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  • vivo
  • After careful mobilization of the affected colon segment, isosulfan blue 1% is injected in vivo into the subserosa circumferentially around the tumor. (clinicaltrials.gov)
  • Pathology
  • 1. A method of treating an individual having a neoplastic pathology comprising applying to cells of a tumor electrical field pulses having a strength of 2-150 V/cm, a repetition frequency of 1 Hz - 100 kHz and a pulse width of 1 μs-100 ms for a time period of 1 second to 60 minutes thereby treating the individual suffering from a neoplastic disorder. (naturalpharmainternational.com)
  • clonal
  • Tumor heterogeneity is defined as the simultaneous presence of multiple clonal subpopulations of tumor cells within a single neoplasm [ 1 ]. (biomedcentral.com)
  • This technique has currently turned out to be the one best suited in drawing the outline of the cross-sectional view of the clonal evolution occurring within individual tumors. (aacrjournals.org)
  • 21 , 22 , 23 ] High levels of viral DNA and clonal integration of the virus in MCC tumors have also been reported [ 24 ] along with expression of certain viral antigens in MCC cells and the presence of antiviral antibodies. (nkch.org)
  • specimens
  • In 2008, a novel polyomavirus (Merkel cell polyoma virus, MCPyV) was first reported in MCC tumor specimens [ 20 ], a finding subsequently confirmed in other laboratories. (nkch.org)
  • 8 , 26 , 27 , 28 ] Various methods have been used to identify and quantify the presence of MCPyV in MCC tumor specimens, other non-MCC tumors, blood, urine, and other tissues. (nkch.org)
  • neuroendocrine
  • This review summarizes the current approach to the diagnosis, classification, grading, and therapeutic stratification of neuroendocrine neoplasms, with a focus on those arising in the lung and thymus, pancreas, and intestines. (labome.org)
  • tissues
  • We applied our previously published mathematical heterogeneity model to decipher tumor heterogeneity through the analysis of genetic copy number aberrations revealed by array CGH data for tumors of three different tissues: breast, colon, and skin. (biomedcentral.com)
  • They are often classified as small round cell tumors arising from soft tissues. (hindawi.com)
  • breast
  • Out of 48 cases, lung was primary site in 16 cases, gastrointestinal and pancreatico biliary tract in 12 cases, breast in 4 cases, thyroid in 5 cases, ovary in 8 cases and kidney in 3 cases. (healthdocbox.com)
  • CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. (semanticscholar.org)
  • Indeed, the ability to locate and quantify tumor growth longitudinally in a single cohort of animals to completion of the study as opposed to sacrificing individual groups of animals at specific assay times has revolutionized how researchers investigate breast cancer metastasis. (jove.com)
  • Using the 4T1 model of breast cancer metastasis, we show that the in vivo activity of a synthetic Smad Binding Element (SBE) promoter was decreased dramatically in pulmonary metastasis as compared to that measured in the primary tumor 4-6 . (jove.com)
  • heterogeneity
  • Thus, heterogeneity is an important feature of tumors. (biomedcentral.com)
  • However, due to limitations in experimental and analytical techniques, tumor heterogeneity has rarely been studied in detail. (biomedcentral.com)
  • Different tumor types have different heterogeneity patterns, thus heterogeneity could be a characteristic feature of a particular tumor type. (biomedcentral.com)
  • The analysis confirms that different tumor types have different heterogeneity patterns. (biomedcentral.com)
  • Our observations imply that tumor heterogeneity could be seen as an independent parameter for determining the characteristics of tumors. (biomedcentral.com)
  • The concept of tumor heterogeneity implies the important fact that all of the components actually both constitute and contribute to a tumor society. (biomedcentral.com)
  • In the present study, a multiple-type tumor collection with a relatively large sample size allowed us to explore some characteristics of tumor heterogeneity. (biomedcentral.com)
  • Through the analysis of array CGH data using our established heterogeneity model, we deciphered DNA copy number profiles for the major subpopulations in each tumor. (biomedcentral.com)
  • Significant differences of tumor heterogeneity between different tumors suggest that tumor heterogeneity could be a characteristic feature and a potential clinical parameter for characterizing tumors. (biomedcentral.com)
  • All microsatellites manifested LOH ranging from 44 to 76% in primary tumor and showed various degree of heterogeneity between primary tumor and lymph node metastasis. (aacrjournals.org)
  • Diagnostic
  • Initially the tumor is small and cannot be detected by available diagnostic tools, and the disease proceeds through its pre-clinical phase . (what-is-cancer.com)
  • examination
  • After initial histopathological examination on haematoxylin and eosin stained section, panel of immunohistochemistry were applied in search of most possible primaries. (healthdocbox.com)
  • macroscopic
  • The sectioning was carried out to cover the entire tumor spread using macroscopic and radiologic findings as references. (nih.gov)
  • stages
  • Here we demonstrate the in vivo utility of these two enzymes such that one luminescence reaction specifically marks the size and location of a developing tumor, while the second luminescent reaction serves as a means to visualize the activation status of specific signaling systems during distinct stages of tumor and metastasis development. (jove.com)
  • hypothesis
  • Halsted's hypothesis, according to which the tumor is the only threat to the patient. (what-is-cancer.com)
  • This hypothesis implies that tumor removal should cure the patient, yet sixty years of intensive effort to remove the tumor, did not change the biological outcome of the disease (Fig. 1). (what-is-cancer.com)