• Sixty-two patients had recurrent disease and 13 had primary tumors. (nih.gov)
  • The primary source of metastatic tumors is more oftentotal is squamous cell carcinoma of the cervix, then - cancer of the endometrium, bladder and urethra. (med-blog.com)
  • In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
  • These lesions are considered to be independent primary lesions rather than metastatic disease when multiple tumors are encountered in the same patient. (allenpress.com)
  • Biopsy was conducted from the right tibia at a primary care hospital in Larkana four months prior to presenting at Indus Hospital, and histopathological analysis confirmed a diagnosis of plasmablastic lymphoma. (hindawi.com)
  • Primary Mediastinal Large B-Cell Lymphoma (PMBL) is a rare neoplasm that arises in the mediastinum, and then forms a mass. (jcimcr.org)
  • incidence rates were highest for leukemia (46.6), central nervous system (CNS) neoplasms (30.8), and lymphoma (27.3). (cdc.gov)
  • Treatment of moderate to severe vasomotor symptoms due to menopause )  Treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to Limitation of Use: When prescribing solely for the treatment of moderate to severe Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism. (gotomydoctor.com)
  • When prescribing solely for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause, topical vaginal products should be considered. (pillintrip.com)
  • When prescribing solely for the treatment of symptoms of vulvar and vaginal atrophy, topical vaginal products should be considered. (pfizermedicalinformation.ca)
  • This summary addresses squamous cell cancer of the vulva and vulvar intraepithelial neoplasias (VIN), some of which are thought to be precursors to invasive squamous cell cancers. (cancer.gov)
  • Invasive and preinvasive neoplasms of the vulva may be HPV-induced, and the carcinogenic effect may be widespread in the vulvar epithelium. (cancer.gov)
  • Frequent and rapid metastasis of vulvar cancer is due to a richly developed lymphatic network that covers the entire vulva and leads the lymph primarily to the inguinal, femoral (deep inguinal) and iliac lymph nodes. (med-blog.com)
  • The outflow of lymph from the posterior parts of the vulva occurs in the inguinal lymph nodes located on the localization side of the tumor, from the anterior sections the outflow occurs in the same lymph nodes and, in addition, through the pre-symphysical plexus to the inguinal lymph nodes located on the opposite side. (med-blog.com)
  • LC can be found on the proximal extremities, trunk, axilla, and oral cavity but also may occur on the penis, scrotum, and the vulva. (astrocyte.in)
  • More than 90% of invasive vulvar cancers are squamous cell carcinomas. (cancer.gov)
  • Human papillomavirus (HPV) infection: In many cases, the development of vulvar cancer is preceded by condyloma or squamous dysplasia. (cancer.gov)
  • Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. (cancer.gov)
  • We analyzed genetic changes in condylomas (four cases), vulvar intraepithelial neoplasia I-III (VIN I-III, eleven cases), and primary vulvar squamous cell carcinomas (VSCC, ten cases) by high-resolution comparative genomic hybridization (HR-CGH) and flowcytometry. (nih.gov)
  • It proved to be a valid biomarker especially in detecting squamous intraepithelial lesions in cervical liquid-based samples and in discerning these lesions from their mimickers, as well as in ovarian, endometrial, vulvar, primary and metastatic melanomas, breast, pancreatic and renal cell carcinomas. (medsci.org)
  • Clinically, the most significant histological forms are malignant neoplasms developing from the integumentary squamous epithelium of the external genital organs. (med-blog.com)
  • Background: Increased risk of a second primary malignancy (SPM) before or after diagnosis of anal squamous cell carcinoma (ASCC) has been reported in a previous single-institution study. (elsevierpure.com)
  • The most recent Patient Webinar: Squamous Cell Skin Cancer occurred in September 2023. (nccn.org)
  • In Russia, in the structure of the incidence of malignant neoplasms of the female genital organs, vulvar cancer is from 3 to 8% and takes fourth place. (med-blog.com)
  • more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (lookformedical.com)
  • Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
  • Gestational choriocarcinoma accounts for 5% of gestational trophoblastic neoplasms. (bvsalud.org)
  • Vulvar cancer accounts for about 6% of cancers of the female genital system in the United States. (cancer.gov)
  • Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer. (cancer.gov)
  • Vulvar cancer - a relatively rare tumor. (med-blog.com)
  • In the US, vulvar cancer accounts for about 4% of all cases of cancer of the female reproductive sphere and 0.6% of all cases of cancer in women. (med-blog.com)
  • The average age of patients with vulvar cancer at the time of detection of the disease is 68 years. (med-blog.com)
  • In girls and women of reproductive age, vulvar cancer is very rare. (med-blog.com)
  • Thus, vulvar cancer is a disease of elderly women. (med-blog.com)
  • The etiology and pathogenesis of vulvar cancer are not well understood. (med-blog.com)
  • The frequency of metastasis of vulvar cancer to the lymph nodes of the inguinal-femoral collector in operable patients is 30-50%, at the first stage superficial inguinal lymph nodes are affected, at the second - deep, located around the main femoral vessels. (med-blog.com)
  • The primary objective of this study was to identify the diagnoses of cancer most likely to occur as SPMs before or after ASCC. (elsevierpure.com)
  • Patients with ASCC had an increased rate of previous malignancy (SIR = 1.23), especially Kaposi sarcoma or vulvar cancer. (elsevierpure.com)
  • To our knowledge this is the first reported case of an isolated vesicocutaneous fistula related to previous radiation therapy for recurrent vulvar cancer. (annals.edu.sg)
  • A soft polypoid mass, which is a rare form of primary vaginal cancer. (brainscape.com)
  • Cancer registries do not routinely collect information about HPV status, so in this report, HPV-associated cancers are defined as those that occur in parts of the body where HPV is often found. (cdc.gov)
  • Based on a CDC study that used population-based data to genotype HPV types from cancer tissue, about 90% of cervical and anal cancers, 70% of oropharyngeal, vaginal, and vulvar cancers, and 60% of penile cancers are attributable to HPV. (cdc.gov)
  • We analyzed the expression of 84 miRNAs in 27 primary melanoma and 5 nevus formalin-fixed paraffin-embedded (FFPE) samples using the Human Cancer PathwayFinder miScript miRNA PCR Array. (bjbms.org)
  • Overall, we identified several miRNAs with significantly altered expression in primary melanomas, including those reported for the first time in this type of cancer. (bjbms.org)
  • Weight loss may occur in esophageal cancer due to decreased food intake or due to the direct effect of the tumor. (indiahealthtour.com)
  • Pain during swallowing may occur due to obstruction caused by the esophageal cancer. (indiahealthtour.com)
  • During fellowship she was trained in advanced colposcopy, high-resolution anoscopy (HRA) and treatment of cervical, vulvar, vaginal and anal disease. (stanford.edu)
  • These are flat, moist, minimally elevated lesions that occur in secondary syphilis. (brainscape.com)
  • and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. (lookformedical.com)
  • The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
  • This paper reviews the clinicopathologic features of this uncommon neoplasm with detailed discussion of the role of Epstein-Barr virus in the pathogenesis. (allenpress.com)
  • Melanoma can occur in any tissue that contains melanocytes. (bjbms.org)
  • The labia majora are the most common sites of vulvar carcinoma and account for about 50% of cases. (cancer.gov)
  • The labia minora account for 15% to 20% of vulvar carcinoma cases. (cancer.gov)
  • May have underlying carcinoma of a vulvar or perineal gland. (brainscape.com)
  • Breast disorders occurring in pediatric patients range from congenital conditions to neonatal infections and from benign disorders such as fibroadenoma in females and gynecomastia in males to breast carcinoma and rhabdomyosarcoma . (medscape.com)
  • Not all vulvar, vaginal, and anal cancers are caused by HPV, and GARDASIL protects only against those vulvar, vaginal, and anal cancers caused by HPV (Human Papillomavirus). (currenthealthscenario.com)
  • This article is intended for primary care clinicians, infectious disease specialists, obstetrician-gynecologists, hematologists/oncologists, nurses, pharmacists, public health officials, and other members of the healthcare team involved in human papillomavirus (HPV) vaccination. (medscape.org)
  • Primary neoplasms that arise in anogenital areas are most commonly associated with chronic human papillomavirus (HPV) infection. (mhmedical.com)
  • Based on data from 2013 to 2017 about 45,300 new cases of HPV-associated cancers occurred in the United States each year, including about 25,400 among women, and about 19,900 among men. (cdc.gov)
