Thus, the elaboration of a protocol for the in vitro cultivation of the erythrocytic stages of Plasmodium falciparum revolutionized research on this important parasite. (nature.com)
The development of a protocol for the routine continuous in vitro culture of Plasmodium falciparum in 1976 1 released malaria researcher from the reliance on in vivo observations. (nature.com)
Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver stages and the disease-causing blood stages of the human malaria parasite Plasmodium falciparum . (nature.com)
Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model. (harvard.edu)
Quantitative assessment of the interactions and activity of combinations of antimalarial agents in continuous in vitro culture of Plasmodium falciparum / by Wilbur K. Milhous. (who.int)
Studies on resistance to chloroquine by Plasmodium falciparum with potential application to the development of a modified in vitro susceptibility test / by Michael Davis Rogers. (who.int)
Plasmodium falciparum in G6PD normal and G6PD-deficient erythrocytes : the parasite cycle and adaptive phenomena / by Esien Archibong Usanga. (who.int)
Here the lipid profiles of red blood cells infected with the five different sexual stages of Plasmodium falciparum were analysed by mass spectrometry and compared to those from uninfected and asexual trophozoite infected erythrocytes. (biomedcentral.com)
The prolonged duration of gametocyte maturation is a unique feature of only a few Plasmodium species infecting higher primates ( P. falciparum and P. reichenowi ) [ 1 , 2 ]. (biomedcentral.com)
Infection with P. falciparum causes by far the highest morbidity of all human Plasmodium species. (biomedcentral.com)
From the 86 positive blood samples, 13 Plasmodium falciparum and 4 Plasmodium vivax were selected and underwent cloning and, subsequently, sequencing and the sequences were subjected to phylogenetic analysis using the neighbor-joining and maximum parsimony methods. (biomedcentral.com)
Plasmodium falciparum is mainly present in Africa and is responsible for high levels of mortality, mainly in children. (ox.ac.uk)
After different attempts for elimination only Plasmodium falciparum could be eliminated but vivax remained, and this is because it forms this kind of structure but falciparum does not. (ox.ac.uk)
Vivax vaccine development is in the early stages of development in comparison to Plasmodium falciparum which is more advanced. (ox.ac.uk)
Plasmodium falciparum-infected erythrocytes (IRBC) synthesize 3 histidine-rich proteins: HRP-I or the knob-associated HRP, HRP-II and HRP-III or SHARP. (ox.ac.uk)
Using a specific technology originally applied to expression of HIV antibodies, we demonstrated that mice can be protected from Plasmodium falciparum infection by antibodies against circumsporozoite protein, an antigen found on the surface of the form of the parasite injected by mosquitoes. (dtic.mil)
Tests of protective efficacy of these MAbs, delivered by AAV vectors, in a non-human primate Aotus nancymaae model of P.falciparum infection. (dtic.mil)
The parasite that causes malaria, Plasmodium falciparum, has humans as its primary host, but it can also infect other primates, such as monkeys and apes, which can act as reservoir hosts. (uaftimes.com)
Vivax7
quotidianae P. perniciosum P. pleurodyniae P. praecox P. quartana P. quotidianum P. sedecimanae P. tenue P. undecimanae P. vegesio-tertaniae P. vivax-minuta Plasmodium shortii and Plasmodium osmaniae are now considered to be junior synonyms of Plasmodium inui. (wikipedia.org)
Plasmodium vivax hypnozoites persist in the liver, cause malaria relapse and represent a major challenge to malaria elimination. (elifesciences.org)
Plasmodium vivax is the most widely distributed form of malaria in the world and it can be present not only in Africa but also in the Western Pacific, and importantly in highly populated areas of Latin America and Asia, where it is a big problem. (ox.ac.uk)
However, an increasing number of autochthonous episodes attributed to Plasmodium vivax have recently been reported from the Atlantic Forest region of Rio de Janeiro state. (unl.pt)
Illustrated by Gertrude H. Nicholson, these two charts depict a cytomorphologic comparison between the parasitesPlasmodium vivax in humans, and Plasmodium simium in monkeys. (cdc.gov)
PCR or blood smears) that detect the presence of parasites in the Plasmodium genus, during the CDC-mandated quarantine period. (cdc.gov)
