation in vitro. (diabetesjournals.org)
  • Hyperglycemia has been implicated as an important factor in the development of phenotypic changes, as many such changes have been induced in vitro by exposing mesangial cells to elevated glucose levels ( 8 - 12 ). (diabetesjournals.org)
  • niche
  • Although recent data suggests that osteoblasts play a key role within the hematopoietic stem cell (HSC) niche, the mechanisms underpinning this remain to be fully defined. (edu.au)
  • The key regulatory effects of major medullar HSPGs are described, focusing on their roles in the interactions between hematopoietic stem cells and their endosteal niche, and on their ability to interact with Heparin Binding Proteins (HBPs). (springer.com)
  • The disease was first described by Ehrlich at the end of nineteenth century [ 20 ] and has been considered to involve primitive stem cell deficiency or more currently considered disorganized stem cell niche [ 21 - 24 ]. (hindawi.com)
  • Mice
  • We have found that mesangial cells isolated from nonobese diabetic mice, a model of type 1 diabetes, exhibit phenotypic changes, including increased type IV collagen synthesis and IGF-I secretion ( 5 , 6 , 13 ). (diabetesjournals.org)
  • We have found that mesangial cells isolated from three different strains of mice with glomerulosclerosis (ROP Os/+, mice transgenic for bovine growth hormone, and aging B6 mice) all exhibit an altered phenotype ( 14 - 16 ). (diabetesjournals.org)
  • We postulated that phenotypic changes would be present in mesangial cell progenitors resident in the BM of mice with diabetic nephropathy. (diabetesjournals.org)
  • Thus, BM mesangial cell progenitors may play an important role in the development and progression of diabetic nephropathy in db / db mice with type 2 diabetes. (diabetesjournals.org)
  • EXPRESSION
  • Adenovirus as an expression vector in muscle cells in vivo . (springer.com)
  • Retinoids regulate expression of the retinol-binding protein in hepathoma cells in culture. (tarifiklan.com)
  • Interestingly, only a portion of the progeny cells within the lentivirus-transduced methylcellulose colonies expressed GFP, in contrast to the homogeneous expression in oncoretrovirus-transduced colonies. (ox.ac.uk)
  • AC133 expression in human stem cells. (ebscohost.com)
  • viral
  • Hepatitis C virus nonstructural proteins are localized in a modified endoplasmic reticulum of cells expressing viral subgenomic replicons. (tarifiklan.com)
  • Secondary plating of the primary GFP(+) lentivirus vector-transduced colonies revealed vector PCR(+) GFP(+) (42%), vector PCR(-) GFP(-) (46%), and vector PCR(+) GFP(-) (13%) secondary colonies, indicating true genetic mosaicism with respect to the viral genome in the progeny cells. (ox.ac.uk)
  • Although cytokine stimulation during transduction correlates with higher transduction efficiency, rapid cell division after transduction may result in loss of the viral genome in the progeny cells. (ox.ac.uk)
  • phenotype
  • The pathogenesis of glomerular lesions in diabetes includes changes in the phenotype of mesangial cells ( 5 , 6 ), such as increases in cell size and turnover and the deposition of excess extracellular matrix (ECM) ( 5 - 8 ). (diabetesjournals.org)
  • Because the lesions in diabetic nephropathy are diffuse, bilateral, and prominent in the mesangial regions, we postulated that mesangial cells carrying the sclerosis phenotype could be derived from a common progenitor. (diabetesjournals.org)
  • We found that the mesangial areas in recipient glomeruli were repopulated with mesangial cells containing the db / db genotype and phenotype and that the recipients developed albuminuria and severe glomerular lesions. (diabetesjournals.org)
  • adult
  • Donor-specific information will be correlated with these research studies to identify factors that may assist with the understanding of adult stem cell biology. (clinicaltrials.gov)
  • stromal
  • Elevated circulating stromal-derived factor-1 levels in sickle cell disease," Acta Haematologica , vol. 122, no. 1, pp. 64-69, 2009. (hindawi.com)