  • CNS neoplasms rates increased until 2017 and then decreased. (cdc.gov)
  • Although further investigation is necessary, GnRH agonists may be of value, for either primary or recurrent, which are not amenable to surgical excision. (surgpath4u.com)
  • The size of the primary tumor is less important in defining prognosis. (cancer.gov)
  • Myeloid sarcoma is a rare solid tumor of the myelogenous cells occurring in an extramedullary site. (nih.gov)
  • Epstein-Barr virus-associated smooth muscle tumor is an uncommon neoplasm associated with immunodeficiency. (allenpress.com)
  • Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) is an uncommon neoplasm typically manifesting in immunodeficient individuals. (allenpress.com)
  • The tumor tends to occur mainly in one location in most patients, but simultaneous occurrences in multiple sites have been reported. (allenpress.com)
  • Primary EMPD originates in epidermis or adnexal structures, whereas secondary EMPD develops in association with internal malignancy, commonly malignancy in the gastrointestinal or urinary tract. (karger.com)
  • A tissue specimen examination, collected by incisional skin biopsy from the lesion at right inguinal area, showed epidermal proliferation with nests of clear cell neoplasm with pagetoid spreading through the epidermis with flattened basal cell layer lying between clear cell neoplasm and the underlying epidermis (Fig. 2 ). (karger.com)
  • Epidermal proliferation with nests of clear cell neoplasm with pagetoid spreading through the epidermis with flattened basal cell layer. (karger.com)
  • Histopathologic examination of the biopsied vulvar papule demonstrated hyperkeratotic epidermis and dilatation of thin-walled lymph vessels in superficial dermal papillae. (astrocyte.in)
  • It is a neoplasm with unusual properties and unconventional clinical development, naturally occurring exclusively in dogs contaminated primarily by sexual contact and possibly by direct contact related with social behaviour (e.g., sniffing, licking of the genitalia, bite wounds during fights). (vin.com)
  • This case of acquired vulvar LC is presented to emphasize that, met with a clinical picture expectant with the possibility of LC, a definite suspicion must be kept if a significant past surgical history exists, which can explain the physiopathology associated with the entity. (astrocyte.in)
  • Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. (nih.gov)
  • Vulvar lesion. (cancer.gov)
  • Presents as a non-painful cyst-like lesion or ill-defined swelling of the vulvar region. (surgpath4u.com)
  • The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secrets 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. (nih.gov)
  • Prognosis depends on the pathological status of the inguinal lymph nodes and whether spread to adjacent structures has occurred. (cancer.gov)
  • In placental mammals this process of gestation occurs inside the reproductive system of the mother of the embryo. (wikipedia.org)
  • The disease usually (80%) occurred in animals of reproductive age (2 to 8 years old) and less often at older ones. (vin.com)
  • Epstein-Barr virus-associated SMT is an uncommon soft tissue neoplasm affecting both adult and pediatric populations. (allenpress.com)
  • They can occur in any organ , but the most common forms occur in the uterus , small bowel and the esophagus . (wikidoc.org)
  • Histopathological analysis revealed sheets and aggregates of neoplasm replacing bone marrow interspersed with sclerotic bony fragments. (hindawi.com)
  • The development of the disease is often induced by hormonal changes occurring in the body of a woman in menopause and postmenopausal periods. (med-blog.com)
  • Occurs most commonly in postmenopausal women. (brainscape.com)
  • the relief of menopausal and postmenopausal symptoms occurring in naturally or surgically induced estrogen deficiency states including vulvar and vaginal atrophy. (pfizermedicalinformation.ca)
  • Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm that occurs in apocrine-bearing areas of skin. (karger.com)
  • TVT was rare in "strictly" supervised home-kept companion animals (4%), occurring only after escape to experience an uncontrolled-unwanted copulation. (vin.com)
  • Primary vulvar involvement is very rare. (astrocyte.in)
  • 1 Subsequently, Chadwick et al 2 reported SMT in human immunodeficiency virus (HIV)-infected children and asserted the association between HIV and these rare neoplasms. (allenpress.com)