Due to concerns over the introduction of Plasmodiumparasites that may cause malaria in humans, treatment to eliminate the infection will be required before infected animals are released from CDC-mandated quarantine. (cdc.gov)
This study was conducted to investigate the distribution of the Plasmodium species based on the molecular detection and to study the molecular phylogeny of these parasites. (biomedcentral.com)
These parasites are known to infect a range of animals from primate to reptiles, theis list also includes birds. (researchmatters.in)
Analogues of these HRP were also absent from asexual parasites of diverse primate and murine malaria species screened with this panel of antibodies. (ox.ac.uk)
Species14
Confusingly Plasmodium tenue was proposed in the same year (1914) for a species found in birds. (wikipedia.org)
The human species is now considered to be likely to have been a misdiagnosis and the bird species is described on the Plasmodium tenue page. (wikipedia.org)
Two additional species within the subgenus Laverania have been identified on the basis of DNA sequences alone: Plasmodium billbrayi and Plasmodium billcollinsi. (wikipedia.org)
The protocol considers what is currently known about the biological behavior of Plasmodium species (including simian species), presence of vector species in the U.S., potential for drug resistance, zoonotic potential, and availability of validated tests. (cdc.gov)
Currently, of the simian Plasmodium species, Plasmodium knowlesi, P. cynomolgi, P. coatneyi, and P. inui have been reported to cause disease in humans. (cdc.gov)
If an NHP is identified as having a Plasmodium infection, ideally the species of the parasite should be identified to guide treatment decisions. (cdc.gov)
In this paper, we review the different protocols available to study human Plasmodium species either by using stem cell or alternative animal models. (wjgnet.com)
Preclinical assessment of correlates of protection in immunization and challenge studies with murine Plasmodium species can identify signatures of immune memory.We have previously established experimental malaria vaccine models, compared vaccine efficacy, and identified targets of CD8+ T cell responses against Plasmodium berghei liver stages by genome-wide epitope profiling. (fu-berlin.de)
the aim of this study was to detect genomic dna of plasmodium species from the faeces of new world monkeys. (liverpool.ac.uk)
They are usually immunologically-naïve to these pathogens, and primate populations can be quickly decimated because of the slow reproductive rates of most species, particularly great apes. (baylor.edu)
The genus Plasmodium consists of nearly 200 species that infect humans, birds, reptiles and mammals. (biomedcentral.com)
There are around 200 species of this parasite and they can infect a wide variety of animals including birds, reptiles, rodents and primates. (ox.ac.uk)
P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. (guidetomalariapharmacology.org)
Knowlesi4
Plasmodium knowlesi is a zoonotic malaria parasite that has gained increasing medical interest over the past two decades. (biomedcentral.com)
In this Thematic Series honouring "The Primate Malarias" book [ 7 ], the stories and research breakthroughs of P. knowlesi are described and reviewed here. (biomedcentral.com)
Urine and faeces were obtained from a Plasmodium knowlesi infected-Japanese macaque (Macaca fuscata) over the course of an experimentally induced infection. (fujita-hu.ac.jp)
P. knowlesi DNA (PkDNA) extracted from urine and faeces were monitored by nested PCR targeting the P. knowlesi specific cytochrome b (cytb) gene.Background: Diagnostic techniques based on PCR for the detection of Plasmodium DNA can be highly sensitive and specific. (fujita-hu.ac.jp)
In this study, we aim to disentangle factors influencing the risk of parasite exposure by exploring the impact of sleeping site ecology on infection with ectoparasites and vector-borne hemoparasites in two sympatric primates endemic to Madagascar. (biomedcentral.com)
Further, our results increase the sparse knowledge on ecological drivers of primate host-parasite interactions and transmission pathways in natural tropical environments. (biomedcentral.com)
Until such a test becomes widely available, infected NHPs should be treated using an antimalarial protocol that considers the potential for antimalarial resistance and the need to eliminate BOTH blood stages AND potential liver stages of Plasmodium . (cdc.gov)
