Unlike classical lung adenocarcinoma, the primary driver genes implicated in SMARCA4-dNSCLC, as revealed by molecular detection tests, primarily involve SMARCA4, TP53, KRAS and STK11 , while the more commonly associated driver genes like EGFR, ALK and ROS1 show no marked association ( 1 ). (spandidos-publications.com)
Mediastinal3
Primary mediastinal malignancies: findings in 219 patients. (medscape.com)
Strollo DC, Rosado de Christenson ML, Jett JR. Primary mediastinal tumors. (medscape.com)
Takeda S, Miyoshi S, Akashi A. Clinical spectrum of primary mediastinal tumors: a comparison of adult and pediatric populations at a single Japanese institution. (medscape.com)
Lung1
Other equally important roles of Cryoinvolve diagnosis of ILD (Interstitial lung disease), Sarcoidosis (an inflammatory disease that affects one or more organs), Lymphoma (cancer that begins in infection-fighting cells of the immune system), removal of foreign body and blood clots from lung, recanalization of an obstructive tracheal and/or bronchial tumor, and diagnosis and treatment of Carcinoid tumor (a tumor that often begins in the stomach)," said Dr. Jha. (chemrobotics.in)
Benign1
Structural problems, such as compression syndromes that involve the bronchi or lungs or superior vena cava syndrome (SVCS), can occur from local spread of benign thymoma, from thymic cysts, or from thymic carcinoma. (medscape.com)
Patients1
Comparative Genomic Landscape of Urothelial Carcinoma of the Bladder Among Patients of East and South Asian Genomic Ancestry. (moffitt.org)
We are reporting the second published case of spindle cell sarcomatoid carcinoma of the trachea and the first reported successful outcome of definitive treatment with tracheal resection. (biomedcentral.com)
Poorly differentiated4
Sarcomatoid carcinomas are a group of poorly differentiated non-small cell lung carcinomas containing a component of sarcoma or sarcoma-like (spindle and/or giant cell) differentiation, categorized into five morphologic subgroups. (biomedcentral.com)
Spindle cell carcinoma belongs to a group of poorly differentiated non-small cell carcinomas known as sarcomatoid carcinomas. (biomedcentral.com)
In this article, we report a case of poorly differentiated salivary duct carcinoma of the submandibular gland with distant metastases who was successfully treated with pembrolizumab monotherapy. (bvsalud.org)
Needle biopsy showed poorly differentiated carcinoma, positive human epidermal growth factor receptor 2, and positive androgen receptor, which suggests salivary duct carcinoma. (bvsalud.org)
Dyspnea3
We present a 75-year-old male, having progressive dyspnea and cough, with a spindle cell sarcomatoid carcinoma tumor visualized on chest computed tomography scan and confirmed with biopsy. (biomedcentral.com)
Here we report a case of a former smoker presenting with progressive dyspnea, discovered to have primary tracheal spindle cell sarcomatoid carcinoma treated definitively with surgical resection. (biomedcentral.com)
In patients with chronic stricture, tracheomalacia may result from weakness of tracheal cartilage and can be a cause of dyspnea. (radiopaedia.org)
Tumors3
Primary malignant tracheal tumors are rare, accounting for approximately 0.2 % of respiratory tract tumors yearly, with squamous cell carcinomas and adenoid cystic carcinomas accounting for two-thirds of these cases. (biomedcentral.com)
Primary tracheal tumors are rare, with malignancy occurring at a rate of 0.1 new cases per 100,000 every year, corresponding to 0.2 % of all tumors involving the respiratory tract [ 1 ]. (biomedcentral.com)
Strollo DC, Rosado de Christenson ML, Jett JR. Primary mediastinal tumors. (medscape.com)
Stenosis2
Tracheal stenosis is usually acquired following intubation or tracheostomy. (radiopaedia.org)
Computed tomography (CT) and ultrasonography (US) showed tumor extension to the right thyroid lobe and between the first and third tracheal rings, which caused severe stenosis of the lumen. (bvsalud.org)
Prognosis1
Generally, tracheal carcinomas have poor prognosis, with 5-year survival rates of up to 15 % and 10-year survival rates of 7 % [ 1 ]. (biomedcentral.com)
Papillary1
Invasive thyroglossal duct cyst papillary carcinoma: a case report. (medscape.com)
Malignancies2
Additionally, no universally accepted TNM classification for tracheal malignancies exists, and proposed staging systems are based on a small number of considered cases [ 1 , 8 ]. (biomedcentral.com)
Primary mediastinal malignancies: findings in 219 patients. (medscape.com)
Salivary2
Salivary gland carcinoma is a rare type of cancer with more than 20 different histopathological types. (bvsalud.org)
Despite the lack of evidence for the efficacy of immune checkpoint inhibitors in salivary gland carcinoma, some cases might successfully respond to this treatment, as in the current case. (bvsalud.org)
Description: Established from the sarcomatoid component of a grade III transitional cell carcinoma. (creative-bioarray.com)
Cancers1
Primary tracheal cancers are more common in current or former male cigarette smokers, with peak incidence in the sixth decade of life [ 2 , 3 ]. (biomedcentral.com)
Variant1
Spindle cell sarcomatoid carcinoma is a rare variant of sarcomatoid carcinomas, consisting of only spindle-shaped tumor cells. (biomedcentral.com)
Based on the aforementioned data, a diagnosis of submandibular carcinoma T4aN2bM1 stage IVC was established. (bvsalud.org)
Lung1
Furthermore, the accumulation of NETs was exhibited in fixed lung tissues, as well as Ansatrienin A in tracheal aspirates of COVID-19 patients on mechanical ventilation [20]. (exposed-skin-care.net)
Metastasis1
While chemotherapy has been the mainstay of treatment for unresectable carcinomas, such as multiple recurrence or distant metastasis, no standard regimen had yet been approved. (bvsalud.org)
Thyroid1
We first suspected anaplastic thyroid carcinoma (ATC) but diagnosed ACC after performing fine-needle aspiration cytology (FNAC). (bvsalud.org)
Case report1
Menstruating from the umbilicus as a rare case of primary umbilical endometriosis: a case report. (medscape.com)
Patient1
We report a case of a patient with parotid carcinoma with skin infiltration who successfully underwent skin reconstruction with the bilobed flap. (bvsalud.org)