  • Therefore, in context of diagnosis, prognosis, and therapy, a bacterial urinary tract infection (UTI) may be viewed as a secondary (or complicating) rather than a primary (or definitive) diagnostic entity. (ivis.org)
  • The patient had received treatment for osteomyelitis after a presumptive diagnosis made by a primary care physician in Larkana a year back. (hindawi.com)
  • A diagnosis of an STI may not be made until serious health consequences have occurred. (wildirismedicaleducation.com)
  • The physiopathological features helped clinch the diagnosis of vulvar lymphangioma circumscriptum. (astrocyte.in)
  • Every year approximately 380000 new cases of UC occur in the world, with an estimated 15210 deaths from disease [ 1 ]. (medsci.org)
  • Budding of the breasts, or thelarche, usually occurs at approximately age 10-11 years in females. (medscape.com)
  • An extra breast (ie, polymastia) or extra nipple (ie, polythelia) occurs in approximately 1% of the population. (medscape.com)
  • Magnetic resonance imaging (MRI) of the primary site demonstrated lobulated abnormal signal intensity enhancing soft tissue mass arising from the medullary cavity of the right tibia. (hindawi.com)
  • An increased number of skin and soft-tissue abscesses caused by community-acquired methicillin-resistant S aureus (MRSA) have occurred in children. (medscape.com)
  • Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined to represent a paraneoplastic syndrome. (medscape.com)
  • Chondrosarcoma is the most common neoplasm in this syndrome, affecting about 30% of patients (see Pathophysiology ). (medscape.com)
  • Patients with Maffucci syndrome usually lead reasonably normal lives with a normal life expectancy if no malignant transformation occurs. (medscape.com)
  • Acanthosis nigricans (AN) manifests as a hyperpigmented, velvety thickening of the skin that usually occurs in the intertriginous zones, including the axillae, groin, neck, and inframammary folds. (medscape.com)
  • No abdominal wall complications occurred in the DIEP flap group, whereas four cases of donor-site morbidity were registered in the TRAM group, even though mesh was used in all cases. (nih.gov)
  • Without antibiotic treatment, complications can occur. (lecturio.com)
  • Neutrophilic eccrine hidradenitis (NEH) is a neutrophilic dermatosis primarily affecting the eccrine glands and occurs most commonly in patients undergoing chemotherapy for a malignancy. (annals.edu.sg)
  • Results: A total of 7,594 patients with primary ASCC were included. (elsevierpure.com)
  • Aggressive (deep) angiomyxoma is a paucicellular neoplasm consisting of spindle-shaped cells with delicate cytoplasmic processes embedded in a loose myxoid stroma. (surgpath4u.com)
  • Deep (aggressive) angiomyxoma typically occurs in the pelvis and perineum of women, although some cases have been reported in the inguinoscrotal region of men. (surgpath4u.com)
  • HMGA2 positivity is also aberrantly expressed in occasional vulvovaginal smooth muscle neoplasms -- it has emerged as a helpful stain in distinguishing aggressive angiomyxomas from other stromal neoplasms and in some cases, assessing resection margins (Oliva, McCluggage 2009). (surgpath4u.com)
  • Why is it Important to Recognize that Bacterial Urinary Tract Infection is not a Primary Diagnostic Entity? (ivis.org)
  • This article reports two cases of familial vulvar EMPD in female siblings. (karger.com)
  • 6 A few cases occurring in the adrenal glands have been reported. (allenpress.com)
  • However, it occurs in a cutaneous or subcutaneous location with more delicate vessels. (surgpath4u.com)
  • Transmission occurs by inoculation of intact neoplastic cells in the damaged mucosa or skin. (vin.com)
  • Neoplastic changes occur in enchondromas. (medscape.com)
  • The disease is categorized by its origins into two forms: primary and secondary. (karger.com)
  • They are classified essentially as primary (true, epithelial) and secondary (pseudo, non-epithelial) based on the presence. (annals.edu.sg)
  • The condition is either primary (usually present at birth or develops in early childhood) or secondary (induced by impaired lymph flow). (astrocyte.in)
  • None of the four most frequent changes in the VSCC samples occurred exclusively in the HPV-positive or -negative samples. (nih.gov)
  • These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. (lookformedical.com)
  • Other paraneoplastic syndromes that commonly occur with AN include tripe palms and the sign of Leser-Trélat (which are discussed below). (medscape.com)
  • The aim of the present study was to compare miRNA expression between primary melanomas from different sites. (bjbms.org)