In the case of malaria, experimental immunizations with arrested liver stages has proven safe and efficacious against challenge infections in mice, primates, and humans. (fu-berlin.de)
However, the molecular tracks of immune recognition and the immune effector mechanisms against Plasmodium pre-erythrocytic stages remain largely unsolved. (fu-berlin.de)
Humans4
cynomolgi, bastianellii) Plasmodium inui Plasmodium schwetzi Plasmodium semiovale[citation needed] Plasmodium simium (Plasmodium brasilianum and Plasmodium rhodiani which have been reported to infect humans, are likely synonymous with P. malariae) One possible experimental infection has been reported with Plasmodium eylesi. (wikipedia.org)
The volunteer (Dr Bennett) had previously been infected by Plasmodium cynomolgi and the infection was not transferable to a gibbon (P. eylesi 's natural host) so this cannot be regarded as definitive evidence of its ability to infect humans. (wikipedia.org)
Quammen devotes the last quarter or so of the book to tracing the discovery and transmission of HIV from primates to humans, and from 1900 to present-day. (scienceblogs.com)
ANSWER Malaria in humans probably evolved independently several times, and both times likely due to a cross-over event from a closely related primate malaria. (malaria.com)
Both of these charts, as well as others were published as Plate I, and Plate XXII respectively, in, "Primate Malarias", by G. Robert Coatney, [et al. (cdc.gov)
If importers choose to screen apparently healthy animals for Plasmodium infection during the quarantine period, positive results must be reported to CDC. (cdc.gov)
Although testing apparently healthy animals for Plasmodium infection during quarantine is optional, importers are reminded that NHPs that develop clinical signs of malaria during quarantine MUST undergo appropriate diagnostic testing to identify the cause of illness. (cdc.gov)
Although naturally acquired leprosy has also been described in captive nonhuman primates, the exact origins of infection remain unclear. (researchgate.net)
Zoonotic1
In particular, monkey faecal samples could be useful for the detection of zoonotic primate malaria in its natural hosts. (fujita-hu.ac.jp)
Nonhuman primates2
The Centers for Disease Control and Prevention's (CDC) Division of Global Migration Health (DGMH) administers regulations governing the importation of nonhuman primates (NHPs) into the United States. (cdc.gov)
Flies form high-density associations with human settlements and groups of nonhuman primates and are implicated in transmitting pathogens. (researchgate.net)
Berghei1
As a result, wild type Plasmodium berghei ANKA (WTPbA) has recently been transformed to express mouse interferon gamma (mIFN-γ). (biomedcentral.com)
Simian1
Unfortunately, a validated diagnostic test to speciate both human and simian Plasmodium isn't currently readily available. (cdc.gov)
Biology4
To better understand Plasmodium biology, researchers can whether proceed to in vitro studies or use in vivo models. (wjgnet.com)
CDC has developed a protocol for treating NHPs identified to be infected with Plasmodium during quarantine. (cdc.gov)
Importers reporting Plasmodium- positive NHPs during the CDC-mandated quarantine period will be required to adhere to the following treatment algorithm before the infected animals will be released from quarantine. (cdc.gov)
Protein1
Adams had identified the Duffy binding protein that is essential for Plasmodium to dock to red blood cells and then enter them. (the-scientist.com)
Vitro1
Thanks to recent progresses, stem cells have been extensively employed to study Plasmodium liver and blood cycle in vitro . (wjgnet.com)
Human1
The chimpanzee genome sequence is a long-awaited milestone, offering alternatives to discover primate evolution and genetic contributions to human physiology and illness. (primatespark.com)
Background: Diagnostic techniques based on PCR for the detection of Plasmodium DNA can be highly sensitive and specific. (fujita-hu.ac.jp)
Bats1
Sivault E, McConkey K, Bretagnolle F, Sengupta A, Lambert J*, Heymann EW *, Herrel A*, Forget PM* (in press) Body mass and skull dimensions predict seed dispersal capacity in bats, primates and carnivores from tropical forests. (dpz.eu)
We investigate the movement of nonhuman primate-associated flies across landscapes surrounding Kibale National Park, Uganda, using a mark-recapture experiment. (researchgate.net)
Belongs1
An animal is considered to be a primate if it belongs to an order called primate . (com.ng)
Flies1
Flies were marked in nine nonhuman primate groups at. (researchgate.net)